Circulating adiponectin and adiponectin receptor expression in skeletal muscle: effects of exercise.

abstract：:A few studies have investigated the relationship between type 1 diabetes mellitus (T1DM) and bone mineral density (BMD) values. This meta-analysis was performed to explore differences between T1DM and healthy individuals in BMD values measured at five bone sites.We searched the database of PubMed for cross-sectional s...

journal_title：Diabetes/metabolism research and reviews

authors： Pan H,Wu N,Yang T,He W

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:Insulin and multiple other autoantigens have been implicated in the pathogenesis of autoimmune type 1 diabetes, but the origin of immunological self-reactivity specifically oriented against insulin-secreting islet beta-cells remains obscure. The primary objective of the present study was to investigate the h...

journal_title：Diabetes/metabolism research and reviews

authors： Kecha-Kamoun O,Achour I,Martens H,Collette J,Lefebvre PJ,Greiner DL,Geenen V

更新日期：2001-03-01 00:00:00

abstract：BACKGROUND:In type 2 diabetes (T2D), copresence of low-density lipoprotein cholesterol (LDL-C) < 2.8 mmol/L with triglyceride < 1.7 mmol/L or with albuminuria synergistically increased cancer risk. We tested whether use of renin angiotensin system inhibitors attenuated the increased cancer risk associated with these tw...

journal_title：Diabetes/metabolism research and reviews

authors： Yang X,Ma RC,So WY,Wang Y,Kong AP,Ozaki R,Xu G,Chan JC

更新日期：2014-07-01 00:00:00

abstract：:Every year, over 1 million people with diabetes lose a leg due to diabetic foot disease. Most amputations are preceded by a foot ulcer. Causes for the development of foot ulcers are generally multifactorial and may include neuropathy, peripheral vasculopathy, abnormal foot mechanics and infection. Multidisciplinary ap...

journal_title：Diabetes/metabolism research and reviews

authors： Cahn A,Elishuv O,Olshtain-Pops K

更新日期：2014-07-01 00:00:00

abstract：:The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines on the prevention and management of diabetic foot disease since 1999. In conjunction with advice from internal and external reviewers and expert consultants in the field, this update is based on a systematic review of ...

journal_title：Diabetes/metabolism research and reviews

authors： Rayman G,Vas P,Dhatariya K,Driver V,Hartemann A,Londahl M,Piaggesi A,Apelqvist J,Attinger C,Game F,International Working Group on the Diabetic Foot (IWGDF).

更新日期：2020-03-01 00:00:00

abstract：:Several interactive and mutually perpetuating abnormal biochemical pathways, such as protein kinase C (PKC) activation, augmented polyol pathway, and non-enzymatic glycation, may be activated as a result of sustained hyperglycemia in diabetes. These abnormal pathways may in turn influence several vasoactive factors, w...

journal_title：Diabetes/metabolism research and reviews

authors： Chakrabarti S,Cukiernik M,Hileeto D,Evans T,Chen S

更新日期：2000-11-01 00:00:00

abstract：:Diabetes is a group of metabolic diseases characterized by elevated blood glucose levels that drive the development of life-threatening complications. Diabetes results from a situation of insufficient insulin action, either by deficient production of the hormone by the pancreas, or by the development of insulin resist...

journal_title：Diabetes/metabolism research and reviews

authors： Castaño C,Novials A,Párrizas M

更新日期：2019-03-01 00:00:00

abstract：:Initiating insulin therapy with a basal insulin analogue has become a standard of care in the treatment of type 2 diabetes mellitus (T2DM). Despite increasing choices in pharmacological approaches, intensified glucose monitoring and improvements in quality of care, many patients do not achieve the desired level of gly...

journal_title：Diabetes/metabolism research and reviews

authors： Forst T,Choudhary P,Schneider D,Linetzky B,Pozzilli P

更新日期：2020-10-23 00:00:00

abstract：:The unique worldwide spread of the human species and the remarkably long post-reproductive survival show that our genome permits excellent adaptation to vastly different environments. Moreover, the main scourges of later age, namely malignant growths and atherosclerosis, appear in humans later than in shorter-living a...

journal_title：Diabetes/metabolism research and reviews

authors： Lev-Ran A

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:A nested case-control (NCC) design within a prospective cohort study can realize substantial benefits for biomarker studies. In this context, it is natural to consider the sample availability in the selection of controls to minimize data loss when implementing the design. However, this violates the randomnes...

journal_title：Diabetes/metabolism research and reviews

authors： Lee HS,Lynch KF,Krischer JP,TEDDY Study Group.

