Basal insulin analogues in diabetic pregnancy: a literature review and baseline results of a randomised, controlled trial in type 1 diabetes.

abstract：:Prevention of diabetic foot ulcers is important to reduce the burden of diabetic foot disease. However, we found that ulcer prevention is underexposed in research and clinical practice. Barriers to explain this are seen in patient's goal-setting; in the lack of interdisciplinary teams for ulcer prevention; in sample s...

journal_title：Diabetes/metabolism research and reviews

authors： Van Netten JJ,Woodburn J,Bus SA

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Higher prothrombotic status and alterations in platelet function and thrombopoiesis are associated with diabetes mellitus (DM). We assessed the impact of diabetes and glucose control on the immature platelet fraction (IPF) and their relationship with prevalence and extent of coronary artery disease (CAD). M...

journal_title：Diabetes/metabolism research and reviews

authors： Verdoia M,Nardin M,Rolla R,Pergolini P,Suryapranata H,Kedhi E,Carriero A,De Luca G,Novara Atherosclerosis Study Group (NAS).

更新日期：2020-05-01 00:00:00

abstract：:Every year, over 1 million people with diabetes lose a leg due to diabetic foot disease. Most amputations are preceded by a foot ulcer. Causes for the development of foot ulcers are generally multifactorial and may include neuropathy, peripheral vasculopathy, abnormal foot mechanics and infection. Multidisciplinary ap...

journal_title：Diabetes/metabolism research and reviews

authors： Cahn A,Elishuv O,Olshtain-Pops K

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Diabetic nephropathy (DN) is the most common cause of end stage renal failure or even death among patients with type 2 diabetes mellitus. Genetic predisposition is widely studied among these patients to identify manageable aspects of the disease pathogenesis. This study was carried out to test ...

journal_title：Diabetes/metabolism research and reviews

authors： Bayoumy NMK,El-Shabrawi MM,Leheta OF,Abo El-Ela AEM,Omar HH

更新日期：2020-07-01 00:00:00

abstract：AIMS:Diabetic neuropathy (DN) is a "Cinderella" complication, particularly in the Middle East. A high prevalence of undiagnosed DN and those at risk of diabetic foot ulceration (DFU) is a major concern. We have determined the prevalence of DN and its risk factors, DFU, and those at risk of DFU in patients with type 2 d...

journal_title：Diabetes/metabolism research and reviews

authors： Ponirakis G,Elhadd T,Chinnaiyan S,Dabbous Z,Siddiqui M,Al-Muhannadi H,Petropoulos IN,Khan A,Ashawesh KAE,Dukhan KMO,Mahfoud ZR,Murgatroyd C,Slevin M,Malik RA

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Adenosine triphosphate (ATP) is a critical determinant of beta-cell insulin secretion in response to glucose. BHE/cdb rats have a mutation in ATP synthase that limits ATP production, yet develop mild diabetes only with ageing. We investigated the cellular basis for reduced insulin secretion and compensatory ...

journal_title：Diabetes/metabolism research and reviews

authors： Saleh MC,Fatehi-Hassanabad Z,Wang R,Nino-Fong R,Wadowska DW,Wright GM,Harper ME,Chan CB

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:Diabetes commonly leads to long-term complications such as cataract. This study investigated the effects of alpha-lipoic acid (LPA) and its gamma-linolenic acid (GLA) conjugate on cataract development in diabetic sand rats. METHODS:Two separate experiments were conducted. In Experiment 1, sand rats were fed...

journal_title：Diabetes/metabolism research and reviews

authors： Borenshtein D,Ofri R,Werman M,Stark A,Tritschler HJ,Moeller W,Madar Z

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:To ascertain which demographic, clinical, and microbiological factors might affect clinical outcomes of patients with diabetic foot infections, excluding known osteomyelitis, by analysing Clinical Assessment Program and Teflaro® Utilization Registry study data of patients treated with ceftaroline fosamil. M...

journal_title：Diabetes/metabolism research and reviews

authors： Lipsky BA,Cannon CM,Ramani A,Jandourek A,Calmaggi A,Friedland HD,Goldstein EJ

更新日期：2015-05-01 00:00:00

abstract：BACKGROUND:Increased activity of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in enhanced adrenocorticotropin (ACTH) and serum glucocorticoid levels, has been described in patients with diabetes mellitus and in animal models of this disease; however, altered steroid production by adrenocortical cells could ...

journal_title：Diabetes/metabolism research and reviews

authors： Astort F,Repetto EM,Martínez Calejman C,Cipelli JM,Sánchez R,Di Gruccio JM,Mercau M,Pignataro OP,Arias P,Cymeryng CB

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:To compare in atrial fibrillation patients with and without diabetes, (1) baseline characteristics, (2) additional risk factors for stroke or peripheric or visceral embolism (hypertension, previous stroke, age >75 years), (3) mortality, (4) stroke or embolism, and (5) oral anticoagulation in the year 2000. ...

