Abstract：
BACKGROUND:The aetiology of painful diabetic neuropathy is unclear. We have evaluated vitamin D levels in diabetic patients with and without painful neuropathy. METHODS:Forty-three patients with type 1 diabetes and painless (DPN) (n = 20) or painful (PDN) (n = 23) neuropathy and 14 non-diabetic healthy control subjects (C) underwent assessment of neurologic deficits, quantitative sensory testing (QST), electrophysiology, skin biopsy, corneal confocal microscopy (CCM) and measurement of serum 25(OH)D. RESULTS:There were no significant differences for age, BMI, HbA1c , lipids, neurological deficits, QST, electrophysiology, intra-epidermal nerve fibre density (IENFD) and corneal nerve morphology between patients with DPN and PDN. Both positive (hyperalgesia and allodynia) and negative symptoms (paraesthesia and numbness) of diabetic neuropathy were greater in PDN compared with DPN (P = .009 and P = .02, respectively). Serum 25(OH)D levels were significantly lower in PDN (24.0 ± 14.1 ng/mL) compared with DPN (34.6 ± 15.0 ng/mL, P = .01) and controls (34.1 ± 8.6 ng/mL, P = .03). The odds ratio in favour of painful diabetic neuropathy was 9.8 [P = .003 (95% CI, 2.2-76.4)] for vitamin D deficiency (<20 ng/mL) and 4.4 [P = .03 (95% CI, 1.1-19.8)] for vitamin D insufficiency (<30 ng/mL). CONCLUSIONS:This study suggests that vitamin D deficiency and insufficiency are associated with painful diabetic neuropathy.
journal_name
Diabetes Metab Res Revjournal_title
Diabetes/metabolism research and reviewsauthors
Alam U,Petropoulos IN,Ponirakis G,Ferdousi M,Asghar O,Jeziorska M,Marshall A,Boulton AJM,Efron N,Malik RAdoi
10.1002/dmrr.3361subject
Has Abstractpub_date
2021-01-01 00:00:00pages
e3361issue
1eissn
1520-7552issn
1520-7560journal_volume
37pub_type
杂志文章abstract：:There is strong evidence that the avoidance of hyperglycemia is essential inoptimizing pregnancy outcome in type 1 diabetes. The price to pay is a striking increase in severe hypoglycemia (SH), defined as episodes requiring help from another person. During type 1 diabetic pregnancy, occurrence rates of SH up to 15 tim...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.271
更新日期：2002-03-01 00:00:00
abstract：BACKGROUND:Dipeptidyl peptidase-IV (DPP-4) inhibitors and sulfonylureas are two important second-line anti-diabetic agents. The objective of this research was to evaluate the efficacy and safety of DPP-4 inhibitors compared with sulfonylureas by meta-analytic approach of available randomized studies. METHODS:We search...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,meta分析,评审
doi：10.1002/dmrr.2482
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND:Stable glucagon-like peptide-1 (GLP-1) mimetics, such as the GLP-1 analogue liraglutide, are approved for treatment of type 2 diabetes. GLP-1 has a spectrum of anti-diabetic effects that are of possible utility in the treatment of more severe forms of diabetes. METHODS:The present study has evaluated the ef...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2608
更新日期：2015-03-01 00:00:00
abstract：BACKGROUND:Visceral adiposity index (VAI) is a novel marker of visceral adipose tissue accumulation and dysfunction. The study aim was to explore the association of VAI with the 10-year type 2 diabetes mellitus (T2DM) incidence in apparently healthy individuals and compare its T2DM predictive ability against common ant...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.3161
更新日期：2019-09-01 00:00:00
abstract：AIMS:Insulin-like growth factor 1 receptor (IGF1R) is involved in cell growth and glucose homeostasis. In the current study, the IGF1R locus was analysed as a candidate gene for type 2 diabetes (T2D) in American Indians. MATERIALS AND METHODS:Whole genome sequence data from 335 American Indians identified 3 novel miss...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.2994
更新日期：2018-05-01 00:00:00
abstract：:Several interactive and mutually perpetuating abnormal biochemical pathways, such as protein kinase C (PKC) activation, augmented polyol pathway, and non-enzymatic glycation, may be activated as a result of sustained hyperglycemia in diabetes. These abnormal pathways may in turn influence several vasoactive factors, w...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/1520-7560(0000)9999:9999<::aid-dmrr157>3.0
更新日期：2000-11-01 00:00:00
abstract：BACKGROUND:HLA region is the major locus (IDDM1) of type 1 diabetes (T1D) susceptibility. It explains approximately 50% of the genetic background of T1D, indicating additional genetic determinants. Genome scans and candidate gene studies have generated several chromosomal candidate regions that may have a role in T1D d...