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is an endocrine disorder which is characterized by the development of resistance to the cellular activity of insulin or inadequate insulin production. It leads to hyperglycemia, prolonged inflammation, and oxidative stress. Oxidative stress is assumed to play an important role in the develo...

journal_title：Diabetes/metabolism research and reviews

authors： Gurel-Gokmen B,Ipekci H,Oktay S,Alev B,Ustundag UV,Ak E,Akakın D,Sener G,Emekli-Alturfan E,Yarat A,Tunali-Akbay T

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:We aimed to predict the incidence of obesity in a Korean population using a genetic risk score (GRS) constructed with obesity-related single nucleotide polymorphisms (SNPs) along with an oxidative stress score (OSS). METHODS:A total of 9460 Korean subjects and 356 974 SNPs were included. The GRS was constru...

journal_title：Diabetes/metabolism research and reviews

authors： Park S,Yoo HJ,Jee SH,Lee JH,Kim M

更新日期：2020-02-01 00:00:00

abstract：BACKGROUND:Brown adipose tissue (BAT) is important for energy expenditure through thermogenesis, although its regulatory factors are not well known in humans. There is evidence suggesting that thyroid hormones affect BAT functions in some mammals, but the effects of thyroid hormones on BAT activity in humans are still ...

journal_title：Diabetes/metabolism research and reviews

authors： Zhang Q,Miao Q,Ye H,Zhang Z,Zuo C,Hua F,Guan Y,Li Y

更新日期：2014-09-01 00:00:00

abstract：:Activation of self-reactive T cells that specifically destroy the pancreatic beta-cells is one of the hallmarks in the development of type 1 diabetes. Thus, for prevention and treatment of this autoimmune disease, approaches to induce and maintain T cell tolerance toward the beta-cells, especially in islet transplanta...

journal_title：Diabetes/metabolism research and reviews

authors： Gao W,Demirci G,Li XC

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:To evaluate possible differences in distal polyneuropathy (PN) characteristics and degree of abnormalities for various small and large fibre parameters in diabetes type 1 (DM1) and type 2 (DM2). METHODS:Sixty-six DM1 and 57 DM2 patients with or without PN symptoms were included. Nerve conduction studies (NC...

journal_title：Diabetes/metabolism research and reviews

authors： Løseth S,Mellgren SI,Jorde R,Lindal S,Stålberg E

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Intensive insulin therapy is the gold standard by which Type 1 diabetes is treated. In addition to this therapy, administration of nicotinamide (NA) can be beneficial. This concept is reinforced by the results of a recent meta-analysis of the use of NA in patients with recent-onset Type 1 diabetes. METHODS:...

journal_title：Diabetes/metabolism research and reviews

authors： Visalli N,Cavallo MG,Signore A,Baroni MG,Buzzetti R,Fioriti E,Mesturino C,Fiori R,Lucentini L,Matteoli MC,Crinò A,Corbi S,Spera S,Teodonio C,Paci F,Amoretti R,Pisano L,Suraci C,Multari G,Sulli N,Cervoni M,De Mat

更新日期：1999-05-01 00:00:00

abstract：:Islet cell antibodies (ICA) are a specific marker for Type 1 (insulin-dependent) diabetes mellitus. ICA are found in the serum of over 80% of newly diagnosed patients and the levels of ICA are directly of prognostic value. Standardisation of ICA and the uniform reporting of ICA levels in international units is critica...

journal_title：Diabetes/metabolism research and reviews

authors： Mire-Sluis AR,Das RG,Lernmark A

更新日期：1999-01-01 00:00:00

abstract：BACKGROUND:The cardiovascular effects of sulfonylureas (SU) in diabetic patients are controversial and it has been suggested that diabetic patients with acute myocardial infarction while on SU were at increased risk. OBJECTIVES:To assess the in-hospital outcome of patients with acute myocardial infarction according to...

journal_title：Diabetes/metabolism research and reviews

authors： Danchin N,Charpentier G,Ledru F,Vaur L,Guéret P,Hanania G,Blanchard D,Lablanche JM,Genès N,Cambou JP

更新日期：2005-03-01 00:00:00

abstract：:Around one of three diabetic patients is affected by distal symmetric polyneuropathy (DSP) which represents a major health problem, as it may present with partly excruciating neuropathic pain and is responsible for substantial morbidity and increased mortality. Treatment is based on four cornerstones: (1) multifactori...

journal_title：Diabetes/metabolism research and reviews

authors： Ziegler D

更新日期：2008-05-01 00:00:00

abstract：BACKGROUND:The present study was undertaken to determine whether there were changes evident in axonal membrane function prior to the onset of neuropathy in patients with type 1 and type 2 diabetes. METHODS:From a cohort of 110 consecutive referrals, nerve excitability was investigated in 40 diabetic patients without c...

