当前位置： SCI文献检索 > DIABETES-METABOLISM RESEARCH AND REVIEWS期刊下所有文献 > Fatty acid-induced effect on glucagon secretion is mediated via fatty acid oxidation.

Fatty acid-induced effect on glucagon secretion is mediated via fatty acid oxidation.

Abstract：

BACKGROUND:While the effect of fatty acids and ectopic triglyceride storage in pancreatic beta cells has been well-defined, only limited information is available on alpha cells. This study evaluates the long-term impact of fatty acids on alpha cell function and proliferation as well as fatty acid oxidation. METHODS:Clonal alpha cells were cultured with fatty acids in the presence of high glucose for up to 3 days. The influence of fatty acids on glucagon secretion, glucagon content and triglyceride accumulation from 24 to 72 h was investigated. After a - 72 h culture, cell proliferation, carnitine palmitoyl transferase-1 mRNA level and the effect of etomoxir were also elucidated. RESULTS:Fatty acids stimulated glucagon secretion and increased triglyceride accumulation in a time- and dose-dependent manner, but inhibited alpha cell proliferation. Lower concentrations (0.125-0.25 mM) of fatty acids significantly increased glucagon secretion at 48 and 72 h, but did not affect triglyceride content. However, a marked increment in triglyceride accumulation occurred in the presence of 0.5 mM fatty acids. Fatty acids caused an up-regulation of the expression of carnitine palmitoyl transferase-1 gene. Etomoxir (1 microM) reversed fatty acid-induced glucagon hypersecretion, but did not inhibit carnitine palmitoyl transferase-1 mRNA level. CONCLUSIONS:Our data indicates that compared with triglyceride accumulation, glucagon secretion is more sensitive to changes in fatty acid concentration. The effect of fatty acids on the glucagon response is mediated through their oxidation. The high carnitine palmitoyl transferase-1 gene expression and the accumulation of triglyceride may initially be a compensatory oxidation reaction to elevated fatty acids.

journal_name

Diabetes Metab Res Rev

journal_title

Diabetes/metabolism research and reviews

authors

Hong J,Jeppesen PB,Nordentoft I,Hermansen K

doi

10.1002/dmrr.663

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

202-10

issue

3

eissn

1520-7552

issn

1520-7560

journal_volume

23

pub_type

杂志文章

相关文献

DIABETES-METABOLISM RESEARCH AND REVIEWS文献大全
  • Association between serum leptin concentration and white blood cell count in middle-aged Japanese men and women.

    abstract：BACKGROUND:Leptin's hematopoietic or proinflammatory role has been experimentally reported. We investigated whether serum leptin concentrations are associated with white blood cell (WBC) counts in humans. METHODS:Serum leptin concentrations of Japanese civil servants aged 40 to 59 years (1082 men and 200 women) were a...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.540

    authors： Mabuchi T,Yatsuya H,Tamakoshi K,Otsuka R,Nagasawa N,Zhang H,Murata C,Wada K,Ishikawa M,Hori Y,Kondo T,Hashimoto S,Toyoshima H

    更新日期：2005-09-01 00:00:00

  • Increased LDL cholesterol and CRP in infants of mothers with type 1 diabetes.

    abstract：BACKGROUND:Proatherogenic stimuli during foetal life may predispose to development of atherosclerosis in adulthood. Elevated plasma low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP) expression is associated with increased risk of atherosclerosis. METHODS AND RESULTS:In this study, we examined how ...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.867

    authors： Lindegaard ML,Svarrer EM,Damm P,Mathiesen ER,Nielsen LB

    更新日期：2008-09-01 00:00:00

  • Diabetes and fasting during Ramadan.

    abstract：:Abstinence from food and liquid during daylight hours is observed by Muslim individuals during the month of Ramadan. Even though the Koran exempts the sick from fasting, many people with diabetes still fast during this religious period. It is essential for patients, family and healthcare professionals to be aware of t...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.1137

    authors： Hui E,Devendra D

    更新日期：2010-11-01 00:00:00

  • A genetic variation in the fat mass- and obesity-associated gene is associated with obesity and newly diagnosed type 2 diabetes in a Chinese population.

