Coincident diabetes mellitus and primary hyperparathyroidism.


:The prevalence of diabetes mellitus in primary hyperparathyroidism is approximately 8% and that of primary hyperparathyroidism in diabetic patients is approximately 1%. Both values are about three-fold higher than the respective expected prevalences in general populations. Patients with both disorders are over 40 years of age and 80% are female; 22% have type 1 and 78% type 2 diabetes. Primary hyperparathyroidism presents first in approximately 20% of patients, and diabetes mellitus in 40%; both disorders present together, or within 1 year, in 40%. Approximately 40% of patients with primary hyperparathyroidism have impaired glucose tolerance. Insulin resistance is present in hyperparathyroidism and probably arises from a raised intracellular free calcium concentration which, by decreasing normal insulin-stimulated glucose transport, increases the requirement for insulin: if this insulin resistance progresses, impaired glucose tolerance and diabetes mellitus would result. Parathyroidectomy has been followed by regression of diabetes and of impaired glucose tolerance in some but not all patients. Early diagnosis of the second disorder is clinically desirable when one disorder is present. Hyperparathyroid patients should therefore be screened for impaired glucose tolerance and diabetes annually, and pre-operatively. Diabetic patients should be checked for hypercalcaemia at appropriate intervals; although only 1% of them may have hyperparathyroidism, this disorder if untreated is associated with hypertension, to which diabetic patients are already prone.


Diabetes Metab Res Rev


Taylor WH,Khaleeli AA





Has Abstract


2001-05-01 00:00:00














  • Prevalence of undiagnosed dysglycemia in an emergency department observation unit.

    abstract:BACKGROUND:The proposed 2015 US Preventive Services Task Force guidelines recommend diabetes screening for individuals ≥45 years or demonstrating other risk factors for dysglycemia. Still, many patients with dysglycemia remain undiagnosed, and opportunities for early intervention are lost. METHODS:To test novel approa...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Silverman RA,Schleicher MG,Valente CJ,Kim M,Romanenko Y,Schulman RC,Tiberio A,Greenblatt B,Rentala M,Salvador-Kelly AV,Kwon NS,Jornsay DL

    更新日期:2016-01-01 00:00:00

  • Oestradiol levels may differ between premenopausal women, ages 18-50, with type 1 diabetes and matched controls.

    abstract:BACKGROUND:This study aimed to investigate whether oestradiol differs between premenopausal women with and without type 1 diabetes and whether levels are associated with such factors as age, reproductive history or diabetes management. METHODS:Oestradiol in premenopausal women with type 1 diabetes (n = 89; age = 18-50...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Hassan LS,Monson RS,Danielson KK

    更新日期:2017-02-01 00:00:00

  • Lipid metabolism in the fetus and the newborn.

    abstract::During late gestation, although maternal adipose tissue lipolytic activity becomes enhanced, lipolytic products cross the placenta with difficulty. Under fasting conditions, free fatty acids (FFA) are used for ketogenesis by the mother, and ketone bodies are used as fuels and lipogenic substrates by the fetus. Materna...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Herrera E,Amusquivar E

    更新日期:2000-05-01 00:00:00

  • Temporal trends in quality of primary care for patients with type 2 diabetes mellitus: A population-based retrospective cohort study after implementation of a quality improvement initiative.

    abstract:BACKGROUND:This study examined whether temporal trends exist in treatment of patients with type 2 diabetes (T2D) and quality of diabetes care after implementation of quality improvement initiative in primary care setting. METHODS:We conducted a population-based retrospective cohort study of 202,284 patients with T2D w...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Wong CKH,Fung CSC,Yu EYT,Wan EYF,Chan AKC,Lam CLK

    更新日期:2018-02-01 00:00:00

  • The changing world demography of type 2 diabetes.

    abstract::In recent years it has been estimated that the current global prevalence of type 2 diabetes amounts to about 150 million patients. Projections suggest that by the year 2025 the number of prevalent patients in the world will reach approximately 300 million. It is assumed that the increase in the number of patients will...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Green A,Christian Hirsch N,Pramming SK

    更新日期:2003-01-01 00:00:00

  • Serum ferritin and glucose homeostasis: change in the association by glycaemic state.

    abstract:BACKGROUND:Data on the association between body iron and glucose homeostasis by the three glycaemic states are scarce. Thus, we investigated the association between body iron as assessed by a serum ferritin concentration and glucose homeostasis using homeostasis model assessment (HOMA) of insulin resistance (HOMA-IR) a...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Aregbesola A,Virtanen JK,Voutilainen S,Mursu J,Lagundoye A,Kauhanen J,Tuomainen TP

