Prevalence and management of diabetic neuropathy in secondary care in Qatar.

Abstract:

AIMS:Diabetic neuropathy (DN) is a "Cinderella" complication, particularly in the Middle East. A high prevalence of undiagnosed DN and those at risk of diabetic foot ulceration (DFU) is a major concern. We have determined the prevalence of DN and its risk factors, DFU, and those at risk of DFU in patients with type 2 diabetes mellitus (T2DM) in secondary care in Qatar. MATERIALS AND METHODS:Adults with T2DM were randomly selected from the two National Diabetes Centers in Qatar. DN was defined by the presence of neuropathic symptoms and a vibration perception threshold (VPT) ≥ 15 V. Participants with a VPT ≥ 25 V were categorized as high risk for DFU. Painful DN was defined by a DN4 score ≥4. Logistic regression analysis was used to identify predictors of DN. RESULTS:In 1082 adults with T2DM (age 54 ± 11 years, duration of diabetes 10.0 ± 7.7 years, 60.6% males), the prevalence of DN was 23.0% (95% CI, 20.5%-25.5%) of whom 33.7% (95% CI, 27.9%-39.6%) were at high risk of DFU, and 6.3% had DFU; 82.0% of the patients with DN were previously undiagnosed. The prevalence of DN increased with age and duration of diabetes and was associated with poor glycaemic control (HbA1c  ≥ 9%) AOR = 2.1 (95% CI, 1.3-3.2), hyperlipidaemia AOR = 2.7 (95% CI, 1.5-5.0), and hypertension AOR = 2.0 (95% CI, 1.2-3.4). CONCLUSIONS:Despite DN affecting 23% of adults with T2DM, 82% had not been previously diagnosed with one-third at high risk for DFU. This argues for annual screening and identification of patients with DN. Furthermore, we identify hyperglycaemia, hyperlipidaemia, and hypertension as predictors of DN.

journal_name

Diabetes Metab Res Rev

authors

Ponirakis G,Elhadd T,Chinnaiyan S,Dabbous Z,Siddiqui M,Al-Muhannadi H,Petropoulos IN,Khan A,Ashawesh KAE,Dukhan KMO,Mahfoud ZR,Murgatroyd C,Slevin M,Malik RA

doi

10.1002/dmrr.3286

subject

Has Abstract

pub_date

2020-05-01 00:00:00

pages

e3286

issue

4

eissn

1520-7552

issn

1520-7560

journal_volume

36

pub_type

杂志文章
  • Gluten-free but also gluten-enriched (gluten+) diet prevent diabetes in NOD mice; the gluten enigma in type 1 diabetes.

    abstract:BACKGROUND:Environmental factors such as nutrition or exposure to infections play a substantial role in the pathogenesis of type 1 diabetes (T1D). We have previously shown that gluten-free, non-purified diet largely prevented diabetes in non-obese diabetic (NOD) mice. In this study we tested hypothesis that early intro...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.748

    authors: Funda DP,Kaas A,Tlaskalová-Hogenová H,Buschard K

    更新日期:2008-01-01 00:00:00

  • Visceral adiposity index outperforms common anthropometric indices in predicting 10-year diabetes risk: Results from the ATTICA study.

    abstract:BACKGROUND:Visceral adiposity index (VAI) is a novel marker of visceral adipose tissue accumulation and dysfunction. The study aim was to explore the association of VAI with the 10-year type 2 diabetes mellitus (T2DM) incidence in apparently healthy individuals and compare its T2DM predictive ability against common ant...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.3161

    authors: Koloverou E,Panagiotakos DB,Kyrou I,Stefanadis C,Chrysohoou C,Georgousopoulou EN,Skoumas I,Tousoulis D,Pitsavos C,ATTICA Study group.

