Sodium-glucose cotransporter 2 (SGLT2) inhibitors and fracture risk in patients with type 2 diabetes mellitus: A meta-analysis.

abstract：BACKGROUND:For cost-effective population-based diabetes prediction and confirmation, islet autoantibody assays must be made more economical. METHODS:We evaluated glutamic acid decarboxylase (GAD)-Ruc (renilla luciferase) and IA2ic (also known as ICA512ic)-Ruc (renilla luciferase) fusion protein constructs in high-thro...

journal_title：Diabetes/metabolism research and reviews

authors： Marcus P,Yan X,Bartley B,Hagopian W

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Mutating the insulin B:9-23 peptide prevents diabetes in NOD mice. Thus, the trimolecular complex of I-Ag7-insulin B:9-23 peptide-TCR may be essential for the development of spontaneous diabetes. Pathogenic T cells recognize the B:9-23 peptide presented by I-Ag7 in what is termed register 3, with the B22 bas...

journal_title：Diabetes/metabolism research and reviews

authors： Zhang L,Stadinski BD,Michels A,Kappler JW,Eisenbarth GS

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Intranasally applied insulin is one of the antigen-specific therapies currently tested in clinical type 1 diabetes prevention trials, for example, in the Type 1 Diabetes Prediction and Prevention Study (DIPP). The possibility that the therapy may cause hypoglycaemia or local irritation and the poorly known i...

journal_title：Diabetes/metabolism research and reviews

authors： Kupila A,Sipilä J,Keskinen P,Simell T,Knip M,Pulkki K,Simell O

更新日期：2003-09-01 00:00:00

abstract：BACKGROUND:Increased production of reactive oxygen species (ROS) in mitochondria has been proposed as the pathogenic mechanism for chronic complications of diabetes. Mitochondrial DNA (mtDNA) is more vulnerable to reactive oxygen species. However, there are few data on the mitochondrial DNA damage in diabetes and these...

journal_title：Diabetes/metabolism research and reviews

authors： Savu O,Sunkari VG,Botusan IR,Grünler J,Nikoshkov A,Catrina SB

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:This study aimed to investigate whether oestradiol differs between premenopausal women with and without type 1 diabetes and whether levels are associated with such factors as age, reproductive history or diabetes management. METHODS:Oestradiol in premenopausal women with type 1 diabetes (n = 89; age = 18-50...

journal_title：Diabetes/metabolism research and reviews

authors： Hassan LS,Monson RS,Danielson KK

更新日期：2017-02-01 00:00:00

abstract：:Glucose can be extracted through intact skin by electro-osmotic flow (a process called 'reverse iontophoresis') upon the application of a low-level electrical current. Recently we have combined iontophoretic extraction with an in situ glucose sensor in a device called the GlucoWatch biographer. Clinical results with t...

journal_title：Diabetes/metabolism research and reviews

authors： Potts RO,Tamada JA,Tierney MJ

更新日期：2002-01-01 00:00:00

abstract：BACKGROUND:The pancreatic islet damage that occurs through an inflammatory response and hypoxia after infusion is a major hurdle in islet transplantation. Because essential phospholipids (EPL) have been shown to exhibit anti-inflammatory properties in liver disease, we analysed their protective effect on islets in infl...

journal_title：Diabetes/metabolism research and reviews

authors： Shahbazov R,Kanak MA,Takita M,Kunnathodi F,Khan O,Borenstein N,Lawrence MC,Levy MF,Naziruddin B

更新日期：2016-03-01 00:00:00

abstract：:Small fibres constitute 70-90% of peripheral nerve fibres and regulate several key functions such as tissue blood flow, temperature and pain perception as well as sweating, all of which are highly relevant to the clinical presentation and adverse outcomes associated with foot ulcerations in patients with diabetes. Rec...

journal_title：Diabetes/metabolism research and reviews

authors： Malik RA,Veves A,Tesfaye S,Smith G,Cameron N,Zochodne D,Lauria G,Toronto Consensus Panel on Diabetic Neuropathy.

更新日期：2011-10-01 00:00:00

abstract：BACKGROUND:Visceral adiposity index (VAI) is a novel marker of visceral adipose tissue accumulation and dysfunction. The study aim was to explore the association of VAI with the 10-year type 2 diabetes mellitus (T2DM) incidence in apparently healthy individuals and compare its T2DM predictive ability against common ant...

journal_title：Diabetes/metabolism research and reviews

authors： Koloverou E,Panagiotakos DB,Kyrou I,Stefanadis C,Chrysohoou C,Georgousopoulou EN,Skoumas I,Tousoulis D,Pitsavos C,ATTICA Study group.

