Exercise training restores abnormal myocardial glucose utilization and cardiac function in diabetes.

Abstract:

BACKGROUND:Clinical and experimental studies have shown that a reduction in myocardial glucose utilization is a factor contributing to diabetic cardiomyopathy. This study determined whether exercise training could prevent the depression in glucose utilization observed in the diabetic rat heart. METHODS:Diabetes was induced in Sprague-Dawley rats by an intravenous injection of streptozotocin (60 mg/kg). After 10 weeks of treadmill running, exogenous myocardial glucose utilization and cardiac function were determined in isolated working hearts perfused under aerobic conditions and then subjected to a 60-min period of low-flow ischemia followed by reperfusion. RESULTS:Compared to aerobically perfused sedentary control hearts, rates of myocardial glucose oxidation and glycolysis were lower in diabetic hearts. Diabetes was also characterized by a pronounced decrease in cardiac function. Following exercise training, rates of myocardial glucose oxidation and glycolysis were restored and cardiac performance was improved compared to sedentary diabetic hearts. During low-flow ischemia, the decrease in glycolysis observed in hearts of sedentary diabetic rats was attenuated following exercise training. Following ischemia, glucose oxidation and glycolysis returned to preischemic levels in all groups. However, hearts from trained diabetic animals had higher rates of glucose oxidation compared to their respective sedentary group. This was accompanied by an enhanced recovery of heart function following ischemia. CONCLUSIONS:Our results indicate that exercise training is effective in preventing the depression in myocardial glucose metabolism observed in the diabetic rat. This may explain the benefits of exercise in preventing cardiac dysfunction in diabetes.

journal_name

Diabetes Metab Res Rev

authors

Broderick TL,Poirier P,Gillis M

doi

10.1002/dmrr.479

keywords:

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

44-50

issue

1

eissn

1520-7552

issn

1520-7560

journal_volume

21

pub_type

杂志文章
  • Serum ferritin and glucose homeostasis: change in the association by glycaemic state.

    abstract:BACKGROUND:Data on the association between body iron and glucose homeostasis by the three glycaemic states are scarce. Thus, we investigated the association between body iron as assessed by a serum ferritin concentration and glucose homeostasis using homeostasis model assessment (HOMA) of insulin resistance (HOMA-IR) a...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2628

    authors: Aregbesola A,Virtanen JK,Voutilainen S,Mursu J,Lagundoye A,Kauhanen J,Tuomainen TP

    更新日期:2015-07-01 00:00:00

  • Self-monitoring of blood glucose in type-2 diabetes: what is the evidence?

    abstract:BACKGROUND:There is a controversy about self-monitoring of blood glucose (SMBG) in patients with type 2 diabetes who are not using insulin. Randomized trials are limited in duration, size, and validity. METHODS:Systematic search for randomized trials and observational studies published since 1990. For inclusion studie...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.749

    authors: McGeoch G,Derry S,Moore RA

    更新日期:2007-09-01 00:00:00

  • Subcutaneous adipose tissue expression of plasminogen activator inhibitor-1 (PAI-1) in nondiabetic and Type 2 diabetic subjects.

    abstract:OBJECTIVE:Increased plasma levels of plasminogen activator inhibitor-1 (PAI-1) have been suggested to be a part of the insulin resistance syndrome, and recent data suggest that adipose tissue participates in the production of PAI-1. We examined the expression and insulin regulation of subcutaneous adipose tissue PAI-1 ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/1520-7560(2000)9999:9999<::aid-dmrr148>3.0

    authors: Koistinen HA,Dusserre E,Ebeling P,Vallier P,Koivisto VA,Vidal H

    更新日期:2000-09-01 00:00:00

  • Validity of diagnostic codes and estimation of prevalence of diabetic foot ulcers using a large electronic medical record database.