journal_title：Diabetes/metabolism research and reviews

authors： Klem I,Wehinger C,Schneider B,Hartl E,Finsterer J,Stöllberger C

更新日期：2003-07-01 00:00:00

abstract：:Since the publication of the United Kingdom Prospective Diabetes Study (UKPDS), the progressive nature of type 2 (DM2) diabetes has been identified as the main cause of failure to maintain a long term glycemic control.[1] The need to adjust treatment as the disease progressed was recognized and algorithms for treatmen...

journal_title：Diabetes/metabolism research and reviews

authors： Eliaschewitz FG,Tambascia MA

更新日期：2012-12-05 00:00:00

abstract：BACKGROUND:This study examined whether temporal trends exist in treatment of patients with type 2 diabetes (T2D) and quality of diabetes care after implementation of quality improvement initiative in primary care setting. METHODS:We conducted a population-based retrospective cohort study of 202,284 patients with T2D w...

journal_title：Diabetes/metabolism research and reviews

authors： Wong CKH,Fung CSC,Yu EYT,Wan EYF,Chan AKC,Lam CLK

更新日期：2018-02-01 00:00:00

abstract：BACKGROUND:To investigate longitudinal associations of maternal glucose/HbA1c and insulin dose with birthweight-related outcomes in women with type 1 diabetes. METHODS:We performed a cohort study including 473 pregnant women with type 1 diabetes with singleton pregnancies. We investigated maternal self-monitored blood...

journal_title：Diabetes/metabolism research and reviews

authors： García-Patterson A,Ovejero D,Miñambres I,Chico A,Gil PA,Martínez MJ,Adelantado JM,de Leiva A,Gich I,Desoye G,de Mouzon SH,Corcoy R

更新日期：2020-07-01 00:00:00

abstract：:It is well established that hyperglycaemia is associated with many negative cardiovascular and immunological effects. Because of the high prevalence of underlying vascular disease along with associated infection, patients with diabetic foot ulcers are especially vulnerable to these adverse consequences. While studies ...

journal_title：Diabetes/metabolism research and reviews

authors： Egan AM,Dinneen SF

更新日期：2016-01-01 00:00:00

abstract：AIMS:To assess the validity of the diagnostic codes relating to diabetic foot ulcer (DFU) in the electronic medical records of a large integrated care provider and to assess the prevalence of DFU among its members. MATERIALS AND METHODS:Data were obtained from the diabetes registry of Maccabi Healthcare Services (MHS)...

journal_title：Diabetes/metabolism research and reviews

authors： Cahn A,Altaras T,Agami T,Liran O,Touaty CE,Drahy M,Pollack R,Raz I,Chodick G,Zucker I

更新日期：2019-02-01 00:00:00

abstract：AIMS:This study was designed to investigate the association between pancreatic fat content (PFC) and insulin secretory capacity as well as glucose tolerance in Korean adults. MATERIALS:A total of 39 participants (mean age 49.9 years, 53% males) without a previous history of diabetes, or those previously diagnosed as h...

journal_title：Diabetes/metabolism research and reviews

authors： Chin SO,Hwang YC,Cho IJ,Jeong IK,Ahn KJ,Chung HY

更新日期：2020-11-30 00:00:00

abstract：BACKGROUND:Leptin's hematopoietic or proinflammatory role has been experimentally reported. We investigated whether serum leptin concentrations are associated with white blood cell (WBC) counts in humans. METHODS:Serum leptin concentrations of Japanese civil servants aged 40 to 59 years (1082 men and 200 women) were a...

journal_title：Diabetes/metabolism research and reviews

authors： Mabuchi T,Yatsuya H,Tamakoshi K,Otsuka R,Nagasawa N,Zhang H,Murata C,Wada K,Ishikawa M,Hori Y,Kondo T,Hashimoto S,Toyoshima H

更新日期：2005-09-01 00:00:00

abstract：BACKGROUND:Diabetic wounds are refractory and very difficult to heal. We aimed to use miRNA to identify novel and specific molecular markers for diabetes mellitus (DM) diagnosis and treatment. METHODS:The expression level of miR-296-5p was determined in tissue samples of 12 DM patients. The effect of miR-296-5p on pro...

journal_title：Diabetes/metabolism research and reviews

authors： Liu X,Wang Y,Zhang X,Zhang X,Guo J,Zhou J,Chai Y,Ma ZL

更新日期：2019-02-01 00:00:00

abstract：BACKGROUND:There is conflicting information regarding the risk of gestational diabetes mellitus in twin pregnancies. This study was conducted to determine whether the risk of gestational diabetes mellitus is higher in pregnant Japanese women with twin versus singleton pregnancy. METHODS:The prevalence of gestational d...

journal_title：Diabetes/metabolism research and reviews

authors： Morikawa M,Yamada T,Akaishi R,Kojima T,Nishida R,Koyama T,Cho K,Minakami H

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:Psammomys obesus gerbil exhibits PKCepsilon over-expression on high-energy (HE) diet. Muscle insulin receptor (IR) signalling and tyrosine kinase activity are inhibited eliciting insulin resistance. We aimed at preventing diabetes by inhibiting PKCepsilon-induced serine phosphorylation of IRS-1 with novel PKC...

