Abstract:
:A few studies have investigated the relationship between type 1 diabetes mellitus (T1DM) and bone mineral density (BMD) values. This meta-analysis was performed to explore differences between T1DM and healthy individuals in BMD values measured at five bone sites.We searched the database of PubMed for cross-sectional studies about the association of T1DM and BMD, and a meta-analysis was conducted.The results suggested significant association between T1DM and decreased BMD values of total body. The pooled mean differences (MDs) were -0.06 [95% confidence interval (CI): -0.11, -0.01] for all people. As for the association between T1DM and spine BMD values, the pooled MDs were -0.04 (95% CI: -0.07, -0.01) for males and -0.03 (95% CI: -0.06, 0.00) for females <20 years old. As for femur BMD values, the pooled MDs were -0.06 (95% CI: -0.13, 0.00) for all people, -0.03 (95% CI: -0.06, -0.01) for females and -0.04(95% CI: -0.05, -0.02) for males. As for hip BMD values, the pooled MDs were -0.06 (95% CI: -0.08, -0.04) for females. As for forearm BMD values, the pooled MDs were -0.01 (95% CI: -0.02, 0.00) for females.The results of this meta-analysis suggest the overall association between T1DM and reduced BMD values. Notably, the influence of T1DM on BMD seems to depend on gender or patient's age. Reduced BMD values may occur early after T1DM diagnosis. Future clinical and basic research studies are needed to further understand the mechanisms of decreased BMD values in T1DM patients.
journal_name
Diabetes Metab Res Revjournal_title
Diabetes/metabolism research and reviewsauthors
Pan H,Wu N,Yang T,He Wdoi
10.1002/dmrr.2508subject
Has Abstractpub_date
2014-10-01 00:00:00pages
531-42issue
7eissn
1520-7552issn
1520-7560journal_volume
30pub_type
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journal_title:Diabetes/metabolism research and reviews
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doi:10.1002/1520-7560(200005/06)16:3<202::aid-dmrr116>
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abstract:BACKGROUND:We conducted this research in order to evaluate the prevalence of glutamic acid decarboxylase antibodies (GADA) in Korean women with gestational diabetes mellitus (GDM), to identify the clinical characteristics of these women, and to gauge the prevalence of diabetes among them after childbirth. METHODS:We s...
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,多中心研究,随机对照试验,评审
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abstract:BACKGROUND:Individuals with diabetes mellitus (DM) homozygous for the haptoglobin (Hp) 1 allele are at decreased risk of retinopathy as compared to DM individuals with the Hp 2 allele. We sought to recapitulate these findings in DM mice genetically modified at the Hp locus. METHODS:An early morphological characteristi...
journal_title:Diabetes/metabolism research and reviews
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doi:10.1002/dmrr.654
更新日期:2007-02-01 00:00:00
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更新日期:2008-07-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
doi:10.1002/dmrr.256
更新日期:2002-01-01 00:00:00
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pub_type: 杂志文章,多中心研究
doi:10.1002/dmrr.2757
更新日期:2015-11-01 00:00:00
abstract:BACKGROUND:Levels of high-sensitivity C-reactive protein (hs-CRP) and adiponectin, reflecting chronic inflammation, are associated with cardiovascular disease in type 2 diabetes. The long-term effects of multifactorial therapy in type 2 diabetes patients on CRP and adiponectin are unknown. METHODS:The ADDITION-NL stud...
journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,随机对照试验
doi:10.1002/dmrr.2669
更新日期:2015-10-01 00:00:00
abstract::This perspective covers a novel area of research describing the inadequacies of current approaches for diagnosing dysglycaemia and proposes that the 1-hour post-load glucose level during the 75-g oral glucose tolerance test may serve as a novel biomarker to detect dysglycaemia earlier than currently recommended screen...
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pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,meta分析,评审
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更新日期:2014-03-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
doi:10.1002/dmrr.744
更新日期:2007-11-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00
abstract:BACKGROUND:This study assesses the autonomic function of patients who have regained awareness of hypoglycaemia following islet cell or whole pancreas transplant. METHODS:Five patients with type 1 diabetes and either islet cell (four patients) or whole pancreas (one patient) transplant were assessed. These patients wer...
journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
doi:10.1002/dmrr.2652
更新日期:2015-09-01 00:00:00
abstract::Diabetic foot disease is an important complication of diabetes. The development and outcome of foot ulcers are related to the interplay between numerous diabetes-related factors such as nerve dysfunction, impaired wound healing and microvascular and/or macrovascular disease.The formation of advanced glycation end prod...
journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,评审
doi:10.1002/dmrr.861
更新日期:2008-05-01 00:00:00
abstract::Every year, over 1 million people with diabetes lose a leg due to diabetic foot disease. Most amputations are preceded by a foot ulcer. Causes for the development of foot ulcers are generally multifactorial and may include neuropathy, peripheral vasculopathy, abnormal foot mechanics and infection. Multidisciplinary ap...
journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章
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更新日期:2014-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1002/dmrr.2586
更新日期:2015-02-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,评审
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更新日期:2004-05-01 00:00:00
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更新日期:2020-11-30 00:00:00
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journal_title:Diabetes/metabolism research and reviews
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更新日期:2013-01-01 00:00:00
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journal_title:Diabetes/metabolism research and reviews
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-09-01 00:00:00
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pub_type: 杂志文章,多中心研究
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abstract::In Mediterranean countries, the incidence (per 100,000 per year) of Type 1 diabetes in children aged under 15 years shows wide variation from country to country, ranging from 2.45 in Macedonia to 34.4 in Sardinia. By interacting with environmental factors such as diet, toxins or viral infections, the HLA plus non-HLA ...
journal_title:Diabetes/metabolism research and reviews
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doi:10.1002/(sici)1520-7560(199903/04)15:2<133::aid-dm
更新日期:1999-03-01 00:00:00
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更新日期:2005-11-01 00:00:00
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更新日期:2019-01-01 00:00:00