Abstract:
BACKGROUND:Human umbilical cord blood derived-mesenchymal stem cells (hUCMSCs) offer an attractive alternative to bone marrow-derived MSCs (BMMSCs) for cell-based therapy as it is a less invasive source of biological material. However, limited studies have been conducted with hUCMSCs as compared to BMMSCs. The present study was conducted to evaluate the effects of hUCMSCs in esophageal carcinoma (EC). METHODS:hUCMSCs together with EC cells were transplanted subcutaneously into BALB/c nude mice to observe the effects of hUCMSCs on tumor establishment. hUCMSCs injected through the caudal vein to the mice with pre-established EC to observe the effects of hUCMSCs on tumor outgrowth. In order to elucidate the underlying mechanisms, we also performed in vitro experiments including directly co-culture, transwell assay, proliferation assay and western blotting analysis. RESULTS:hUCMSCs promoted EC formation in nude mice. In the in vivo model of pre-established EC, intravenously injected hUCMSCs potently promoted tumor growth. When in vitro co-cultured with hUCMSCs, EC cells proliferation increased. After co-cultured with hUCMSCs through transwell system, EC cells showed increased proliferation. Through transwell assay, we also observed that EC cells recruited MSCs, and MSCs promoted EC cells migration and invasion. Western blotting data showed that the expressions of proliferation related proteins Bcl-2, survivin and metastasis related proteins MMP-2 and MMP-9 were up-regulated in the EC cells transwell co-cultured with hUCMSCs. CONCLUSIONS:Our results indicated that hUCMSCs could favor tumor growth in vivo and in vitro. Thus, the exploitation of hUCMSCs in new therapeutic strategies should be cautious under the malignant conditions.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Yang X,Li Z,Ma Y,Gao J,Liu S,Gao Y,Wang Gdoi
10.1186/s12935-014-0093-9subject
Has Abstractpub_date
2014-09-24 00:00:00pages
93issue
1issn
1475-2867pii
93journal_volume
14pub_type
杂志文章abstract:BACKGROUND:Avenanthramides (AVN) are a relatively unstudied family of phytochemicals that could be novel chemotherapeutics. These compounds, found in oats, are non-toxic to healthy cells and have been shown to reduce viability of human colon and liver cancers in vitro. However, these studies do not elucidate a molecula...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0464-0
更新日期:2017-10-18 00:00:00
abstract:Background:In recent years, the B cell receptor (BCR) signaling pathway has become a "hot point" because it plays a critical role in B-cell proliferation and function. Bruton's tyrosine kinase (BTK) is overexpressed in many subtypes of B-cell lymphoma as a downstream kinase in the BCR signaling pathway. Ibrutinib, the ...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-020-01518-y
更新日期:2020-09-29 00:00:00
abstract:BACKGROUND:Mutational inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene has been linked to hereditary as well as sporadic clear cell renal carcinomas. The product of the VHL gene, pVHL, acts to target hypoxia-inducible factor alpha (HIF-alpha) subunits for ubiquitination and subsequent degradation. Usin...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-7-13
更新日期:2007-06-28 00:00:00
abstract:Background:Transgelin, an actin-binding protein, is associated with cytoskeleton remodeling. Findings from our previous studies demonstrated that transgelin was up-regulated in node-positive colorectal cancer (CRC) versus node-negative disease. Over-expression of TAGLN affected the expression of 256 downstream transcri...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01461-y
更新日期:2020-08-03 00:00:00
abstract:Background:Emergence of resistance to molecular targeted therapy constitutes a limitation to clinical benefits in cancer treatment. Cross-resistance commonly happens with chemotherapeutic agents but might not with targeted agents. Methods:In the current study, TP53 wild-type cell lines with druggable MAPK pathway muta...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0768-3
更新日期:2019-03-07 00:00:00
abstract:Background:T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood. In this study, we tried to explore the physiological role of CD59 in T-ALL. Methods:In this study, we collected the bone marrow samples from 17 T-A...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0714-9
更新日期:2019-01-08 00:00:00
abstract::Sineoculis homeobox homolog 1 (Six1), normally a developmentally restricted transcriptional regulator, is frequently dysregulated in mutiple cancers. Increasing evidences show that overexpression of Six1 plays a key role in tumorigenesis. However, the Six1 expression status and its relationship with the clinicopatholo...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0215-z
更新日期:2015-06-20 00:00:00
abstract:Background:Recent studies have demonstrated that the kallikrein and kallikrein-related peptidases (KLKs) exhibit aberrant expression in patients with colorectal cancer (CRC) and might be considered as potential prognostic biomarkers of CRC. However, inconsistent findings have been reported, which promote us to summariz...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01350-4
更新日期:2020-06-22 00:00:00
abstract::[This corrects the article DOI: 10.1186/s12935-019-0742-0.]. ...
journal_title:Cancer cell international
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12935-019-0797-y
更新日期:2019-04-11 00:00:00
abstract:BACKGROUND:Mononuclear platinum anticancer agents hold a pivotal place in the treatment of many forms of cancers, however, there is a potential to improve response to evade resistance development and toxic side effects. BBR3464 is a promising trinuclear platinum anticancer agent, which is a polyamine mimic. The aim was...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-12-20
更新日期:2012-05-28 00:00:00
abstract:BACKGROUND:Compounds of plant origin and food components have attracted scientific attention for use as agents for cancer prevention and treatment. