Glucose monitoring by reverse iontophoresis.

Abstract:

:Glucose can be extracted through intact skin by electro-osmotic flow (a process called 'reverse iontophoresis') upon the application of a low-level electrical current. Recently we have combined iontophoretic extraction with an in situ glucose sensor in a device called the GlucoWatch biographer. Clinical results with this device show close tracking of blood glucose over a range of 2.2 to 22.2 mmol/l for up to 12 h using a single blood glucose value as calibration. The biographer readings lag behind blood glucose values by an average of 18 min. An analysis of data from 92 diabetic subjects in a controlled clinical setting shows a linear relationship (r=0.88) between GlucoWatch biographer readings and blood glucose. The mean absolute relative difference between the two measurements was 15.6% and more than 96% of the data fell in the (A+B) regions of the Clarke error grid. Similar results have been obtained from subjects using the GlucoWatch biographer in an uncontrolled home environment. The automatic, frequent, and non-invasive measurements obtained with the GlucoWatch biographer provide substantially more information about glucose levels than do the current fingerstick methods. This information can be used for improved decisions about all aspects of diabetes management.

journal_name

Diabetes Metab Res Rev

authors

Potts RO,Tamada JA,Tierney MJ

doi

10.1002/dmrr.210

keywords:

subject

Has Abstract

pub_date

2002-01-01 00:00:00

pages

S49-53

eissn

1520-7552

issn

1520-7560

pii

10.1002/dmrr.210

journal_volume

18 Suppl 1

pub_type

杂志文章,评审
  • Polyneuropathy in type 1 and type 2 diabetes: comparison of nerve conduction studies, thermal perception thresholds and intraepidermal nerve fibre densities.

    abstract:BACKGROUND:To evaluate possible differences in distal polyneuropathy (PN) characteristics and degree of abnormalities for various small and large fibre parameters in diabetes type 1 (DM1) and type 2 (DM2). METHODS:Sixty-six DM1 and 57 DM2 patients with or without PN symptoms were included. Nerve conduction studies (NC...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1049

    authors: Løseth S,Mellgren SI,Jorde R,Lindal S,Stålberg E

    更新日期:2010-02-01 00:00:00

  • Normal renal function 8 to 13 years after cyclosporin A therapy in 285 diabetic patients.

    abstract:BACKGROUND:Cyclosporin A (CyA) may induce acute nephrotoxicity. The question has been raised of the possible long-term unfavorable course of CyA-induced lesions. Advantage was taken of a large cohort of diabetic patients treated for several months using moderate CyA dosage to evaluate the long-term evolution of renal f...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 临床试验,杂志文章

    doi:10.1002/dmrr.325

    authors: Assan R,Blanchet F,Feutren G,Timsit J,Larger E,Boitard C,Amiel C,Bach JF

    更新日期:2002-11-01 00:00:00

  • Surgical management of Charcot neuroarthropathy of the ankle and hindfoot in patients with diabetes.

    abstract:BACKGROUND:Charcot neuroarthropathy (CN) of the ankle and hindfoot (Sanders/Frykberg Type IV) is challenging to treat surgically or nonsurgically. The deformities associated with ankle/hindfoot CN are often multiplanar, resulting in sagittal, frontal and rotational malalignment. In addition, shortening of the limb ofte...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2748

    authors: Wukich DK,Raspovic KM,Hobizal KB,Sadoskas D

    更新日期:2016-01-01 00:00:00

  • The use of antimicrobials as adjuvant therapy for the treatment of obesity and insulin resistance: Effects and associated mechanisms.

    abstract::The intestinal microbiota has come to be considered an additional risk factor for the development of metabolic diseases. Considering the potential role of antimicrobials as modulators of the intestinal microbiota, they have been investigated for use in the adjuvant treatment of obesity and insulin resistance (IR). In ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.3014

    authors: Dos Reis SA,do Carmo Gouveia Peluzio M,Bressan J

    更新日期:2018-09-01 00:00:00

  • Diabetic fatty liver disease is associated with specific changes in blood-borne markers.

    abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) can lead to cirrhosis and hepatocellular carcinoma and is strongly associated with obesity and insulin resistance. The aim of this study was to assess if plasma markers associated with NAFLD are increased in people with concomitant diabetes compared with those withou...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2269

    authors: Sharma S,Barrett F,Adamson J,Todd A,Megson IL,Zentler-Munro PL,MacRury SM

    更新日期:2012-05-01 00:00:00

  • The prevalence of GAD antibodies in Korean women with gestational diabetes mellitus and their clinical characteristics during and after pregnancy.

