Mitochondrial dysfunction as a central event for mechanisms underlying insulin resistance: the roles of long chain fatty acids.

abstract：BACKGROUND:Intensive insulin therapy is the gold standard by which Type 1 diabetes is treated. In addition to this therapy, administration of nicotinamide (NA) can be beneficial. This concept is reinforced by the results of a recent meta-analysis of the use of NA in patients with recent-onset Type 1 diabetes. METHODS:...

journal_title：Diabetes/metabolism research and reviews

authors： Visalli N,Cavallo MG,Signore A,Baroni MG,Buzzetti R,Fioriti E,Mesturino C,Fiori R,Lucentini L,Matteoli MC,Crinò A,Corbi S,Spera S,Teodonio C,Paci F,Amoretti R,Pisano L,Suraci C,Multari G,Sulli N,Cervoni M,De Mat

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:Human leukocyte antigen (HLA) genotypes associated with increased risk for type 1 diabetes mellitus (T1D) have been reported to be associated with increased birth weight. We set out to investigate the association between HLA haplotypes conferring risk for T1D and birth weight and search for possible differen...

journal_title：Diabetes/metabolism research and reviews

authors： Peet A,Kool P,Ilonen J,Knip M,Tillmann V,DIABIMMUNE Study Group.

更新日期：2012-07-01 00:00:00

abstract：:The exact cause of the obesity epidemic remains unknown; however, both environmental and genetic factors are involved. People at risk of developing obesity include children with type 1 diabetes mellitus (T1DM), which in turn increases their cardiovascular disease risk. Here, we discuss the clinical and genetic factors...

journal_title：Diabetes/metabolism research and reviews

authors： Łuczyński W,Głowińska-Olszewska B,Bossowski A

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Diabetes commonly leads to long-term complications such as cataract. This study investigated the effects of alpha-lipoic acid (LPA) and its gamma-linolenic acid (GLA) conjugate on cataract development in diabetic sand rats. METHODS:Two separate experiments were conducted. In Experiment 1, sand rats were fed...

journal_title：Diabetes/metabolism research and reviews

authors： Borenshtein D,Ofri R,Werman M,Stark A,Tritschler HJ,Moeller W,Madar Z

更新日期：2001-01-01 00:00:00

abstract：:Ethnic minorities living in high-income countries usually exhibit a greater risk of developing diabetes along with higher morbidity and mortality rates. We evaluated the effectiveness of interventions to improve glycaemic control in ethnic minority groups. Results of major controlled trials, systematic reviews and met...

journal_title：Diabetes/metabolism research and reviews

authors： Lirussi F

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Previous works indicated that the stress on the endoplasmic reticulum (ER) affected nonalcoholic fatty liver disease (NAFLD). However, there is no clear evident on the effect of the regulation of ER stress by angiotensin-converting enzyme 2 (ACE2) on the prevention of NAFLD. METHODS:HepG2 cells were treated...

journal_title：Diabetes/metabolism research and reviews

authors： Cao X,Song LN,Zhang YC,Li Q,Shi TT,Yang FY,Yuan MX,Xin Z,Yang JK

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:There is conflicting information regarding the risk of gestational diabetes mellitus in twin pregnancies. This study was conducted to determine whether the risk of gestational diabetes mellitus is higher in pregnant Japanese women with twin versus singleton pregnancy. METHODS:The prevalence of gestational d...

journal_title：Diabetes/metabolism research and reviews

authors： Morikawa M,Yamada T,Akaishi R,Kojima T,Nishida R,Koyama T,Cho K,Minakami H

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Neck circumference, beyond a measure of obesity, is a unique fat depot with increasing significance. This study aimed to investigate the association between neck circumference and biomarkers, indicators of cardiovascular risk. METHODS:During 2009, 490 volunteers (46 ± 16 years, 40% men) were consecutively e...

journal_title：Diabetes/metabolism research and reviews

authors： Vallianou NG,Evangelopoulos AA,Bountziouka V,Vogiatzakis ED,Bonou MS,Barbetseas J,Avgerinos PC,Panagiotakos DB

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:Securing an early accurate diagnosis of diabetic foot infections and assessment of their severity are of paramount importance since these infections can cause great morbidity and potentially mortality and present formidable challenges in surgical and antimicrobial treatment. METHODS:In June 2018, we searche...

journal_title：Diabetes/metabolism research and reviews

authors： Senneville É,Lipsky BA,Abbas ZG,Aragón-Sánchez J,Diggle M,Embil JM,Kono S,Lavery LA,Malone M,van Asten SA,Urbančič-Rovan V,Peters EJG

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:This article aims to describe the implementation and initial results of an audit-feedback quality improvement initiative in Belgian diabetic foot clinics. METHODS:Using self-developed software and questionnaires, diabetic foot clinics collected data in 2005, 2008 and 2011, covering characteristics, history ...

journal_title：Diabetes/metabolism research and reviews

authors： Doggen K,Van Acker K,Beele H,Dumont I,Félix P,Lauwers P,Lavens A,Matricali GA,Randon C,Weber E,Van Casteren V,Nobels F,Initiative for Quality Improvement and Epidemiology in Diabetic Foot Clinics (IQED-Foot) Study Group.

