Abstract：
BACKGROUND:We aimed to predict the incidence of obesity in a Korean population using a genetic risk score (GRS) constructed with obesity-related single nucleotide polymorphisms (SNPs) along with an oxidative stress score (OSS). METHODS:A total of 9460 Korean subjects and 356 974 SNPs were included. The GRS was constructed using three significant obesity-related SNP loci, and the OSS was calculated with three reliable oxidative stress biomarkers. RESULTS:The GRS showed a more significant association with increased obesity (OR = 2.879) than did individual SNPs after adjusting for age and sex. Three oxidative stress biomarkers, including malondialdehyde, oxidized low-density lipoprotein, and 8-epi-prostaglandin F2α , showed significantly high levels in the obese group. The OSS, which was the sum of each oxidative stress biomarker score, showed a markedly high association with the incidence of obesity, with an OR of 3.213. Based on the results of the regression tests and a receiver-operating characteristic (ROC) curve analysis, we found that HOMA-IR, high-sensitivity C-reactive protein (hs-CRP), the GRS, and the OSS were the most relevant factors for the increased risk of obesity and were significantly associated with the incidence of obesity. The area under the ROC curve was improved when the GRS was added to the model (from 74.2% to 75.1%). CONCLUSIONS:We first identified that subjects with an obesity GRS and a high OSS might have a higher risk of obesity. Our findings and weighting approaches were effective in predicting the incidence of obesity; furthermore, the GRS is a relevant factor that significantly predicts the risk of obesity.
journal_name
Diabetes Metab Res Revjournal_title
Diabetes/metabolism research and reviewsauthors
Park S,Yoo HJ,Jee SH,Lee JH,Kim Mdoi
10.1002/dmrr.3230subject
Has Abstractpub_date
2020-02-01 00:00:00pages
e3230issue
2eissn
1520-7552issn
1520-7560journal_volume
36pub_type
杂志文章abstract：AIMS:Type 2 diabetes (T2D) is a global health problem that will be diagnosed in almost 300 million people by 2025 according to the World Health Organization. Before being diagnosed with T2D, individuals may have glucose levels above normal but below the diabetic range. This condition is known as prediabetes. Studies sh...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.3405
更新日期：2020-09-10 00:00:00
abstract：BACKGROUND:Smooth muscle cells proliferation and extracellular matrix (ECM) protein deposition are key features of diabetic macroangiopathy. In the present study, we have studied the role of endothelin(A) (ET(A)) receptor, the predominant receptor on smooth muscle cells, in diabetes-induced vascular hypertrophy and rem...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.527
更新日期：2005-07-01 00:00:00
abstract：BACKGROUND:Sustained hyperglycaemia induces increased renal oxygen consumption resulting in reduced oxygen availability in the diabetic kidney. We investigated the roles of the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase and the neuronal nitric oxide synthase (nNOS) for the increased oxygen consumption ...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.1099
更新日期：2010-07-01 00:00:00
abstract：:Hyperglycemia unawareness is the term suggested to me (M. Muggeo, personal communication, 1997) to encompass very broadly all of the stages in diabetes mellitus from the onset of any degree of hyperglycemia until the diagnosis is actually made. Diabetes and its handmaiden, obesity, are growing in epidemic proportions ...
journal_title：Diabetes/metabolism research and reviews
pub_type： 评论,社论
doi：10.1002/1520-7560(200007/08)16:4<228::aid-dmrr125>
更新日期：2000-07-01 00:00:00
abstract：BACKGROUND:The active cognitive-motor demands of driving may have a significant metabolic demand that could contribute to the development of hypoglycemia. Conversely, symptoms caused by the stress of driving may be confused with hypoglycemia and lead to false alarms. This study examined the metabolic demand and the phy...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.306
更新日期：2002-09-01 00:00:00
abstract：:The immediate consequences of gestational diabetes on pregnancy are well known but the complications decades later for the mother and child are just now emerging. This trio of papers discuss the long-term consequences of gestational diabetes, the importance of screening this high risk group of women for type 2 diabete...