    abstract:AIMS:To assess the validity of the diagnostic codes relating to diabetic foot ulcer (DFU) in the electronic medical records of a large integrated care provider and to assess the prevalence of DFU among its members. MATERIALS AND METHODS:Data were obtained from the diabetes registry of Maccabi Healthcare Services (MHS)...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.3094

    authors: Cahn A,Altaras T,Agami T,Liran O,Touaty CE,Drahy M,Pollack R,Raz I,Chodick G,Zucker I

    更新日期:2019-02-01 00:00:00

  • Widening awareness of hyperglycemia unawareness.

    abstract::Hyperglycemia unawareness is the term suggested to me (M. Muggeo, personal communication, 1997) to encompass very broadly all of the stages in diabetes mellitus from the onset of any degree of hyperglycemia until the diagnosis is actually made. Diabetes and its handmaiden, obesity, are growing in epidemic proportions ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 评论,社论

    doi:10.1002/1520-7560(200007/08)16:4<228::aid-dmrr125>

    authors: Roth J

    更新日期:2000-07-01 00:00:00

  • Nocturnal hypoglycaemia in type 1 diabetes--consequences and assessment.

    abstract::Hypoglycaemia is inevitable when striving for low HbA1c values. Nocturnal hypoglycaemia often occurs without symptoms, but results in diminished next day well-being and hypoglycaemia unawareness. Frequency of nocturnal hypoglycaemia was first assessed in research ward settings, but suffered from insufficient glucose s...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.513

    authors: DeVries JH,Wentholt IM,Masurel N,Mantel I,Poscia A,Maran A,Heine RJ

    更新日期:2004-11-01 00:00:00

  • A multi-centre randomized trial of two different doses of nicotinamide in patients with recent-onset type 1 diabetes (the IMDIAB VI).

    abstract:BACKGROUND:Intensive insulin therapy is the gold standard by which Type 1 diabetes is treated. In addition to this therapy, administration of nicotinamide (NA) can be beneficial. This concept is reinforced by the results of a recent meta-analysis of the use of NA in patients with recent-onset Type 1 diabetes. METHODS:...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/(sici)1520-7560(199905/06)15:3<181::aid-dm

    authors: Visalli N,Cavallo MG,Signore A,Baroni MG,Buzzetti R,Fioriti E,Mesturino C,Fiori R,Lucentini L,Matteoli MC,Crinò A,Corbi S,Spera S,Teodonio C,Paci F,Amoretti R,Pisano L,Suraci C,Multari G,Sulli N,Cervoni M,De Mat

    更新日期:1999-05-01 00:00:00

  • Association of iron indices and type 2 diabetes: a meta-analysis of observational studies.

    abstract::The literature on the role of body iron status in the development of type 2 diabetes (T2D) in humans is inconsistent. We aimed to assess the association between iron indices and T2D by a meta-analysis of previously published studies. A systematic literature search was conducted in PubMed and EMBASE. Observational stud...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/dmrr.2506

    authors: Orban E,Schwab S,Thorand B,Huth C

    更新日期:2014-07-01 00:00:00

  • Elevated serum urate concentration independently predicts poor outcome following stroke in patients with diabetes.

    abstract:BACKGROUND:Type 2 diabetes is a risk factor for stroke and confers increased risk of poor outcome and further vascular events following stroke. Hyperuricaemia occurs commonly in patients with type 2 diabetes, but its significance as a predictor of outcome following stroke is uncertain. We sought to investigate the prog...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.585

    authors: Newman EJ,Rahman FS,Lees KR,Weir CJ,Walters MR

    更新日期:2006-01-01 00:00:00

  • Small fibre neuropathy: role in the diagnosis of diabetic sensorimotor polyneuropathy.

    abstract::Small fibres constitute 70-90% of peripheral nerve fibres and regulate several key functions such as tissue blood flow, temperature and pain perception as well as sweating, all of which are highly relevant to the clinical presentation and adverse outcomes associated with foot ulcerations in patients with diabetes. Rec...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,实务指引

    doi:10.1002/dmrr.1222

    authors: Malik RA,Veves A,Tesfaye S,Smith G,Cameron N,Zochodne D,Lauria G,Toronto Consensus Panel on Diabetic Neuropathy.