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:The genetic basis of the autoimmune disease type 1 diabetes (T1D) has now been largely determined, so now we can compare these findings with emerging genetic knowledge of disorders and phenotypes that have been negatively or positively associated with T1D historically. Here, we assessed the role in T1D of va...

journal_title：Diabetes/metabolism research and reviews

authors： Saleh NM,Raj SM,Smyth DJ,Wallace C,Howson JM,Bell L,Walker NM,Stevens HE,Todd JA

更新日期：2011-11-01 00:00:00

abstract：:In the last few years, there has been increasing focus on the impact of interventions on cardiovascular outcomes in patients with type 2 diabetes. Insulin resistance and hyperglycaemia often co-exist with a cluster of risk factors for coronary artery disease, but the underlying mechanisms leading to the development of...

journal_title：Diabetes/metabolism research and reviews

authors： Ceriello A

更新日期：2008-01-01 00:00:00

abstract：AIMS:This study was designed to investigate the association between pancreatic fat content (PFC) and insulin secretory capacity as well as glucose tolerance in Korean adults. MATERIALS:A total of 39 participants (mean age 49.9 years, 53% males) without a previous history of diabetes, or those previously diagnosed as h...

journal_title：Diabetes/metabolism research and reviews

authors： Chin SO,Hwang YC,Cho IJ,Jeong IK,Ahn KJ,Chung HY

更新日期：2020-11-30 00:00:00

abstract：:Neuropathy is a frequent complication in diabetes and most commonly seen as distal symmetrical sensorimotor polyneuropathy (PN). Involvement of the motor system is infrequently seen at the clinical examination. However, with the application of quantitative techniques, that is, isokinetic dynamometry, type 1 and type 2...

journal_title：Diabetes/metabolism research and reviews

authors： Andersen H

更新日期：2012-02-01 00:00:00

abstract：:Diabetes mellitus is one of the most challenging health concerns of the 21st century. With at least 30% of the diabetic population remaining undiagnosed, effective and early diagnosis is of critical concern. Development of a diagnostic test, more convenient and reliable than those currently used, would therefore be hi...

journal_title：Diabetes/metabolism research and reviews

authors： Matheson A,Willcox MD,Flanagan J,Walsh BJ

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:The prevalence of type 2 diabetes in China is increasing rapidly. Appropriate management of glycemia, blood pressure and dyslipidemia in this population is a major public health concern. OBJECTIVE:The aim of this study was to assess metabolic control including glycated hemoglobin A1c (HbA1c ), blood pressur...

journal_title：Diabetes/metabolism research and reviews

authors： Liu L,Lou Q,Guo X,Yuan L,Shen L,Sun Z,Zhao F,Dai X,Huang J,Yang H,Mordes JP,Chinese Diabetes Education Status Survey Study Group.

更新日期：2015-11-01 00:00:00

abstract：:Sodium-glucose cotransporter (SGLT) inhibitors added to insulin therapy have been proposed as treatment strategy for type 1 diabetes (T1D). We thus conducted a meta-analysis of randomized controlled trials (RCTs) to assess the efficacy and adverse effects of this combination in T1D. We searched the PubMed, EMBASE, and...

journal_title：Diabetes/metabolism research and reviews

authors： Lu J,Tang L,Meng H,Zhao J,Liang Y

更新日期：2019-10-01 00:00:00

abstract：:Whether diabetic foot ulcerations arise from an amalgam of neuro-ischemic factors or because of arterial occlusive disease alone, the arterial circulation must be thoroughly evaluated. Clinical evaluation is foremost, but numerous non-invasive diagnostic options such as duplex ultrasonography and MRA are often enliste...

journal_title：Diabetes/metabolism research and reviews

authors： Andros G

更新日期：2004-05-01 00:00:00

abstract：:Studies on skeletal involvement in patients with diabetes mellitus have generated conflicting results, largely because of the pathogenetic complexity of the condition. Several mechanisms may contribute to skeletal damage, including the increased urinary excretion coupled with the lower intestinal absorption of calcium...

journal_title：Diabetes/metabolism research and reviews

authors： Carnevale V,Romagnoli E,D'Erasmo E

更新日期：2004-05-01 00:00:00

abstract：:Patients with type 2 diabetes mellitus using sulfonylurea derivatives or insulin may experience hypoglycaemia. However, recent data regarding the incidence of hypoglycaemia are scarce. We conducted a systematic review and meta-analysis to determine the proportion of patients with type 2 diabetes mellitus that experien...