    更新日期:2015-07-01 00:00:00

  • Exercise training restores abnormal myocardial glucose utilization and cardiac function in diabetes.

    abstract:BACKGROUND:Clinical and experimental studies have shown that a reduction in myocardial glucose utilization is a factor contributing to diabetic cardiomyopathy. This study determined whether exercise training could prevent the depression in glucose utilization observed in the diabetic rat heart. METHODS:Diabetes was in...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Broderick TL,Poirier P,Gillis M

    更新日期:2005-01-01 00:00:00

  • Identification of specific angiotensin-converting enzyme variants and haplotypes that confer risk and protection against type 2 diabetic nephropathy.

    abstract:BACKGROUND:Cross-sectional and family studies identified angiotensin-converting enzyme (ACE) gene as a risk factor for diabetic nephropathy (DN). The contribution of ACE gene variants to DN development and progression is controversial and varies among different ethnic/racial groups. METHODS:We investigated the associa...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Ezzidi I,Mtiraoui N,Kacem M,Chaieb M,Mahjoub T,Almawi WY

    更新日期:2009-11-01 00:00:00

  • Advanced glycation end products and diabetic foot disease.

    abstract::Diabetic foot disease is an important complication of diabetes. The development and outcome of foot ulcers are related to the interplay between numerous diabetes-related factors such as nerve dysfunction, impaired wound healing and microvascular and/or macrovascular disease.The formation of advanced glycation end prod...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Huijberts MS,Schaper NC,Schalkwijk CG

    更新日期:2008-05-01 00:00:00

  • Positive effects of GLP-1 receptor activation with liraglutide on pancreatic islet morphology and metabolic control in C57BL/KsJ db/db mice with degenerative diabetes.

    abstract:BACKGROUND:Stable glucagon-like peptide-1 (GLP-1) mimetics, such as the GLP-1 analogue liraglutide, are approved for treatment of type 2 diabetes. GLP-1 has a spectrum of anti-diabetic effects that are of possible utility in the treatment of more severe forms of diabetes. METHODS:The present study has evaluated the ef...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Moffett RC,Patterson S,Irwin N,Flatt PR

    更新日期:2015-03-01 00:00:00

  • Insulin pump therapy in type 1 pediatric patients: now and into the year 2000.

    abstract::There are a number of medical conditions such as growth failure in children, pregnancy, lipid abnormalities, and early complications that are improved by the meticulous glycemic control that can be achieved with insulin pump therapy (CSII). By using an insulin pump, many patients with severe hypoglycemia, the dawn phe...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Kaufman FR,Halvorson M,Miller D,Mackenzie M,Fisher LK,Pitukcheewanont P

    更新日期:1999-09-01 00:00:00

  • Establishing a multidisciplinary diabetic foot team in a large tertiary hospital: a workshop.

    abstract::Every year, over 1 million people with diabetes lose a leg due to diabetic foot disease. Most amputations are preceded by a foot ulcer. Causes for the development of foot ulcers are generally multifactorial and may include neuropathy, peripheral vasculopathy, abnormal foot mechanics and infection. Multidisciplinary ap...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Cahn A,Elishuv O,Olshtain-Pops K

    更新日期:2014-07-01 00:00:00

  • Can we prevent beta cell apoptosis in type 2 diabetes?

    abstract::Since the publication of the United Kingdom Prospective Diabetes Study (UKPDS), the progressive nature of type 2 (DM2) diabetes has been identified as the main cause of failure to maintain a long term glycemic control.[1] The need to adjust treatment as the disease progressed was recognized and algorithms for treatmen...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Eliaschewitz FG,Tambascia MA

    更新日期:2012-12-05 00:00:00

  • Risk factors in V-shaped risk associations with all-cause mortality in type 2 diabetes-The Hong Kong Diabetes Registry.

    abstract:BACKGROUND:Body mass index (BMI) is associated with death in a V-shaped manner in general populations but it is unknown whether BMI or other risk factors also exhibit V-shaped relationships with death in type 2 diabetic patients. METHODS:A prospective cohort of 7534 Chinese, type 2 diabetic patients enrolled since 199...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: So WY,Yang X,Ma RC,Kong AP,Lam CW,Ho CS,Cockram CS,Ko GT,Chow CC,Wong V,Tong PC,Chan JC

