Abstract：
:Increasing coprevalence of diabetes mellitus (DM) and tuberculosis (TB) in low-income and middle-income countries (LMICs) indicates a rising threat to the decades of progress made against TB and requires global attention. This systematic review provides a summary of type 2 diabetes and tuberculosis coprevalence in various LMICs. We searched PubMed, Ovid Medline, Embase, and PsychINFO databases for studies that provided estimates of TB-DM coprevalence in LMICs published between 1990 and 2016. Studies that were non-English and exclusively conducted in multidrug resistant-tuberculosis or type 1 diabetes and inpatient settings were excluded. We reviewed 84 studies from 31 countries. There were huge diversity of study designs and diagnostic methods used to estimate coprevalence, and this precluded pooling of the results. Most studies (n = 78) were from small, localized settings. The DM prevalence among TB patients in various LMICs varied from 1.8% to 45%, with the majority (n = 44) between 10% and 30%. The TB prevalence among people with DM ranged from 0.1% to 6.0% with most studies (n = 9) reporting prevalences less than 2%. Coprevalence of TB-DM was higher than general population prevalence of either diseases in these countries. This study underscores the need for intervention and more focused research on TB DM bidirectional screening programs in low-income and middle-income countries as well as integrated chronic disease management.
journal_name
Diabetes Metab Res Revjournal_title
Diabetes/metabolism research and reviewsauthors
McMurry HS,Mendenhall E,Rajendrakumar A,Nambiar L,Satyanarayana S,Shivashankar Rdoi
10.1002/dmrr.3066subject
Has Abstractpub_date
2019-01-01 00:00:00pages
e3066issue
1eissn
1520-7552issn
1520-7560journal_volume
35pub_type
杂志文章abstract：OBJECTIVE:Increased plasma levels of plasminogen activator inhibitor-1 (PAI-1) have been suggested to be a part of the insulin resistance syndrome, and recent data suggest that adipose tissue participates in the production of PAI-1. We examined the expression and insulin regulation of subcutaneous adipose tissue PAI-1 ...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/1520-7560(2000)9999:9999<::aid-dmrr148>3.0
更新日期：2000-09-01 00:00:00
abstract：:Whether diabetic foot ulcerations arise from an amalgam of neuro-ischemic factors or because of arterial occlusive disease alone, the arterial circulation must be thoroughly evaluated. Clinical evaluation is foremost, but numerous non-invasive diagnostic options such as duplex ultrasonography and MRA are often enliste...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.468
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:Human leukocyte antigen (HLA) genotypes associated with increased risk for type 1 diabetes mellitus (T1D) have been reported to be associated with increased birth weight. We set out to investigate the association between HLA haplotypes conferring risk for T1D and birth weight and search for possible differen...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,多中心研究
doi：10.1002/dmrr.2303
更新日期：2012-07-01 00:00:00
abstract：:During late gestation, although maternal adipose tissue lipolytic activity becomes enhanced, lipolytic products cross the placenta with difficulty. Under fasting conditions, free fatty acids (FFA) are used for ketogenesis by the mother, and ketone bodies are used as fuels and lipogenic substrates by the fetus. Materna...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/1520-7560(200005/06)16:3<202::aid-dmrr116>
更新日期：2000-05-01 00:00:00
abstract：BACKGROUND:Patients with impaired 50-g oral glucose challenge test (OGCT) have not been investigated for fetal anterior abdominal wall thickness until now. We aimed to investigate patients with impaired 50-g OGCT, but not gestational diabetes and match them with healthy uneventful pregnant participants for anterior abd...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2511
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM. METHODS:2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7-8 years of follow-up. RESULTS:NGT and IFG subjects who returned th...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.1084
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:To investigate longitudinal associations of maternal glucose/HbA1c and insulin dose with birthweight-related outcomes in women with type 1 diabetes. METHODS:We performed a cohort study including 473 pregnant women with type 1 diabetes with singleton pregnancies. We investigated maternal self-monitored blood...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.3300
更新日期：2020-07-01 00:00:00
