Lack of association of insulin resistance and carotid intimal medial thickness in non-diabetic Asian Indian subjects.


OBJECTIVE:Atherosclerosis is associated with insulin resistance (IR) and dyslipidaemia. Impaired glucose tolerance (IGT) is characterised by IR and is associated with a higher risk of atherosclerosis. The objective of the present study was to test whether early atherosclerosis indicated by intimal medial thickness (IMT) of common carotid artery (CCA) and internal carotid artery (ICA) is higher in IGT than in normoglycaemic subjects (NGT) and to look for an association of IMT with IR and dyslipidaemia. STUDY DESIGN AND METHODS:Ninety-nine randomly selected non-diabetic subjects aged >or=35 years (48 NGT and 51 IGT) were studied. Measurements of body mass index (BMI), waist/hip ratio (WHR), blood pressure, cholesterol-total, HDL, LDL, VLDL, triglycerides (TG), lipoprotein (a), apolipoprotein-A1 (Apo A1) and apolipoprotein-B (Apo B) and ratio of Apo A1/Apo B were estimated. Insulin resistance (HOMA-IR) was calculated using the fasting plasma insulin and glucose values. IMT of CCA and ICA were measured using high-resolution beta-mode ultrasonography. RESULTS:Subjects with IGT and NGT were matched for BMI and WHR; HOMA-IR was higher in IGT vs NGT (7.92+/-4.2 vs 6.07+/-3.76, p = 0.028). Age-adjusted IMT values were similar in NGT and IGT (CCA 0.59+/-0.17 and 0.63+/-0.22 mm and ICA 0.44+/-0.10 and 0.45+/-0.10 mm, respectively). Further analyses were done in the total group. Multiple linear regression analyses showed that CCA-IMT was significantly associated with age and negatively associated with Apo A1/Apo B ratio. ICA-IMT was associated with age only. IMT was significantly correlated with cholesterol-total and LDL-cholesterol and apolipoproteins. It was not associated with IR. CONCLUSION:In southern Indians, IGT did not influence the IMT. Although insulin resistance was higher in IGT, it was not associated with higher IMT. Conventional risk factors such as cholesterol, LDL-cholesterol and apolipoproteins showed association with IMT in the insulin-resistant population.


Diabetes Metab Res Rev


Snehalatha C,Vijay V,Suresh Mohan R,Satyavani K,Sivasankari S,Megha T,Radhika S,Ramachandran A





Has Abstract


2001-11-01 00:00:00














  • Nocturnal hypoglycaemia in type 1 diabetes--consequences and assessment.

    abstract::Hypoglycaemia is inevitable when striving for low HbA1c values. Nocturnal hypoglycaemia often occurs without symptoms, but results in diminished next day well-being and hypoglycaemia unawareness. Frequency of nocturnal hypoglycaemia was first assessed in research ward settings, but suffered from insufficient glucose s...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: DeVries JH,Wentholt IM,Masurel N,Mantel I,Poscia A,Maran A,Heine RJ

    更新日期:2004-11-01 00:00:00

  • Insulin pump therapy in type 1 pediatric patients: now and into the year 2000.

    abstract::There are a number of medical conditions such as growth failure in children, pregnancy, lipid abnormalities, and early complications that are improved by the meticulous glycemic control that can be achieved with insulin pump therapy (CSII). By using an insulin pump, many patients with severe hypoglycemia, the dawn phe...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Kaufman FR,Halvorson M,Miller D,Mackenzie M,Fisher LK,Pitukcheewanont P

    更新日期:1999-09-01 00:00:00

  • Recent findings on fulminant type 1 diabetes.

    abstract::Fulminant type 1 diabetes (fT1D) is a new subtype of type 1 diabetes proposed by Imagawa in 2000. It is a clinical syndrome characterized by a markedly rapid and almost complete destruction of pancreatic β cells. Metabolic derangement is more severe in this subtype than in autoimmune type 1 diabetes. The incidence of ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Liu L,Zeng L,Sang D,Lu Z,Shen J

    更新日期:2018-01-01 00:00:00

  • Self-monitoring of blood glucose (SMBG) improves glycaemic control in oral hypoglycaemic agent (OHA)-treated type 2 diabetes (SMBG-OHA study).

    abstract:BACKGROUND:We conducted a clinical research study to determine the effect of self-monitoring of blood glucose (SMBG) on glycaemic control and the value of a putatively less painful blood sampling technique on SMBG in oral hypoglycaemic agent-treated type 2 diabetes patients; SMBG has not been broadly applied in non-ins...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,随机对照试验


    authors: Harashima S,Fukushima T,Sasaki M,Nishi Y,Fujimoto S,Ogura M,Yamane S,Tanaka D,Harada N,Hamasaki A,Nagashima K,Nakahigashi Y,Seino Y,Inagaki N

