Autoantibodies against PFDN2 are associated with an increased risk of type 2 diabetes: A case-control study.

Abstract:

BACKGROUND:The adaptive immune system is involved in type 2 diabetes mellitus (T2DM), indicating the presence of unidentified autoantibodies that might be useful biomarkers for emerging immunomodulatory therapy. A prior microarray study with a small number of participants suggested the association of novel autoantibodies with T2DM in Southwest American Indians. We therefore sought to determine whether antibodies against 14 target proteins are associated with T2DM in a large case-control study. METHODS:Participants were adults (age 20-59 y) of Southwest American Indian heritage. Plasma antibodies against 14 possible target proteins were measured in 476 cases with T2DM of less than 5 years duration and compared with 424 controls with normal glucose regulation. RESULTS:Higher levels of antibodies against prefoldin subunit 2 (PFDN2) were associated with T2DM (P = .0001; Bonferroni-corrected threshold for multiple tests = 0.0036 [α = 0.05]). The association between anti-PFDN2 antibodies and T2DM remained in multivariable logistic regression (odds ratio 1.27; 95% confidence interval, 1.09-1.49; per one SD difference in anti-PFDN2 antibody). The odds of T2DM were increased in the highest anti-PFDN2 antibody quintile by 66% compared with the lowest quintile. Differences in anti-PFDN2 antibodies were most prominent among cases with earlier onset of disease (ie, age 20-39 y) compared with controls. CONCLUSIONS:Anti-PFDN2 antibodies are associated with T2DM and might be a useful biomarker. These findings indicate that autoimmunity may play a role in T2DM in Southwest American Indians, especially among adults presenting with young onset of disease.

journal_name

Diabetes Metab Res Rev

authors

Chang DC,Piaggi P,Hanson RL,Knowler WC,Bogardus C,Krakoff J

doi

10.1002/dmrr.2922

subject

Has Abstract

pub_date

2017-11-01 00:00:00

issue

8

eissn

1520-7552

issn

1520-7560

journal_volume

33

pub_type

杂志文章
  • Hyperbaric oxygen therapy and the diabetic foot.

    abstract::Common causes for non-healing of diabetic foot ulcers are infection and/or ischaemia. Diabetic patients are compromised hosts as far as wound healing is concerned. Diabetes mellitus is associated with a defective cellular and humoral immunity. In particular, decreased chemotaxis, decreased phagocytosis, impaired bacte...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/1520-7560(200009/10)16:1+<::aid-dmrr132>3.

    authors: Bakker DJ

    更新日期:2000-09-01 00:00:00

  • Treatment of new-onset type 1 diabetes with peptide DiaPep277 is safe and associated with preserved beta-cell function: extension of a randomized, double-blind, phase II trial.

    abstract:BACKGROUND:Treatment with DiaPep277, a peptide derived from HSP60, has been shown to preserve beta-cell function in non-obese diabetic mouse (NOD) mice and in a trial with newly diagnosed human patients with type 1 diabetes treated over a 10-month period. This article extends the clinical trial observations to a total ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,随机对照试验

    doi:10.1002/dmrr.712

    authors: Raz I,Avron A,Tamir M,Metzger M,Symer L,Eldor R,Cohen IR,Elias D

    更新日期:2007-05-01 00:00:00

  • The roles of NADPH-oxidase and nNOS for the increased oxidative stress and the oxygen consumption in the diabetic kidney.

    abstract:BACKGROUND:Sustained hyperglycaemia induces increased renal oxygen consumption resulting in reduced oxygen availability in the diabetic kidney. We investigated the roles of the nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase and the neuronal nitric oxide synthase (nNOS) for the increased oxygen consumption ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1099

    authors: Edlund J,Fasching A,Liss P,Hansell P,Palm F

    更新日期:2010-07-01 00:00:00

  • Early transcriptional regulation by C-peptide in freshly isolated rat proximal tubular cells.