    更新日期:2019-09-01 00:00:00

  • Negative T cell costimulation and islet tolerance.

    abstract::Activation of self-reactive T cells that specifically destroy the pancreatic beta-cells is one of the hallmarks in the development of type 1 diabetes. Thus, for prevention and treatment of this autoimmune disease, approaches to induce and maintain T cell tolerance toward the beta-cells, especially in islet transplanta...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.345

    authors: Gao W,Demirci G,Li XC

    更新日期:2003-05-01 00:00:00

  • Risk of type 1 diabetes in childhood and maternal age at delivery, interaction with ACP1 and sex.

    abstract:BACKGROUND:We have investigated the possible role of ACP1 (also known as cLMWPTP: cytosolic low molecular weight phosphotyrosine phosphatase), a highly polymorphic enzyme involved in signal transduction of T-cell receptor, insulin receptor and other growth factors in the relationship between maternal age at delivery an...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.521

    authors: Bottini N,Meloni GF,Lucarelli P,Amante A,Saccucci P,Gloria-Bottini F,Bottini E

    更新日期:2005-07-01 00:00:00

  • Coprevalence of type 2 diabetes mellitus and tuberculosis in low-income and middle-income countries: A systematic review.

    abstract::Increasing coprevalence of diabetes mellitus (DM) and tuberculosis (TB) in low-income and middle-income countries (LMICs) indicates a rising threat to the decades of progress made against TB and requires global attention. This systematic review provides a summary of type 2 diabetes and tuberculosis coprevalence in var...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.3066

    authors: McMurry HS,Mendenhall E,Rajendrakumar A,Nambiar L,Satyanarayana S,Shivashankar R

    更新日期:2019-01-01 00:00:00

  • Identification and functional analysis of a novel G310D variant in the insulin-like growth factor 1 receptor (IGF1R) gene associated with type 2 diabetes in American Indians.

    abstract:AIMS:Insulin-like growth factor 1 receptor (IGF1R) is involved in cell growth and glucose homeostasis. In the current study, the IGF1R locus was analysed as a candidate gene for type 2 diabetes (T2D) in American Indians. MATERIALS AND METHODS:Whole genome sequence data from 335 American Indians identified 3 novel miss...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2994

    authors: Muller YL,Skelton G,Piaggi P,Chen P,Nair A,Kobes S,Hsueh WC,Knowler WC,Hanson RL,Baier LJ,Bogardus C

    更新日期:2018-05-01 00:00:00

  • 24-Hour Fasting with Diabetes: guide to physicians advising patients on medication adjustments prior to religious observances (or outpatient surgical procedures).

    abstract::Patients with diabetes may undergo an approximately 24-h fast for a voluntary religious observance or in preparation for a medical procedure. Commonly, patients will manage their diabetes before and during such fasting without guidelines from their doctors, often because they did not ask for advice. The physician shou...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1169

    authors: Grajower MM

    更新日期:2011-07-01 00:00:00

  • A case-control study: The association of serum paraoxonase 1 activity and concentration with the development of type 2 diabetes mellitus.

    abstract:BACKGROUND:A longitudinal study assessed serum paraoxonase 1 (PON1) activity and concentration as affected by age and as associated with the development of type 2 diabetes (T2D). PON1's recently established physiological function is the hydrolysis of lipolactones in oxidized LDL particles. METHODS:Serum samples and cl...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2967

    authors: Crow JA,Meek EC,Wills RW,Chambers JE

    更新日期:2018-03-01 00:00:00

  • Open bypass and endoluminal therapy: complementary techniques for revascularization in diabetic patients with critical limb ischaemia.

    abstract::The use of endovascular therapy (EVT) for lower extremity atherosclerosis is markedly increasing while open surgical bypass is in decline. The results of EVT for critical limb ischaemia (CLI) are difficult to evaluate, especially for patients with diabetes. To date, only one randomized, prospective trial has been publ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.829

    authors: Mills JL Sr

    更新日期:2008-05-01 00:00:00

  • Genetic association analyses of atopic illness and proinflammatory cytokine genes with type 1 diabetes.

    abstract:BACKGROUND:The genetic basis of the autoimmune disease type 1 diabetes (T1D) has now been largely determined, so now we can compare these findings with emerging genetic knowledge of disorders and phenotypes that have been negatively or positively associated with T1D historically. Here, we assessed the role in T1D of va...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1259

    authors: Saleh NM,Raj SM,Smyth DJ,Wallace C,Howson JM,Bell L,Walker NM,Stevens HE,Todd JA