    更新日期:2013-01-01 00:00:00

  • Diabetes and microvascular pathophysiology: role of epidermal growth factor receptor tyrosine kinase.

    abstract::Type 2 diabetes is responsible for the increased prevalence of ischaemic heart disease, generally related to coronary artery disease, which is associated with increased morbidity and death in diabetic patients. Epidermal growth factor receptor (EGFR) tyrosine kinase, one of the many factors involved in cell growth and...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Matrougui K

    更新日期:2010-01-01 00:00:00

  • Leptin decreases apoptosis and alters BCL-2 : Bax ratio in clonal rodent pancreatic beta-cells.

    abstract:AIMS/HYPOTHESIS:The adipocyte derived peptide hormone leptin is known to regulate apoptosis and cell viability in several cells and tissues, as well as having several pancreatic islet beta-cell specific effects such as inhibition of glucose-stimulated insulin secretion. This study investigated the effects of leptin upo...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Brown JE,Dunmore SJ

    更新日期:2007-09-01 00:00:00

  • A case-control study: The association of serum paraoxonase 1 activity and concentration with the development of type 2 diabetes mellitus.

    abstract:BACKGROUND:A longitudinal study assessed serum paraoxonase 1 (PON1) activity and concentration as affected by age and as associated with the development of type 2 diabetes (T2D). PON1's recently established physiological function is the hydrolysis of lipolactones in oxidized LDL particles. METHODS:Serum samples and cl...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Crow JA,Meek EC,Wills RW,Chambers JE

    更新日期:2018-03-01 00:00:00

  • Global DNA methylation as a possible biomarker for diabetic retinopathy.

    abstract:BACKGROUND:We evaluated whether global levels of DNA methylation status were associated with retinopathy as well as providing a predictive role of DNA methylation in developing retinopathy in a case-control study of 168 patients with type 2 diabetes. METHODS:The 5-methylcytosine content was assessed by reversed-phase ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Maghbooli Z,Hossein-nezhad A,Larijani B,Amini M,Keshtkar A

    更新日期:2015-02-01 00:00:00

  • Effects of sodium-glucose cotransporter (SGLT) inhibitors in addition to insulin therapy on glucose control and safety outcomes in adults with type 1 diabetes: A meta-analysis of randomized controlled trials.

    abstract::Sodium-glucose cotransporter (SGLT) inhibitors added to insulin therapy have been proposed as treatment strategy for type 1 diabetes (T1D). We thus conducted a meta-analysis of randomized controlled trials (RCTs) to assess the efficacy and adverse effects of this combination in T1D. We searched the PubMed, EMBASE, and...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Lu J,Tang L,Meng H,Zhao J,Liang Y

    更新日期:2019-10-01 00:00:00

  • Differences in cardiovascular risk profile based on relationship between post-load plasma glucose and fasting plasma levels.

    abstract:BACKGROUND:It has been shown that subjects with normal glucose tolerance (NGT), whose plasma glucose (PG) levels do not return to their fasting PG level within 2 h during an oral glucose tolerance test (OGTT) (Group I), have a significantly higher risk to develop type 2 diabetes than NGT subjects whose 2-h glucose retu...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Succurro E,Marini MA,Grembiale A,Lugarà M,Andreozzi F,Sciacqua A,Hribal ML,Lauro R,Perticone F,Sesti G

    更新日期:2009-05-01 00:00:00

  • Nonenzymatic glycation of high-density lipoprotein impairs its anti-inflammatory effects in innate immunity.

    abstract:AIMS/HYPOTHESIS:In type 2 diabetes mellitus (T2DM), the abnormal protein and lipid composition of diabetic high-density lipoprotein (HDL) could impair its anti-inflammatory functions. Whether nonenzymatic glycation directly impaired the anti-inflammatory effects of HDL in innate immunity remained unclear. METHODS:Huma...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Liu D,Ji L,Zhang D,Tong X,Pan B,Liu P,Zhang Y,Huang Y,Su J,Willard B,Zheng L

    更新日期:2012-02-01 00:00:00

  • Birth weight influences the clinical phenotype and the metabolic control of patients with type 1 diabetes (T1D).

    abstract:BACKGROUND:High birth weight has been related to an increased risk of type 1 diabetes (T1D), while suboptimal birth weight (both high and low) has been related to obesity, insulin resistance and type 2 diabetes. Insulin resistance, as a consequence of poor metabolic control, has been described in T1D patients. The aims...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Benevento D,Bizzarri C,Patera IP,Ravà L,Schiaffini R,Ciampalini P,Cianfarani S,Cappa M