    abstract:BACKGROUND:We conducted this research in order to evaluate the prevalence of glutamic acid decarboxylase antibodies (GADA) in Korean women with gestational diabetes mellitus (GDM), to identify the clinical characteristics of these women, and to gauge the prevalence of diabetes among them after childbirth. METHODS:We s...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.963

    authors: Yu SH,Park S,Kim HS,Park SY,Yim CH,Han KO,Yoon HK,Jang HC,Chung HY,Kim SH

    更新日期:2009-05-01 00:00:00

  • Diabetes and microvascular pathophysiology: role of epidermal growth factor receptor tyrosine kinase.

    abstract::Type 2 diabetes is responsible for the increased prevalence of ischaemic heart disease, generally related to coronary artery disease, which is associated with increased morbidity and death in diabetic patients. Epidermal growth factor receptor (EGFR) tyrosine kinase, one of the many factors involved in cell growth and...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.1050

    authors: Matrougui K

    更新日期:2010-01-01 00:00:00

  • Metabolic syndrome and pre-diabetes contribute to racial disparities in breast cancer outcomes: hypothesis and proposed pathways.

    abstract:BACKGROUND:Women with obesity and type 2 diabetes (T2D) are at greater risk of dying from breast cancer than women without these conditions. Obesity and T2D are associated with insulin resistance and endogenous hyperinsulinemia and are more common in Black women. There is increasing disparity in breast cancer mortality...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2795

    authors: Gallagher EJ,LeRoith D,Franco R,Antoniou IM,Nayak A,Livaudais-Toman J,Bickell NA

    更新日期:2016-10-01 00:00:00

  • MicroRNA-296-5p promotes healing of diabetic wound by targeting sodium-glucose transporter 2 (SGLT2).

    abstract:BACKGROUND:Diabetic wounds are refractory and very difficult to heal. We aimed to use miRNA to identify novel and specific molecular markers for diabetes mellitus (DM) diagnosis and treatment. METHODS:The expression level of miR-296-5p was determined in tissue samples of 12 DM patients. The effect of miR-296-5p on pro...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.3104

    authors: Liu X,Wang Y,Zhang X,Zhang X,Guo J,Zhou J,Chai Y,Ma ZL

    更新日期:2019-02-01 00:00:00

  • Painful diabetic neuropathy: treatment and future aspects.

    abstract::Around one of three diabetic patients is affected by distal symmetric polyneuropathy (DSP) which represents a major health problem, as it may present with partly excruciating neuropathic pain and is responsible for substantial morbidity and increased mortality. Treatment is based on four cornerstones: (1) multifactori...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.817

    authors: Ziegler D

    更新日期:2008-05-01 00:00:00

  • Role of previous treatment with sulfonylureas in diabetic patients with acute myocardial infarction: results from a nationwide French registry.

    abstract:BACKGROUND:The cardiovascular effects of sulfonylureas (SU) in diabetic patients are controversial and it has been suggested that diabetic patients with acute myocardial infarction while on SU were at increased risk. OBJECTIVES:To assess the in-hospital outcome of patients with acute myocardial infarction according to...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,多中心研究

    doi:10.1002/dmrr.498

    authors: Danchin N,Charpentier G,Ledru F,Vaur L,Guéret P,Hanania G,Blanchard D,Lablanche JM,Genès N,Cambou JP

    更新日期:2005-03-01 00:00:00

  • Overexpression of ZAC impairs glucose-stimulated insulin translation and secretion in clonal pancreatic beta-cells.

    abstract:BACKGROUND:ZAC (Zinc finger protein that regulates apoptosis and cell-cycle arrest) is a candidate gene for transient neonatal diabetes mellitus (TNDM). This condition involves severe insulin deficiency at birth that reverses over weeks or months but may relapse with diabetes recurring in later life. ZAC overexpression...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2325

    authors: Du X,Ounissi-Benkalha H,Loder MK,Rutter GA,Polychronakos C

    更新日期:2012-11-01 00:00:00

  • Birth weight influences the clinical phenotype and the metabolic control of patients with type 1 diabetes (T1D).

    abstract:BACKGROUND:High birth weight has been related to an increased risk of type 1 diabetes (T1D), while suboptimal birth weight (both high and low) has been related to obesity, insulin resistance and type 2 diabetes. Insulin resistance, as a consequence of poor metabolic control, has been described in T1D patients. The aims...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2361

    authors: Benevento D,Bizzarri C,Patera IP,Ravà L,Schiaffini R,Ciampalini P,Cianfarani S,Cappa M

    更新日期:2013-01-01 00:00:00

  • Oestradiol levels may differ between premenopausal women, ages 18-50, with type 1 diabetes and matched controls.

    abstract:BACKGROUND:This study aimed to investigate whether oestradiol differs between premenopausal women with and without type 1 diabetes and whether levels are associated with such factors as age, reproductive history or diabetes management. METHODS:Oestradiol in premenopausal women with type 1 diabetes (n = 89; age = 18-50...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2829

    authors: Hassan LS,Monson RS,Danielson KK

    更新日期:2017-02-01 00:00:00

  • Prevalence and management of diabetic neuropathy in secondary care in Qatar.