abstract：BACKGROUND:Variants in TCF7L2 have been associated with the age at onset of type 2 diabetes in Mexican Americans. However, there is a lack of data on this relationship in Caucasians. Furthermore, risk alleles in TCF7L2 have been suggested to account for decreased conversion of proinsulin to insulin and decreased expres...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.1194
更新日期：2011-07-01 00:00:00
abstract：:Small fibres constitute 70-90% of peripheral nerve fibres and regulate several key functions such as tissue blood flow, temperature and pain perception as well as sweating, all of which are highly relevant to the clinical presentation and adverse outcomes associated with foot ulcerations in patients with diabetes. Rec...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,实务指引
doi：10.1002/dmrr.1222
更新日期：2011-10-01 00:00:00
abstract：BACKGROUND:Prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in developing countries, but its causes are not known. We aimed to ascertain the prevalence and determinants of NAFLD in a new largely unmedicated population-based cohort from the rapidly gentrifying region of Pinggu, China. METHODS:We ran...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.3156
更新日期：2019-07-01 00:00:00
abstract：BACKGROUND:In patients with type 1 diabetes, three main variables need to be assessed to optimize meal-related insulin boluses: pre-meal blood glucose (BG), insulin to carbohydrate ratio (I : C), and basal insulin. We are presenting data for a novel use of the hyperinsulinaemic-euglycaemic clamp (HEC) in patients with ...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.727
更新日期：2007-09-01 00:00:00
abstract：:Diabetic patients are at higher risk of developing physical disabilities than non-diabetic subjects. Physical disability appears to be related, at least in part, to muscle dysfunction. Several studies have reported reduced muscle strength and power under dynamic and static conditions in both the upper and lower limbs ...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.2658
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:The pancreatic islet damage that occurs through an inflammatory response and hypoxia after infusion is a major hurdle in islet transplantation. Because essential phospholipids (EPL) have been shown to exhibit anti-inflammatory properties in liver disease, we analysed their protective effect on islets in infl...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2714
更新日期：2016-03-01 00:00:00
abstract：:Around one of three diabetic patients is affected by distal symmetric polyneuropathy (DSP) which represents a major health problem, as it may present with partly excruciating neuropathic pain and is responsible for substantial morbidity and increased mortality. Treatment is based on four cornerstones: (1) multifactori...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.817
更新日期：2008-05-01 00:00:00
abstract：:Foot problems complicating diabetes are a source of major patient suffering and societal costs. Investing in evidence-based, internationally appropriate diabetic foot care guidance is likely among the most cost-effective forms of healthcare expenditure, provided it is goal-focused and properly implemented. The Interna...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2694
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:A longitudinal study assessed serum paraoxonase 1 (PON1) activity and concentration as affected by age and as associated with the development of type 2 diabetes (T2D). PON1's recently established physiological function is the hydrolysis of lipolactones in oxidized LDL particles. METHODS:Serum samples and cl...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2967
更新日期：2018-03-01 00:00:00
abstract：BACKGROUND:Increased activity of the hypothalamic-pituitary-adrenal (HPA) axis, resulting in enhanced adrenocorticotropin (ACTH) and serum glucocorticoid levels, has been described in patients with diabetes mellitus and in animal models of this disease; however, altered steroid production by adrenocortical cells could ...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.978
更新日期：2009-07-01 00:00:00
abstract：BACKGROUND:Physical exercise provides health benefits for people with type 2 diabetes mellitus, partly by enhancing skeletal muscle insulin action. We tested the hypothesis that changes in expression of key genes in skeletal muscles relate to exercise-induced improvements in type 2 diabetic patients. METHODS:We determ...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.656
更新日期：2006-11-01 00:00:00
abstract：BACKGROUND:Sodium-glucose cotransporter 2 (SGLT2) inhibitors could potentially alter calcium and phosphate homeostasis and may increase the risk of bone fracture. METHODS:The current meta-analysis was conducted to investigate the fracture risk among patients with type 2 diabetes mellitus treated with SGLT2 inhibitors....
