Effect of six years intensified multifactorial treatment on levels of hs-CRP and adiponectin in patients with screen detected type 2 diabetes: the ADDITION-Netherlands randomized trial.


BACKGROUND:Levels of high-sensitivity C-reactive protein (hs-CRP) and adiponectin, reflecting chronic inflammation, are associated with cardiovascular disease in type 2 diabetes. The long-term effects of multifactorial therapy in type 2 diabetes patients on CRP and adiponectin are unknown. METHODS:The ADDITION-NL study is a randomized clinical trial among screen-detected type 2 diabetes patients, randomized to intensive treatment (HbA1c <7.0% (53 mmol/mol), blood pressure ≤135/85 mmHg, total cholesterol ≤3.5 mmol/L) or routine care. Hs-CRP and adiponectin were measured before and 1, 2 and 6 years after inclusion. We analysed the effectiveness of the intervention on hs-CRP and adiponectin levels using a mixed effects model, taking into account practice, baseline levels and different medications. RESULTS:A total of 424 patients were included (intensive care n = 235; routine care n = 189). Both groups were well matched. Body mass index, systolic blood pressure, total cholesterol and HbA1c improved significantly more in the intensive care group compared to routine care group. Levels of hs-CRP decreased significantly in both treatment groups over time. Mean hs-CRP in the routine care group was 24% higher (p = 0.0027) than in the intensive treatment group during follow-up. After an initial increase the adiponectin values levelled off to nearly baseline values in both groups. The difference between the two groups after 6 years was 0.44 µg/mL (p = 0.27). CONCLUSIONS:Intensified multifactorial treatment in type 2 diabetes results in an enhanced decrease in hs-CRP. Whether this is clinically meaningful remains uncertain. The link to adiponectin seems to be more complex.


Diabetes Metab Res Rev


den Ouden H,Berends J,Stellato RK,Beulens JW,Rutten GE




Has Abstract


2015-10-01 00:00:00












  • Impact of unhealthy childhood and unfavorable parents' characteristics on adiposity in schoolchildren.

    abstract:BACKGROUND:Childhood obesity is encouraged by low physical activity (PA), time spent using screens (screen time, ST), and by sugar-sweetened beverage consumption (SSBc). It is also influenced by unfavorable parents' characteristics, such as a high body mass index (BMI) and low education level (EL). Our aim was to evalu...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Vinciguerra F,Tumminia A,Roppolo F,Romeo LC,La Spina N,Baratta R,Parrino C,Sciacca L,Vigneri R,Frittitta L

    更新日期:2019-11-01 00:00:00

  • Management status and its predictive factors in patients with type 2 diabetes in China: A Nationwide Multicenter Study: A Nationwide Multicenter Study.

    abstract:BACKGROUND:The prevalence of type 2 diabetes in China is increasing rapidly. Appropriate management of glycemia, blood pressure and dyslipidemia in this population is a major public health concern. OBJECTIVE:The aim of this study was to assess metabolic control including glycated hemoglobin A1c (HbA1c ), blood pressur...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,多中心研究


    authors: Liu L,Lou Q,Guo X,Yuan L,Shen L,Sun Z,Zhao F,Dai X,Huang J,Yang H,Mordes JP,Chinese Diabetes Education Status Survey Study Group.

    更新日期:2015-11-01 00:00:00

  • Mutated ATP synthase induces oxidative stress and impaired insulin secretion in beta-cells of female BHE/cdb rats.

    abstract:BACKGROUND:Adenosine triphosphate (ATP) is a critical determinant of beta-cell insulin secretion in response to glucose. BHE/cdb rats have a mutation in ATP synthase that limits ATP production, yet develop mild diabetes only with ageing. We investigated the cellular basis for reduced insulin secretion and compensatory ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Saleh MC,Fatehi-Hassanabad Z,Wang R,Nino-Fong R,Wadowska DW,Wright GM,Harper ME,Chan CB

    更新日期:2008-07-01 00:00:00

  • Vitamin D deficiency is associated with painful diabetic neuropathy.

    abstract:BACKGROUND:The aetiology of painful diabetic neuropathy is unclear. We have evaluated vitamin D levels in diabetic patients with and without painful neuropathy. METHODS:Forty-three patients with type 1 diabetes and painless (DPN) (n = 20) or painful (PDN) (n = 23) neuropathy and 14 non-diabetic healthy control subject...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Alam U,Petropoulos IN,Ponirakis G,Ferdousi M,Asghar O,Jeziorska M,Marshall A,Boulton AJM,Efron N,Malik RA

    更新日期:2021-01-01 00:00:00

  • Can we prevent beta cell apoptosis in type 2 diabetes?