    更新日期:2011-11-01 00:00:00

  • Diabetes and fasting during Ramadan.

    abstract::Abstinence from food and liquid during daylight hours is observed by Muslim individuals during the month of Ramadan. Even though the Koran exempts the sick from fasting, many people with diabetes still fast during this religious period. It is essential for patients, family and healthcare professionals to be aware of t...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1137

    authors: Hui E,Devendra D

    更新日期:2010-11-01 00:00:00

  • The association between fasting plasma glucose and all-cause and cause-specific mortality by gender: The rural Chinese cohort study.

    abstract:BACKGROUND:To evaluate the association between fasting plasma glucose (FPG) and mortality by gender. METHODS:A total of 17 248 eligible participants from a rural Chinese prospective cohort population were included. The same questionnaire interview and anthropometric and laboratory measurements were performed at both b...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.3129

    authors: Liu L,Chen X,Liu Y,Sun X,Yin Z,Li H,Zhang M,Wang B,Ren Y,Zhao Y,Liu D,Zhou J,Liu X,Zhang D,Cheng C,Liu F,Zhou Q,Xu Q,Xiong Y,Liu J,You Z,Hong S,Wang C,Hu D

    更新日期:2019-05-01 00:00:00

  • Advanced complicated diabetes mellitus is associated with a reduced risk of thoracic and abdominal aortic aneurysm rupture: a population-based cohort study.

    abstract:BACKGROUND:Studies have associated diabetes mellitus (DM) with the reduced risk of abdominal aortic aneurysm and thoracic aortic aneurysm and dissection. We used the national insurance data of Taiwan to examine these correlations for an Asian population. The association was also evaluated by DM severity. METHODS:We id...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2585

    authors: Tsai CL,Lin CL,Wu YY,Shieh DC,Sung FC,Kao CH

    更新日期:2015-02-01 00:00:00

  • Sodium-glucose cotransporter 2 (SGLT2) inhibitors and fracture risk in patients with type 2 diabetes mellitus: A meta-analysis.

    abstract:BACKGROUND:Sodium-glucose cotransporter 2 (SGLT2) inhibitors could potentially alter calcium and phosphate homeostasis and may increase the risk of bone fracture. METHODS:The current meta-analysis was conducted to investigate the fracture risk among patients with type 2 diabetes mellitus treated with SGLT2 inhibitors....

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/dmrr.2903

    authors: Ruanpeng D,Ungprasert P,Sangtian J,Harindhanavudhi T

    更新日期:2017-09-01 00:00:00

  • Prevalence of undiagnosed dysglycemia in an emergency department observation unit.

    abstract:BACKGROUND:The proposed 2015 US Preventive Services Task Force guidelines recommend diabetes screening for individuals ≥45 years or demonstrating other risk factors for dysglycemia. Still, many patients with dysglycemia remain undiagnosed, and opportunities for early intervention are lost. METHODS:To test novel approa...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2674

    authors: Silverman RA,Schleicher MG,Valente CJ,Kim M,Romanenko Y,Schulman RC,Tiberio A,Greenblatt B,Rentala M,Salvador-Kelly AV,Kwon NS,Jornsay DL

    更新日期:2016-01-01 00:00:00

  • Basal insulin analogues in diabetic pregnancy: a literature review and baseline results of a randomised, controlled trial in type 1 diabetes.

    abstract::As basal insulin analogues are being used off-label, there is a need to evaluate their safety (maternal hypoglycaemia and fetal and perinatal outcomes) and efficacy [haemoglobin A1c(HbA1c), fasting plasma glucose, and maternal weight gain]. The aim of this review is to provide an overview of the current literature con...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,多中心研究,随机对照试验,评审

    doi:10.1002/dmrr.1213

    authors: Mathiesen ER,Damm P,Jovanovic L,McCance DR,Thyregod C,Jensen AB,Hod M

    更新日期:2011-09-01 00:00:00

  • Effects of sodium-glucose cotransporter (SGLT) inhibitors in addition to insulin therapy on glucose control and safety outcomes in adults with type 1 diabetes: A meta-analysis of randomized controlled trials.