    abstract:BACKGROUND:Clinical studies have shown that proinsulin C-peptide exerts renoprotective effects in type 1 diabetes, although the underlying mechanisms are poorly understood. As C-peptide has been shown to induce several intracellular events and to localize to nuclei, we aimed to determine whether gene transcription is a...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1220

    authors: Lindahl E,Nordquist L,Müller P,El Agha E,Friederich M,Dahlman-Wright K,Palm F,Jörnvall H

    更新日期:2011-10-01 00:00:00

  • Lessons learned from the 1-hour post-load glucose level during OGTT: Current screening recommendations for dysglycaemia should be revised.

    abstract::This perspective covers a novel area of research describing the inadequacies of current approaches for diagnosing dysglycaemia and proposes that the 1-hour post-load glucose level during the 75-g oral glucose tolerance test may serve as a novel biomarker to detect dysglycaemia earlier than currently recommended screen...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2992

    authors: Bergman M,Jagannathan R,Buysschaert M,Pareek M,Olsen MH,Nilsson PM,Medina JL,Roth J,Chetrit A,Groop L,Dankner R

    更新日期:2018-07-01 00:00:00

  • Assessment of the relationship between hypoglycaemia awareness and autonomic function following islet cell/pancreas transplantation.

    abstract:BACKGROUND:This study assesses the autonomic function of patients who have regained awareness of hypoglycaemia following islet cell or whole pancreas transplant. METHODS:Five patients with type 1 diabetes and either islet cell (four patients) or whole pancreas (one patient) transplant were assessed. These patients wer...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2652

    authors: Kamel JT,Goodman DJ,Howe K,Cook MJ,Ward GM,Roberts LJ

    更新日期:2015-09-01 00:00:00

  • Basal insulin analogues in diabetic pregnancy: a literature review and baseline results of a randomised, controlled trial in type 1 diabetes.

    abstract::As basal insulin analogues are being used off-label, there is a need to evaluate their safety (maternal hypoglycaemia and fetal and perinatal outcomes) and efficacy [haemoglobin A1c(HbA1c), fasting plasma glucose, and maternal weight gain]. The aim of this review is to provide an overview of the current literature con...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,多中心研究,随机对照试验,评审

    doi:10.1002/dmrr.1213

    authors: Mathiesen ER,Damm P,Jovanovic L,McCance DR,Thyregod C,Jensen AB,Hod M

    更新日期:2011-09-01 00:00:00

  • Role of vasoactive factors in the pathogenesis of early changes in diabetic retinopathy.

    abstract::Several interactive and mutually perpetuating abnormal biochemical pathways, such as protein kinase C (PKC) activation, augmented polyol pathway, and non-enzymatic glycation, may be activated as a result of sustained hyperglycemia in diabetes. These abnormal pathways may in turn influence several vasoactive factors, w...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/1520-7560(0000)9999:9999<::aid-dmrr157>3.0

    authors: Chakrabarti S,Cukiernik M,Hileeto D,Evans T,Chen S

    更新日期:2000-11-01 00:00:00

  • Immune regulation by CTLA-4--relevance to autoimmune diabetes in a transgenic mouse model.

    abstract:BACKGROUND:The importance of cytotoxic T lymphocyte antigen-4 (CTLA-4) in immune regulation is unquestioned, yet a precise understanding of which cells express it, and how it mediates immune inhibitory function, is lacking. Regulatory T cells are known to constitutively express CTLA-4 intracellularly, whereas conventio...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1277

    authors: Wang CJ,Schmidt EM,Attridge K,Kenefeck R,Wardzinski L,Chamberlain JL,Soulier A,Clough LE,Manzotti CN,Narendran P,Walker LS

    更新日期:2011-11-01 00:00:00

  • Prognostic value of serum liver enzymes levels in type 2 diabetic patients.

