Thiazolidinediones as anti-inflammatory and anti-atherogenic agents.

abstract：:Rising experimental evidence suggests that thiazolidinediones (TZDs) exert a protective effect on breast cancer. However, studies concerning this issue were inconsistent and limited. Hence, we performed a meta-analysis with data from currently available studies to evaluate the effect of TZDs on breast cancer risk amon...

journal_title：Diabetes/metabolism research and reviews

authors： Du R,Lin L,Cheng D,Xu Y,Xu M,Chen Y,Wang W,Bi Y,Li D,Lu J

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:We have investigated the possible role of ACP1 (also known as cLMWPTP: cytosolic low molecular weight phosphotyrosine phosphatase), a highly polymorphic enzyme involved in signal transduction of T-cell receptor, insulin receptor and other growth factors in the relationship between maternal age at delivery an...

journal_title：Diabetes/metabolism research and reviews

authors： Bottini N,Meloni GF,Lucarelli P,Amante A,Saccucci P,Gloria-Bottini F,Bottini E

更新日期：2005-07-01 00:00:00

abstract：:There are a number of medical conditions such as growth failure in children, pregnancy, lipid abnormalities, and early complications that are improved by the meticulous glycemic control that can be achieved with insulin pump therapy (CSII). By using an insulin pump, many patients with severe hypoglycemia, the dawn phe...

journal_title：Diabetes/metabolism research and reviews

authors： Kaufman FR,Halvorson M,Miller D,Mackenzie M,Fisher LK,Pitukcheewanont P

更新日期：1999-09-01 00:00:00

abstract：AIMS:To assess the validity of the diagnostic codes relating to diabetic foot ulcer (DFU) in the electronic medical records of a large integrated care provider and to assess the prevalence of DFU among its members. MATERIALS AND METHODS:Data were obtained from the diabetes registry of Maccabi Healthcare Services (MHS)...

journal_title：Diabetes/metabolism research and reviews

authors： Cahn A,Altaras T,Agami T,Liran O,Touaty CE,Drahy M,Pollack R,Raz I,Chodick G,Zucker I

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:Mutating the insulin B:9-23 peptide prevents diabetes in NOD mice. Thus, the trimolecular complex of I-Ag7-insulin B:9-23 peptide-TCR may be essential for the development of spontaneous diabetes. Pathogenic T cells recognize the B:9-23 peptide presented by I-Ag7 in what is termed register 3, with the B22 bas...

journal_title：Diabetes/metabolism research and reviews

authors： Zhang L,Stadinski BD,Michels A,Kappler JW,Eisenbarth GS

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Human leukocyte antigen (HLA) genotypes associated with increased risk for type 1 diabetes mellitus (T1D) have been reported to be associated with increased birth weight. We set out to investigate the association between HLA haplotypes conferring risk for T1D and birth weight and search for possible differen...

journal_title：Diabetes/metabolism research and reviews

authors： Peet A,Kool P,Ilonen J,Knip M,Tillmann V,DIABIMMUNE Study Group.

更新日期：2012-07-01 00:00:00

abstract：:The United Kingdom Prospective Diabetes Study (UKPDS) showed that tight glycemic control with any of several therapeutic regimens has the potential to significantly reduce the risk for long-term microvascular complications of type 2 diabetes. An important question that remains to be answered is what is the best approa...

journal_title：Diabetes/metabolism research and reviews

authors： Yki-Järvinen H

更新日期：2002-09-01 00:00:00

abstract：:The intestinal microbiota has come to be considered an additional risk factor for the development of metabolic diseases. Considering the potential role of antimicrobials as modulators of the intestinal microbiota, they have been investigated for use in the adjuvant treatment of obesity and insulin resistance (IR). In ...

journal_title：Diabetes/metabolism research and reviews

authors： Dos Reis SA,do Carmo Gouveia Peluzio M,Bressan J

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:Adiponectin acts as an insulin sensitizer in rodent models. The direct effect of adiponectin in intact type 2 diabetic muscle is unknown. We examined whether adiponectin stimulates glucose transport in isolated skeletal muscle strips from type 2 diabetic men. METHODS:We obtained open muscle biopsies from 12...

journal_title：Diabetes/metabolism research and reviews

authors： Kuoppamaa H,Skrobuk P,Sihvo M,Hiukka A,Chibalin AV,Zierath JR,Koistinen HA

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Cyclosporin A (CyA) may induce acute nephrotoxicity. The question has been raised of the possible long-term unfavorable course of CyA-induced lesions. Advantage was taken of a large cohort of diabetic patients treated for several months using moderate CyA dosage to evaluate the long-term evolution of renal f...

journal_title：Diabetes/metabolism research and reviews

authors： Assan R,Blanchet F,Feutren G,Timsit J,Larger E,Boitard C,Amiel C,Bach JF

更新日期：2002-11-01 00:00:00

abstract：BACKGROUND:Visceral adiposity index (VAI) is a novel marker of visceral adipose tissue accumulation and dysfunction. The study aim was to explore the association of VAI with the 10-year type 2 diabetes mellitus (T2DM) incidence in apparently healthy individuals and compare its T2DM predictive ability against common ant...

journal_title：Diabetes/metabolism research and reviews

authors： Koloverou E,Panagiotakos DB,Kyrou I,Stefanadis C,Chrysohoou C,Georgousopoulou EN,Skoumas I,Tousoulis D,Pitsavos C,ATTICA Study group.