    更新日期:2008-03-01 00:00:00

  • Blood group AB is protective factor for gestational diabetes mellitus: a prospective population-based study in Tianjin, China.

    abstract:BACKGROUND:The ABO blood types are associated with cancers, cardiovascular diseases and type 2 diabetes mellitus but whether they are also associated with gestational diabetes mellitus (GDM) is unknown. We examined the relationship between the ABO blood types and the risk of GDM in a prospective population-based Chines...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Zhang C,Li Y,Wang L,Sun S,Liu G,Leng J,Guo J,Lv L,Li W,Zhang C,Hu G,Yu Z,Yang X

    更新日期:2015-09-01 00:00:00

  • Basal insulin analogues in diabetic pregnancy: a literature review and baseline results of a randomised, controlled trial in type 1 diabetes.

    abstract::As basal insulin analogues are being used off-label, there is a need to evaluate their safety (maternal hypoglycaemia and fetal and perinatal outcomes) and efficacy [haemoglobin A1c(HbA1c), fasting plasma glucose, and maternal weight gain]. The aim of this review is to provide an overview of the current literature con...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,多中心研究,随机对照试验,评审


    authors: Mathiesen ER,Damm P,Jovanovic L,McCance DR,Thyregod C,Jensen AB,Hod M

    更新日期:2011-09-01 00:00:00

  • Endothelin-mediated remodeling in aortas of diabetic rats.

    abstract:BACKGROUND:Smooth muscle cells proliferation and extracellular matrix (ECM) protein deposition are key features of diabetic macroangiopathy. In the present study, we have studied the role of endothelin(A) (ET(A)) receptor, the predominant receptor on smooth muscle cells, in diabetes-induced vascular hypertrophy and rem...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Fukuda G,Khan ZA,Barbin YP,Farhangkhoee H,Tilton RG,Chakrabarti S

    更新日期:2005-07-01 00:00:00

  • Circulating TNF receptors 1 and 2 predict progression of diabetic kidney disease: A meta-analysis.

    abstract:BACKGROUND:We conducted a meta-analysis to investigate the association of circulating tumor necrosis factor-1 (TNFR-1) and TNFR-2 with diabetic kidney disease (DKD) progression, which is the first-ever quantitative analysis of these associations thus far. Whether TNFRs were better than albumin-creatinine ratio (ACR) in...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,meta分析


    authors: Ye X,Luo T,Wang K,Wang Y,Yang S,Li Q,Hu J

    更新日期:2019-11-01 00:00:00

  • Diabetes trends in Africa.

    abstract::Diabetes is an important cause of morbidity and mortality in Africa. Although a dramatic increase in disease burden is projected, it remains to be seen what effect the ongoing devastation of HIV disease will have on the epidemiology of such chronic diseases as diabetes. Recent data on type 2 diabetes prevalence indica...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Motala AA

    更新日期:2002-09-01 00:00:00

  • Outcomes of hyperglycemia in patients with and without diabetes hospitalized for infectious diseases.

    abstract:OBJECTIVE:To examine the prognostic implications of diabetes mellitus (DM) and the importance of glycemic control during hospitalization for infectious diseases. METHODS:Historical prospectively collected data of patients hospitalized between 2011 and 2013. Infection-related hospitalizations were classified according ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Akirov A,Diker-Cohen T,Masri-Iraqi H,Duskin-Bitan H,Shimon I,Gorshtein A

    更新日期:2018-10-01 00:00:00

  • Lessons learned from the 1-hour post-load glucose level during OGTT: Current screening recommendations for dysglycaemia should be revised.

    abstract::This perspective covers a novel area of research describing the inadequacies of current approaches for diagnosing dysglycaemia and proposes that the 1-hour post-load glucose level during the 75-g oral glucose tolerance test may serve as a novel biomarker to detect dysglycaemia earlier than currently recommended screen...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Bergman M,Jagannathan R,Buysschaert M,Pareek M,Olsen MH,Nilsson PM,Medina JL,Roth J,Chetrit A,Groop L,Dankner R

    更新日期:2018-07-01 00:00:00

  • Neuromuscular dysfunction in type 2 diabetes: underlying mechanisms and effect of resistance training.

    abstract::Diabetic patients are at higher risk of developing physical disabilities than non-diabetic subjects. Physical disability appears to be related, at least in part, to muscle dysfunction. Several studies have reported reduced muscle strength and power under dynamic and static conditions in both the upper and lower limbs ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Orlando G,Balducci S,Bazzucchi I,Pugliese G,Sacchetti M

