Sodium-glucose cotransporter 2 (SGLT2) inhibitors and fracture risk in patients with type 2 diabetes mellitus: A meta-analysis.

abstract：:There is strong evidence that the avoidance of hyperglycemia is essential inoptimizing pregnancy outcome in type 1 diabetes. The price to pay is a striking increase in severe hypoglycemia (SH), defined as episodes requiring help from another person. During type 1 diabetic pregnancy, occurrence rates of SH up to 15 tim...

journal_title：Diabetes/metabolism research and reviews

authors： ter Braak EW,Evers IM,Willem Erkelens D,Visser GH

更新日期：2002-03-01 00:00:00

abstract：:Cardiovascular disease now is the leading cause of mortality among patients with type 1 diabetes (T1D). The risk of death from cardiovascular events in subjects with T1D is 2-10 times higher than the general population, depending on blood glucose control. Although complications of cardiovascular disease occur in middl...

journal_title：Diabetes/metabolism research and reviews

authors： Shi M,Tang R,Huang F,Zhong T,Chen Y,Li X,Zhou Z

更新日期：2020-11-30 00:00:00

abstract：:Abstinence from food and liquid during daylight hours is observed by Muslim individuals during the month of Ramadan. Even though the Koran exempts the sick from fasting, many people with diabetes still fast during this religious period. It is essential for patients, family and healthcare professionals to be aware of t...

journal_title：Diabetes/metabolism research and reviews

authors： Hui E,Devendra D

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND:The aim of this study was to assess the clinical implications of calculating an individualized HbA1c target using a recently published algorithm in a real-life clinical setting. METHODS:General practitioners (GPs) from the Spanish Society of Family Medicine Diabetes Expert Group were invited to participate ...

journal_title：Diabetes/metabolism research and reviews

authors： Alvarez-Guisasola F,Cebrián-Cuenca AM,Cos X,Ruiz-Quintero M,Millaruelo JM,Cahn A,Raz I,Orozco-Beltrán D,Spanish Society of Family Medicine Diabetes Group.

更新日期：2018-03-01 00:00:00

abstract：BACKGROUND:Diabetes commonly leads to long-term complications such as cataract. This study investigated the effects of alpha-lipoic acid (LPA) and its gamma-linolenic acid (GLA) conjugate on cataract development in diabetic sand rats. METHODS:Two separate experiments were conducted. In Experiment 1, sand rats were fed...

journal_title：Diabetes/metabolism research and reviews

authors： Borenshtein D,Ofri R,Werman M,Stark A,Tritschler HJ,Moeller W,Madar Z

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Heparanase is an endo-beta-D-glucuronidase that cleaves heparan sulfate saccharide chains. The enzyme promotes cell adhesion, migration and invasion, and was shown to play a significant role in cancer metastasis and angiogenesis. METHODS:The present study focuses on the involvement of heparanase in autoimmu...

journal_title：Diabetes/metabolism research and reviews

authors： Bitan M,Weiss L,Zeira M,Reich S,Pappo O,Vlodavsky I,Slavin S

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:In patients with type 1 diabetes, three main variables need to be assessed to optimize meal-related insulin boluses: pre-meal blood glucose (BG), insulin to carbohydrate ratio (I : C), and basal insulin. We are presenting data for a novel use of the hyperinsulinaemic-euglycaemic clamp (HEC) in patients with ...

journal_title：Diabetes/metabolism research and reviews

authors： Bevier WC,Zisser H,Palerm CC,Finan DA,Seborg DE,Doyle FJ,Wollitzer AO,Jovanovic L

更新日期：2007-09-01 00:00:00

abstract：:This perspective covers a novel area of research describing the inadequacies of current approaches for diagnosing dysglycaemia and proposes that the 1-hour post-load glucose level during the 75-g oral glucose tolerance test may serve as a novel biomarker to detect dysglycaemia earlier than currently recommended screen...

journal_title：Diabetes/metabolism research and reviews

authors： Bergman M,Jagannathan R,Buysschaert M,Pareek M,Olsen MH,Nilsson PM,Medina JL,Roth J,Chetrit A,Groop L,Dankner R

更新日期：2018-07-01 00:00:00

abstract：BACKGROUND:Brown adipose tissue (BAT) is important for energy expenditure through thermogenesis, although its regulatory factors are not well known in humans. There is evidence suggesting that thyroid hormones affect BAT functions in some mammals, but the effects of thyroid hormones on BAT activity in humans are still ...

journal_title：Diabetes/metabolism research and reviews

authors： Zhang Q,Miao Q,Ye H,Zhang Z,Zuo C,Hua F,Guan Y,Li Y

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in developing countries, but its causes are not known. We aimed to ascertain the prevalence and determinants of NAFLD in a new largely unmedicated population-based cohort from the rapidly gentrifying region of Pinggu, China. METHODS:We ran...

