Coprevalence of type 2 diabetes mellitus and tuberculosis in low-income and middle-income countries: A systematic review.


:Increasing coprevalence of diabetes mellitus (DM) and tuberculosis (TB) in low-income and middle-income countries (LMICs) indicates a rising threat to the decades of progress made against TB and requires global attention. This systematic review provides a summary of type 2 diabetes and tuberculosis coprevalence in various LMICs. We searched PubMed, Ovid Medline, Embase, and PsychINFO databases for studies that provided estimates of TB-DM coprevalence in LMICs published between 1990 and 2016. Studies that were non-English and exclusively conducted in multidrug resistant-tuberculosis or type 1 diabetes and inpatient settings were excluded. We reviewed 84 studies from 31 countries. There were huge diversity of study designs and diagnostic methods used to estimate coprevalence, and this precluded pooling of the results. Most studies (n = 78) were from small, localized settings. The DM prevalence among TB patients in various LMICs varied from 1.8% to 45%, with the majority (n = 44) between 10% and 30%. The TB prevalence among people with DM ranged from 0.1% to 6.0% with most studies (n = 9) reporting prevalences less than 2%. Coprevalence of TB-DM was higher than general population prevalence of either diseases in these countries. This study underscores the need for intervention and more focused research on TB DM bidirectional screening programs in low-income and middle-income countries as well as integrated chronic disease management.


Diabetes Metab Res Rev


McMurry HS,Mendenhall E,Rajendrakumar A,Nambiar L,Satyanarayana S,Shivashankar R




Has Abstract


2019-01-01 00:00:00












  • The changing world demography of type 2 diabetes.

    abstract::In recent years it has been estimated that the current global prevalence of type 2 diabetes amounts to about 150 million patients. Projections suggest that by the year 2025 the number of prevalent patients in the world will reach approximately 300 million. It is assumed that the increase in the number of patients will...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Green A,Christian Hirsch N,Pramming SK

    更新日期:2003-01-01 00:00:00

  • A genetic variation in the fat mass- and obesity-associated gene is associated with obesity and newly diagnosed type 2 diabetes in a Chinese population.

    abstract:BACKGROUND:Recently, a genome-wide association study identified a strong association between the fat mass- and obesity-associated rs9939609 single nucleotide polymorphism (SNP) and the risk of obesity in European population. However, the results in Chinese population were reported to be contradictory. Therefore, our ai...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Li X,Song F,Jiang H,Zhang M,Lin J,Bao W,Yao P,Yang X,Hao L,Liu L

    更新日期:2010-02-01 00:00:00

  • Prevalence of diabetes mellitus secondary to pancreatic diseases (type 3c).

    abstract:BACKGROUND:Diabetes mellitus secondary to pancreatic diseases is a condition seldom thought of in clinical practice. Yet, a high percentage of exocrine pancreatic insufficiency has been reported for the general population and especially for diabetic subjects. Thus, we investigated the prevalence of diabetes mellitus du...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Ewald N,Kaufmann C,Raspe A,Kloer HU,Bretzel RG,Hardt PD

    更新日期:2012-05-01 00:00:00

  • Head-to-head comparison of dipeptidyl peptidase-IV inhibitors and sulfonylureas - a meta-analysis from randomized clinical trials.

    abstract:BACKGROUND:Dipeptidyl peptidase-IV (DPP-4) inhibitors and sulfonylureas are two important second-line anti-diabetic agents. The objective of this research was to evaluate the efficacy and safety of DPP-4 inhibitors compared with sulfonylureas by meta-analytic approach of available randomized studies. METHODS:We search...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Zhang Y,Hong J,Chi J,Gu W,Ning G,Wang W

    更新日期:2014-03-01 00:00:00

  • Advanced complicated diabetes mellitus is associated with a reduced risk of thoracic and abdominal aortic aneurysm rupture: a population-based cohort study.

    abstract:BACKGROUND:Studies have associated diabetes mellitus (DM) with the reduced risk of abdominal aortic aneurysm and thoracic aortic aneurysm and dissection. We used the national insurance data of Taiwan to examine these correlations for an Asian population. The association was also evaluated by DM severity. METHODS:We id...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Tsai CL,Lin CL,Wu YY,Shieh DC,Sung FC,Kao CH

    更新日期:2015-02-01 00:00:00

  • Statin users have an elevated risk of dysglycemia and new-onset-diabetes.

    abstract:OBJECTIVE:Statins are one of the most widely prescribed medications in the United States; however, there is a concern that they are associated with new-onset-diabetes (NOD) development. We sought to understand the risk of dysglycemia and NOD for a cohort of individuals that reflect real-world physician prescribing patt...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Zigmont VA,Shoben AB,Lu B,Kaye GL,Clinton SK,Harris RE,Olivo-Marston SE