更新日期：2019-09-01 00:00:00

abstract：:Cardiovascular disease now is the leading cause of mortality among patients with type 1 diabetes (T1D). The risk of death from cardiovascular events in subjects with T1D is 2-10 times higher than the general population, depending on blood glucose control. Although complications of cardiovascular disease occur in middl...

journal_title：Diabetes/metabolism research and reviews

authors： Shi M,Tang R,Huang F,Zhong T,Chen Y,Li X,Zhou Z

更新日期：2020-11-30 00:00:00

abstract：:The literature on the role of body iron status in the development of type 2 diabetes (T2D) in humans is inconsistent. We aimed to assess the association between iron indices and T2D by a meta-analysis of previously published studies. A systematic literature search was conducted in PubMed and EMBASE. Observational stud...

journal_title：Diabetes/metabolism research and reviews

authors： Orban E,Schwab S,Thorand B,Huth C

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Type 2 diabetes is a risk factor for stroke and confers increased risk of poor outcome and further vascular events following stroke. Hyperuricaemia occurs commonly in patients with type 2 diabetes, but its significance as a predictor of outcome following stroke is uncertain. We sought to investigate the prog...

journal_title：Diabetes/metabolism research and reviews

authors： Newman EJ,Rahman FS,Lees KR,Weir CJ,Walters MR

更新日期：2006-01-01 00:00:00

abstract：:The exact cause of the obesity epidemic remains unknown; however, both environmental and genetic factors are involved. People at risk of developing obesity include children with type 1 diabetes mellitus (T1DM), which in turn increases their cardiovascular disease risk. Here, we discuss the clinical and genetic factors...

journal_title：Diabetes/metabolism research and reviews

authors： Łuczyński W,Głowińska-Olszewska B,Bossowski A

更新日期：2016-10-01 00:00:00

abstract：:Biomechanical issues are now widely recognized as being important in the treatment of diabetic foot disease. The purpose of the present review is to identify advances that have occurred since the previous International Conference on the Diabetic Foot in 1995 in the understanding of foot biomechanics in relation to dia...

journal_title：Diabetes/metabolism research and reviews

authors： Cavanagh PR,Ulbrecht JS,Caputo GM

更新日期：2000-09-01 00:00:00

abstract：:Diabetic patients are at higher risk of developing physical disabilities than non-diabetic subjects. Physical disability appears to be related, at least in part, to muscle dysfunction. Several studies have reported reduced muscle strength and power under dynamic and static conditions in both the upper and lower limbs ...

journal_title：Diabetes/metabolism research and reviews

authors： Orlando G,Balducci S,Bazzucchi I,Pugliese G,Sacchetti M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Latent autoimmune diabetes in adults (LADA) exhibits significant clinical heterogeneity, but the underlying causes remain unclear. The aim of this study was to investigate whether age of onset of LADA contributes to the observed clinical heterogeneity by comparing the clinical, metabolic, and immunogenetic c...

journal_title：Diabetes/metabolism research and reviews

authors： Niu X,Luo S,Li X,Xie Z,Xiang Y,Huang G,Lin J,Yang L,Liu Z,Wang X,Leslie RD,Zhou Z

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:The proposed 2015 US Preventive Services Task Force guidelines recommend diabetes screening for individuals ≥45 years or demonstrating other risk factors for dysglycemia. Still, many patients with dysglycemia remain undiagnosed, and opportunities for early intervention are lost. METHODS:To test novel approa...

journal_title：Diabetes/metabolism research and reviews

authors： Silverman RA,Schleicher MG,Valente CJ,Kim M,Romanenko Y,Schulman RC,Tiberio A,Greenblatt B,Rentala M,Salvador-Kelly AV,Kwon NS,Jornsay DL

更新日期：2016-01-01 00:00:00

abstract：:The actual pathophysiology behind gestational diabetes mellitus (GDM) is still unclear, but a deterioration in insulin resistance beyond that induced by pregnancy, combined with beta cell dysfunction, plays a key role. Interventions that help improve glucose tolerance by attenuating pregnancy-induced insulin resistanc...

journal_title：Diabetes/metabolism research and reviews

authors： Ruchat SM,Mottola MF

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:To evaluate the association between fasting plasma glucose (FPG) and mortality by gender. METHODS:A total of 17 248 eligible participants from a rural Chinese prospective cohort population were included. The same questionnaire interview and anthropometric and laboratory measurements were performed at both b...

journal_title：Diabetes/metabolism research and reviews

authors： Liu L,Chen X,Liu Y,Sun X,Yin Z,Li H,Zhang M,Wang B,Ren Y,Zhao Y,Liu D,Zhou J,Liu X,Zhang D,Cheng C,Liu F,Zhou Q,Xu Q,Xiong Y,Liu J,You Z,Hong S,Wang C,Hu D

更新日期：2019-05-01 00:00:00

abstract：BACKGROUND:Dipeptidyl peptidase-IV (DPP-4) inhibitors and sulfonylureas are two important second-line anti-diabetic agents. The objective of this research was to evaluate the efficacy and safety of DPP-4 inhibitors compared with sulfonylureas by meta-analytic approach of available randomized studies. METHODS:We search...