    abstract：BACKGROUND:Recently, a genome-wide association study identified a strong association between the fat mass- and obesity-associated rs9939609 single nucleotide polymorphism (SNP) and the risk of obesity in European population. However, the results in Chinese population were reported to be contradictory. Therefore, our ai...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.1066

    authors： Li X,Song F,Jiang H,Zhang M,Lin J,Bao W,Yao P,Yang X,Hao L,Liu L

    更新日期：2010-02-01 00:00:00

  • Statins are associated with new onset type 2 diabetes mellitus (T2DM) in Medicare patients ≥65 years.

    abstract：BACKGROUND:To evaluate the association of statins and co-morbidities with new onset type 2 diabetes mellitus (T2DM) in patients 65 years and older. METHODS:This retrospective study used de-identified administrative healthcare claims and enrolment data from a Medicare Advantage Prescription Drug (MAPD) health plan offe...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.3310

    authors： Tangelloju S,Little BB,Esterhay RJ,Brock G,LaJoie S

    更新日期：2020-09-01 00:00:00

  • Intranasally administered insulin intended for prevention of type 1 diabetes--a safety study in healthy adults.

    abstract：BACKGROUND:Intranasally applied insulin is one of the antigen-specific therapies currently tested in clinical type 1 diabetes prevention trials, for example, in the Type 1 Diabetes Prediction and Prevention Study (DIPP). The possibility that the therapy may cause hypoglycaemia or local irritation and the poorly known i...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1002/dmrr.397

    authors： Kupila A,Sipilä J,Keskinen P,Simell T,Knip M,Pulkki K,Simell O

    更新日期：2003-09-01 00:00:00

  • Diagnosis of infection in the foot in diabetes: a systematic review.

    abstract：BACKGROUND:Securing an early accurate diagnosis of diabetic foot infections and assessment of their severity are of paramount importance since these infections can cause great morbidity and potentially mortality and present formidable challenges in surgical and antimicrobial treatment. METHODS:In June 2018, we searche...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.3281

    authors： Senneville É,Lipsky BA,Abbas ZG,Aragón-Sánchez J,Diggle M,Embil JM,Kono S,Lavery LA,Malone M,van Asten SA,Urbančič-Rovan V,Peters EJG

    更新日期：2020-03-01 00:00:00

  • Cardiovascular disease in patients with type 1 diabetes: Early evaluation, risk factors and possible relation with cardiac autoimmunity.

    abstract：:Cardiovascular disease now is the leading cause of mortality among patients with type 1 diabetes (T1D). The risk of death from cardiovascular events in subjects with T1D is 2-10 times higher than the general population, depending on blood glucose control. Although complications of cardiovascular disease occur in middl...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章,评审

    doi：10.1002/dmrr.3423

    authors： Shi M,Tang R,Huang F,Zhong T,Chen Y,Li X,Zhou Z

    更新日期：2020-11-30 00:00:00

  • The development of a World Health Organisation international standard for islet cell antibodies: the aims and design of an international collaborative study.

    abstract：:Islet cell antibodies (ICA) are a specific marker for Type 1 (insulin-dependent) diabetes mellitus. ICA are found in the serum of over 80% of newly diagnosed patients and the levels of ICA are directly of prognostic value. Standardisation of ICA and the uniform reporting of ICA levels in international units is critica...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/(sici)1520-7560(199901/02)15:1<72::aid-dmr

    authors： Mire-Sluis AR,Das RG,Lernmark A

    更新日期：1999-01-01 00:00:00

  • The roles of NADPH-oxidase and nNOS for the increased oxidative stress and the oxygen consumption in the diabetic kidney.

    abstract：BACKGROUND:Sustained hyperglycaemia induces increased renal oxygen consumption resulting in reduced oxygen availability in the diabetic kidney. We investigated the roles of the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase and the neuronal nitric oxide synthase (nNOS) for the increased oxygen consumption ...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.1099

    authors： Edlund J,Fasching A,Liss P,Hansell P,Palm F

    更新日期：2010-07-01 00:00:00

  • Negative T cell costimulation and islet tolerance.

