Management status and its predictive factors in patients with type 2 diabetes in China: A Nationwide Multicenter Study: A Nationwide Multicenter Study.

abstract：BACKGROUND:Type 2 diabetes is a risk factor for stroke and confers increased risk of poor outcome and further vascular events following stroke. Hyperuricaemia occurs commonly in patients with type 2 diabetes, but its significance as a predictor of outcome following stroke is uncertain. We sought to investigate the prog...

journal_title：Diabetes/metabolism research and reviews

authors： Newman EJ,Rahman FS,Lees KR,Weir CJ,Walters MR

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Recently, a genome-wide association study identified a strong association between the fat mass- and obesity-associated rs9939609 single nucleotide polymorphism (SNP) and the risk of obesity in European population. However, the results in Chinese population were reported to be contradictory. Therefore, our ai...

journal_title：Diabetes/metabolism research and reviews

authors： Li X,Song F,Jiang H,Zhang M,Lin J,Bao W,Yao P,Yang X,Hao L,Liu L

更新日期：2010-02-01 00:00:00

abstract：:There is strong evidence that the avoidance of hyperglycemia is essential inoptimizing pregnancy outcome in type 1 diabetes. The price to pay is a striking increase in severe hypoglycemia (SH), defined as episodes requiring help from another person. During type 1 diabetic pregnancy, occurrence rates of SH up to 15 tim...

journal_title：Diabetes/metabolism research and reviews

authors： ter Braak EW,Evers IM,Willem Erkelens D,Visser GH

更新日期：2002-03-01 00:00:00

abstract：BACKGROUND:Visceral adiposity index (VAI) is a novel marker of visceral adipose tissue accumulation and dysfunction. The study aim was to explore the association of VAI with the 10-year type 2 diabetes mellitus (T2DM) incidence in apparently healthy individuals and compare its T2DM predictive ability against common ant...

journal_title：Diabetes/metabolism research and reviews

authors： Koloverou E,Panagiotakos DB,Kyrou I,Stefanadis C,Chrysohoou C,Georgousopoulou EN,Skoumas I,Tousoulis D,Pitsavos C,ATTICA Study group.

更新日期：2019-09-01 00:00:00

abstract：:Rising rates of diabetes in pregnancy have led to an escalation in research in this area. As in any area of clinical research, definitions of outcomes vary from study to study, making it difficult to compare research findings and draw conclusions. Our aim was to compile and create a repository of definitions, which co...

journal_title：Diabetes/metabolism research and reviews

authors： International Association of Diabetes in Pregnancy Study Group (IADPSG) Working Group on Outcome Definitions.,Feig DS,Corcoy R,Jensen DM,Kautzky-Willer A,Nolan CJ,Oats JJ,Sacks DA,Caimari F,McIntyre HD

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Insulin and multiple other autoantigens have been implicated in the pathogenesis of autoimmune type 1 diabetes, but the origin of immunological self-reactivity specifically oriented against insulin-secreting islet beta-cells remains obscure. The primary objective of the present study was to investigate the h...

journal_title：Diabetes/metabolism research and reviews

authors： Kecha-Kamoun O,Achour I,Martens H,Collette J,Lefebvre PJ,Greiner DL,Geenen V

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:Environmental factors such as nutrition or exposure to infections play a substantial role in the pathogenesis of type 1 diabetes (T1D). We have previously shown that gluten-free, non-purified diet largely prevented diabetes in non-obese diabetic (NOD) mice. In this study we tested hypothesis that early intro...

journal_title：Diabetes/metabolism research and reviews

authors： Funda DP,Kaas A,Tlaskalová-Hogenová H,Buschard K

更新日期：2008-01-01 00:00:00

abstract：BACKGROUND:A longitudinal study assessed serum paraoxonase 1 (PON1) activity and concentration as affected by age and as associated with the development of type 2 diabetes (T2D). PON1's recently established physiological function is the hydrolysis of lipolactones in oxidized LDL particles. METHODS:Serum samples and cl...

journal_title：Diabetes/metabolism research and reviews

authors： Crow JA,Meek EC,Wills RW,Chambers JE

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Diabetic nephropathy (DN) is the most common cause of end stage renal failure or even death among patients with type 2 diabetes mellitus. Genetic predisposition is widely studied among these patients to identify manageable aspects of the disease pathogenesis. This study was carried out to test ...

journal_title：Diabetes/metabolism research and reviews

authors： Bayoumy NMK,El-Shabrawi MM,Leheta OF,Abo El-Ela AEM,Omar HH

更新日期：2020-07-01 00:00:00

abstract：:Now that the reduction in beta-mass has been clearly established in humans with type 2 diabetes mellitus (T2DM) 1-4, the debate focuses on the possible mechanisms responsible for decreased beta-cell number and impaired beta-cell function and their multifactorial etiology. Appropriate inbred rodent models are essential...