    更新日期:2019-11-01 00:00:00

  • Nocturnal hypoglycaemia in type 1 diabetes--consequences and assessment.

    abstract::Hypoglycaemia is inevitable when striving for low HbA1c values. Nocturnal hypoglycaemia often occurs without symptoms, but results in diminished next day well-being and hypoglycaemia unawareness. Frequency of nocturnal hypoglycaemia was first assessed in research ward settings, but suffered from insufficient glucose s...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: DeVries JH,Wentholt IM,Masurel N,Mantel I,Poscia A,Maran A,Heine RJ

    更新日期:2004-11-01 00:00:00

  • Immunization with an insulin peptide-MHC complex to prevent type 1 diabetes of NOD mice.

    abstract:BACKGROUND:Mutating the insulin B:9-23 peptide prevents diabetes in NOD mice. Thus, the trimolecular complex of I-Ag7-insulin B:9-23 peptide-TCR may be essential for the development of spontaneous diabetes. Pathogenic T cells recognize the B:9-23 peptide presented by I-Ag7 in what is termed register 3, with the B22 bas...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Zhang L,Stadinski BD,Michels A,Kappler JW,Eisenbarth GS

    更新日期:2011-11-01 00:00:00

  • Effectiveness of bedside investigations to diagnose peripheral artery disease among people with diabetes mellitus: a systematic review.

    abstract::Non-invasive tests for the detection of peripheral artery disease (PAD) among individuals with diabetes mellitus are important to estimate the risk of amputation, ulceration, wound healing and the presence of cardiovascular disease, yet there are no consensus recommendations to support a particular diagnostic modality...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Brownrigg JR,Hinchliffe RJ,Apelqvist J,Boyko EJ,Fitridge R,Mills JL,Reekers J,Shearman CP,Zierler RE,Schaper NC,International Working Group on the Diabetic Foot.

    更新日期:2016-01-01 00:00:00

  • A multi-centre randomized trial of two different doses of nicotinamide in patients with recent-onset type 1 diabetes (the IMDIAB VI).

    abstract:BACKGROUND:Intensive insulin therapy is the gold standard by which Type 1 diabetes is treated. In addition to this therapy, administration of nicotinamide (NA) can be beneficial. This concept is reinforced by the results of a recent meta-analysis of the use of NA in patients with recent-onset Type 1 diabetes. METHODS:...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Visalli N,Cavallo MG,Signore A,Baroni MG,Buzzetti R,Fioriti E,Mesturino C,Fiori R,Lucentini L,Matteoli MC,Crinò A,Corbi S,Spera S,Teodonio C,Paci F,Amoretti R,Pisano L,Suraci C,Multari G,Sulli N,Cervoni M,De Mat

    更新日期:1999-05-01 00:00:00

  • Programmed disorders of beta-cell development and function as one cause for type 2 diabetes? The GK rat paradigm.

    abstract::Now that the reduction in beta-mass has been clearly established in humans with type 2 diabetes mellitus (T2DM) 1-4, the debate focuses on the possible mechanisms responsible for decreased beta-cell number and impaired beta-cell function and their multifactorial etiology. Appropriate inbred rodent models are essential...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Portha B

    更新日期:2005-11-01 00:00:00

  • Axonal dysfunction prior to neuropathy onset in type 1 diabetes.

    abstract:BACKGROUND:The present study was undertaken to determine whether there were changes evident in axonal membrane function prior to the onset of neuropathy in patients with type 1 and type 2 diabetes. METHODS:From a cohort of 110 consecutive referrals, nerve excitability was investigated in 40 diabetic patients without c...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Arnold R,Kwai N,Lin CS,Poynten AM,Kiernan MC,Krishnan AV

    更新日期:2013-01-01 00:00:00

  • Coincident diabetes mellitus and primary hyperparathyroidism.

    abstract::The prevalence of diabetes mellitus in primary hyperparathyroidism is approximately 8% and that of primary hyperparathyroidism in diabetic patients is approximately 1%. Both values are about three-fold higher than the respective expected prevalences in general populations. Patients with both disorders are over 40 year...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Taylor WH,Khaleeli AA

    更新日期:2001-05-01 00:00:00

  • Temporal trends in quality of primary care for patients with type 2 diabetes mellitus: A population-based retrospective cohort study after implementation of a quality improvement initiative.

    abstract:BACKGROUND:This study examined whether temporal trends exist in treatment of patients with type 2 diabetes (T2D) and quality of diabetes care after implementation of quality improvement initiative in primary care setting. METHODS:We conducted a population-based retrospective cohort study of 202,284 patients with T2D w...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Wong CKH,Fung CSC,Yu EYT,Wan EYF,Chan AKC,Lam CLK