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/dmrr.2903
更新日期：2017-09-01 00:00:00
abstract：:Non-invasive tests for the detection of peripheral artery disease (PAD) among individuals with diabetes mellitus are important to estimate the risk of amputation, ulceration, wound healing and the presence of cardiovascular disease, yet there are no consensus recommendations to support a particular diagnostic modality...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.2703
更新日期：2016-01-01 00:00:00
abstract：BACKGROUND:Type 1 diabetes mellitus (DM) has been shown to alter the properties of bone and impair fracture healing in both humans and animals. The objective of this study was to examine changes in the histomorphometrical, histological and mechanical parameters of bone and remodeling during fracture healing, depending ...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.537
更新日期：2005-05-01 00:00:00
abstract：BACKGROUND:The present study was undertaken to determine whether there were changes evident in axonal membrane function prior to the onset of neuropathy in patients with type 1 and type 2 diabetes. METHODS:From a cohort of 110 consecutive referrals, nerve excitability was investigated in 40 diabetic patients without c...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2360
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Insulin and multiple other autoantigens have been implicated in the pathogenesis of autoimmune type 1 diabetes, but the origin of immunological self-reactivity specifically oriented against insulin-secreting islet beta-cells remains obscure. The primary objective of the present study was to investigate the h...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.182
更新日期：2001-03-01 00:00:00
abstract：AIMS/HYPOTHESIS:The adipocyte derived peptide hormone leptin is known to regulate apoptosis and cell viability in several cells and tissues, as well as having several pancreatic islet beta-cell specific effects such as inhibition of glucose-stimulated insulin secretion. This study investigated the effects of leptin upo...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.726
更新日期：2007-09-01 00:00:00
abstract：:Common causes for non-healing of diabetic foot ulcers are infection and/or ischaemia. Diabetic patients are compromised hosts as far as wound healing is concerned. Diabetes mellitus is associated with a defective cellular and humoral immunity. In particular, decreased chemotaxis, decreased phagocytosis, impaired bacte...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/1520-7560(200009/10)16:1+<::aid-dmrr132>3.
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:The genetic basis of the autoimmune disease type 1 diabetes (T1D) has now been largely determined, so now we can compare these findings with emerging genetic knowledge of disorders and phenotypes that have been negatively or positively associated with T1D historically. Here, we assessed the role in T1D of va...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.1259
更新日期：2011-11-01 00:00:00
abstract：BACKGROUND:Neck circumference, beyond a measure of obesity, is a unique fat depot with increasing significance. This study aimed to investigate the association between neck circumference and biomarkers, indicators of cardiovascular risk. METHODS:During 2009, 490 volunteers (46 ± 16 years, 40% men) were consecutively e...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2369
更新日期：2013-01-01 00:00:00
abstract：BACKGROUND:Individuals with normal glucose tolerance (NGT) and type 2 diabetes mellitus (T2DM) represent heterogeneous groups with differences in beta-cell function and genetic background. The aim of the present study was to compare serum protein profiles of NGT and T2DM individuals and determine the influence of the g...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.789
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND:Proatherogenic stimuli during foetal life may predispose to development of atherosclerosis in adulthood. Elevated plasma low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP) expression is associated with increased risk of atherosclerosis. METHODS AND RESULTS:In this study, we examined how ...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.867
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:Atherosclerosis is associated with insulin resistance (IR) and dyslipidaemia. Impaired glucose tolerance (IGT) is characterised by IR and is associated with a higher risk of atherosclerosis. The objective of the present study was to test whether early atherosclerosis indicated by intimal medial thickness (IMT...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.226
更新日期：2001-11-01 00:00:00