journal_title：Diabetes/metabolism research and reviews

authors： Zhou X,Li Y,Zhang X,Guan YY,Puentes Y,Zhang F,Speliotes EK,Ji L

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Proatherogenic stimuli during foetal life may predispose to development of atherosclerosis in adulthood. Elevated plasma low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP) expression is associated with increased risk of atherosclerosis. METHODS AND RESULTS:In this study, we examined how ...

journal_title：Diabetes/metabolism research and reviews

authors： Lindegaard ML,Svarrer EM,Damm P,Mathiesen ER,Nielsen LB

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Physical functioning may be an important pre-clinical marker of chronic disease, used as a tool to identify patients at risk for future cardiometabolic abnormalities. This study evaluated if self-reported physical functioning was associated with the development of cardiometabolic abnormalities or their clust...

journal_title：Diabetes/metabolism research and reviews

authors： Ylitalo KR,Karvonen-Gutierrez C,McClure C,El Khoudary SR,Jackson EA,Sternfeld B,Harlow SD

更新日期：2016-05-01 00:00:00

abstract：BACKGROUND:fulminant type 1 diabetes mellitus (T1DM) is characterized by abrupt onset of hyperglycemia and rapid progression to ketoacidosis. This study aimed at examining the clinical and autoimmunity features of fulminant T1DM in Chinese. METHODS:a total of 24 patients with fulminant T1DM and 48 classical autoimmune...

journal_title：Diabetes/metabolism research and reviews

authors： Zheng C,Zhou Z,Yang L,Lin J,Huang G,Li X,Zhou W,Wang X,Liu Z

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND:Charcot neuroarthropathy (CN) of the ankle and hindfoot (Sanders/Frykberg Type IV) is challenging to treat surgically or nonsurgically. The deformities associated with ankle/hindfoot CN are often multiplanar, resulting in sagittal, frontal and rotational malalignment. In addition, shortening of the limb ofte...

journal_title：Diabetes/metabolism research and reviews

authors： Wukich DK,Raspovic KM,Hobizal KB,Sadoskas D

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Despite the correlation between the use of protease inhibitors (PI) and adverse metabolic glycemic events, no prospective study has examined these parameters in pregnant women who use these drugs. METHODS:A prospective study was conducted on 57 pregnant women to investigate the effect of antiretroviral drug...

journal_title：Diabetes/metabolism research and reviews

authors： El Beitune P,Duarte G,Foss MC,Montenegro RM Jr,Spara P,Quintana SM,Figueiró-Filho EA,da Costa AG,Filho FM

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:Psammomys obesus gerbil exhibits PKCepsilon over-expression on high-energy (HE) diet. Muscle insulin receptor (IR) signalling and tyrosine kinase activity are inhibited eliciting insulin resistance. We aimed at preventing diabetes by inhibiting PKCepsilon-induced serine phosphorylation of IRS-1 with novel PKC...

journal_title：Diabetes/metabolism research and reviews

authors： Mack E,Ziv E,Reuveni H,Kalman R,Niv MY,Jörns A,Lenzen S,Shafrir E

更新日期：2008-10-01 00:00:00

abstract：:The role of peripheral arterial disease in ulcerated diabetic feet has long been underestimated. Progressive claudication, rest pain and the extent of irreversible tissue loss have frequently been indications for revascularization for neuroischaemic ulcers in diabetic patients. These typical ischaemic symptoms are war...

journal_title：Diabetes/metabolism research and reviews

authors： Apelqvist JA,Lepäntalo MJ

更新日期：2012-02-01 00:00:00

abstract：:Diabetes foot infections are a common condition and a major causal pathway to lower extremity amputation. Identification of causative pathogens is vital in directing antimicrobial therapy. Historically, clinicians have relied upon culture-dependent techniques that are now acknowledged as both being selective for micro...

journal_title：Diabetes/metabolism research and reviews

authors： Malone M,Gosbell IB,Dickson HG,Vickery K,Espedido BA,Jensen SO

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Compare glycated hemoglobin (HbA1c ) diagnostic tests for prediabetes and diabetes with plasma glucose criteria and compare the metabolic profiles of people classified by HbA1c versus by glucose levels. METHODS:Participants were recruited for the San Juan Overweight Adults Longitudinal Study. The participan...

journal_title：Diabetes/metabolism research and reviews

authors： Vega-Vázquez MA,Ramírez-Vick M,Muñoz-Torres FJ,González-Rodríguez LA,Joshipura K

更新日期：2017-05-01 00:00:00

abstract：:Diabetes mellitus is one of the most challenging health concerns of the 21st century. With at least 30% of the diabetic population remaining undiagnosed, effective and early diagnosis is of critical concern. Development of a diagnostic test, more convenient and reliable than those currently used, would therefore be hi...

journal_title：Diabetes/metabolism research and reviews

authors： Matheson A,Willcox MD,Flanagan J,Walsh BJ

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND:This study aimed to investigate whether oestradiol differs between premenopausal women with and without type 1 diabetes and whether levels are associated with such factors as age, reproductive history or diabetes management. METHODS:Oestradiol in premenopausal women with type 1 diabetes (n = 89; age = 18-50...