    abstract::Since the publication of the United Kingdom Prospective Diabetes Study (UKPDS), the progressive nature of type 2 (DM2) diabetes has been identified as the main cause of failure to maintain a long term glycemic control.[1] The need to adjust treatment as the disease progressed was recognized and algorithms for treatmen...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Eliaschewitz FG,Tambascia MA

    更新日期:2012-12-05 00:00:00

  • Overexpression of ZAC impairs glucose-stimulated insulin translation and secretion in clonal pancreatic beta-cells.

    abstract:BACKGROUND:ZAC (Zinc finger protein that regulates apoptosis and cell-cycle arrest) is a candidate gene for transient neonatal diabetes mellitus (TNDM). This condition involves severe insulin deficiency at birth that reverses over weeks or months but may relapse with diabetes recurring in later life. ZAC overexpression...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Du X,Ounissi-Benkalha H,Loder MK,Rutter GA,Polychronakos C

    更新日期:2012-11-01 00:00:00

  • Is self-reported physical functioning associated with incident cardiometabolic abnormalities or the metabolic syndrome?

    abstract:BACKGROUND:Physical functioning may be an important pre-clinical marker of chronic disease, used as a tool to identify patients at risk for future cardiometabolic abnormalities. This study evaluated if self-reported physical functioning was associated with the development of cardiometabolic abnormalities or their clust...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,多中心研究


    authors: Ylitalo KR,Karvonen-Gutierrez C,McClure C,El Khoudary SR,Jackson EA,Sternfeld B,Harlow SD

    更新日期:2016-05-01 00:00:00

  • New developments in the biomechanics of the diabetic foot.

    abstract::Biomechanical issues are now widely recognized as being important in the treatment of diabetic foot disease. The purpose of the present review is to identify advances that have occurred since the previous International Conference on the Diabetic Foot in 1995 in the understanding of foot biomechanics in relation to dia...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Cavanagh PR,Ulbrecht JS,Caputo GM

    更新日期:2000-09-01 00:00:00

  • A genetic variation in the fat mass- and obesity-associated gene is associated with obesity and newly diagnosed type 2 diabetes in a Chinese population.

    abstract:BACKGROUND:Recently, a genome-wide association study identified a strong association between the fat mass- and obesity-associated rs9939609 single nucleotide polymorphism (SNP) and the risk of obesity in European population. However, the results in Chinese population were reported to be contradictory. Therefore, our ai...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Li X,Song F,Jiang H,Zhang M,Lin J,Bao W,Yao P,Yang X,Hao L,Liu L

    更新日期:2010-02-01 00:00:00

  • Thiazolidinedione therapy and breast cancer risk in diabetic women: A systematic review and meta-analysis.

    abstract::Rising experimental evidence suggests that thiazolidinediones (TZDs) exert a protective effect on breast cancer. However, studies concerning this issue were inconsistent and limited. Hence, we performed a meta-analysis with data from currently available studies to evaluate the effect of TZDs on breast cancer risk amon...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Du R,Lin L,Cheng D,Xu Y,Xu M,Chen Y,Wang W,Bi Y,Li D,Lu J

    更新日期:2018-02-01 00:00:00

  • Guidelines on use of interventions to enhance healing of chronic foot ulcers in diabetes (IWGDF 2019 update).

    abstract::The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines on the prevention and management of diabetic foot disease since 1999. In conjunction with advice from internal and external reviewers and expert consultants in the field, this update is based on a systematic review of ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Rayman G,Vas P,Dhatariya K,Driver V,Hartemann A,Londahl M,Piaggesi A,Apelqvist J,Attinger C,Game F,International Working Group on the Diabetic Foot (IWGDF).

    更新日期:2020-03-01 00:00:00

  • Long-term diabetic complications may be ameliorated by targeting Rho kinase.

    abstract::This review addresses the roles of Rho/Rho-kinase (ROCK) pathway in the pathogenesis of diabetes complications. Diabetes can cause many serious complications and can result in physical disability or even increased mortality. However, there are not many effective ways to treat these complications. The small guanosine-5...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Zhou H,Li Y

    更新日期:2011-05-01 00:00:00

  • Coprevalence of type 2 diabetes mellitus and tuberculosis in low-income and middle-income countries: A systematic review.

    abstract::Increasing coprevalence of diabetes mellitus (DM) and tuberculosis (TB) in low-income and middle-income countries (LMICs) indicates a rising threat to the decades of progress made against TB and requires global attention. This systematic review provides a summary of type 2 diabetes and tuberculosis coprevalence in var...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: McMurry HS,Mendenhall E,Rajendrakumar A,Nambiar L,Satyanarayana S,Shivashankar R

    更新日期:2019-01-01 00:00:00

  • Calculating the insulin to carbohydrate ratio using the hyperinsulinaemic-euglycaemic clamp-a novel use for a proven technique.