    更新日期:2013-01-01 00:00:00

  • Ceftaroline fosamil for treatment of diabetic foot infections: the CAPTURE study experience.

    abstract:BACKGROUND:To ascertain which demographic, clinical, and microbiological factors might affect clinical outcomes of patients with diabetic foot infections, excluding known osteomyelitis, by analysing Clinical Assessment Program and Teflaro® Utilization Registry study data of patients treated with ceftaroline fosamil. M...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,多中心研究


    authors: Lipsky BA,Cannon CM,Ramani A,Jandourek A,Calmaggi A,Friedland HD,Goldstein EJ

    更新日期:2015-05-01 00:00:00

  • In-hospital metabolic regulation in patients with a diabetic foot ulcer: is it worthwhile?

    abstract::It is well established that hyperglycaemia is associated with many negative cardiovascular and immunological effects. Because of the high prevalence of underlying vascular disease along with associated infection, patients with diabetic foot ulcers are especially vulnerable to these adverse consequences. While studies ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Egan AM,Dinneen SF

    更新日期:2016-01-01 00:00:00

  • Angiotensin-converting enzyme 2 inhibits endoplasmic reticulum stress-associated pathway to preserve nonalcoholic fatty liver disease.

    abstract:BACKGROUND:Previous works indicated that the stress on the endoplasmic reticulum (ER) affected nonalcoholic fatty liver disease (NAFLD). However, there is no clear evident on the effect of the regulation of ER stress by angiotensin-converting enzyme 2 (ACE2) on the prevention of NAFLD. METHODS:HepG2 cells were treated...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Cao X,Song LN,Zhang YC,Li Q,Shi TT,Yang FY,Yuan MX,Xin Z,Yang JK

    更新日期:2019-05-01 00:00:00

  • Gluten-free but also gluten-enriched (gluten+) diet prevent diabetes in NOD mice; the gluten enigma in type 1 diabetes.

    abstract:BACKGROUND:Environmental factors such as nutrition or exposure to infections play a substantial role in the pathogenesis of type 1 diabetes (T1D). We have previously shown that gluten-free, non-purified diet largely prevented diabetes in non-obese diabetic (NOD) mice. In this study we tested hypothesis that early intro...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Funda DP,Kaas A,Tlaskalová-Hogenová H,Buschard K

    更新日期:2008-01-01 00:00:00

  • Guidelines on use of interventions to enhance healing of chronic foot ulcers in diabetes (IWGDF 2019 update).

    abstract::The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines on the prevention and management of diabetic foot disease since 1999. In conjunction with advice from internal and external reviewers and expert consultants in the field, this update is based on a systematic review of ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Rayman G,Vas P,Dhatariya K,Driver V,Hartemann A,Londahl M,Piaggesi A,Apelqvist J,Attinger C,Game F,International Working Group on the Diabetic Foot (IWGDF).

    更新日期:2020-03-01 00:00:00

  • Association of TCF7L2 SNPs with age at onset of type 2 diabetes and proinsulin/insulin ratio but not with glucagon-like peptide 1.

    abstract:BACKGROUND:Variants in TCF7L2 have been associated with the age at onset of type 2 diabetes in Mexican Americans. However, there is a lack of data on this relationship in Caucasians. Furthermore, risk alleles in TCF7L2 have been suggested to account for decreased conversion of proinsulin to insulin and decreased expres...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Silbernagel G,Renner W,Grammer TB,Hügl SR,Bertram J,Kleber ME,Hoffmann MM,Winkelmann BR,März W,Boehm BO

    更新日期:2011-07-01 00:00:00

  • Self-monitoring of blood glucose in type-2 diabetes: what is the evidence?

    abstract:BACKGROUND:There is a controversy about self-monitoring of blood glucose (SMBG) in patients with type 2 diabetes who are not using insulin. Randomized trials are limited in duration, size, and validity. METHODS:Systematic search for randomized trials and observational studies published since 1990. For inclusion studie...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: McGeoch G,Derry S,Moore RA

    更新日期:2007-09-01 00:00:00

  • Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus.

    abstract:BACKGROUND:Malonyl-CoA, an allosteric inhibitor of carnitine palmitoyl transferase, controls the oxidation of fatty acids in muscle and other tissues by regulating their entrance into mitochondria. The level of malonyl-CoA in muscle is influenced by the uptake of energy substrates such as glucose, the precursor of its ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Shafrir E,Ziv E,Saha AK,Ruderman NB

    更新日期:2002-05-01 00:00:00

  • Glucose monitoring by reverse iontophoresis.

    abstract::Glucose can be extracted through intact skin by electro-osmotic flow (a process called 'reverse iontophoresis') upon the application of a low-level electrical current. Recently we have combined iontophoretic extraction with an in situ glucose sensor in a device called the GlucoWatch biographer. Clinical results with t...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Potts RO,Tamada JA,Tierney MJ

