Retinal capillary basement membrane thickness in diabetic mice genetically modified at the haptoglobin locus.

abstract：:Whether diabetic foot ulcerations arise from an amalgam of neuro-ischemic factors or because of arterial occlusive disease alone, the arterial circulation must be thoroughly evaluated. Clinical evaluation is foremost, but numerous non-invasive diagnostic options such as duplex ultrasonography and MRA are often enliste...

journal_title：Diabetes/metabolism research and reviews

authors： Andros G

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Recently, a genome-wide association study identified a strong association between the fat mass- and obesity-associated rs9939609 single nucleotide polymorphism (SNP) and the risk of obesity in European population. However, the results in Chinese population were reported to be contradictory. Therefore, our ai...

journal_title：Diabetes/metabolism research and reviews

authors： Li X,Song F,Jiang H,Zhang M,Lin J,Bao W,Yao P,Yang X,Hao L,Liu L

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND:Sustained hyperglycaemia induces increased renal oxygen consumption resulting in reduced oxygen availability in the diabetic kidney. We investigated the roles of the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase and the neuronal nitric oxide synthase (nNOS) for the increased oxygen consumption ...

journal_title：Diabetes/metabolism research and reviews

authors： Edlund J,Fasching A,Liss P,Hansell P,Palm F

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND:Physical exercise provides health benefits for people with type 2 diabetes mellitus, partly by enhancing skeletal muscle insulin action. We tested the hypothesis that changes in expression of key genes in skeletal muscles relate to exercise-induced improvements in type 2 diabetic patients. METHODS:We determ...

journal_title：Diabetes/metabolism research and reviews

authors： Fritz T,Krämer DK,Karlsson HK,Galuska D,Engfeldt P,Zierath JR,Krook A

更新日期：2006-11-01 00:00:00

abstract：:Diabetes foot infections are a common condition and a major causal pathway to lower extremity amputation. Identification of causative pathogens is vital in directing antimicrobial therapy. Historically, clinicians have relied upon culture-dependent techniques that are now acknowledged as both being selective for micro...

journal_title：Diabetes/metabolism research and reviews

authors： Malone M,Gosbell IB,Dickson HG,Vickery K,Espedido BA,Jensen SO

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:This study assesses the autonomic function of patients who have regained awareness of hypoglycaemia following islet cell or whole pancreas transplant. METHODS:Five patients with type 1 diabetes and either islet cell (four patients) or whole pancreas (one patient) transplant were assessed. These patients wer...

journal_title：Diabetes/metabolism research and reviews

authors： Kamel JT,Goodman DJ,Howe K,Cook MJ,Ward GM,Roberts LJ

更新日期：2015-09-01 00:00:00

abstract：BACKGROUND:We conducted a clinical research study to determine the effect of self-monitoring of blood glucose (SMBG) on glycaemic control and the value of a putatively less painful blood sampling technique on SMBG in oral hypoglycaemic agent-treated type 2 diabetes patients; SMBG has not been broadly applied in non-ins...

journal_title：Diabetes/metabolism research and reviews

authors： Harashima S,Fukushima T,Sasaki M,Nishi Y,Fujimoto S,Ogura M,Yamane S,Tanaka D,Harada N,Hamasaki A,Nagashima K,Nakahigashi Y,Seino Y,Inagaki N

更新日期：2013-01-01 00:00:00

abstract：BACKGROUND:To compare in atrial fibrillation patients with and without diabetes, (1) baseline characteristics, (2) additional risk factors for stroke or peripheric or visceral embolism (hypertension, previous stroke, age >75 years), (3) mortality, (4) stroke or embolism, and (5) oral anticoagulation in the year 2000. ...

journal_title：Diabetes/metabolism research and reviews

authors： Klem I,Wehinger C,Schneider B,Hartl E,Finsterer J,Stöllberger C

更新日期：2003-07-01 00:00:00

abstract：:Studies on skeletal involvement in patients with diabetes mellitus have generated conflicting results, largely because of the pathogenetic complexity of the condition. Several mechanisms may contribute to skeletal damage, including the increased urinary excretion coupled with the lower intestinal absorption of calcium...

journal_title：Diabetes/metabolism research and reviews

authors： Carnevale V,Romagnoli E,D'Erasmo E

更新日期：2004-05-01 00:00:00

abstract：:Diabetic patients are at higher risk of developing physical disabilities than non-diabetic subjects. Physical disability appears to be related, at least in part, to muscle dysfunction. Several studies have reported reduced muscle strength and power under dynamic and static conditions in both the upper and lower limbs ...

journal_title：Diabetes/metabolism research and reviews

authors： Orlando G,Balducci S,Bazzucchi I,Pugliese G,Sacchetti M

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Human leukocyte antigen (HLA) genotypes associated with increased risk for type 1 diabetes mellitus (T1D) have been reported to be associated with increased birth weight. We set out to investigate the association between HLA haplotypes conferring risk for T1D and birth weight and search for possible differen...

journal_title：Diabetes/metabolism research and reviews

authors： Peet A,Kool P,Ilonen J,Knip M,Tillmann V,DIABIMMUNE Study Group.