    abstract::Sodium-glucose cotransporter (SGLT) inhibitors added to insulin therapy have been proposed as treatment strategy for type 1 diabetes (T1D). We thus conducted a meta-analysis of randomized controlled trials (RCTs) to assess the efficacy and adverse effects of this combination in T1D. We searched the PubMed, EMBASE, and...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/dmrr.3169

    authors: Lu J,Tang L,Meng H,Zhao J,Liang Y

    更新日期:2019-10-01 00:00:00

  • Hepatic glucose uptake, gluconeogenesis and the regulation of glycogen synthesis.

    abstract::Hepatic glycogen is replenished during the absorptive period postprandially. This repletion is prompted partly by an increased hepatic uptake of glucose by the liver, partly by metabolite and hormonal signals in the portal vein, and partly by an increased gluconeogenic flux to glycogen (glyconeogenesis). There is some...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.217

    authors: Radziuk J,Pye S

    更新日期:2001-07-01 00:00:00

  • A subset of human pancreatic beta cells express functional CD14 receptors: a signaling pathway for beta cell-related glycolipids, sulfatide and β-galactosylceramide.

    abstract:BACKGROUND:T1DM is a T-cell-mediated autoimmune disease targeting insulin-producing beta-cells. Multiple factors may contribute to the development of T1DM. Among these, the metabolic state of beta-cells and pro-inflammatory cytokines, produced by infiltrating immune cells, have been implicated in the precipitation of T...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1134

    authors: Osterbye T,Funda DP,Fundová P,Månsson JE,Tlaskalová-Hogenová H,Buschard K

    更新日期:2010-11-01 00:00:00

  • Hyperbaric oxygen therapy and the diabetic foot.

    abstract::Common causes for non-healing of diabetic foot ulcers are infection and/or ischaemia. Diabetic patients are compromised hosts as far as wound healing is concerned. Diabetes mellitus is associated with a defective cellular and humoral immunity. In particular, decreased chemotaxis, decreased phagocytosis, impaired bacte...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/1520-7560(200009/10)16:1+<::aid-dmrr132>3.

    authors: Bakker DJ

    更新日期:2000-09-01 00:00:00

  • Prevalence of early and late prematurity is similar among pediatric type 1 diabetes patients and the general population.

    abstract:BACKGROUND:The incidence of type 1 diabetes mellitus (T1DM) has increased in recent decades, as has the incidence of preterm births (<37 weeks). We aimed to evaluate and compare the prevalence of prematurity and early prematurity (<34 weeks) and birth season variability among T1DM and non-T1DM children. METHODS:A nati...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2996

    authors: Adar A,Shalitin S,Eyal O,Loewenthal N,Pinhas-Hamiel O,Levy M,Dally-Gottfried O,Landau Z,Zung A,Levy-Khademi F,Zangen D,Tenenbaum-Rakover Y,Rachmiel M

    更新日期:2018-07-01 00:00:00

  • Intranasally administered insulin intended for prevention of type 1 diabetes--a safety study in healthy adults.

    abstract:BACKGROUND:Intranasally applied insulin is one of the antigen-specific therapies currently tested in clinical type 1 diabetes prevention trials, for example, in the Type 1 Diabetes Prediction and Prevention Study (DIPP). The possibility that the therapy may cause hypoglycaemia or local irritation and the poorly known i...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/dmrr.397

    authors: Kupila A,Sipilä J,Keskinen P,Simell T,Knip M,Pulkki K,Simell O

    更新日期:2003-09-01 00:00:00

  • Renin angiotensin system inhibitors may attenuate low LDL cholesterol-related cancer risk in type 2 diabetes.

    abstract:BACKGROUND:In type 2 diabetes (T2D), copresence of low-density lipoprotein cholesterol (LDL-C) < 2.8 mmol/L with triglyceride < 1.7 mmol/L or with albuminuria synergistically increased cancer risk. We tested whether use of renin angiotensin system inhibitors attenuated the increased cancer risk associated with these tw...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2504

    authors: Yang X,Ma RC,So WY,Wang Y,Kong AP,Ozaki R,Xu G,Chan JC

    更新日期:2014-07-01 00:00:00

  • Painful diabetic neuropathy: treatment and future aspects.