journal_title：Diabetes/metabolism research and reviews

authors： Schopman JE,Simon AC,Hoefnagel SJ,Hoekstra JB,Scholten RJ,Holleman F

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Increased production of reactive oxygen species (ROS) in mitochondria has been proposed as the pathogenic mechanism for chronic complications of diabetes. Mitochondrial DNA (mtDNA) is more vulnerable to reactive oxygen species. However, there are few data on the mitochondrial DNA damage in diabetes and these...

journal_title：Diabetes/metabolism research and reviews

authors： Savu O,Sunkari VG,Botusan IR,Grünler J,Nikoshkov A,Catrina SB

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Periodontal disease is a frequent complication of diabetes in adults, and both conditions are associated with systemic inflammatory states. This systematic review and meta-analysis was conducted to establish the relative severity of periodontal disease risk markers in children and adolescents with type 1 dia...

journal_title：Diabetes/metabolism research and reviews

authors： Jensen E,Allen G,Bednarz J,Couper J,Peña A

更新日期：2021-01-01 00:00:00

abstract：:Prevention of diabetic foot ulcers is important to reduce the burden of diabetic foot disease. However, we found that ulcer prevention is underexposed in research and clinical practice. Barriers to explain this are seen in patient's goal-setting; in the lack of interdisciplinary teams for ulcer prevention; in sample s...

journal_title：Diabetes/metabolism research and reviews

authors： Van Netten JJ,Woodburn J,Bus SA

更新日期：2020-03-01 00:00:00

abstract：:During the last decades, the central nervous system (CNS) was intensively tested as a site for islet transplantation in different animal models of diabetes. Immunoprivilege properties of intracranial and intrathecal sites were found to delay and reduce rejection of transplanted allo-islets and xeno-islets, especially ...

journal_title：Diabetes/metabolism research and reviews

authors： Lazard D,Vardi P,Bloch K

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:fulminant type 1 diabetes mellitus (T1DM) is characterized by abrupt onset of hyperglycemia and rapid progression to ketoacidosis. This study aimed at examining the clinical and autoimmunity features of fulminant T1DM in Chinese. METHODS:a total of 24 patients with fulminant T1DM and 48 classical autoimmune...

journal_title：Diabetes/metabolism research and reviews

authors： Zheng C,Zhou Z,Yang L,Lin J,Huang G,Li X,Zhou W,Wang X,Liu Z

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Current guidelines recommend screening the feet of diabetic subjects with a 10-g monofilament or tuning fork. We investigated which tests and locations on the feet have the best predictive value regarding 1-year ulcer-free survival in diabetic subjects participating in the prospective Rotterdam Diabetic Foot...

journal_title：Diabetes/metabolism research and reviews

authors： Rinkel WD,van der Oest MJW,Dijkstra DA,Castro Cabezas M,Coert JH

更新日期：2019-03-01 00:00:00

abstract：BACKGROUND:Studies have associated diabetes mellitus (DM) with the reduced risk of abdominal aortic aneurysm and thoracic aortic aneurysm and dissection. We used the national insurance data of Taiwan to examine these correlations for an Asian population. The association was also evaluated by DM severity. METHODS:We id...

journal_title：Diabetes/metabolism research and reviews

authors： Tsai CL,Lin CL,Wu YY,Shieh DC,Sung FC,Kao CH

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Sustained hyperglycaemia induces increased renal oxygen consumption resulting in reduced oxygen availability in the diabetic kidney. We investigated the roles of the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase and the neuronal nitric oxide synthase (nNOS) for the increased oxygen consumption ...

journal_title：Diabetes/metabolism research and reviews

authors： Edlund J,Fasching A,Liss P,Hansell P,Palm F

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Dipeptidyl peptidase-IV (DPP-4) inhibitors and sulfonylureas are two important second-line anti-diabetic agents. The objective of this research was to evaluate the efficacy and safety of DPP-4 inhibitors compared with sulfonylureas by meta-analytic approach of available randomized studies. METHODS:We search...

journal_title：Diabetes/metabolism research and reviews

authors： Zhang Y,Hong J,Chi J,Gu W,Ning G,Wang W

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:HLA region is the major locus (IDDM1) of type 1 diabetes (T1D) susceptibility. It explains approximately 50% of the genetic background of T1D, indicating additional genetic determinants. Genome scans and candidate gene studies have generated several chromosomal candidate regions that may have a role in T1D d...

journal_title：Diabetes/metabolism research and reviews

authors： Laine AP,Nejentsev S,Veijola R,Korpinen E,Sjöroos M,Simell O,Knip M,Akerblom HK,Ilonen J

更新日期：2004-03-01 00:00:00