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing in developing countries, but its causes are not known. We aimed to ascertain the prevalence and determinants of NAFLD in a new largely unmedicated population-based cohort from the rapidly gentrifying region of Pinggu, China. METHODS:We ran...

journal_title：Diabetes/metabolism research and reviews

authors： Zhou X,Li Y,Zhang X,Guan YY,Puentes Y,Zhang F,Speliotes EK,Ji L

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:ZAC (Zinc finger protein that regulates apoptosis and cell-cycle arrest) is a candidate gene for transient neonatal diabetes mellitus (TNDM). This condition involves severe insulin deficiency at birth that reverses over weeks or months but may relapse with diabetes recurring in later life. ZAC overexpression...

journal_title：Diabetes/metabolism research and reviews

authors： Du X,Ounissi-Benkalha H,Loder MK,Rutter GA,Polychronakos C

更新日期：2012-11-01 00:00:00

abstract：BACKGROUND:The pancreatic islet damage that occurs through an inflammatory response and hypoxia after infusion is a major hurdle in islet transplantation. Because essential phospholipids (EPL) have been shown to exhibit anti-inflammatory properties in liver disease, we analysed their protective effect on islets in infl...

journal_title：Diabetes/metabolism research and reviews

authors： Shahbazov R,Kanak MA,Takita M,Kunnathodi F,Khan O,Borenstein N,Lawrence MC,Levy MF,Naziruddin B

更新日期：2016-03-01 00:00:00

abstract：:Four kinds of subcutaneous continuous glucose monitoring (CGM) machines have been currently introduced in clinical practice. These machines exhibit real-time glucose on the monitor every 5 minutes and have alarms to indicate hypoglycaemia and hyperglycaemia. However, thus far, there is no clear consensus about the cli...

journal_title：Diabetes/metabolism research and reviews

authors： Kim HS,Shin JA,Chang JS,Cho JH,Son HY,Yoon KH

更新日期：2012-12-01 00:00:00

abstract：BACKGROUND:The proposed 2015 US Preventive Services Task Force guidelines recommend diabetes screening for individuals ≥45 years or demonstrating other risk factors for dysglycemia. Still, many patients with dysglycemia remain undiagnosed, and opportunities for early intervention are lost. METHODS:To test novel approa...

journal_title：Diabetes/metabolism research and reviews

authors： Silverman RA,Schleicher MG,Valente CJ,Kim M,Romanenko Y,Schulman RC,Tiberio A,Greenblatt B,Rentala M,Salvador-Kelly AV,Kwon NS,Jornsay DL

更新日期：2016-01-01 00:00:00

abstract：BACKGROUND:Although obesity has been associated with a higher risk for premature death, the sex and ethnic-origin specific body mass index (BMI) levels that are associated with increased mortality are controversial. We investigated the 40-year cumulative all-cause mortality, in relation to the BMI in adult life, among ...

journal_title：Diabetes/metabolism research and reviews

authors： Dankner R,Shanik M,Roth J,Luski A,Lubin F,Chetrit A

更新日期：2015-07-01 00:00:00

abstract：BACKGROUND:The importance of cytotoxic T lymphocyte antigen-4 (CTLA-4) in immune regulation is unquestioned, yet a precise understanding of which cells express it, and how it mediates immune inhibitory function, is lacking. Regulatory T cells are known to constitutively express CTLA-4 intracellularly, whereas conventio...

journal_title：Diabetes/metabolism research and reviews

authors： Wang CJ,Schmidt EM,Attridge K,Kenefeck R,Wardzinski L,Chamberlain JL,Soulier A,Clough LE,Manzotti CN,Narendran P,Walker LS

更新日期：2011-11-01 00:00:00

abstract：BACKGROUND:Stable glucagon-like peptide-1 (GLP-1) mimetics, such as the GLP-1 analogue liraglutide, are approved for treatment of type 2 diabetes. GLP-1 has a spectrum of anti-diabetic effects that are of possible utility in the treatment of more severe forms of diabetes. METHODS:The present study has evaluated the ef...

journal_title：Diabetes/metabolism research and reviews

authors： Moffett RC,Patterson S,Irwin N,Flatt PR

更新日期：2015-03-01 00:00:00

abstract：:Now that the reduction in beta-mass has been clearly established in humans with type 2 diabetes mellitus (T2DM) 1-4, the debate focuses on the possible mechanisms responsible for decreased beta-cell number and impaired beta-cell function and their multifactorial etiology. Appropriate inbred rodent models are essential...