    abstract:BACKGROUND:Elevated liver enzymes are associated with cardiovascular disease, while their relationship with cancer-related mortality has not been assessed so far in diabetic patients. METHODS:An observational cohort study was performed on a consecutive series of 1952 type 2 diabetic patients. The association of liver ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.744

    authors: Monami M,Balzi D,Lamanna C,Melani C,Cocca C,Lotti E,Fedeli A,Masotti G,Marchionni N,Mannucci E

    更新日期:2007-11-01 00:00:00

  • Risk factors in V-shaped risk associations with all-cause mortality in type 2 diabetes-The Hong Kong Diabetes Registry.

    abstract:BACKGROUND:Body mass index (BMI) is associated with death in a V-shaped manner in general populations but it is unknown whether BMI or other risk factors also exhibit V-shaped relationships with death in type 2 diabetic patients. METHODS:A prospective cohort of 7534 Chinese, type 2 diabetic patients enrolled since 199...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.792

    authors: So WY,Yang X,Ma RC,Kong AP,Lam CW,Ho CS,Cockram CS,Ko GT,Chow CC,Wong V,Tong PC,Chan JC

    更新日期:2008-03-01 00:00:00

  • The global challenge of type 2 diabetes and the strategies for response in ethnic minority groups.

    abstract::Ethnic minorities living in high-income countries usually exhibit a greater risk of developing diabetes along with higher morbidity and mortality rates. We evaluated the effectiveness of interventions to improve glycaemic control in ethnic minority groups. Results of major controlled trials, systematic reviews and met...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.1105

    authors: Lirussi F

    更新日期:2010-09-01 00:00:00

  • Increased LDL cholesterol and CRP in infants of mothers with type 1 diabetes.

    abstract:BACKGROUND:Proatherogenic stimuli during foetal life may predispose to development of atherosclerosis in adulthood. Elevated plasma low-density lipoprotein (LDL) cholesterol and C-reactive protein (CRP) expression is associated with increased risk of atherosclerosis. METHODS AND RESULTS:In this study, we examined how ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.867

    authors: Lindegaard ML,Svarrer EM,Damm P,Mathiesen ER,Nielsen LB

    更新日期:2008-09-01 00:00:00

  • Should we change the target blood pressure in diabetic patients?

    abstract::Hypertension is a major modifiable risk factor for cardiovascular morbidity and mortality in diabetic patients. Guidelines recommend lowering blood pressure (BP) to less than 130/80 mmHg in diabetic patients. These recommendations are based on several studies in diabetic patients that showed the benefit of intensive B...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.2348

    authors: Shlomai G,Grossman E

    更新日期:2012-12-01 00:00:00

  • Stability of mitochondrial DNA against reactive oxygen species (ROS) generated in diabetes.

    abstract:BACKGROUND:Increased production of reactive oxygen species (ROS) in mitochondria has been proposed as the pathogenic mechanism for chronic complications of diabetes. Mitochondrial DNA (mtDNA) is more vulnerable to reactive oxygen species. However, there are few data on the mitochondrial DNA damage in diabetes and these...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1203

    authors: Savu O,Sunkari VG,Botusan IR,Grünler J,Nikoshkov A,Catrina SB

    更新日期:2011-07-01 00:00:00

  • Nested case-control data analysis using weighted conditional logistic regression in The Environmental Determinants of Diabetes in the Young (TEDDY) study: A novel approach.

    abstract:BACKGROUND:A nested case-control (NCC) design within a prospective cohort study can realize substantial benefits for biomarker studies. In this context, it is natural to consider the sample availability in the selection of controls to minimize data loss when implementing the design. However, this violates the randomnes...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.3204

    authors: Lee HS,Lynch KF,Krischer JP,TEDDY Study Group.