    abstract：:Activation of self-reactive T cells that specifically destroy the pancreatic beta-cells is one of the hallmarks in the development of type 1 diabetes. Thus, for prevention and treatment of this autoimmune disease, approaches to induce and maintain T cell tolerance toward the beta-cells, especially in islet transplanta...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章,评审

    doi：10.1002/dmrr.345

    authors： Gao W,Demirci G,Li XC

    更新日期：2003-05-01 00:00:00

  • Heparanase prevents the development of type 1 diabetes in non-obese diabetic mice by regulating T-cell activation and cytokines production.

    abstract：BACKGROUND:Heparanase is an endo-beta-D-glucuronidase that cleaves heparan sulfate saccharide chains. The enzyme promotes cell adhesion, migration and invasion, and was shown to play a significant role in cancer metastasis and angiogenesis. METHODS:The present study focuses on the involvement of heparanase in autoimmu...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.868

    authors： Bitan M,Weiss L,Zeira M,Reich S,Pappo O,Vlodavsky I,Slavin S

    更新日期：2008-07-01 00:00:00

  • LIPS islet autoantibody assays in high-throughput format for DASP 2010.

    abstract：BACKGROUND:For cost-effective population-based diabetes prediction and confirmation, islet autoantibody assays must be made more economical. METHODS:We evaluated glutamic acid decarboxylase (GAD)-Ruc (renilla luciferase) and IA2ic (also known as ICA512ic)-Ruc (renilla luciferase) fusion protein constructs in high-thro...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.1268

    authors： Marcus P,Yan X,Bartley B,Hagopian W

    更新日期：2011-11-01 00:00:00

  • Angiotensin-converting enzyme 2 inhibits endoplasmic reticulum stress-associated pathway to preserve nonalcoholic fatty liver disease.

    abstract：BACKGROUND:Previous works indicated that the stress on the endoplasmic reticulum (ER) affected nonalcoholic fatty liver disease (NAFLD). However, there is no clear evident on the effect of the regulation of ER stress by angiotensin-converting enzyme 2 (ACE2) on the prevention of NAFLD. METHODS:HepG2 cells were treated...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.3123

    authors： Cao X,Song LN,Zhang YC,Li Q,Shi TT,Yang FY,Yuan MX,Xin Z,Yang JK

    更新日期：2019-05-01 00:00:00

  • Guidelines on use of interventions to enhance healing of chronic foot ulcers in diabetes (IWGDF 2019 update).

    abstract：:The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines on the prevention and management of diabetic foot disease since 1999. In conjunction with advice from internal and external reviewers and expert consultants in the field, this update is based on a systematic review of ...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章,评审

    doi：10.1002/dmrr.3283

    authors： Rayman G,Vas P,Dhatariya K,Driver V,Hartemann A,Londahl M,Piaggesi A,Apelqvist J,Attinger C,Game F,International Working Group on the Diabetic Foot (IWGDF).

    更新日期：2020-03-01 00:00:00

  • Calculating individualized glycaemic targets using an algorithm based on expert worldwide diabetologists: Implications in real-life clinical practice.

    abstract：BACKGROUND:The aim of this study was to assess the clinical implications of calculating an individualized HbA1c target using a recently published algorithm in a real-life clinical setting. METHODS:General practitioners (GPs) from the Spanish Society of Family Medicine Diabetes Expert Group were invited to participate ...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.2976

    authors： Alvarez-Guisasola F,Cebrián-Cuenca AM,Cos X,Ruiz-Quintero M,Millaruelo JM,Cahn A,Raz I,Orozco-Beltrán D,Spanish Society of Family Medicine Diabetes Group.