    更新日期:2011-10-01 00:00:00

  • Association of TCF7L2 SNPs with age at onset of type 2 diabetes and proinsulin/insulin ratio but not with glucagon-like peptide 1.

    abstract:BACKGROUND:Variants in TCF7L2 have been associated with the age at onset of type 2 diabetes in Mexican Americans. However, there is a lack of data on this relationship in Caucasians. Furthermore, risk alleles in TCF7L2 have been suggested to account for decreased conversion of proinsulin to insulin and decreased expres...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1194

    authors: Silbernagel G,Renner W,Grammer TB,Hügl SR,Bertram J,Kleber ME,Hoffmann MM,Winkelmann BR,März W,Boehm BO

    更新日期:2011-07-01 00:00:00

  • Motor dysfunction in diabetes.

    abstract::Neuropathy is a frequent complication in diabetes and most commonly seen as distal symmetrical sensorimotor polyneuropathy (PN). Involvement of the motor system is infrequently seen at the clinical examination. However, with the application of quantitative techniques, that is, isokinetic dynamometry, type 1 and type 2...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.2257

    authors: Andersen H

    更新日期:2012-02-01 00:00:00

  • Visceral adiposity index outperforms common anthropometric indices in predicting 10-year diabetes risk: Results from the ATTICA study.

    abstract:BACKGROUND:Visceral adiposity index (VAI) is a novel marker of visceral adipose tissue accumulation and dysfunction. The study aim was to explore the association of VAI with the 10-year type 2 diabetes mellitus (T2DM) incidence in apparently healthy individuals and compare its T2DM predictive ability against common ant...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.3161

    authors: Koloverou E,Panagiotakos DB,Kyrou I,Stefanadis C,Chrysohoou C,Georgousopoulou EN,Skoumas I,Tousoulis D,Pitsavos C,ATTICA Study group.

    更新日期:2019-09-01 00:00:00

  • Thiazolidinediones as anti-inflammatory and anti-atherogenic agents.

    abstract::In the last few years, there has been increasing focus on the impact of interventions on cardiovascular outcomes in patients with type 2 diabetes. Insulin resistance and hyperglycaemia often co-exist with a cluster of risk factors for coronary artery disease, but the underlying mechanisms leading to the development of...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.790

    authors: Ceriello A

    更新日期:2008-01-01 00:00:00

  • LIPS islet autoantibody assays in high-throughput format for DASP 2010.

    abstract:BACKGROUND:For cost-effective population-based diabetes prediction and confirmation, islet autoantibody assays must be made more economical. METHODS:We evaluated glutamic acid decarboxylase (GAD)-Ruc (renilla luciferase) and IA2ic (also known as ICA512ic)-Ruc (renilla luciferase) fusion protein constructs in high-thro...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1268

    authors: Marcus P,Yan X,Bartley B,Hagopian W

    更新日期:2011-11-01 00:00:00

  • A subset of human pancreatic beta cells express functional CD14 receptors: a signaling pathway for beta cell-related glycolipids, sulfatide and β-galactosylceramide.

    abstract:BACKGROUND:T1DM is a T-cell-mediated autoimmune disease targeting insulin-producing beta-cells. Multiple factors may contribute to the development of T1DM. Among these, the metabolic state of beta-cells and pro-inflammatory cytokines, produced by infiltrating immune cells, have been implicated in the precipitation of T...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1134

    authors: Osterbye T,Funda DP,Fundová P,Månsson JE,Tlaskalová-Hogenová H,Buschard K

    更新日期:2010-11-01 00:00:00

  • Self glucose monitoring and physical exercise in diabetes.

