Abstract:
BACKGROUND:The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM. METHODS:2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7-8 years of follow-up. RESULTS:NGT and IFG subjects who returned their plasma glucose concentration following an ingested glucose load below FPG within 60 min had increased insulin sensitivity, greater insulin secretion and lower risk for future T2DM compared to NGT and IFG subjects whose post-load plasma glucose concentration required 120 min or longer to return their plasma glucose level to FPG level. IGT subjects who had a lower plasma glucose concentration at 1-h compared to 2-h during OGTT had greater insulin sensitivity, better beta cell function and lower risk for future T2DM. CONCLUSIONS:These data suggest that the shape of glucose curve can be utilized to assess future risk for T2DM.
journal_name
Diabetes Metab Res Revjournal_title
Diabetes/metabolism research and reviewsauthors
Abdul-Ghani MA,Lyssenko V,Tuomi T,Defronzo RA,Groop Ldoi
10.1002/dmrr.1084subject
Has Abstractpub_date
2010-05-01 00:00:00pages
280-6issue
4eissn
1520-7552issn
1520-7560journal_volume
26pub_type
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