    更新日期：2018-03-01 00:00:00

  • Recent findings on fulminant type 1 diabetes.

    abstract：:Fulminant type 1 diabetes (fT1D) is a new subtype of type 1 diabetes proposed by Imagawa in 2000. It is a clinical syndrome characterized by a markedly rapid and almost complete destruction of pancreatic β cells. Metabolic derangement is more severe in this subtype than in autoimmune type 1 diabetes. The incidence of ...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章,评审

    doi：10.1002/dmrr.2928

    authors： Liu L,Zeng L,Sang D,Lu Z,Shen J

    更新日期：2018-01-01 00:00:00

  • Early transcriptional regulation by C-peptide in freshly isolated rat proximal tubular cells.

    abstract：BACKGROUND:Clinical studies have shown that proinsulin C-peptide exerts renoprotective effects in type 1 diabetes, although the underlying mechanisms are poorly understood. As C-peptide has been shown to induce several intracellular events and to localize to nuclei, we aimed to determine whether gene transcription is a...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.1220

    authors： Lindahl E,Nordquist L,Müller P,El Agha E,Friederich M,Dahlman-Wright K,Palm F,Jörnvall H

    更新日期：2011-10-01 00:00:00

  • Treatment of new-onset type 1 diabetes with peptide DiaPep277 is safe and associated with preserved beta-cell function: extension of a randomized, double-blind, phase II trial.

    abstract：BACKGROUND:Treatment with DiaPep277, a peptide derived from HSP60, has been shown to preserve beta-cell function in non-obese diabetic mouse (NOD) mice and in a trial with newly diagnosed human patients with type 1 diabetes treated over a 10-month period. This article extends the clinical trial observations to a total ...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章,随机对照试验

    doi：10.1002/dmrr.712

    authors： Raz I,Avron A,Tamir M,Metzger M,Symer L,Eldor R,Cohen IR,Elias D

    更新日期：2007-05-01 00:00:00

  • Overexpression of ZAC impairs glucose-stimulated insulin translation and secretion in clonal pancreatic beta-cells.

    abstract：BACKGROUND:ZAC (Zinc finger protein that regulates apoptosis and cell-cycle arrest) is a candidate gene for transient neonatal diabetes mellitus (TNDM). This condition involves severe insulin deficiency at birth that reverses over weeks or months but may relapse with diabetes recurring in later life. ZAC overexpression...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.2325

    authors： Du X,Ounissi-Benkalha H,Loder MK,Rutter GA,Polychronakos C

    更新日期：2012-11-01 00:00:00

  • The decrement in circulating endothelial progenitor cells (EPCs) in type 2 diabetes is independent of the severity of the hypoadiponectemia.

    abstract：BACKGROUND:Type 2 diabetes mellitus (DM) is associated with a decreased level of circulating endothelial progenitor cells (EPCs) and adiponectin. Experimental studies suggest a potential link between hypoadiponectinaemia and the depletion of the EPC level. This study investigated the relationships between adiponectin l...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.1159

    authors： Li M,Ho JC,Lai KW,Au KK,Xu A,Cheung BM,Lam KS,Tse HF

    更新日期：2011-02-01 00:00:00

  • Differences in cardiovascular risk profile based on relationship between post-load plasma glucose and fasting plasma levels.

    abstract：BACKGROUND:It has been shown that subjects with normal glucose tolerance (NGT), whose plasma glucose (PG) levels do not return to their fasting PG level within 2 h during an oral glucose tolerance test (OGTT) (Group I), have a significantly higher risk to develop type 2 diabetes than NGT subjects whose 2-h glucose retu...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.951

    authors： Succurro E,Marini MA,Grembiale A,Lugarà M,Andreozzi F,Sciacqua A,Hribal ML,Lauro R,Perticone F,Sesti G

    更新日期：2009-05-01 00:00:00

  • Skeletal involvement in patients with diabetes mellitus.

    abstract：:Studies on skeletal involvement in patients with diabetes mellitus have generated conflicting results, largely because of the pathogenetic complexity of the condition. Several mechanisms may contribute to skeletal damage, including the increased urinary excretion coupled with the lower intestinal absorption of calcium...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章,评审

    doi：10.1002/dmrr.449

    authors： Carnevale V,Romagnoli E,D'Erasmo E

    更新日期：2004-05-01 00:00:00

  • Identification of specific angiotensin-converting enzyme variants and haplotypes that confer risk and protection against type 2 diabetic nephropathy.