    abstract:AIMS:Diabetic neuropathy (DN) is a "Cinderella" complication, particularly in the Middle East. A high prevalence of undiagnosed DN and those at risk of diabetic foot ulceration (DFU) is a major concern. We have determined the prevalence of DN and its risk factors, DFU, and those at risk of DFU in patients with type 2 d...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.3286

    authors: Ponirakis G,Elhadd T,Chinnaiyan S,Dabbous Z,Siddiqui M,Al-Muhannadi H,Petropoulos IN,Khan A,Ashawesh KAE,Dukhan KMO,Mahfoud ZR,Murgatroyd C,Slevin M,Malik RA

    更新日期:2020-05-01 00:00:00

  • Subcutaneous adipose tissue expression of plasminogen activator inhibitor-1 (PAI-1) in nondiabetic and Type 2 diabetic subjects.

    abstract:OBJECTIVE:Increased plasma levels of plasminogen activator inhibitor-1 (PAI-1) have been suggested to be a part of the insulin resistance syndrome, and recent data suggest that adipose tissue participates in the production of PAI-1. We examined the expression and insulin regulation of subcutaneous adipose tissue PAI-1 ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/1520-7560(2000)9999:9999<::aid-dmrr148>3.0

    authors: Koistinen HA,Dusserre E,Ebeling P,Vallier P,Koivisto VA,Vidal H

    更新日期:2000-09-01 00:00:00

  • Implementation of a quality improvement initiative in Belgian diabetic foot clinics: feasibility and initial results.

    abstract:BACKGROUND:This article aims to describe the implementation and initial results of an audit-feedback quality improvement initiative in Belgian diabetic foot clinics. METHODS:Using self-developed software and questionnaires, diabetic foot clinics collected data in 2005, 2008 and 2011, covering characteristics, history ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2524

    authors: Doggen K,Van Acker K,Beele H,Dumont I,Félix P,Lauwers P,Lavens A,Matricali GA,Randon C,Weber E,Van Casteren V,Nobels F,Initiative for Quality Improvement and Epidemiology in Diabetic Foot Clinics (IQED-Foot) Study Group.

    更新日期:2014-07-01 00:00:00

  • The global challenge of type 2 diabetes and the strategies for response in ethnic minority groups.

    abstract::Ethnic minorities living in high-income countries usually exhibit a greater risk of developing diabetes along with higher morbidity and mortality rates. We evaluated the effectiveness of interventions to improve glycaemic control in ethnic minority groups. Results of major controlled trials, systematic reviews and met...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.1105

    authors: Lirussi F

    更新日期:2010-09-01 00:00:00

  • Nocturnal hypoglycaemia in type 1 diabetes--consequences and assessment.

    abstract::Hypoglycaemia is inevitable when striving for low HbA1c values. Nocturnal hypoglycaemia often occurs without symptoms, but results in diminished next day well-being and hypoglycaemia unawareness. Frequency of nocturnal hypoglycaemia was first assessed in research ward settings, but suffered from insufficient glucose s...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.513

    authors: DeVries JH,Wentholt IM,Masurel N,Mantel I,Poscia A,Maran A,Heine RJ

    更新日期:2004-11-01 00:00:00

  • Association of iron indices and type 2 diabetes: a meta-analysis of observational studies.

    abstract::The literature on the role of body iron status in the development of type 2 diabetes (T2D) in humans is inconsistent. We aimed to assess the association between iron indices and T2D by a meta-analysis of previously published studies. A systematic literature search was conducted in PubMed and EMBASE. Observational stud...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/dmrr.2506

    authors: Orban E,Schwab S,Thorand B,Huth C

    更新日期:2014-07-01 00:00:00

  • Validity of diagnostic codes and estimation of prevalence of diabetic foot ulcers using a large electronic medical record database.

    abstract:AIMS:To assess the validity of the diagnostic codes relating to diabetic foot ulcer (DFU) in the electronic medical records of a large integrated care provider and to assess the prevalence of DFU among its members. MATERIALS AND METHODS:Data were obtained from the diabetes registry of Maccabi Healthcare Services (MHS)...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.3094

    authors: Cahn A,Altaras T,Agami T,Liran O,Touaty CE,Drahy M,Pollack R,Raz I,Chodick G,Zucker I

    更新日期:2019-02-01 00:00:00

  • Serum protein patterns in newly diagnosed type 2 diabetes mellitus--influence of diabetic environment and family history of diabetes.