journal_title：Diabetes/metabolism research and reviews

authors： Arnold R,Kwai N,Lin CS,Poynten AM,Kiernan MC,Krishnan AV

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:A longitudinal study assessed serum paraoxonase 1 (PON1) activity and concentration as affected by age and as associated with the development of type 2 diabetes (T2D). PON1's recently established physiological function is the hydrolysis of lipolactones in oxidized LDL particles. METHODS:Serum samples and cl...

journal_title：Diabetes/metabolism research and reviews

authors： Crow JA,Meek EC,Wills RW,Chambers JE

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes is a risk factor for stroke and confers increased risk of poor outcome and further vascular events following stroke. Hyperuricaemia occurs commonly in patients with type 2 diabetes, but its significance as a predictor of outcome following stroke is uncertain. We sought to investigate the prog...

journal_title：Diabetes/metabolism research and reviews

authors： Newman EJ,Rahman FS,Lees KR,Weir CJ,Walters MR

更新日期：2006-01-01 00:00:00

abstract：:In Mediterranean countries, the incidence (per 100,000 per year) of Type 1 diabetes in children aged under 15 years shows wide variation from country to country, ranging from 2.45 in Macedonia to 34.4 in Sardinia. By interacting with environmental factors such as diet, toxins or viral infections, the HLA plus non-HLA ...

journal_title：Diabetes/metabolism research and reviews

authors： Muntoni S,Muntoni S

更新日期：1999-03-01 00:00:00

abstract：BACKGROUND:Hybrid closed-loop (HCL) therapy is rarely studied in pregnancy. We present three cases of women with type 1 diabetes who used the Medtronic 670G HCL system for most or all of gestation. METHODS:The Medtronic 670G system has a manual mode (no automated insulin delivery) and an auto mode (AM, HCL therapy). W...

journal_title：Diabetes/metabolism research and reviews

authors： Polsky S,Akturk HK

更新日期：2020-03-01 00:00:00

abstract：:Abstinence from food and liquid during daylight hours is observed by Muslim individuals during the month of Ramadan. Even though the Koran exempts the sick from fasting, many people with diabetes still fast during this religious period. It is essential for patients, family and healthcare professionals to be aware of t...

journal_title：Diabetes/metabolism research and reviews

authors： Hui E,Devendra D

更新日期：2010-11-01 00:00:00

abstract：:The United Kingdom Prospective Diabetes Study (UKPDS) showed that tight glycemic control with any of several therapeutic regimens has the potential to significantly reduce the risk for long-term microvascular complications of type 2 diabetes. An important question that remains to be answered is what is the best approa...

journal_title：Diabetes/metabolism research and reviews

authors： Yki-Järvinen H

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:It has been shown that subjects with normal glucose tolerance (NGT), whose plasma glucose (PG) levels do not return to their fasting PG level within 2 h during an oral glucose tolerance test (OGTT) (Group I), have a significantly higher risk to develop type 2 diabetes than NGT subjects whose 2-h glucose retu...

journal_title：Diabetes/metabolism research and reviews

authors： Succurro E,Marini MA,Grembiale A,Lugarà M,Andreozzi F,Sciacqua A,Hribal ML,Lauro R,Perticone F,Sesti G

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Latent autoimmune diabetes in adults (LADA) exhibits significant clinical heterogeneity, but the underlying causes remain unclear. The aim of this study was to investigate whether age of onset of LADA contributes to the observed clinical heterogeneity by comparing the clinical, metabolic, and immunogenetic c...

journal_title：Diabetes/metabolism research and reviews

authors： Niu X,Luo S,Li X,Xie Z,Xiang Y,Huang G,Lin J,Yang L,Liu Z,Wang X,Leslie RD,Zhou Z

更新日期：2019-01-01 00:00:00

abstract：:Cardiovascular disease now is the leading cause of mortality among patients with type 1 diabetes (T1D). The risk of death from cardiovascular events in subjects with T1D is 2-10 times higher than the general population, depending on blood glucose control. Although complications of cardiovascular disease occur in middl...

journal_title：Diabetes/metabolism research and reviews

authors： Shi M,Tang R,Huang F,Zhong T,Chen Y,Li X,Zhou Z

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:Adiponectin acts as an insulin sensitizer in rodent models. The direct effect of adiponectin in intact type 2 diabetic muscle is unknown. We examined whether adiponectin stimulates glucose transport in isolated skeletal muscle strips from type 2 diabetic men. METHODS:We obtained open muscle biopsies from 12...

journal_title：Diabetes/metabolism research and reviews

authors： Kuoppamaa H,Skrobuk P,Sihvo M,Hiukka A,Chibalin AV,Zierath JR,Koistinen HA

更新日期：2008-10-01 00:00:00