    abstract：BACKGROUND:Cross-sectional and family studies identified angiotensin-converting enzyme (ACE) gene as a risk factor for diabetic nephropathy (DN). The contribution of ACE gene variants to DN development and progression is controversial and varies among different ethnic/racial groups. METHODS:We investigated the associa...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.1006

    authors： Ezzidi I,Mtiraoui N,Kacem M,Chaieb M,Mahjoub T,Almawi WY

    更新日期：2009-11-01 00:00:00

  • The important role of physical activity in the prevention and management of gestational diabetes mellitus.

    abstract：:The actual pathophysiology behind gestational diabetes mellitus (GDM) is still unclear, but a deterioration in insulin resistance beyond that induced by pregnancy, combined with beta cell dysfunction, plays a key role. Interventions that help improve glucose tolerance by attenuating pregnancy-induced insulin resistanc...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章,评审

    doi：10.1002/dmrr.2402

    authors： Ruchat SM,Mottola MF

    更新日期：2013-07-01 00:00:00

  • The future for diabetic foot ulcer prevention: A paradigm shift from stratified healthcare towards personalized medicine.

    abstract：:Prevention of diabetic foot ulcers is important to reduce the burden of diabetic foot disease. However, we found that ulcer prevention is underexposed in research and clinical practice. Barriers to explain this are seen in patient's goal-setting; in the lack of interdisciplinary teams for ulcer prevention; in sample s...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.3234

    authors： Van Netten JJ,Woodburn J,Bus SA

    更新日期：2020-03-01 00:00:00

  • Pancreatic fat accumulation is associated with decreased β-cell function and deterioration in glucose tolerance in Korean adults.

    abstract：AIMS:This study was designed to investigate the association between pancreatic fat content (PFC) and insulin secretory capacity as well as glucose tolerance in Korean adults. MATERIALS:A total of 39 participants (mean age 49.9 years, 53% males) without a previous history of diabetes, or those previously diagnosed as h...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.3425

    authors： Chin SO,Hwang YC,Cho IJ,Jeong IK,Ahn KJ,Chung HY

    更新日期：2020-11-30 00:00:00

  • Painful diabetic neuropathy: treatment and future aspects.

    abstract：:Around one of three diabetic patients is affected by distal symmetric polyneuropathy (DSP) which represents a major health problem, as it may present with partly excruciating neuropathic pain and is responsible for substantial morbidity and increased mortality. Treatment is based on four cornerstones: (1) multifactori...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章,评审

    doi：10.1002/dmrr.817

    authors： Ziegler D

    更新日期：2008-05-01 00:00:00

  • Sex and ethnic-origin specific BMI cut points improve prediction of 40-year mortality: the Israel GOH study.

    abstract：BACKGROUND:Although obesity has been associated with a higher risk for premature death, the sex and ethnic-origin specific body mass index (BMI) levels that are associated with increased mortality are controversial. We investigated the 40-year cumulative all-cause mortality, in relation to the BMI in adult life, among ...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章

    doi：10.1002/dmrr.2642

    authors： Dankner R,Shanik M,Roth J,Luski A,Lubin F,Chetrit A

    更新日期：2015-07-01 00:00:00

  • New developments in the biomechanics of the diabetic foot.

    abstract：:Biomechanical issues are now widely recognized as being important in the treatment of diabetic foot disease. The purpose of the present review is to identify advances that have occurred since the previous International Conference on the Diabetic Foot in 1995 in the understanding of foot biomechanics in relation to dia...

    journal_title：Diabetes/metabolism research and reviews

    pub_type： 杂志文章,评审

    doi：10.1002/1520-7560(200009/10)16:1+<::aid-dmrr130>3.

    authors： Cavanagh PR,Ulbrecht JS,Caputo GM

    更新日期：2000-09-01 00:00:00