    更新日期:2016-01-01 00:00:00

  • Visceral adiposity index outperforms common anthropometric indices in predicting 10-year diabetes risk: Results from the ATTICA study.

    abstract:BACKGROUND:Visceral adiposity index (VAI) is a novel marker of visceral adipose tissue accumulation and dysfunction. The study aim was to explore the association of VAI with the 10-year type 2 diabetes mellitus (T2DM) incidence in apparently healthy individuals and compare its T2DM predictive ability against common ant...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Koloverou E,Panagiotakos DB,Kyrou I,Stefanadis C,Chrysohoou C,Georgousopoulou EN,Skoumas I,Tousoulis D,Pitsavos C,ATTICA Study group.

    更新日期:2019-09-01 00:00:00

  • Coprevalence of type 2 diabetes mellitus and tuberculosis in low-income and middle-income countries: A systematic review.

    abstract::Increasing coprevalence of diabetes mellitus (DM) and tuberculosis (TB) in low-income and middle-income countries (LMICs) indicates a rising threat to the decades of progress made against TB and requires global attention. This systematic review provides a summary of type 2 diabetes and tuberculosis coprevalence in var...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: McMurry HS,Mendenhall E,Rajendrakumar A,Nambiar L,Satyanarayana S,Shivashankar R

    更新日期:2019-01-01 00:00:00

  • Prognostic value of serum liver enzymes levels in type 2 diabetic patients.

    abstract:BACKGROUND:Elevated liver enzymes are associated with cardiovascular disease, while their relationship with cancer-related mortality has not been assessed so far in diabetic patients. METHODS:An observational cohort study was performed on a consecutive series of 1952 type 2 diabetic patients. The association of liver ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Monami M,Balzi D,Lamanna C,Melani C,Cocca C,Lotti E,Fedeli A,Masotti G,Marchionni N,Mannucci E

    更新日期:2007-11-01 00:00:00

  • Vitamin D deficiency is associated with painful diabetic neuropathy.

    abstract:BACKGROUND:The aetiology of painful diabetic neuropathy is unclear. We have evaluated vitamin D levels in diabetic patients with and without painful neuropathy. METHODS:Forty-three patients with type 1 diabetes and painless (DPN) (n = 20) or painful (PDN) (n = 23) neuropathy and 14 non-diabetic healthy control subject...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Alam U,Petropoulos IN,Ponirakis G,Ferdousi M,Asghar O,Jeziorska M,Marshall A,Boulton AJM,Efron N,Malik RA

    更新日期:2021-01-01 00:00:00

  • Negative T cell costimulation and islet tolerance.

    abstract::Activation of self-reactive T cells that specifically destroy the pancreatic beta-cells is one of the hallmarks in the development of type 1 diabetes. Thus, for prevention and treatment of this autoimmune disease, approaches to induce and maintain T cell tolerance toward the beta-cells, especially in islet transplanta...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Gao W,Demirci G,Li XC

    更新日期:2003-05-01 00:00:00

  • Diabetes and microvascular pathophysiology: role of epidermal growth factor receptor tyrosine kinase.

    abstract::Type 2 diabetes is responsible for the increased prevalence of ischaemic heart disease, generally related to coronary artery disease, which is associated with increased morbidity and death in diabetic patients. Epidermal growth factor receptor (EGFR) tyrosine kinase, one of the many factors involved in cell growth and...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Matrougui K

    更新日期:2010-01-01 00:00:00

  • Should we change the target blood pressure in diabetic patients?

    abstract::Hypertension is a major modifiable risk factor for cardiovascular morbidity and mortality in diabetic patients. Guidelines recommend lowering blood pressure (BP) to less than 130/80 mmHg in diabetic patients. These recommendations are based on several studies in diabetic patients that showed the benefit of intensive B...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Shlomai G,Grossman E

    更新日期:2012-12-01 00:00:00

  • Anti-diabetic and neuroprotective effects of pancreatic islet transplantation into the central nervous system.

    abstract::During the last decades, the central nervous system (CNS) was intensively tested as a site for islet transplantation in different animal models of diabetes. Immunoprivilege properties of intracranial and intrathecal sites were found to delay and reduce rejection of transplanted allo-islets and xeno-islets, especially ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Lazard D,Vardi P,Bloch K

    更新日期:2016-01-01 00:00:00