journal_title：Diabetes/metabolism research and reviews

authors： Portha B

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:Levels of high-sensitivity C-reactive protein (hs-CRP) and adiponectin, reflecting chronic inflammation, are associated with cardiovascular disease in type 2 diabetes. The long-term effects of multifactorial therapy in type 2 diabetes patients on CRP and adiponectin are unknown. METHODS:The ADDITION-NL stud...

journal_title：Diabetes/metabolism research and reviews

authors： den Ouden H,Berends J,Stellato RK,Beulens JW,Rutten GE

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:In type 2 diabetes (T2D), copresence of low-density lipoprotein cholesterol (LDL-C) < 2.8 mmol/L with triglyceride < 1.7 mmol/L or with albuminuria synergistically increased cancer risk. We tested whether use of renin angiotensin system inhibitors attenuated the increased cancer risk associated with these tw...

journal_title：Diabetes/metabolism research and reviews

authors： Yang X,Ma RC,So WY,Wang Y,Kong AP,Ozaki R,Xu G,Chan JC

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:We have investigated the possible role of ACP1 (also known as cLMWPTP: cytosolic low molecular weight phosphotyrosine phosphatase), a highly polymorphic enzyme involved in signal transduction of T-cell receptor, insulin receptor and other growth factors in the relationship between maternal age at delivery an...

journal_title：Diabetes/metabolism research and reviews

authors： Bottini N,Meloni GF,Lucarelli P,Amante A,Saccucci P,Gloria-Bottini F,Bottini E

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:Proatherogenic stimuli during foetal life may predispose to development of atherosclerosis in adulthood. Elevated plasma low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP) expression is associated with increased risk of atherosclerosis. METHODS AND RESULTS:In this study, we examined how ...

journal_title：Diabetes/metabolism research and reviews

authors： Lindegaard ML,Svarrer EM,Damm P,Mathiesen ER,Nielsen LB

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in developing countries, but its causes are not known. We aimed to ascertain the prevalence and determinants of NAFLD in a new largely unmedicated population-based cohort from the rapidly gentrifying region of Pinggu, China. METHODS:We ran...

journal_title：Diabetes/metabolism research and reviews

authors： Zhou X,Li Y,Zhang X,Guan YY,Puentes Y,Zhang F,Speliotes EK,Ji L

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Body mass index (BMI) is associated with death in a V-shaped manner in general populations but it is unknown whether BMI or other risk factors also exhibit V-shaped relationships with death in type 2 diabetic patients. METHODS:A prospective cohort of 7534 Chinese, type 2 diabetic patients enrolled since 199...

journal_title：Diabetes/metabolism research and reviews

authors： So WY,Yang X,Ma RC,Kong AP,Lam CW,Ho CS,Cockram CS,Ko GT,Chow CC,Wong V,Tong PC,Chan JC

更新日期：2008-03-01 00:00:00

abstract：:Every year, over 1 million people with diabetes lose a leg due to diabetic foot disease. Most amputations are preceded by a foot ulcer. Causes for the development of foot ulcers are generally multifactorial and may include neuropathy, peripheral vasculopathy, abnormal foot mechanics and infection. Multidisciplinary ap...

journal_title：Diabetes/metabolism research and reviews

authors： Cahn A,Elishuv O,Olshtain-Pops K

更新日期：2014-07-01 00:00:00

abstract：:Studies on skeletal involvement in patients with diabetes mellitus have generated conflicting results, largely because of the pathogenetic complexity of the condition. Several mechanisms may contribute to skeletal damage, including the increased urinary excretion coupled with the lower intestinal absorption of calcium...

journal_title：Diabetes/metabolism research and reviews

authors： Carnevale V,Romagnoli E,D'Erasmo E

更新日期：2004-05-01 00:00:00

abstract：:Around one of three diabetic patients is affected by distal symmetric polyneuropathy (DSP) which represents a major health problem, as it may present with partly excruciating neuropathic pain and is responsible for substantial morbidity and increased mortality. Treatment is based on four cornerstones: (1) multifactori...

journal_title：Diabetes/metabolism research and reviews

authors： Ziegler D

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:To evaluate the association between fasting plasma glucose (FPG) and mortality by gender. METHODS:A total of 17 248 eligible participants from a rural Chinese prospective cohort population were included. The same questionnaire interview and anthropometric and laboratory measurements were performed at both b...

journal_title：Diabetes/metabolism research and reviews

authors： Liu L,Chen X,Liu Y,Sun X,Yin Z,Li H,Zhang M,Wang B,Ren Y,Zhao Y,Liu D,Zhou J,Liu X,Zhang D,Cheng C,Liu F,Zhou Q,Xu Q,Xiong Y,Liu J,You Z,Hong S,Wang C,Hu D

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Leptin's hematopoietic or proinflammatory role has been experimentally reported. We investigated whether serum leptin concentrations are associated with white blood cell (WBC) counts in humans. METHODS:Serum leptin concentrations of Japanese civil servants aged 40 to 59 years (1082 men and 200 women) were a...