    abstract::Cardiorespiratory fitness, which is determined mainly by the level of physical activity, is inversely related to mortality in the general population as well as in subjects with diabetes, the incidence of which is also increased by low exercise capacity. Exercise is capable of promoting glucose utilization in normal su...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.982

    authors: Pugliese G,Zanuso S,Alessi E,Simonelli P,Fallucca S,Fallucca F,Balducci S

    更新日期:2009-09-01 00:00:00

  • Oestradiol levels may differ between premenopausal women, ages 18-50, with type 1 diabetes and matched controls.

    abstract:BACKGROUND:This study aimed to investigate whether oestradiol differs between premenopausal women with and without type 1 diabetes and whether levels are associated with such factors as age, reproductive history or diabetes management. METHODS:Oestradiol in premenopausal women with type 1 diabetes (n = 89; age = 18-50...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2829

    authors: Hassan LS,Monson RS,Danielson KK

    更新日期:2017-02-01 00:00:00

  • Normal renal function 8 to 13 years after cyclosporin A therapy in 285 diabetic patients.

    abstract:BACKGROUND:Cyclosporin A (CyA) may induce acute nephrotoxicity. The question has been raised of the possible long-term unfavorable course of CyA-induced lesions. Advantage was taken of a large cohort of diabetic patients treated for several months using moderate CyA dosage to evaluate the long-term evolution of renal f...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 临床试验,杂志文章

    doi:10.1002/dmrr.325

    authors: Assan R,Blanchet F,Feutren G,Timsit J,Larger E,Boitard C,Amiel C,Bach JF

    更新日期:2002-11-01 00:00:00

  • Sex and ethnic-origin specific BMI cut points improve prediction of 40-year mortality: the Israel GOH study.

    abstract:BACKGROUND:Although obesity has been associated with a higher risk for premature death, the sex and ethnic-origin specific body mass index (BMI) levels that are associated with increased mortality are controversial. We investigated the 40-year cumulative all-cause mortality, in relation to the BMI in adult life, among ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2642

    authors: Dankner R,Shanik M,Roth J,Luski A,Lubin F,Chetrit A

    更新日期:2015-07-01 00:00:00

  • A shift in priority in diabetic foot care and research: 75% of foot ulcers are preventable.

    abstract::Diabetic foot ulceration poses a heavy burden on the patient and the healthcare system, but prevention thereof receives little attention. For every euro spent on ulcer prevention, ten are spent on ulcer healing, and for every randomized controlled trial conducted on prevention, ten are conducted on healing. In this ar...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2738

    authors: Bus SA,van Netten JJ

    更新日期:2016-01-01 00:00:00

  • Guidelines on use of interventions to enhance healing of chronic foot ulcers in diabetes (IWGDF 2019 update).

    abstract::The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines on the prevention and management of diabetic foot disease since 1999. In conjunction with advice from internal and external reviewers and expert consultants in the field, this update is based on a systematic review of ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.3283

    authors: Rayman G,Vas P,Dhatariya K,Driver V,Hartemann A,Londahl M,Piaggesi A,Apelqvist J,Attinger C,Game F,International Working Group on the Diabetic Foot (IWGDF).

    更新日期:2020-03-01 00:00:00

  • The elevated gene expression level of the A(2B) adenosine receptor is associated with hyperglycemia in women with gestational diabetes mellitus.

    abstract:BACKGROUND:Adenosine receptors denoted by A1 , A2A , A2B , and A3 and encoded by ADORA1, ADORA2A, ADORA2B, and ADORA3 genes, respectively, are adenosine-activated G-protein-coupled receptors that play an important role in obesity and type 2 diabetes mellitus. However, little is known about their significance in gestati...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2446

    authors: Wojcik M,Zieleniak A,Mac-Marcjanek K,Wozniak LA,Cypryk K

    更新日期:2014-01-01 00:00:00

  • In-hospital metabolic regulation in patients with a diabetic foot ulcer: is it worthwhile?