journal_title：Diabetes/metabolism research and reviews
pub_type： 社论
doi：10.1002/dmrr.2280
更新日期：2012-05-01 00:00:00
abstract：BACKGROUND:The ABO blood types are associated with cancers, cardiovascular diseases and type 2 diabetes mellitus but whether they are also associated with gestational diabetes mellitus (GDM) is unknown. We examined the relationship between the ABO blood types and the risk of GDM in a prospective population-based Chines...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2650
更新日期：2015-09-01 00:00:00
abstract：BACKGROUND:Diabetes mellitus secondary to pancreatic diseases is a condition seldom thought of in clinical practice. Yet, a high percentage of exocrine pancreatic insufficiency has been reported for the general population and especially for diabetic subjects. Thus, we investigated the prevalence of diabetes mellitus du...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2260
更新日期：2012-05-01 00:00:00
abstract：:The role of peripheral arterial disease in ulcerated diabetic feet has long been underestimated. Progressive claudication, rest pain and the extent of irreversible tissue loss have frequently been indications for revascularization for neuroischaemic ulcers in diabetic patients. These typical ischaemic symptoms are war...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.2259
更新日期：2012-02-01 00:00:00
abstract：:The actual pathophysiology behind gestational diabetes mellitus (GDM) is still unclear, but a deterioration in insulin resistance beyond that induced by pregnancy, combined with beta cell dysfunction, plays a key role. Interventions that help improve glucose tolerance by attenuating pregnancy-induced insulin resistanc...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.2402
更新日期：2013-07-01 00:00:00
abstract：:Increasing coprevalence of diabetes mellitus (DM) and tuberculosis (TB) in low-income and middle-income countries (LMICs) indicates a rising threat to the decades of progress made against TB and requires global attention. This systematic review provides a summary of type 2 diabetes and tuberculosis coprevalence in var...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.3066
更新日期：2019-01-01 00:00:00
abstract：:Diabetes is a group of metabolic diseases characterized by elevated blood glucose levels that drive the development of life-threatening complications. Diabetes results from a situation of insufficient insulin action, either by deficient production of the hormone by the pancreas, or by the development of insulin resist...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.3107
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Leptin's hematopoietic or proinflammatory role has been experimentally reported. We investigated whether serum leptin concentrations are associated with white blood cell (WBC) counts in humans. METHODS:Serum leptin concentrations of Japanese civil servants aged 40 to 59 years (1082 men and 200 women) were a...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.540
更新日期：2005-09-01 00:00:00
abstract：BACKGROUND:A longitudinal study assessed serum paraoxonase 1 (PON1) activity and concentration as affected by age and as associated with the development of type 2 diabetes (T2D). PON1's recently established physiological function is the hydrolysis of lipolactones in oxidized LDL particles. METHODS:Serum samples and cl...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2967
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:Higher prothrombotic status and alterations in platelet function and thrombopoiesis are associated with diabetes mellitus (DM). We assessed the impact of diabetes and glucose control on the immature platelet fraction (IPF) and their relationship with prevalence and extent of coronary artery disease (CAD). M...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.3290
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:It has been shown that subjects with normal glucose tolerance (NGT), whose plasma glucose (PG) levels do not return to their fasting PG level within 2 h during an oral glucose tolerance test (OGTT) (Group I), have a significantly higher risk to develop type 2 diabetes than NGT subjects whose 2-h glucose retu...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.951
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:We have investigated the possible role of ACP1 (also known as cLMWPTP: cytosolic low molecular weight phosphotyrosine phosphatase), a highly polymorphic enzyme involved in signal transduction of T-cell receptor, insulin receptor and other growth factors in the relationship between maternal age at delivery an...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.521
更新日期：2005-07-01 00:00:00
abstract：BACKGROUND:Data on the association between body iron and glucose homeostasis by the three glycaemic states are scarce. Thus, we investigated the association between body iron as assessed by a serum ferritin concentration and glucose homeostasis using homeostasis model assessment (HOMA) of insulin resistance (HOMA-IR) a...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2628
