Abstract:
BACKGROUND:We evaluated whether global levels of DNA methylation status were associated with retinopathy as well as providing a predictive role of DNA methylation in developing retinopathy in a case-control study of 168 patients with type 2 diabetes. METHODS:The 5-methylcytosine content was assessed by reversed-phase high-pressure liquid chromatography of peripheral blood leukocytes to determine an individual's global DNA methylation status in the two groups, either with or without retinopathy. RESULTS:The global DNA methylation levels were significantly higher in diabetic retinopathy patients compared with those in non-retinopathy patients (4.90 ± 0.12 vs. 4.22 ± 0.13, respectively; p = 0.001). There was a significant increasing trend in global DNA methylation levels in terms of progressing retinopathy (without retinopathy, 4.22 ± 0.13; non-proliferative diabetic retinopathy, 4.62 ± 0.17; proliferative diabetic retinopathy, 5.07 ± 0.21) (p = 0.006). Additionally, global DNA methylation independent of retinopathy risk factors, which include dyslipidaemia, hypertension, hyperglycaemia and duration of diabetes, was a predictive factor for retinopathy (OR = 1.53, p = 0.015). CONCLUSIONS:Global DNA methylation is modulated during or possibly before the primary stage of diabetes. This observation verifies the metabolic memory effect of hyperglycaemia in early stage of an aetiological process that leads to type 2 diabetes and its associated complications.
journal_name
Diabetes Metab Res Revjournal_title
Diabetes/metabolism research and reviewsauthors
Maghbooli Z,Hossein-nezhad A,Larijani B,Amini M,Keshtkar Adoi
10.1002/dmrr.2584subject
Has Abstractpub_date
2015-02-01 00:00:00pages
183-9issue
2eissn
1520-7552issn
1520-7560journal_volume
31pub_type
杂志文章abstract:BACKGROUND:Non-alcoholic fatty liver disease (NAFLD) can lead to cirrhosis and hepatocellular carcinoma and is strongly associated with obesity and insulin resistance. The aim of this study was to assess if plasma markers associated with NAFLD are increased in people with concomitant diabetes compared with those withou...
journal_title:Diabetes/metabolism research and reviews
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更新日期:2012-05-01 00:00:00
abstract::The role of peripheral arterial disease in ulcerated diabetic feet has long been underestimated. Progressive claudication, rest pain and the extent of irreversible tissue loss have frequently been indications for revascularization for neuroischaemic ulcers in diabetic patients. These typical ischaemic symptoms are war...
journal_title:Diabetes/metabolism research and reviews
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,评审
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更新日期:2000-09-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
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doi:10.1002/dmrr.861
更新日期:2008-05-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
doi:10.1002/dmrr.1220
更新日期:2011-10-01 00:00:00
abstract:BACKGROUND:Platelet activation contributes to cardiovascular disease (CVD), the main complication of type 2 diabetes mellitus (T2DM) and pre-diabetic conditions. Mean platelet volume is an easy-to-measure platelet parameter that has been associated with CVD. We sought to assess mean platelet volume, platelet distributi...
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journal_title:Diabetes/metabolism research and reviews
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-01-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
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更新日期:1999-01-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,评审
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更新日期:2018-09-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,评审
doi:10.1002/dmrr.513
更新日期:2004-11-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
doi:10.1002/dmrr.2556
更新日期:2014-09-01 00:00:00
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doi:10.1002/dmrr.3123
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更新日期:2003-07-01 00:00:00
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,多中心研究
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journal_title:Diabetes/metabolism research and reviews
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,评审
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journal_title:Diabetes/metabolism research and reviews
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更新日期:2014-03-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
doi:10.1002/dmrr.1203
更新日期:2011-07-01 00:00:00
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更新日期:2010-07-01 00:00:00