    abstract::It is well established that hyperglycaemia is associated with many negative cardiovascular and immunological effects. Because of the high prevalence of underlying vascular disease along with associated infection, patients with diabetic foot ulcers are especially vulnerable to these adverse consequences. While studies ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.2741

    authors: Egan AM,Dinneen SF

    更新日期:2016-01-01 00:00:00

  • The influence of clinical and genetic factors on the development of obesity in children with type 1 diabetes.

    abstract::The exact cause of the obesity epidemic remains unknown; however, both environmental and genetic factors are involved. People at risk of developing obesity include children with type 1 diabetes mellitus (T1DM), which in turn increases their cardiovascular disease risk. Here, we discuss the clinical and genetic factors...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.2797

    authors: Łuczyński W,Głowińska-Olszewska B,Bossowski A

    更新日期:2016-10-01 00:00:00

  • Ceftaroline fosamil for treatment of diabetic foot infections: the CAPTURE study experience.

    abstract:BACKGROUND:To ascertain which demographic, clinical, and microbiological factors might affect clinical outcomes of patients with diabetic foot infections, excluding known osteomyelitis, by analysing Clinical Assessment Program and Teflaro® Utilization Registry study data of patients treated with ceftaroline fosamil. M...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,多中心研究

    doi:10.1002/dmrr.2624

    authors: Lipsky BA,Cannon CM,Ramani A,Jandourek A,Calmaggi A,Friedland HD,Goldstein EJ

    更新日期:2015-05-01 00:00:00

  • Is self-reported physical functioning associated with incident cardiometabolic abnormalities or the metabolic syndrome?

    abstract:BACKGROUND:Physical functioning may be an important pre-clinical marker of chronic disease, used as a tool to identify patients at risk for future cardiometabolic abnormalities. This study evaluated if self-reported physical functioning was associated with the development of cardiometabolic abnormalities or their clust...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,多中心研究

    doi:10.1002/dmrr.2765

    authors: Ylitalo KR,Karvonen-Gutierrez C,McClure C,El Khoudary SR,Jackson EA,Sternfeld B,Harlow SD

    更新日期:2016-05-01 00:00:00

  • Immune regulation by CTLA-4--relevance to autoimmune diabetes in a transgenic mouse model.

    abstract:BACKGROUND:The importance of cytotoxic T lymphocyte antigen-4 (CTLA-4) in immune regulation is unquestioned, yet a precise understanding of which cells express it, and how it mediates immune inhibitory function, is lacking. Regulatory T cells are known to constitutively express CTLA-4 intracellularly, whereas conventio...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1277

    authors: Wang CJ,Schmidt EM,Attridge K,Kenefeck R,Wardzinski L,Chamberlain JL,Soulier A,Clough LE,Manzotti CN,Narendran P,Walker LS

    更新日期:2011-11-01 00:00:00

  • Temporal trends in quality of primary care for patients with type 2 diabetes mellitus: A population-based retrospective cohort study after implementation of a quality improvement initiative.

    abstract:BACKGROUND:This study examined whether temporal trends exist in treatment of patients with type 2 diabetes (T2D) and quality of diabetes care after implementation of quality improvement initiative in primary care setting. METHODS:We conducted a population-based retrospective cohort study of 202,284 patients with T2D w...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2952

    authors: Wong CKH,Fung CSC,Yu EYT,Wan EYF,Chan AKC,Lam CLK

    更新日期:2018-02-01 00:00:00

  • A case-control study: The association of serum paraoxonase 1 activity and concentration with the development of type 2 diabetes mellitus.

    abstract:BACKGROUND:A longitudinal study assessed serum paraoxonase 1 (PON1) activity and concentration as affected by age and as associated with the development of type 2 diabetes (T2D). PON1's recently established physiological function is the hydrolysis of lipolactones in oxidized LDL particles. METHODS:Serum samples and cl...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2967

    authors: Crow JA,Meek EC,Wills RW,Chambers JE

    更新日期:2018-03-01 00:00:00