journal_title：Diabetes/metabolism research and reviews

authors： Mabuchi T,Yatsuya H,Tamakoshi K,Otsuka R,Nagasawa N,Zhang H,Murata C,Wada K,Ishikawa M,Hori Y,Kondo T,Hashimoto S,Toyoshima H

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Both metabolic syndrome (MetS) and N-amino terminal fragment of the prohormone B-type natriuretic peptide (NT-proBNP) confer increased risk of cardiovascular diseases (CVD). We assessed if NT-proBNP levels were greater in people with uncomplicated MetS, who had neither CVD/chronic kidney disease (CKD) nor di...

journal_title：Diabetes/metabolism research and reviews

authors： Bruno G,Barutta F,Landi A,Pinach S,Caropreso P,Mengozzi G,Baldassarre S,Fragapani S,Civera S,Cavallo Perin P,Gruden G

更新日期：2015-05-01 00:00:00

abstract：AIMS:This study was designed to investigate the association between pancreatic fat content (PFC) and insulin secretory capacity as well as glucose tolerance in Korean adults. MATERIALS:A total of 39 participants (mean age 49.9 years, 53% males) without a previous history of diabetes, or those previously diagnosed as h...

journal_title：Diabetes/metabolism research and reviews

authors： Chin SO,Hwang YC,Cho IJ,Jeong IK,Ahn KJ,Chung HY

更新日期：2020-11-30 00:00:00

abstract：:Hypoglycaemia is inevitable when striving for low HbA1c values. Nocturnal hypoglycaemia often occurs without symptoms, but results in diminished next day well-being and hypoglycaemia unawareness. Frequency of nocturnal hypoglycaemia was first assessed in research ward settings, but suffered from insufficient glucose s...

journal_title：Diabetes/metabolism research and reviews

authors： DeVries JH,Wentholt IM,Masurel N,Mantel I,Poscia A,Maran A,Heine RJ

更新日期：2004-11-01 00:00:00

abstract：BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) can lead to cirrhosis and hepatocellular carcinoma and is strongly associated with obesity and insulin resistance. The aim of this study was to assess if plasma markers associated with NAFLD are increased in people with concomitant diabetes compared with those withou...

journal_title：Diabetes/metabolism research and reviews

authors： Sharma S,Barrett F,Adamson J,Todd A,Megson IL,Zentler-Munro PL,MacRury SM

更新日期：2012-05-01 00:00:00

abstract：:Hepatic glycogen is replenished during the absorptive period postprandially. This repletion is prompted partly by an increased hepatic uptake of glucose by the liver, partly by metabolite and hormonal signals in the portal vein, and partly by an increased gluconeogenic flux to glycogen (glyconeogenesis). There is some...

journal_title：Diabetes/metabolism research and reviews

authors： Radziuk J,Pye S

更新日期：2001-07-01 00:00:00

abstract：BACKGROUND:Vitamin D insufficiency and type 2 diabetes are both common in Finland, and low vitamin D status has been suggested as a risk factor for type 2 diabetes. Our aim was to study the associations between serum 25-hydroxyvitamin D [25(OH)D], a marker of vitamin D status, and glucose homeostasis and type 2 diabete...

journal_title：Diabetes/metabolism research and reviews

authors： Hurskainen AR,Virtanen JK,Tuomainen TP,Nurmi T,Voutilainen S

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:The incidence of type 1 diabetes mellitus (T1DM) has increased in recent decades, as has the incidence of preterm births (<37 weeks). We aimed to evaluate and compare the prevalence of prematurity and early prematurity (<34 weeks) and birth season variability among T1DM and non-T1DM children. METHODS:A nati...

journal_title：Diabetes/metabolism research and reviews

authors： Adar A,Shalitin S,Eyal O,Loewenthal N,Pinhas-Hamiel O,Levy M,Dally-Gottfried O,Landau Z,Zung A,Levy-Khademi F,Zangen D,Tenenbaum-Rakover Y,Rachmiel M

更新日期：2018-07-01 00:00:00

abstract：OBJECTIVE:To investigate the relationship between ankle-branchial index (ABI) and cardiovascular disease in type 2 diabetes patients. METHODS:A total of 634 inpatients with type 2 diabetes were recruited in this cross-sectional study. All patients were measured with ABI and computed tomography angiography (CTA) scan f...

journal_title：Diabetes/metabolism research and reviews

authors： Xu L,He R,Hua X,Zhao J,Zhao J,Zeng H,Li L,Liu F,Jia W

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Clinical studies have shown that proinsulin C-peptide exerts renoprotective effects in type 1 diabetes, although the underlying mechanisms are poorly understood. As C-peptide has been shown to induce several intracellular events and to localize to nuclei, we aimed to determine whether gene transcription is a...

journal_title：Diabetes/metabolism research and reviews

authors： Lindahl E,Nordquist L,Müller P,El Agha E,Friederich M,Dahlman-Wright K,Palm F,Jörnvall H

更新日期：2011-10-01 00:00:00