journal_title：Diabetes/metabolism research and reviews

authors： Portha B

更新日期：2005-11-01 00:00:00

abstract：BACKGROUND:In type 2 diabetes (T2D), copresence of low-density lipoprotein cholesterol (LDL-C) < 2.8 mmol/L with triglyceride < 1.7 mmol/L or with albuminuria synergistically increased cancer risk. We tested whether use of renin angiotensin system inhibitors attenuated the increased cancer risk associated with these tw...

journal_title：Diabetes/metabolism research and reviews

authors： Yang X,Ma RC,So WY,Wang Y,Kong AP,Ozaki R,Xu G,Chan JC

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:The active cognitive-motor demands of driving may have a significant metabolic demand that could contribute to the development of hypoglycemia. Conversely, symptoms caused by the stress of driving may be confused with hypoglycemia and lead to false alarms. This study examined the metabolic demand and the phy...

journal_title：Diabetes/metabolism research and reviews

authors： Cox DJ,Gonder-Frederick LA,Kovatchev BP,Clarke WL

更新日期：2002-09-01 00:00:00

abstract：BACKGROUND:We conducted this research in order to evaluate the prevalence of glutamic acid decarboxylase antibodies (GADA) in Korean women with gestational diabetes mellitus (GDM), to identify the clinical characteristics of these women, and to gauge the prevalence of diabetes among them after childbirth. METHODS:We s...

journal_title：Diabetes/metabolism research and reviews

authors： Yu SH,Park S,Kim HS,Park SY,Yim CH,Han KO,Yoon HK,Jang HC,Chung HY,Kim SH

更新日期：2009-05-01 00:00:00

abstract：BACKGROUND:Brown adipose tissue (BAT) is important for energy expenditure through thermogenesis, although its regulatory factors are not well known in humans. There is evidence suggesting that thyroid hormones affect BAT functions in some mammals, but the effects of thyroid hormones on BAT activity in humans are still ...

journal_title：Diabetes/metabolism research and reviews

authors： Zhang Q,Miao Q,Ye H,Zhang Z,Zuo C,Hua F,Guan Y,Li Y

更新日期：2014-09-01 00:00:00

abstract：BACKGROUND:Periodontal disease is a frequent complication of diabetes in adults, and both conditions are associated with systemic inflammatory states. This systematic review and meta-analysis was conducted to establish the relative severity of periodontal disease risk markers in children and adolescents with type 1 dia...

journal_title：Diabetes/metabolism research and reviews

authors： Jensen E,Allen G,Bednarz J,Couper J,Peña A

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Despite the correlation between the use of protease inhibitors (PI) and adverse metabolic glycemic events, no prospective study has examined these parameters in pregnant women who use these drugs. METHODS:A prospective study was conducted on 57 pregnant women to investigate the effect of antiretroviral drug...

journal_title：Diabetes/metabolism research and reviews

authors： El Beitune P,Duarte G,Foss MC,Montenegro RM Jr,Spara P,Quintana SM,Figueiró-Filho EA,da Costa AG,Filho FM

更新日期：2006-01-01 00:00:00

abstract：BACKGROUND:Adenosine receptors denoted by A1 , A2A , A2B , and A3 and encoded by ADORA1, ADORA2A, ADORA2B, and ADORA3 genes, respectively, are adenosine-activated G-protein-coupled receptors that play an important role in obesity and type 2 diabetes mellitus. However, little is known about their significance in gestati...

journal_title：Diabetes/metabolism research and reviews

authors： Wojcik M,Zieleniak A,Mac-Marcjanek K,Wozniak LA,Cypryk K

更新日期：2014-01-01 00:00:00

abstract：:Insulin-producing pancreatic beta-cells are known to be extremely susceptible to destruction, primarily by autoimmune mechanisms, infectious agents, and by chemical toxins that cause overt type I diabetes. As development of highly protected insulin-producing cells would be important for successful cell therapy of diab...

journal_title：Diabetes/metabolism research and reviews

authors： Bloch K,Vardi P

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:To evaluate possible differences in distal polyneuropathy (PN) characteristics and degree of abnormalities for various small and large fibre parameters in diabetes type 1 (DM1) and type 2 (DM2). METHODS:Sixty-six DM1 and 57 DM2 patients with or without PN symptoms were included. Nerve conduction studies (NC...

journal_title：Diabetes/metabolism research and reviews

authors： Løseth S,Mellgren SI,Jorde R,Lindal S,Stålberg E

更新日期：2010-02-01 00:00:00

abstract：:Biomechanical issues are now widely recognized as being important in the treatment of diabetic foot disease. The purpose of the present review is to identify advances that have occurred since the previous International Conference on the Diabetic Foot in 1995 in the understanding of foot biomechanics in relation to dia...

journal_title：Diabetes/metabolism research and reviews

authors： Cavanagh PR,Ulbrecht JS,Caputo GM

更新日期：2000-09-01 00:00:00