    abstract:BACKGROUND:In patients with type 1 diabetes, three main variables need to be assessed to optimize meal-related insulin boluses: pre-meal blood glucose (BG), insulin to carbohydrate ratio (I : C), and basal insulin. We are presenting data for a novel use of the hyperinsulinaemic-euglycaemic clamp (HEC) in patients with ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Bevier WC,Zisser H,Palerm CC,Finan DA,Seborg DE,Doyle FJ,Wollitzer AO,Jovanovic L

    更新日期:2007-09-01 00:00:00

  • The effect of impaired 50-gram oral glucose challenge test on fetal abdominal wall thickness.

    abstract:BACKGROUND:Patients with impaired 50-g oral glucose challenge test (OGCT) have not been investigated for fetal anterior abdominal wall thickness until now. We aimed to investigate patients with impaired 50-g OGCT, but not gestational diabetes and match them with healthy uneventful pregnant participants for anterior abd...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Aksoy H,Aksoy U,Açmaz G,Tutuş S

    更新日期:2014-10-01 00:00:00

  • Regulation of muscle malonyl-CoA levels in the nutritionally insulin-resistant desert gerbil, Psammomys obesus.

    abstract:BACKGROUND:Malonyl-CoA, an allosteric inhibitor of carnitine palmitoyl transferase, controls the oxidation of fatty acids in muscle and other tissues by regulating their entrance into mitochondria. The level of malonyl-CoA in muscle is influenced by the uptake of energy substrates such as glucose, the precursor of its ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Shafrir E,Ziv E,Saha AK,Ruderman NB

    更新日期:2002-05-01 00:00:00

  • Association of TCF7L2 SNPs with age at onset of type 2 diabetes and proinsulin/insulin ratio but not with glucagon-like peptide 1.

    abstract:BACKGROUND:Variants in TCF7L2 have been associated with the age at onset of type 2 diabetes in Mexican Americans. However, there is a lack of data on this relationship in Caucasians. Furthermore, risk alleles in TCF7L2 have been suggested to account for decreased conversion of proinsulin to insulin and decreased expres...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Silbernagel G,Renner W,Grammer TB,Hügl SR,Bertram J,Kleber ME,Hoffmann MM,Winkelmann BR,März W,Boehm BO

    更新日期:2011-07-01 00:00:00

  • Nested case-control data analysis using weighted conditional logistic regression in The Environmental Determinants of Diabetes in the Young (TEDDY) study: A novel approach.

    abstract:BACKGROUND:A nested case-control (NCC) design within a prospective cohort study can realize substantial benefits for biomarker studies. In this context, it is natural to consider the sample availability in the selection of controls to minimize data loss when implementing the design. However, this violates the randomnes...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Lee HS,Lynch KF,Krischer JP,TEDDY Study Group.

    更新日期:2020-01-01 00:00:00

  • Programmed disorders of beta-cell development and function as one cause for type 2 diabetes? The GK rat paradigm.

    abstract::Now that the reduction in beta-mass has been clearly established in humans with type 2 diabetes mellitus (T2DM) 1-4, the debate focuses on the possible mechanisms responsible for decreased beta-cell number and impaired beta-cell function and their multifactorial etiology. Appropriate inbred rodent models are essential...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Portha B

    更新日期:2005-11-01 00:00:00

  • Angiotensin-converting enzyme 2 inhibits endoplasmic reticulum stress-associated pathway to preserve nonalcoholic fatty liver disease.

    abstract:BACKGROUND:Previous works indicated that the stress on the endoplasmic reticulum (ER) affected nonalcoholic fatty liver disease (NAFLD). However, there is no clear evident on the effect of the regulation of ER stress by angiotensin-converting enzyme 2 (ACE2) on the prevention of NAFLD. METHODS:HepG2 cells were treated...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Cao X,Song LN,Zhang YC,Li Q,Shi TT,Yang FY,Yuan MX,Xin Z,Yang JK

    更新日期:2019-05-01 00:00:00

  • Implementation of a quality improvement initiative in Belgian diabetic foot clinics: feasibility and initial results.

    abstract:BACKGROUND:This article aims to describe the implementation and initial results of an audit-feedback quality improvement initiative in Belgian diabetic foot clinics. METHODS:Using self-developed software and questionnaires, diabetic foot clinics collected data in 2005, 2008 and 2011, covering characteristics, history ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Doggen K,Van Acker K,Beele H,Dumont I,Félix P,Lauwers P,Lavens A,Matricali GA,Randon C,Weber E,Van Casteren V,Nobels F,Initiative for Quality Improvement and Epidemiology in Diabetic Foot Clinics (IQED-Foot) Study Group.