更新日期：2015-07-01 00:00:00
abstract：:Non-invasive tests for the detection of peripheral artery disease (PAD) among individuals with diabetes mellitus are important to estimate the risk of amputation, ulceration, wound healing and the presence of cardiovascular disease, yet there are no consensus recommendations to support a particular diagnostic modality...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.2703
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:High birth weight has been related to an increased risk of type 1 diabetes (T1D), while suboptimal birth weight (both high and low) has been related to obesity, insulin resistance and type 2 diabetes. Insulin resistance, as a consequence of poor metabolic control, has been described in T1D patients. The aims...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2361
更新日期：2013-01-01 00:00:00
abstract：OBJECTIVE:Statins are one of the most widely prescribed medications in the United States; however, there is a concern that they are associated with new-onset-diabetes (NOD) development. We sought to understand the risk of dysglycemia and NOD for a cohort of individuals that reflect real-world physician prescribing patt...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.3189
更新日期：2019-11-01 00:00:00
abstract：:Patients with type 2 diabetes mellitus using sulfonylurea derivatives or insulin may experience hypoglycaemia. However, recent data regarding the incidence of hypoglycaemia are scarce. We conducted a systematic review and meta-analysis to determine the proportion of patients with type 2 diabetes mellitus that experien...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/dmrr.2470
更新日期：2014-01-01 00:00:00
abstract：BACKGROUND:T1DM is a T-cell-mediated autoimmune disease targeting insulin-producing beta-cells. Multiple factors may contribute to the development of T1DM. Among these, the metabolic state of beta-cells and pro-inflammatory cytokines, produced by infiltrating immune cells, have been implicated in the precipitation of T...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.1134
更新日期：2010-11-01 00:00:00
abstract：:Hypertension is a major modifiable risk factor for cardiovascular morbidity and mortality in diabetic patients. Guidelines recommend lowering blood pressure (BP) to less than 130/80 mmHg in diabetic patients. These recommendations are based on several studies in diabetic patients that showed the benefit of intensive B...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.2348
更新日期：2012-12-01 00:00:00
abstract：:This perspective covers a novel area of research describing the inadequacies of current approaches for diagnosing dysglycaemia and proposes that the 1-hour post-load glucose level during the 75-g oral glucose tolerance test may serve as a novel biomarker to detect dysglycaemia earlier than currently recommended screen...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2992
更新日期：2018-07-01 00:00:00
abstract：BACKGROUND:Increased activity of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in enhanced adrenocorticotropin (ACTH) and serum glucocorticoid levels, has been described in patients with diabetes mellitus and in animal models of this disease; however, altered steroid production by adrenocortical cells could ...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.978
更新日期：2009-07-01 00:00:00
abstract：:In recent years it has been estimated that the current global prevalence of type 2 diabetes amounts to about 150 million patients. Projections suggest that by the year 2025 the number of prevalent patients in the world will reach approximately 300 million. It is assumed that the increase in the number of patients will...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.340
更新日期：2003-01-01 00:00:00
abstract：BACKGROUND:Prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in developing countries, but its causes are not known. We aimed to ascertain the prevalence and determinants of NAFLD in a new largely unmedicated population-based cohort from the rapidly gentrifying region of Pinggu, China. METHODS:We ran...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.3156
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:To evaluate possible differences in distal polyneuropathy (PN) characteristics and degree of abnormalities for various small and large fibre parameters in diabetes type 1 (DM1) and type 2 (DM2). METHODS:Sixty-six DM1 and 57 DM2 patients with or without PN symptoms were included. Nerve conduction studies (NC...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.1049
更新日期：2010-02-01 00:00:00
abstract：:Neuropathy is a frequent complication in diabetes and most commonly seen as distal symmetrical sensorimotor polyneuropathy (PN). Involvement of the motor system is infrequently seen at the clinical examination. However, with the application of quantitative techniques, that is, isokinetic dynamometry, type 1 and type 2...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.2257
更新日期：2012-02-01 00:00:00