    更新日期:2020-01-01 00:00:00

  • Predicting ulcer-free survival using the discriminative value of screening test locations.

    abstract:BACKGROUND:Current guidelines recommend screening the feet of diabetic subjects with a 10-g monofilament or tuning fork. We investigated which tests and locations on the feet have the best predictive value regarding 1-year ulcer-free survival in diabetic subjects participating in the prospective Rotterdam Diabetic Foot...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.3119

    authors: Rinkel WD,van der Oest MJW,Dijkstra DA,Castro Cabezas M,Coert JH

    更新日期:2019-03-01 00:00:00

  • Guidelines on use of interventions to enhance healing of chronic foot ulcers in diabetes (IWGDF 2019 update).

    abstract::The International Working Group on the Diabetic Foot (IWGDF) has published evidence-based guidelines on the prevention and management of diabetic foot disease since 1999. In conjunction with advice from internal and external reviewers and expert consultants in the field, this update is based on a systematic review of ...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.3283

    authors: Rayman G,Vas P,Dhatariya K,Driver V,Hartemann A,Londahl M,Piaggesi A,Apelqvist J,Attinger C,Game F,International Working Group on the Diabetic Foot (IWGDF).

    更新日期:2020-03-01 00:00:00

  • The development of a World Health Organisation international standard for islet cell antibodies: the aims and design of an international collaborative study.

    abstract::Islet cell antibodies (ICA) are a specific marker for Type 1 (insulin-dependent) diabetes mellitus. ICA are found in the serum of over 80% of newly diagnosed patients and the levels of ICA are directly of prognostic value. Standardisation of ICA and the uniform reporting of ICA levels in international units is critica...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/(sici)1520-7560(199901/02)15:1<72::aid-dmr

    authors: Mire-Sluis AR,Das RG,Lernmark A

    更新日期:1999-01-01 00:00:00

  • Painful diabetic neuropathy: treatment and future aspects.

    abstract::Around one of three diabetic patients is affected by distal symmetric polyneuropathy (DSP) which represents a major health problem, as it may present with partly excruciating neuropathic pain and is responsible for substantial morbidity and increased mortality. Treatment is based on four cornerstones: (1) multifactori...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.817

    authors: Ziegler D

    更新日期:2008-05-01 00:00:00

  • Diabetes trends in Africa.

    abstract::Diabetes is an important cause of morbidity and mortality in Africa. Although a dramatic increase in disease burden is projected, it remains to be seen what effect the ongoing devastation of HIV disease will have on the epidemiology of such chronic diseases as diabetes. Recent data on type 2 diabetes prevalence indica...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.284

    authors: Motala AA

    更新日期:2002-09-01 00:00:00

  • Exosomes and diabetes.

    abstract::Diabetes is a group of metabolic diseases characterized by elevated blood glucose levels that drive the development of life-threatening complications. Diabetes results from a situation of insufficient insulin action, either by deficient production of the hormone by the pancreas, or by the development of insulin resist...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.3107

    authors: Castaño C,Novials A,Párrizas M

    更新日期:2019-03-01 00:00:00

  • Angiotensin-converting enzyme 2 inhibits endoplasmic reticulum stress-associated pathway to preserve nonalcoholic fatty liver disease.

    abstract:BACKGROUND:Previous works indicated that the stress on the endoplasmic reticulum (ER) affected nonalcoholic fatty liver disease (NAFLD). However, there is no clear evident on the effect of the regulation of ER stress by angiotensin-converting enzyme 2 (ACE2) on the prevention of NAFLD. METHODS:HepG2 cells were treated...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.3123

    authors: Cao X,Song LN,Zhang YC,Li Q,Shi TT,Yang FY,Yuan MX,Xin Z,Yang JK

    更新日期:2019-05-01 00:00:00

  • Coprevalence of type 2 diabetes mellitus and tuberculosis in low-income and middle-income countries: A systematic review.