    更新日期:2014-07-01 00:00:00

  • Assessment of the relationship between hypoglycaemia awareness and autonomic function following islet cell/pancreas transplantation.

    abstract:BACKGROUND:This study assesses the autonomic function of patients who have regained awareness of hypoglycaemia following islet cell or whole pancreas transplant. METHODS:Five patients with type 1 diabetes and either islet cell (four patients) or whole pancreas (one patient) transplant were assessed. These patients wer...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Kamel JT,Goodman DJ,Howe K,Cook MJ,Ward GM,Roberts LJ

    更新日期:2015-09-01 00:00:00

  • Advanced glycosylation end products (AGEs), insulin-like growth factor-1 (IGF-1) and IGF-binding protein-3 (IGFBP-3) in patients with type 2 diabetes mellitus.

    abstract:BACKGROUND:Advanced glycosylation end product (AGE) formation is a major mechanism for the development of complications in diabetes, and the possible roles of insulin-like growth factor 1 (IGF-1) and IGF binding protein 3 (IGFBP-3) are not clearly established. METHODS:We examined the associations of AGEs, free IGF-I a...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Garay-Sevilla ME,Nava LE,Malacara JM,Wróbel K,Wróbel K,Pérez U

    更新日期:2000-03-01 00:00:00

  • Identification of specific angiotensin-converting enzyme variants and haplotypes that confer risk and protection against type 2 diabetic nephropathy.

    abstract:BACKGROUND:Cross-sectional and family studies identified angiotensin-converting enzyme (ACE) gene as a risk factor for diabetic nephropathy (DN). The contribution of ACE gene variants to DN development and progression is controversial and varies among different ethnic/racial groups. METHODS:We investigated the associa...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Ezzidi I,Mtiraoui N,Kacem M,Chaieb M,Mahjoub T,Almawi WY

    更新日期:2009-11-01 00:00:00

  • Platelet mean volume, distribution width, and count in type 2 diabetes, impaired fasting glucose, and metabolic syndrome: a meta-analysis.

    abstract:BACKGROUND:Platelet activation contributes to cardiovascular disease (CVD), the main complication of type 2 diabetes mellitus (T2DM) and pre-diabetic conditions. Mean platelet volume is an easy-to-measure platelet parameter that has been associated with CVD. We sought to assess mean platelet volume, platelet distributi...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,meta分析,评审


    authors: Zaccardi F,Rocca B,Pitocco D,Tanese L,Rizzi A,Ghirlanda G

    更新日期:2015-05-01 00:00:00

  • Influence of diabetic metabolic state on fracture healing in spontaneously diabetic rats.

    abstract:BACKGROUND:Type 1 diabetes mellitus (DM) has been shown to alter the properties of bone and impair fracture healing in both humans and animals. The objective of this study was to examine changes in the histomorphometrical, histological and mechanical parameters of bone and remodeling during fracture healing, depending ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Follak N,Klöting I,Merk H

    更新日期:2005-05-01 00:00:00

  • Small fibre neuropathy: role in the diagnosis of diabetic sensorimotor polyneuropathy.

    abstract::Small fibres constitute 70-90% of peripheral nerve fibres and regulate several key functions such as tissue blood flow, temperature and pain perception as well as sweating, all of which are highly relevant to the clinical presentation and adverse outcomes associated with foot ulcerations in patients with diabetes. Rec...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,实务指引


    authors: Malik RA,Veves A,Tesfaye S,Smith G,Cameron N,Zochodne D,Lauria G,Toronto Consensus Panel on Diabetic Neuropathy.

    更新日期:2011-10-01 00:00:00

  • Association of serum 25-hydroxyvitamin D with type 2 diabetes and markers of insulin resistance in a general older population in Finland.

    abstract:BACKGROUND:Vitamin D insufficiency and type 2 diabetes are both common in Finland, and low vitamin D status has been suggested as a risk factor for type 2 diabetes. Our aim was to study the associations between serum 25-hydroxyvitamin D [25(OH)D], a marker of vitamin D status, and glucose homeostasis and type 2 diabete...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Hurskainen AR,Virtanen JK,Tuomainen TP,Nurmi T,Voutilainen S

    更新日期:2012-07-01 00:00:00

  • Pancreatic fat accumulation is associated with decreased β-cell function and deterioration in glucose tolerance in Korean adults.

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    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章


    authors: Chin SO,Hwang YC,Cho IJ,Jeong IK,Ahn KJ,Chung HY

    更新日期:2020-11-30 00:00:00

  • The global challenge of type 2 diabetes and the strategies for response in ethnic minority groups.

    abstract::Ethnic minorities living in high-income countries usually exhibit a greater risk of developing diabetes along with higher morbidity and mortality rates. We evaluated the effectiveness of interventions to improve glycaemic control in ethnic minority groups. Results of major controlled trials, systematic reviews and met...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审


    authors: Lirussi F

    更新日期:2010-09-01 00:00:00