    abstract::Around one of three diabetic patients is affected by distal symmetric polyneuropathy (DSP) which represents a major health problem, as it may present with partly excruciating neuropathic pain and is responsible for substantial morbidity and increased mortality. Treatment is based on four cornerstones: (1) multifactori...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.817

    authors: Ziegler D

    更新日期:2008-05-01 00:00:00

  • Association of ELMO1 gene polymorphism and diabetic nephropathy among Egyptian patients with type 2 diabetes mellitus.

    abstract:BACKGROUND AND OBJECTIVE:Diabetic nephropathy (DN) is the most common cause of end stage renal failure or even death among patients with type 2 diabetes mellitus. Genetic predisposition is widely studied among these patients to identify manageable aspects of the disease pathogenesis. This study was carried out to test ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.3299

    authors: Bayoumy NMK,El-Shabrawi MM,Leheta OF,Abo El-Ela AEM,Omar HH

    更新日期:2020-07-01 00:00:00

  • Pilot study on the significance of random intrasite placement of the Semmes-Weinstein monofilament.

    abstract:BACKGROUND:The possible effect of random intrasite placement on the outcome of the Semmes-Weinstein monofilament (SWF) test is not known. We sought to determine the significance of this variable in the diagnosis of loss of protective sensation (LOPS) in patients with diabetes. METHODS:Forty-five patients with diabetes...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2388

    authors: Slater RA,Koren S,Ramot Y,Buchs A,Rapoport MJ

    更新日期:2013-03-01 00:00:00

  • Global DNA methylation as a possible biomarker for diabetic retinopathy.

    abstract:BACKGROUND:We evaluated whether global levels of DNA methylation status were associated with retinopathy as well as providing a predictive role of DNA methylation in developing retinopathy in a case-control study of 168 patients with type 2 diabetes. METHODS:The 5-methylcytosine content was assessed by reversed-phase ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2584

    authors: Maghbooli Z,Hossein-nezhad A,Larijani B,Amini M,Keshtkar A

    更新日期:2015-02-01 00:00:00

  • Immune regulation by CTLA-4--relevance to autoimmune diabetes in a transgenic mouse model.

    abstract:BACKGROUND:The importance of cytotoxic T lymphocyte antigen-4 (CTLA-4) in immune regulation is unquestioned, yet a precise understanding of which cells express it, and how it mediates immune inhibitory function, is lacking. Regulatory T cells are known to constitutively express CTLA-4 intracellularly, whereas conventio...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1277

    authors: Wang CJ,Schmidt EM,Attridge K,Kenefeck R,Wardzinski L,Chamberlain JL,Soulier A,Clough LE,Manzotti CN,Narendran P,Walker LS

    更新日期:2011-11-01 00:00:00

  • A genetic variation in the fat mass- and obesity-associated gene is associated with obesity and newly diagnosed type 2 diabetes in a Chinese population.

    abstract:BACKGROUND:Recently, a genome-wide association study identified a strong association between the fat mass- and obesity-associated rs9939609 single nucleotide polymorphism (SNP) and the risk of obesity in European population. However, the results in Chinese population were reported to be contradictory. Therefore, our ai...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1066

    authors: Li X,Song F,Jiang H,Zhang M,Lin J,Bao W,Yao P,Yang X,Hao L,Liu L

    更新日期:2010-02-01 00:00:00

  • A linkage study of 12 IDDM susceptibility loci in the Finnish population.

    abstract:BACKGROUND:HLA region is the major locus (IDDM1) of type 1 diabetes (T1D) susceptibility. It explains approximately 50% of the genetic background of T1D, indicating additional genetic determinants. Genome scans and candidate gene studies have generated several chromosomal candidate regions that may have a role in T1D d...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 临床试验,杂志文章

    doi:10.1002/dmrr.424

    authors: Laine AP,Nejentsev S,Veijola R,Korpinen E,Sjöroos M,Simell O,Knip M,Akerblom HK,Ilonen J

    更新日期:2004-03-01 00:00:00