    abstract:BACKGROUND:Individuals with normal glucose tolerance (NGT) and type 2 diabetes mellitus (T2DM) represent heterogeneous groups with differences in beta-cell function and genetic background. The aim of the present study was to compare serum protein profiles of NGT and T2DM individuals and determine the influence of the g...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.789

    authors: Sundsten T,Ostenson CG,Bergsten P

    更新日期:2008-02-01 00:00:00

  • Elevated serum urate concentration independently predicts poor outcome following stroke in patients with diabetes.

    abstract:BACKGROUND:Type 2 diabetes is a risk factor for stroke and confers increased risk of poor outcome and further vascular events following stroke. Hyperuricaemia occurs commonly in patients with type 2 diabetes, but its significance as a predictor of outcome following stroke is uncertain. We sought to investigate the prog...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.585

    authors: Newman EJ,Rahman FS,Lees KR,Weir CJ,Walters MR

    更新日期:2006-01-01 00:00:00

  • Fatty acid-induced effect on glucagon secretion is mediated via fatty acid oxidation.

    abstract:BACKGROUND:While the effect of fatty acids and ectopic triglyceride storage in pancreatic beta cells has been well-defined, only limited information is available on alpha cells. This study evaluates the long-term impact of fatty acids on alpha cell function and proliferation as well as fatty acid oxidation. METHODS:Cl...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.663

    authors: Hong J,Jeppesen PB,Nordentoft I,Hermansen K

    更新日期:2007-03-01 00:00:00

  • Renin angiotensin system inhibitors may attenuate low LDL cholesterol-related cancer risk in type 2 diabetes.

    abstract:BACKGROUND:In type 2 diabetes (T2D), copresence of low-density lipoprotein cholesterol (LDL-C) < 2.8 mmol/L with triglyceride < 1.7 mmol/L or with albuminuria synergistically increased cancer risk. We tested whether use of renin angiotensin system inhibitors attenuated the increased cancer risk associated with these tw...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2504

    authors: Yang X,Ma RC,So WY,Wang Y,Kong AP,Ozaki R,Xu G,Chan JC

    更新日期:2014-07-01 00:00:00

  • Thiazolidinediones: effects on the development and progression of type 2 diabetes and associated vascular complications.

    abstract::In addition to reducing hyperglycaemia, the metabolic actions of TZDs (pioglitazone and rosiglitazone) in theory might improve the prognosis of patients with type 2 diabetes. However, it appears from recent data that pioglitazone and rosiglitazone have different cardiovascular risk profiles. The scope of this paper is...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.937

    authors: Krentz A

    更新日期:2009-02-01 00:00:00

  • The incidence of mild and severe hypoglycaemia in patients with type 2 diabetes mellitus treated with sulfonylureas: a systematic review and meta-analysis.

    abstract::Patients with type 2 diabetes mellitus using sulfonylurea derivatives or insulin may experience hypoglycaemia. However, recent data regarding the incidence of hypoglycaemia are scarce. We conducted a systematic review and meta-analysis to determine the proportion of patients with type 2 diabetes mellitus that experien...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/dmrr.2470

    authors: Schopman JE,Simon AC,Hoefnagel SJ,Hoekstra JB,Scholten RJ,Holleman F

    更新日期:2014-01-01 00:00:00

  • Association of TCF7L2 SNPs with age at onset of type 2 diabetes and proinsulin/insulin ratio but not with glucagon-like peptide 1.

    abstract:BACKGROUND:Variants in TCF7L2 have been associated with the age at onset of type 2 diabetes in Mexican Americans. However, there is a lack of data on this relationship in Caucasians. Furthermore, risk alleles in TCF7L2 have been suggested to account for decreased conversion of proinsulin to insulin and decreased expres...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1194

    authors: Silbernagel G,Renner W,Grammer TB,Hügl SR,Bertram J,Kleber ME,Hoffmann MM,Winkelmann BR,März W,Boehm BO

    更新日期:2011-07-01 00:00:00

  • Diabetic foot ulcer classification system for research purposes: a progress report on criteria for including patients in research studies.

    abstract::Various different systems have been proposed to classify diabetic foot ulcers, but none has gained widespread acceptance. The International Working Group of the Diabetic Foot (IWGDF) developed a classification system for research purposes, which is described in this report. In this PEDIS system, all foot ulcers should...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.464

    authors: Schaper NC

    更新日期:2004-05-01 00:00:00

  • Anti-diabetic and neuroprotective effects of pancreatic islet transplantation into the central nervous system.

    abstract::During the last decades, the central nervous system (CNS) was intensively tested as a site for islet transplantation in different animal models of diabetes. Immunoprivilege properties of intracranial and intrathecal sites were found to delay and reduce rejection of transplanted allo-islets and xeno-islets, especially ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.2644

    authors: Lazard D,Vardi P,Bloch K

    更新日期:2016-01-01 00:00:00