更新日期：2019-09-01 00:00:00

abstract：BACKGROUND:Individuals with diabetes mellitus (DM) homozygous for the haptoglobin (Hp) 1 allele are at decreased risk of retinopathy as compared to DM individuals with the Hp 2 allele. We sought to recapitulate these findings in DM mice genetically modified at the Hp locus. METHODS:An early morphological characteristi...

journal_title：Diabetes/metabolism research and reviews

authors： Miller-Lotan R,Miller B,Nakhoul F,Aronson D,Asaf R,Levy AP

更新日期：2007-02-01 00:00:00

abstract：:Diabetic foot ulceration poses a heavy burden on the patient and the healthcare system, but prevention thereof receives little attention. For every euro spent on ulcer prevention, ten are spent on ulcer healing, and for every randomized controlled trial conducted on prevention, ten are conducted on healing. In this ar...

journal_title：Diabetes/metabolism research and reviews

authors： Bus SA,van Netten JJ

更新日期：2016-01-01 00:00:00

abstract：AIMS:Insulin-like growth factor 1 receptor (IGF1R) is involved in cell growth and glucose homeostasis. In the current study, the IGF1R locus was analysed as a candidate gene for type 2 diabetes (T2D) in American Indians. MATERIALS AND METHODS:Whole genome sequence data from 335 American Indians identified 3 novel miss...

journal_title：Diabetes/metabolism research and reviews

authors： Muller YL,Skelton G,Piaggi P,Chen P,Nair A,Kobes S,Hsueh WC,Knowler WC,Hanson RL,Baier LJ,Bogardus C

更新日期：2018-05-01 00:00:00

abstract：:Whether diabetic foot ulcerations arise from an amalgam of neuro-ischemic factors or because of arterial occlusive disease alone, the arterial circulation must be thoroughly evaluated. Clinical evaluation is foremost, but numerous non-invasive diagnostic options such as duplex ultrasonography and MRA are often enliste...

journal_title：Diabetes/metabolism research and reviews

authors： Andros G

更新日期：2004-05-01 00:00:00

abstract：:Foot problems complicating diabetes are a source of major patient suffering and societal costs. Investing in evidence-based, internationally appropriate diabetic foot care guidance is likely among the most cost-effective forms of healthcare expenditure, provided it is goal-focused and properly implemented. The Interna...

journal_title：Diabetes/metabolism research and reviews

authors： Bakker K,Apelqvist J,Lipsky BA,Van Netten JJ,International Working Group on the Diabetic Foot.

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is an endocrine disorder which is characterized by the development of resistance to the cellular activity of insulin or inadequate insulin production. It leads to hyperglycemia, prolonged inflammation, and oxidative stress. Oxidative stress is assumed to play an important role in the develo...

journal_title：Diabetes/metabolism research and reviews

authors： Gurel-Gokmen B,Ipekci H,Oktay S,Alev B,Ustundag UV,Ak E,Akakın D,Sener G,Emekli-Alturfan E,Yarat A,Tunali-Akbay T

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:High birth weight has been related to an increased risk of type 1 diabetes (T1D), while suboptimal birth weight (both high and low) has been related to obesity, insulin resistance and type 2 diabetes. Insulin resistance, as a consequence of poor metabolic control, has been described in T1D patients. The aims...

journal_title：Diabetes/metabolism research and reviews

authors： Benevento D,Bizzarri C,Patera IP,Ravà L,Schiaffini R,Ciampalini P,Cianfarani S,Cappa M

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:HLA region is the major locus (IDDM1) of type 1 diabetes (T1D) susceptibility. It explains approximately 50% of the genetic background of T1D, indicating additional genetic determinants. Genome scans and candidate gene studies have generated several chromosomal candidate regions that may have a role in T1D d...

journal_title：Diabetes/metabolism research and reviews

authors： Laine AP,Nejentsev S,Veijola R,Korpinen E,Sjöroos M,Simell O,Knip M,Akerblom HK,Ilonen J

更新日期：2004-03-01 00:00:00

abstract：:Diabetes is an important cause of morbidity and mortality in Africa. Although a dramatic increase in disease burden is projected, it remains to be seen what effect the ongoing devastation of HIV disease will have on the epidemiology of such chronic diseases as diabetes. Recent data on type 2 diabetes prevalence indica...

journal_title：Diabetes/metabolism research and reviews

authors： Motala AA

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:A nested case-control (NCC) design within a prospective cohort study can realize substantial benefits for biomarker studies. In this context, it is natural to consider the sample availability in the selection of controls to minimize data loss when implementing the design. However, this violates the randomnes...

journal_title：Diabetes/metabolism research and reviews

authors： Lee HS,Lynch KF,Krischer JP,TEDDY Study Group.