journal_title：Diabetes/metabolism research and reviews

authors： Mack E,Ziv E,Reuveni H,Kalman R,Niv MY,Jörns A,Lenzen S,Shafrir E

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:T1DM is a T-cell-mediated autoimmune disease targeting insulin-producing beta-cells. Multiple factors may contribute to the development of T1DM. Among these, the metabolic state of beta-cells and pro-inflammatory cytokines, produced by infiltrating immune cells, have been implicated in the precipitation of T...

journal_title：Diabetes/metabolism research and reviews

authors： Osterbye T,Funda DP,Fundová P,Månsson JE,Tlaskalová-Hogenová H,Buschard K

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:The proposed 2015 US Preventive Services Task Force guidelines recommend diabetes screening for individuals ≥45 years or demonstrating other risk factors for dysglycemia. Still, many patients with dysglycemia remain undiagnosed, and opportunities for early intervention are lost. METHODS:To test novel approa...

journal_title：Diabetes/metabolism research and reviews

authors： Silverman RA,Schleicher MG,Valente CJ,Kim M,Romanenko Y,Schulman RC,Tiberio A,Greenblatt B,Rentala M,Salvador-Kelly AV,Kwon NS,Jornsay DL

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Increased production of reactive oxygen species (ROS) in mitochondria has been proposed as the pathogenic mechanism for chronic complications of diabetes. Mitochondrial DNA (mtDNA) is more vulnerable to reactive oxygen species. However, there are few data on the mitochondrial DNA damage in diabetes and these...

journal_title：Diabetes/metabolism research and reviews

authors： Savu O,Sunkari VG,Botusan IR,Grünler J,Nikoshkov A,Catrina SB

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:Women with obesity and type 2 diabetes (T2D) are at greater risk of dying from breast cancer than women without these conditions. Obesity and T2D are associated with insulin resistance and endogenous hyperinsulinemia and are more common in Black women. There is increasing disparity in breast cancer mortality...

journal_title：Diabetes/metabolism research and reviews

authors： Gallagher EJ,LeRoith D,Franco R,Antoniou IM,Nayak A,Livaudais-Toman J,Bickell NA

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:High birth weight has been related to an increased risk of type 1 diabetes (T1D), while suboptimal birth weight (both high and low) has been related to obesity, insulin resistance and type 2 diabetes. Insulin resistance, as a consequence of poor metabolic control, has been described in T1D patients. The aims...

journal_title：Diabetes/metabolism research and reviews

authors： Benevento D,Bizzarri C,Patera IP,Ravà L,Schiaffini R,Ciampalini P,Cianfarani S,Cappa M

更新日期：2013-01-01 00:00:00

abstract：:Insulin-producing pancreatic beta-cells are known to be extremely susceptible to destruction, primarily by autoimmune mechanisms, infectious agents, and by chemical toxins that cause overt type I diabetes. As development of highly protected insulin-producing cells would be important for successful cell therapy of diab...

journal_title：Diabetes/metabolism research and reviews

authors： Bloch K,Vardi P

更新日期：2005-05-01 00:00:00

abstract：:Rising rates of diabetes in pregnancy have led to an escalation in research in this area. As in any area of clinical research, definitions of outcomes vary from study to study, making it difficult to compare research findings and draw conclusions. Our aim was to compile and create a repository of definitions, which co...

journal_title：Diabetes/metabolism research and reviews

authors： International Association of Diabetes in Pregnancy Study Group (IADPSG) Working Group on Outcome Definitions.,Feig DS,Corcoy R,Jensen DM,Kautzky-Willer A,Nolan CJ,Oats JJ,Sacks DA,Caimari F,McIntyre HD

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:Adiponectin acts as an insulin sensitizer in rodent models. The direct effect of adiponectin in intact type 2 diabetic muscle is unknown. We examined whether adiponectin stimulates glucose transport in isolated skeletal muscle strips from type 2 diabetic men. METHODS:We obtained open muscle biopsies from 12...

journal_title：Diabetes/metabolism research and reviews

authors： Kuoppamaa H,Skrobuk P,Sihvo M,Hiukka A,Chibalin AV,Zierath JR,Koistinen HA

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:Prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in developing countries, but its causes are not known. We aimed to ascertain the prevalence and determinants of NAFLD in a new largely unmedicated population-based cohort from the rapidly gentrifying region of Pinggu, China. METHODS:We ran...

journal_title：Diabetes/metabolism research and reviews

authors： Zhou X,Li Y,Zhang X,Guan YY,Puentes Y,Zhang F,Speliotes EK,Ji L

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:We conducted a clinical research study to determine the effect of self-monitoring of blood glucose (SMBG) on glycaemic control and the value of a putatively less painful blood sampling technique on SMBG in oral hypoglycaemic agent-treated type 2 diabetes patients; SMBG has not been broadly applied in non-ins...

journal_title：Diabetes/metabolism research and reviews

authors： Harashima S,Fukushima T,Sasaki M,Nishi Y,Fujimoto S,Ogura M,Yamane S,Tanaka D,Harada N,Hamasaki A,Nagashima K,Nakahigashi Y,Seino Y,Inagaki N

更新日期：2013-01-01 00:00:00