journal_title：Diabetes/metabolism research and reviews

authors： Zhang Y,Hong J,Chi J,Gu W,Ning G,Wang W

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Recently, a genome-wide association study identified a strong association between the fat mass- and obesity-associated rs9939609 single nucleotide polymorphism (SNP) and the risk of obesity in European population. However, the results in Chinese population were reported to be contradictory. Therefore, our ai...

journal_title：Diabetes/metabolism research and reviews

authors： Li X,Song F,Jiang H,Zhang M,Lin J,Bao W,Yao P,Yang X,Hao L,Liu L

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:The active cognitive-motor demands of driving may have a significant metabolic demand that could contribute to the development of hypoglycemia. Conversely, symptoms caused by the stress of driving may be confused with hypoglycemia and lead to false alarms. This study examined the metabolic demand and the phy...

journal_title：Diabetes/metabolism research and reviews

authors： Cox DJ,Gonder-Frederick LA,Kovatchev BP,Clarke WL

更新日期：2002-09-01 00:00:00

abstract：:In addition to reducing hyperglycaemia, the metabolic actions of TZDs (pioglitazone and rosiglitazone) in theory might improve the prognosis of patients with type 2 diabetes. However, it appears from recent data that pioglitazone and rosiglitazone have different cardiovascular risk profiles. The scope of this paper is...

journal_title：Diabetes/metabolism research and reviews

authors： Krentz A

更新日期：2009-02-01 00:00:00

abstract：:The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines on the prevention and management of diabetic foot disease since 1999. In conjunction with advice from internal and external reviewers and expert consultants in the field, this update is based on a systematic review of ...

journal_title：Diabetes/metabolism research and reviews

authors： Rayman G,Vas P,Dhatariya K,Driver V,Hartemann A,Londahl M,Piaggesi A,Apelqvist J,Attinger C,Game F,International Working Group on the Diabetic Foot (IWGDF).

更新日期：2020-03-01 00:00:00

abstract：:The prevalence of diabetes mellitus in primary hyperparathyroidism is approximately 8% and that of primary hyperparathyroidism in diabetic patients is approximately 1%. Both values are about three-fold higher than the respective expected prevalences in general populations. Patients with both disorders are over 40 year...

journal_title：Diabetes/metabolism research and reviews

authors： Taylor WH,Khaleeli AA

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:Increased plasma levels of plasminogen activator inhibitor-1 (PAI-1) have been suggested to be a part of the insulin resistance syndrome, and recent data suggest that adipose tissue participates in the production of PAI-1. We examined the expression and insulin regulation of subcutaneous adipose tissue PAI-1 ...

journal_title：Diabetes/metabolism research and reviews

authors： Koistinen HA,Dusserre E,Ebeling P,Vallier P,Koivisto VA,Vidal H

更新日期：2000-09-01 00:00:00

abstract：BACKGROUND:The prevalence of type 2 diabetes in China is increasing rapidly. Appropriate management of glycemia, blood pressure and dyslipidemia in this population is a major public health concern. OBJECTIVE:The aim of this study was to assess metabolic control including glycated hemoglobin A1c (HbA1c ), blood pressur...

journal_title：Diabetes/metabolism research and reviews

authors： Liu L,Lou Q,Guo X,Yuan L,Shen L,Sun Z,Zhao F,Dai X,Huang J,Yang H,Mordes JP,Chinese Diabetes Education Status Survey Study Group.

更新日期：2015-11-01 00:00:00

abstract：AIM:We systematically review the available systems used to classify diabetic foot ulcers in order to synthesize their methodological qualitative issues and accuracy to predict lower extremity amputation, as this may represent a critical point in these patients' care. MATERIAL AND METHODS:Two investigators searched, in...

journal_title：Diabetes/metabolism research and reviews

authors： Monteiro-Soares M,Martins-Mendes D,Vaz-Carneiro A,Sampaio S,Dinis-Ribeiro M

更新日期：2014-10-01 00:00:00

abstract：BACKGROUND:To investigate longitudinal associations of maternal glucose/HbA1c and insulin dose with birthweight-related outcomes in women with type 1 diabetes. METHODS:We performed a cohort study including 473 pregnant women with type 1 diabetes with singleton pregnancies. We investigated maternal self-monitored blood...

journal_title：Diabetes/metabolism research and reviews

authors： García-Patterson A,Ovejero D,Miñambres I,Chico A,Gil PA,Martínez MJ,Adelantado JM,de Leiva A,Gich I,Desoye G,de Mouzon SH,Corcoy R

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Human leukocyte antigen (HLA) genotypes associated with increased risk for type 1 diabetes mellitus (T1D) have been reported to be associated with increased birth weight. We set out to investigate the association between HLA haplotypes conferring risk for T1D and birth weight and search for possible differen...

journal_title：Diabetes/metabolism research and reviews

authors： Peet A,Kool P,Ilonen J,Knip M,Tillmann V,DIABIMMUNE Study Group.

更新日期：2012-07-01 00:00:00