更新日期：2020-01-01 00:00:00

abstract：:Initiating insulin therapy with a basal insulin analogue has become a standard of care in the treatment of type 2 diabetes mellitus (T2DM). Despite increasing choices in pharmacological approaches, intensified glucose monitoring and improvements in quality of care, many patients do not achieve the desired level of gly...

journal_title：Diabetes/metabolism research and reviews

authors： Forst T,Choudhary P,Schneider D,Linetzky B,Pozzilli P

更新日期：2020-10-23 00:00:00

abstract：:Insulin-producing pancreatic beta-cells are known to be extremely susceptible to destruction, primarily by autoimmune mechanisms, infectious agents, and by chemical toxins that cause overt type I diabetes. As development of highly protected insulin-producing cells would be important for successful cell therapy of diab...

journal_title：Diabetes/metabolism research and reviews

authors： Bloch K,Vardi P

更新日期：2005-05-01 00:00:00

abstract：:Type 2 diabetes is responsible for the increased prevalence of ischaemic heart disease, generally related to coronary artery disease, which is associated with increased morbidity and death in diabetic patients. Epidermal growth factor receptor (EGFR) tyrosine kinase, one of the many factors involved in cell growth and...

journal_title：Diabetes/metabolism research and reviews

authors： Matrougui K

更新日期：2010-01-01 00:00:00

abstract：:This review addresses the roles of Rho/Rho-kinase (ROCK) pathway in the pathogenesis of diabetes complications. Diabetes can cause many serious complications and can result in physical disability or even increased mortality. However, there are not many effective ways to treat these complications. The small guanosine-5...

journal_title：Diabetes/metabolism research and reviews

authors： Zhou H,Li Y

更新日期：2011-05-01 00:00:00

abstract：BACKGROUND:Smooth muscle cells proliferation and extracellular matrix (ECM) protein deposition are key features of diabetic macroangiopathy. In the present study, we have studied the role of endothelin(A) (ET(A)) receptor, the predominant receptor on smooth muscle cells, in diabetes-induced vascular hypertrophy and rem...

journal_title：Diabetes/metabolism research and reviews

authors： Fukuda G,Khan ZA,Barbin YP,Farhangkhoee H,Tilton RG,Chakrabarti S

更新日期：2005-07-01 00:00:00

abstract：BACKGROUND:ZAC (Zinc finger protein that regulates apoptosis and cell-cycle arrest) is a candidate gene for transient neonatal diabetes mellitus (TNDM). This condition involves severe insulin deficiency at birth that reverses over weeks or months but may relapse with diabetes recurring in later life. ZAC overexpression...

journal_title：Diabetes/metabolism research and reviews

authors： Du X,Ounissi-Benkalha H,Loder MK,Rutter GA,Polychronakos C

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:Patients with impaired 50-g oral glucose challenge test (OGCT) have not been investigated for fetal anterior abdominal wall thickness until now. We aimed to investigate patients with impaired 50-g OGCT, but not gestational diabetes and match them with healthy uneventful pregnant participants for anterior abd...

journal_title：Diabetes/metabolism research and reviews

authors： Aksoy H,Aksoy U,Açmaz G,Tutuş S

更新日期：2014-10-01 00:00:00

abstract：:Ethnic minorities living in high-income countries usually exhibit a greater risk of developing diabetes along with higher morbidity and mortality rates. We evaluated the effectiveness of interventions to improve glycaemic control in ethnic minority groups. Results of major controlled trials, systematic reviews and met...

journal_title：Diabetes/metabolism research and reviews

authors： Lirussi F

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Adenosine triphosphate (ATP) is a critical determinant of beta-cell insulin secretion in response to glucose. BHE/cdb rats have a mutation in ATP synthase that limits ATP production, yet develop mild diabetes only with ageing. We investigated the cellular basis for reduced insulin secretion and compensatory ...

journal_title：Diabetes/metabolism research and reviews

authors： Saleh MC,Fatehi-Hassanabad Z,Wang R,Nino-Fong R,Wadowska DW,Wright GM,Harper ME,Chan CB

更新日期：2008-07-01 00:00:00