    更新日期:2002-01-01 00:00:00

  • The influence of clinical and genetic factors on the development of obesity in children with type 1 diabetes.

    abstract::The exact cause of the obesity epidemic remains unknown; however, both environmental and genetic factors are involved. People at risk of developing obesity include children with type 1 diabetes mellitus (T1DM), which in turn increases their cardiovascular disease risk. Here, we discuss the clinical and genetic factors...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Łuczyński W,Głowińska-Olszewska B,Bossowski A

    更新日期:2016-10-01 00:00:00

  • The elevated gene expression level of the A(2B) adenosine receptor is associated with hyperglycemia in women with gestational diabetes mellitus.

    abstract:BACKGROUND:Adenosine receptors denoted by A1 , A2A , A2B , and A3 and encoded by ADORA1, ADORA2A, ADORA2B, and ADORA3 genes, respectively, are adenosine-activated G-protein-coupled receptors that play an important role in obesity and type 2 diabetes mellitus. However, little is known about their significance in gestati...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Wojcik M,Zieleniak A,Mac-Marcjanek K,Wozniak LA,Cypryk K

    更新日期:2014-01-01 00:00:00

  • Influence of diabetic metabolic state on fracture healing in spontaneously diabetic rats.

    abstract:BACKGROUND:Type 1 diabetes mellitus (DM) has been shown to alter the properties of bone and impair fracture healing in both humans and animals. The objective of this study was to examine changes in the histomorphometrical, histological and mechanical parameters of bone and remodeling during fracture healing, depending ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Follak N,Klöting I,Merk H

    更新日期:2005-05-01 00:00:00

  • Axonal dysfunction prior to neuropathy onset in type 1 diabetes.

    abstract:BACKGROUND:The present study was undertaken to determine whether there were changes evident in axonal membrane function prior to the onset of neuropathy in patients with type 1 and type 2 diabetes. METHODS:From a cohort of 110 consecutive referrals, nerve excitability was investigated in 40 diabetic patients without c...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Arnold R,Kwai N,Lin CS,Poynten AM,Kiernan MC,Krishnan AV

    更新日期:2013-01-01 00:00:00

  • Lipid metabolism in the fetus and the newborn.

    abstract::During late gestation, although maternal adipose tissue lipolytic activity becomes enhanced, lipolytic products cross the placenta with difficulty. Under fasting conditions, free fatty acids (FFA) are used for ketogenesis by the mother, and ketone bodies are used as fuels and lipogenic substrates by the fetus. Materna...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Herrera E,Amusquivar E

    更新日期:2000-05-01 00:00:00

  • Economic aspects of diabetic foot care in a multidisciplinary setting: a review.

    abstract:BACKGROUND:To evaluate the economic aspects of diabetic foot care in a multidisciplinary setting. METHOD:A review of the English language literature, published from 1966 to November 2005. RESULTS:The results of available studies on the cost-of-illness of diabetic foot problems are difficult to compare. Nevertheless t...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Matricali GA,Dereymaeker G,Muls E,Flour M,Mathieu C

    更新日期:2007-07-01 00:00:00

  • Classification systems for lower extremity amputation prediction in subjects with active diabetic foot ulcer: a systematic review and meta-analysis.

    abstract:AIM:We systematically review the available systems used to classify diabetic foot ulcers in order to synthesize their methodological qualitative issues and accuracy to predict lower extremity amputation, as this may represent a critical point in these patients' care. MATERIAL AND METHODS:Two investigators searched, in...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Monteiro-Soares M,Martins-Mendes D,Vaz-Carneiro A,Sampaio S,Dinis-Ribeiro M

    更新日期:2014-10-01 00:00:00

  • Statin users have an elevated risk of dysglycemia and new-onset-diabetes.

    abstract:OBJECTIVE:Statins are one of the most widely prescribed medications in the United States; however, there is a concern that they are associated with new-onset-diabetes (NOD) development. We sought to understand the risk of dysglycemia and NOD for a cohort of individuals that reflect real-world physician prescribing patt...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Zigmont VA,Shoben AB,Lu B,Kaye GL,Clinton SK,Harris RE,Olivo-Marston SE

    更新日期:2019-11-01 00:00:00

  • Thiazolidinediones: effects on the development and progression of type 2 diabetes and associated vascular complications.

    abstract::In addition to reducing hyperglycaemia, the metabolic actions of TZDs (pioglitazone and rosiglitazone) in theory might improve the prognosis of patients with type 2 diabetes. However, it appears from recent data that pioglitazone and rosiglitazone have different cardiovascular risk profiles. The scope of this paper is...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Krentz A

    更新日期:2009-02-01 00:00:00