    更新日期:2018-02-01 00:00:00

  • Surgical management of Charcot neuroarthropathy of the ankle and hindfoot in patients with diabetes.

    abstract:BACKGROUND:Charcot neuroarthropathy (CN) of the ankle and hindfoot (Sanders/Frykberg Type IV) is challenging to treat surgically or nonsurgically. The deformities associated with ankle/hindfoot CN are often multiplanar, resulting in sagittal, frontal and rotational malalignment. In addition, shortening of the limb ofte...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Wukich DK,Raspovic KM,Hobizal KB,Sadoskas D

    更新日期:2016-01-01 00:00:00

  • Can molecular DNA-based techniques unravel the truth about diabetic foot infections?

    abstract::Diabetes foot infections are a common condition and a major causal pathway to lower extremity amputation. Identification of causative pathogens is vital in directing antimicrobial therapy. Historically, clinicians have relied upon culture-dependent techniques that are now acknowledged as both being selective for micro...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Malone M,Gosbell IB,Dickson HG,Vickery K,Espedido BA,Jensen SO

    更新日期:2017-01-01 00:00:00

  • Calculating the insulin to carbohydrate ratio using the hyperinsulinaemic-euglycaemic clamp-a novel use for a proven technique.

    abstract:BACKGROUND:In patients with type 1 diabetes, three main variables need to be assessed to optimize meal-related insulin boluses: pre-meal blood glucose (BG), insulin to carbohydrate ratio (I : C), and basal insulin. We are presenting data for a novel use of the hyperinsulinaemic-euglycaemic clamp (HEC) in patients with ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Bevier WC,Zisser H,Palerm CC,Finan DA,Seborg DE,Doyle FJ,Wollitzer AO,Jovanovic L

    更新日期:2007-09-01 00:00:00

  • Nonenzymatic glycation of high-density lipoprotein impairs its anti-inflammatory effects in innate immunity.

    abstract:AIMS/HYPOTHESIS:In type 2 diabetes mellitus (T2DM), the abnormal protein and lipid composition of diabetic high-density lipoprotein (HDL) could impair its anti-inflammatory functions. Whether nonenzymatic glycation directly impaired the anti-inflammatory effects of HDL in innate immunity remained unclear. METHODS:Huma...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Liu D,Ji L,Zhang D,Tong X,Pan B,Liu P,Zhang Y,Huang Y,Su J,Willard B,Zheng L

    更新日期:2012-02-01 00:00:00

  • Global DNA methylation as a possible biomarker for diabetic retinopathy.

    abstract:BACKGROUND:We evaluated whether global levels of DNA methylation status were associated with retinopathy as well as providing a predictive role of DNA methylation in developing retinopathy in a case-control study of 168 patients with type 2 diabetes. METHODS:The 5-methylcytosine content was assessed by reversed-phase ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Maghbooli Z,Hossein-nezhad A,Larijani B,Amini M,Keshtkar A

    更新日期:2015-02-01 00:00:00

  • Risk of type 1 diabetes in childhood and maternal age at delivery, interaction with ACP1 and sex.

    abstract:BACKGROUND:We have investigated the possible role of ACP1 (also known as cLMWPTP: cytosolic low molecular weight phosphotyrosine phosphatase), a highly polymorphic enzyme involved in signal transduction of T-cell receptor, insulin receptor and other growth factors in the relationship between maternal age at delivery an...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Bottini N,Meloni GF,Lucarelli P,Amante A,Saccucci P,Gloria-Bottini F,Bottini E

    更新日期:2005-07-01 00:00:00

  • Mutated ATP synthase induces oxidative stress and impaired insulin secretion in beta-cells of female BHE/cdb rats.

    abstract:BACKGROUND:Adenosine triphosphate (ATP) is a critical determinant of beta-cell insulin secretion in response to glucose. BHE/cdb rats have a mutation in ATP synthase that limits ATP production, yet develop mild diabetes only with ageing. We investigated the cellular basis for reduced insulin secretion and compensatory ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Saleh MC,Fatehi-Hassanabad Z,Wang R,Nino-Fong R,Wadowska DW,Wright GM,Harper ME,Chan CB

    更新日期:2008-07-01 00:00:00

  • The use of antimicrobials as adjuvant therapy for the treatment of obesity and insulin resistance: Effects and associated mechanisms.

    abstract::The intestinal microbiota has come to be considered an additional risk factor for the development of metabolic diseases. Considering the potential role of antimicrobials as modulators of the intestinal microbiota, they have been investigated for use in the adjuvant treatment of obesity and insulin resistance (IR). In ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Dos Reis SA,do Carmo Gouveia Peluzio M,Bressan J

