Abstract:
:During the last decades, the central nervous system (CNS) was intensively tested as a site for islet transplantation in different animal models of diabetes. Immunoprivilege properties of intracranial and intrathecal sites were found to delay and reduce rejection of transplanted allo-islets and xeno-islets, especially in the form of dispersed single cells. Insulin released from islets grafted in CNS was shown to cross the blood-brain barrier and to act as a regulator of peripheral glucose metabolism. In diabetic animals, sufficient nutrition and oxygen supply to islets grafted in the CNS provide adequate insulin response to increase glucose level resulting in rapid normoglycemia. In addition to insulin, pancreatic islets produce and secrete several other hormones, as well as neurotrophic and angiogenic factors with potential neuroprotective properties. Recent experimental studies and clinical trials provide a strong support for delivery of islet-derived macromolecules to CNS as a promising strategy to treat various brain disorders. This review article focuses mainly on analysis of current status of intracranial and intrathecal islet transplantations for treatment of experimental diabetes and discusses the possible neuroprotective properties of grafted islets into CNS as a novel therapeutic approach to brain disorders with cognitive dysfunctions characterized by impaired brain insulin signalling. Copyright © 2015 John Wiley & Sons, Ltd.
journal_name
Diabetes Metab Res Revjournal_title
Diabetes/metabolism research and reviewsauthors
Lazard D,Vardi P,Bloch Kdoi
10.1002/dmrr.2644subject
Has Abstractpub_date
2016-01-01 00:00:00pages
11-20issue
1eissn
1520-7552issn
1520-7560journal_volume
32pub_type
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,评审
doi:10.1002/dmrr.1050
更新日期:2010-01-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
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pub_type: 杂志文章,多中心研究
doi:10.1002/dmrr.2624
更新日期:2015-05-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,评审
doi:10.1002/dmrr.271
更新日期:2002-03-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,评审
doi:10.1002/dmrr.449
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
doi:10.1002/dmrr.2524
更新日期:2014-07-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
doi:10.1002/dmrr.1169
更新日期:2011-07-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
doi:10.1002/dmrr.521
更新日期:2005-07-01 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1002/dmrr.1066
更新日期:2010-02-01 00:00:00
abstract:AIMS/HYPOTHESIS:The adipocyte derived peptide hormone leptin is known to regulate apoptosis and cell viability in several cells and tissues, as well as having several pancreatic islet beta-cell specific effects such as inhibition of glucose-stimulated insulin secretion. This study investigated the effects of leptin upo...
journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
doi:10.1002/dmrr.726
更新日期:2007-09-01 00:00:00
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pub_type: 杂志文章,评审
doi:10.1002/dmrr.817
更新日期:2008-05-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
doi:10.1002/dmrr.288
更新日期:2002-05-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-01-01 00:00:00
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doi:10.1002/dmrr.2738
更新日期:2016-01-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,随机对照试验
doi:10.1002/dmrr.2669
更新日期:2015-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/dmrr.2976
更新日期:2018-03-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/dmrr.2628
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更新日期:2005-07-01 00:00:00
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pub_type: 杂志文章,评审
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,评审
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journal_title:Diabetes/metabolism research and reviews
pub_type: 临床试验,杂志文章
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更新日期:2004-03-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,多中心研究
doi:10.1002/dmrr.2757
更新日期:2015-11-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
doi:10.1002/dmrr.2714
更新日期:2016-03-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
doi:10.1002/dmrr.3129
更新日期:2019-05-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,评审
doi:10.1002/dmrr.2346
更新日期:2012-12-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-03-01 00:00:00