    abstract::Increasing coprevalence of diabetes mellitus (DM) and tuberculosis (TB) in low-income and middle-income countries (LMICs) indicates a rising threat to the decades of progress made against TB and requires global attention. This systematic review provides a summary of type 2 diabetes and tuberculosis coprevalence in var...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.3066

    authors: McMurry HS,Mendenhall E,Rajendrakumar A,Nambiar L,Satyanarayana S,Shivashankar R

    更新日期:2019-01-01 00:00:00

  • A linkage study of 12 IDDM susceptibility loci in the Finnish population.

    abstract:BACKGROUND:HLA region is the major locus (IDDM1) of type 1 diabetes (T1D) susceptibility. It explains approximately 50% of the genetic background of T1D, indicating additional genetic determinants. Genome scans and candidate gene studies have generated several chromosomal candidate regions that may have a role in T1D d...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 临床试验,杂志文章

    doi:10.1002/dmrr.424

    authors: Laine AP,Nejentsev S,Veijola R,Korpinen E,Sjöroos M,Simell O,Knip M,Akerblom HK,Ilonen J

    更新日期:2004-03-01 00:00:00

  • Effect of antiretroviral agents on carbohydrate metabolism in HIV-1 infected pregnant women.

    abstract:BACKGROUND:Despite the correlation between the use of protease inhibitors (PI) and adverse metabolic glycemic events, no prospective study has examined these parameters in pregnant women who use these drugs. METHODS:A prospective study was conducted on 57 pregnant women to investigate the effect of antiretroviral drug...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.576

    authors: El Beitune P,Duarte G,Foss MC,Montenegro RM Jr,Spara P,Quintana SM,Figueiró-Filho EA,da Costa AG,Filho FM

    更新日期:2006-01-01 00:00:00

  • Questions on therapy with DPP-4 inhibitors and bone homeostasis.

    abstract::A recent study from Gallagher et al. aimed to investigate the effect of a new depeptidyl-peptidase-4 inhibitor, MK-0626, on bone turnover in a mouse model developing insulin resistance and diabetes (MKR mice). Authors have found that treatment with MK-0626 did not affect either MKR mice fasting glucose or parameters o...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 评论,杂志文章

    doi:10.1002/dmrr.2505

    authors: Napoli N

    更新日期:2014-03-01 00:00:00

  • Integrating palliative care with usual care of diabetic foot wounds.

    abstract::Palliative care is a philosophy and a system for deciding care and can be used alone or integrated with usual chronic disease care. Palliative care encompasses end-of-life care. Palliative care aims to enhance quality of life, optimize function and manage symptoms including early in the course of chronic diseases. The...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章,评审

    doi:10.1002/dmrr.2758

    authors: Dunning T

    更新日期:2016-01-01 00:00:00

  • The decrement in circulating endothelial progenitor cells (EPCs) in type 2 diabetes is independent of the severity of the hypoadiponectemia.

    abstract:BACKGROUND:Type 2 diabetes mellitus (DM) is associated with a decreased level of circulating endothelial progenitor cells (EPCs) and adiponectin. Experimental studies suggest a potential link between hypoadiponectinaemia and the depletion of the EPC level. This study investigated the relationships between adiponectin l...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.1159

    authors: Li M,Ho JC,Lai KW,Au KK,Xu A,Cheung BM,Lam KS,Tse HF

    更新日期:2011-02-01 00:00:00

  • Axonal dysfunction prior to neuropathy onset in type 1 diabetes.

    abstract:BACKGROUND:The present study was undertaken to determine whether there were changes evident in axonal membrane function prior to the onset of neuropathy in patients with type 1 and type 2 diabetes. METHODS:From a cohort of 110 consecutive referrals, nerve excitability was investigated in 40 diabetic patients without c...

    journal_title:Diabetes/metabolism research and reviews

    pub_type: 杂志文章

    doi:10.1002/dmrr.2360

    authors: Arnold R,Kwai N,Lin CS,Poynten AM,Kiernan MC,Krishnan AV

    更新日期:2013-01-01 00:00:00