    更新日期:2018-09-01 00:00:00

  • Prevalence of undiagnosed dysglycemia in an emergency department observation unit.

    abstract:BACKGROUND:The proposed 2015 US Preventive Services Task Force guidelines recommend diabetes screening for individuals ≥45 years or demonstrating other risk factors for dysglycemia. Still, many patients with dysglycemia remain undiagnosed, and opportunities for early intervention are lost. METHODS:To test novel approa...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Silverman RA,Schleicher MG,Valente CJ,Kim M,Romanenko Y,Schulman RC,Tiberio A,Greenblatt B,Rentala M,Salvador-Kelly AV,Kwon NS,Jornsay DL

    更新日期:2016-01-01 00:00:00

  • Validity of diagnostic codes and estimation of prevalence of diabetic foot ulcers using a large electronic medical record database.

    abstract:AIMS:To assess the validity of the diagnostic codes relating to diabetic foot ulcer (DFU) in the electronic medical records of a large integrated care provider and to assess the prevalence of DFU among its members. MATERIALS AND METHODS:Data were obtained from the diabetes registry of Maccabi Healthcare Services (MHS)...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Cahn A,Altaras T,Agami T,Liran O,Touaty CE,Drahy M,Pollack R,Raz I,Chodick G,Zucker I

    更新日期:2019-02-01 00:00:00

  • Nested case-control data analysis using weighted conditional logistic regression in The Environmental Determinants of Diabetes in the Young (TEDDY) study: A novel approach.

    abstract:BACKGROUND:A nested case-control (NCC) design within a prospective cohort study can realize substantial benefits for biomarker studies. In this context, it is natural to consider the sample availability in the selection of controls to minimize data loss when implementing the design. However, this violates the randomnes...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Lee HS,Lynch KF,Krischer JP,TEDDY Study Group.

    更新日期:2020-01-01 00:00:00

  • Small fibre neuropathy: role in the diagnosis of diabetic sensorimotor polyneuropathy.

    abstract::Small fibres constitute 70-90% of peripheral nerve fibres and regulate several key functions such as tissue blood flow, temperature and pain perception as well as sweating, all of which are highly relevant to the clinical presentation and adverse outcomes associated with foot ulcerations in patients with diabetes. Rec...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,实务指引


    authors: Malik RA,Veves A,Tesfaye S,Smith G,Cameron N,Zochodne D,Lauria G,Toronto Consensus Panel on Diabetic Neuropathy.

    更新日期:2011-10-01 00:00:00

  • Ceftaroline fosamil for treatment of diabetic foot infections: the CAPTURE study experience.

    abstract:BACKGROUND:To ascertain which demographic, clinical, and microbiological factors might affect clinical outcomes of patients with diabetic foot infections, excluding known osteomyelitis, by analysing Clinical Assessment Program and Teflaro® Utilization Registry study data of patients treated with ceftaroline fosamil. M...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,多中心研究


    authors: Lipsky BA,Cannon CM,Ramani A,Jandourek A,Calmaggi A,Friedland HD,Goldstein EJ

    更新日期:2015-05-01 00:00:00

  • Thiazolidinedione therapy and breast cancer risk in diabetic women: A systematic review and meta-analysis.

    abstract::Rising experimental evidence suggests that thiazolidinediones (TZDs) exert a protective effect on breast cancer. However, studies concerning this issue were inconsistent and limited. Hence, we performed a meta-analysis with data from currently available studies to evaluate the effect of TZDs on breast cancer risk amon...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Du R,Lin L,Cheng D,Xu Y,Xu M,Chen Y,Wang W,Bi Y,Li D,Lu J

    更新日期:2018-02-01 00:00:00

  • The effects of thyroid hormones on brown adipose tissue in humans: a PET-CT study.

    abstract:BACKGROUND:Brown adipose tissue (BAT) is important for energy expenditure through thermogenesis, although its regulatory factors are not well known in humans. There is evidence suggesting that thyroid hormones affect BAT functions in some mammals, but the effects of thyroid hormones on BAT activity in humans are still ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Zhang Q,Miao Q,Ye H,Zhang Z,Zuo C,Hua F,Guan Y,Li Y

    更新日期:2014-09-01 00:00:00

  • Exercise training restores abnormal myocardial glucose utilization and cardiac function in diabetes.

    abstract:BACKGROUND:Clinical and experimental studies have shown that a reduction in myocardial glucose utilization is a factor contributing to diabetic cardiomyopathy. This study determined whether exercise training could prevent the depression in glucose utilization observed in the diabetic rat heart. METHODS:Diabetes was in...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Broderick TL,Poirier P,Gillis M

    更新日期:2005-01-01 00:00:00