Abstract：
BACKGROUND:The active cognitive-motor demands of driving may have a significant metabolic demand that could contribute to the development of hypoglycemia. Conversely, symptoms caused by the stress of driving may be confused with hypoglycemia and lead to false alarms. This study examined the metabolic demand and the physiological stress of driving on type 1 diabetes mellitus (T1DM) drivers. METHODS:Forty-three T1DM drivers were placed on a constant insulin infusion/variable dextrose infusion to maintain euglycemia for 30 min while either watching a driving video or actually driving a simulator, in a counterbalanced crossover design. Dextrose infusion, heart rate, epinephrine, and subjective symptom ratings were measured every 5 min. Additionally, subjects were monitored for self-treatment (drinking soda). RESULTS:While blood glucose (BG) levels were equivalent across both conditions, actual driving was associated with a higher dextrose infusion rate (p = 0.02), more autonomic symptoms (p < 0.05), increased heart rate (p < 0.001), a trend (p = 0.09) for greater epinephrine release, and more frequent hypoglycemic self-treatment (p < 0.001). CONCLUSIONS:Driving is a task with a significant metabolic demand, which may lower BG, and also that driving stress may be associated with symptoms similar to those of hypoglycemia. Physicians should discuss with their T1DM patients hypoglycemia and driving, and encourage measuring blood glucose before driving and during long drives.
journal_name
Diabetes Metab Res Revjournal_title
Diabetes/metabolism research and reviewsauthors
Cox DJ,Gonder-Frederick LA,Kovatchev BP,Clarke WLdoi
10.1002/dmrr.306keywords:
subject
Has Abstractpub_date
2002-09-01 00:00:00pages
381-5issue
5eissn
1520-7552issn
1520-7560journal_volume
18pub_type
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journal_title：Diabetes/metabolism research and reviews
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更新日期：2008-07-01 00:00:00
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更新日期：2020-03-01 00:00:00
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更新日期：2004-07-01 00:00:00
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更新日期：2020-09-01 00:00:00