journal_title：Diabetes/metabolism research and reviews

authors： Hassan LS,Monson RS,Danielson KK

更新日期：2017-02-01 00:00:00

abstract：:Small fibres constitute 70-90% of peripheral nerve fibres and regulate several key functions such as tissue blood flow, temperature and pain perception as well as sweating, all of which are highly relevant to the clinical presentation and adverse outcomes associated with foot ulcerations in patients with diabetes. Rec...

journal_title：Diabetes/metabolism research and reviews

authors： Malik RA,Veves A,Tesfaye S,Smith G,Cameron N,Zochodne D,Lauria G,Toronto Consensus Panel on Diabetic Neuropathy.

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:The cardiovascular effects of sulfonylureas (SU) in diabetic patients are controversial and it has been suggested that diabetic patients with acute myocardial infarction while on SU were at increased risk. OBJECTIVES:To assess the in-hospital outcome of patients with acute myocardial infarction according to...

journal_title：Diabetes/metabolism research and reviews

authors： Danchin N,Charpentier G,Ledru F,Vaur L,Guéret P,Hanania G,Blanchard D,Lablanche JM,Genès N,Cambou JP

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Diabetes mellitus is an endocrine disorder which is characterized by the development of resistance to the cellular activity of insulin or inadequate insulin production. It leads to hyperglycemia, prolonged inflammation, and oxidative stress. Oxidative stress is assumed to play an important role in the develo...

journal_title：Diabetes/metabolism research and reviews

authors： Gurel-Gokmen B,Ipekci H,Oktay S,Alev B,Ustundag UV,Ak E,Akakın D,Sener G,Emekli-Alturfan E,Yarat A,Tunali-Akbay T

更新日期：2018-11-01 00:00:00

abstract：BACKGROUND:Lispro Mix 25% insulin lispro/75% insulin lispro protamine (LM25) and Lispro Mix 50% insulin lispro/50% insulin lispro protamine (LM50) were compared as starter insulins in East Asian patients with type 2 diabetes. METHODS:Phase 4, open-label, randomized trial conducted in China, Japan, Korea, and Turkey. S...

journal_title：Diabetes/metabolism research and reviews

authors： Watada H,Su Q,Li PF,Iwamoto N,Qian L,Yang WY

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Latent autoimmune diabetes in adults (LADA) exhibits significant clinical heterogeneity, but the underlying causes remain unclear. The aim of this study was to investigate whether age of onset of LADA contributes to the observed clinical heterogeneity by comparing the clinical, metabolic, and immunogenetic c...

journal_title：Diabetes/metabolism research and reviews

authors： Niu X,Luo S,Li X,Xie Z,Xiang Y,Huang G,Lin J,Yang L,Liu Z,Wang X,Leslie RD,Zhou Z

更新日期：2019-01-01 00:00:00

abstract：:The intestinal microbiota has come to be considered an additional risk factor for the development of metabolic diseases. Considering the potential role of antimicrobials as modulators of the intestinal microbiota, they have been investigated for use in the adjuvant treatment of obesity and insulin resistance (IR). In ...

journal_title：Diabetes/metabolism research and reviews

authors： Dos Reis SA,do Carmo Gouveia Peluzio M,Bressan J

更新日期：2018-09-01 00:00:00

abstract：BACKGROUND:The possible effect of random intrasite placement on the outcome of the Semmes-Weinstein monofilament (SWF) test is not known. We sought to determine the significance of this variable in the diagnosis of loss of protective sensation (LOPS) in patients with diabetes. METHODS:Forty-five patients with diabetes...

journal_title：Diabetes/metabolism research and reviews

authors： Slater RA,Koren S,Ramot Y,Buchs A,Rapoport MJ

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:The goal of the present study was to determine whether cytokines in the peripheral blood of naive NOD mice correlate with the disease process and thereby would provide a marker for monitoring disease activity. METHODS:Female NOD mice (5, 10 and 14-16 weeks of age) were investigated in a cross-sectional stud...

journal_title：Diabetes/metabolism research and reviews

authors： Schloot NC,Hanifi-Moghaddam P,Goebel C,Shatavi SV,Flohé S,Kolb H,Rothe H

更新日期：2002-01-01 00:00:00

abstract：AIMS:Insulin-like growth factor 1 receptor (IGF1R) is involved in cell growth and glucose homeostasis. In the current study, the IGF1R locus was analysed as a candidate gene for type 2 diabetes (T2D) in American Indians. MATERIALS AND METHODS:Whole genome sequence data from 335 American Indians identified 3 novel miss...

journal_title：Diabetes/metabolism research and reviews

authors： Muller YL,Skelton G,Piaggi P,Chen P,Nair A,Kobes S,Hsueh WC,Knowler WC,Hanson RL,Baier LJ,Bogardus C

更新日期：2018-05-01 00:00:00