journal_title：Diabetes/metabolism research and reviews
pub_type： 临床试验,杂志文章
doi：10.1002/dmrr.424
更新日期：2004-03-01 00:00:00
abstract：:The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines on the prevention and management of diabetic foot disease since 1999. In conjunction with advice from internal and external reviewers and expert consultants in the field, this update is based on a systematic review of ...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.3283
更新日期：2020-03-01 00:00:00
abstract：BACKGROUND:We aimed to predict the incidence of obesity in a Korean population using a genetic risk score (GRS) constructed with obesity-related single nucleotide polymorphisms (SNPs) along with an oxidative stress score (OSS). METHODS:A total of 9460 Korean subjects and 356 974 SNPs were included. The GRS was constru...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.3230
更新日期：2020-02-01 00:00:00
abstract：:Various different systems have been proposed to classify diabetic foot ulcers, but none has gained widespread acceptance. The International Working Group of the Diabetic Foot (IWGDF) developed a classification system for research purposes, which is described in this report. In this PEDIS system, all foot ulcers should...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.464
更新日期：2004-05-01 00:00:00
abstract：BACKGROUND:Childhood obesity is encouraged by low physical activity (PA), time spent using screens (screen time, ST), and by sugar-sweetened beverage consumption (SSBc). It is also influenced by unfavorable parents' characteristics, such as a high body mass index (BMI) and low education level (EL). Our aim was to evalu...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.3199
更新日期：2019-11-01 00:00:00
abstract：:Cardiorespiratory fitness, which is determined mainly by the level of physical activity, is inversely related to mortality in the general population as well as in subjects with diabetes, the incidence of which is also increased by low exercise capacity. Exercise is capable of promoting glucose utilization in normal su...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.982
更新日期：2009-09-01 00:00:00
abstract：:Glucose can be extracted through intact skin by electro-osmotic flow (a process called 'reverse iontophoresis') upon the application of a low-level electrical current. Recently we have combined iontophoretic extraction with an in situ glucose sensor in a device called the GlucoWatch biographer. Clinical results with t...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.210
更新日期：2002-01-01 00:00:00
abstract：BACKGROUND:Cardiac hypertrophy is a key structural feature of diabetic cardiomyopathy. Previous studies have shown that diabetes-induced endothelin-1 (ET-1) and sodium hydrogen exchanger-1 (NHE-1) mediate structural and functional deficits in the heart. In order to gain a mechanistic understanding of the role of ET-1 a...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.689
更新日期：2007-07-01 00:00:00
abstract：BACKGROUND:To evaluate possible differences in distal polyneuropathy (PN) characteristics and degree of abnormalities for various small and large fibre parameters in diabetes type 1 (DM1) and type 2 (DM2). METHODS:Sixty-six DM1 and 57 DM2 patients with or without PN symptoms were included. Nerve conduction studies (NC...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.1049
更新日期：2010-02-01 00:00:00
abstract：:Biomechanical issues are now widely recognized as being important in the treatment of diabetic foot disease. The purpose of the present review is to identify advances that have occurred since the previous International Conference on the Diabetic Foot in 1995 in the understanding of foot biomechanics in relation to dia...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/1520-7560(200009/10)16:1+<::aid-dmrr130>3.
更新日期：2000-09-01 00:00:00
abstract：BACKGROUND:It has been shown that subjects with normal glucose tolerance (NGT), whose plasma glucose (PG) levels do not return to their fasting PG level within 2 h during an oral glucose tolerance test (OGTT) (Group I), have a significantly higher risk to develop type 2 diabetes than NGT subjects whose 2-h glucose retu...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.951
更新日期：2009-05-01 00:00:00
abstract：BACKGROUND:Treatment with DiaPep277, a peptide derived from HSP60, has been shown to preserve beta-cell function in non-obese diabetic mouse (NOD) mice and in a trial with newly diagnosed human patients with type 1 diabetes treated over a 10-month period. This article extends the clinical trial observations to a total ...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,随机对照试验
doi：10.1002/dmrr.712
更新日期：2007-05-01 00:00:00
abstract：OBJECTIVE:Psammomys obesus gerbil exhibits PKCepsilon over-expression on high-energy (HE) diet. Muscle insulin receptor (IR) signalling and tyrosine kinase activity are inhibited eliciting insulin resistance. We aimed at preventing diabetes by inhibiting PKCepsilon-induced serine phosphorylation of IRS-1 with novel PKC...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.881
更新日期：2008-10-01 00:00:00
abstract：:This review addresses the roles of Rho/Rho-kinase (ROCK) pathway in the pathogenesis of diabetes complications. Diabetes can cause many serious complications and can result in physical disability or even increased mortality. However, there are not many effective ways to treat these complications. The small guanosine-5...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.1182
更新日期：2011-05-01 00:00:00
abstract：:An appropriate diet represents the cornerstone for diabetes therapy. Diets that differ in their carbohydrate, lipid and protein content are used but the evidence of their effects on the long term is missing. Several confounding factors and compliance to diet render difficult the evaluation of the 'best diet' for diabe...
journal_title：Diabetes/metabolism research and reviews
pub_type：
doi：10.1002/dmrr.2512
更新日期：2014-03-01 00:00:00
abstract：:The prevalence of diabetes mellitus in primary hyperparathyroidism is approximately 8% and that of primary hyperparathyroidism in diabetic patients is approximately 1%. Both values are about three-fold higher than the respective expected prevalences in general populations. Patients with both disorders are over 40 year...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.199
更新日期：2001-05-01 00:00:00
abstract：BACKGROUND:Clinical and experimental studies have shown that a reduction in myocardial glucose utilization is a factor contributing to diabetic cardiomyopathy. This study determined whether exercise training could prevent the depression in glucose utilization observed in the diabetic rat heart. METHODS:Diabetes was in...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.479
更新日期：2005-01-01 00:00:00
abstract：BACKGROUND:The goal of the present study was to determine whether cytokines in the peripheral blood of naive NOD mice correlate with the disease process and thereby would provide a marker for monitoring disease activity. METHODS:Female NOD mice (5, 10 and 14-16 weeks of age) were investigated in a cross-sectional stud...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.256
更新日期：2002-01-01 00:00:00
abstract：AIMS:Diabetic neuropathy (DN) is a "Cinderella" complication, particularly in the Middle East. A high prevalence of undiagnosed DN and those at risk of diabetic foot ulceration (DFU) is a major concern. We have determined the prevalence of DN and its risk factors, DFU, and those at risk of DFU in patients with type 2 d...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.3286
更新日期：2020-05-01 00:00:00
abstract：BACKGROUND:The aim of the study is to assess the relationship between the shape of plasma glucose concentration during the OGTT and future risk for T2DM. METHODS:2445 non-diabetic subjects from the Botnia study received an OGTT at baseline and after 7-8 years of follow-up. RESULTS:NGT and IFG subjects who returned th...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.1084
更新日期：2010-05-01 00:00:00
abstract：BACKGROUND:Individuals with diabetes mellitus (DM) homozygous for the haptoglobin (Hp) 1 allele are at decreased risk of retinopathy as compared to DM individuals with the Hp 2 allele. We sought to recapitulate these findings in DM mice genetically modified at the Hp locus. METHODS:An early morphological characteristi...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.654
更新日期：2007-02-01 00:00:00
abstract：:The use of endovascular therapy (EVT) for lower extremity atherosclerosis is markedly increasing while open surgical bypass is in decline. The results of EVT for critical limb ischaemia (CLI) are difficult to evaluate, especially for patients with diabetes. To date, only one randomized, prospective trial has been publ...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.829
更新日期：2008-05-01 00:00:00
abstract：BACKGROUND:Increased production of reactive oxygen species (ROS) in mitochondria has been proposed as the pathogenic mechanism for chronic complications of diabetes. Mitochondrial DNA (mtDNA) is more vulnerable to reactive oxygen species. However, there are few data on the mitochondrial DNA damage in diabetes and these...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章
doi：10.1002/dmrr.1203
更新日期：2011-07-01 00:00:00
abstract：:Insulin-producing pancreatic beta-cells are known to be extremely susceptible to destruction, primarily by autoimmune mechanisms, infectious agents, and by chemical toxins that cause overt type I diabetes. As development of highly protected insulin-producing cells would be important for successful cell therapy of diab...
journal_title：Diabetes/metabolism research and reviews
pub_type： 杂志文章,评审
doi：10.1002/dmrr.545
更新日期：2005-05-01 00:00:00
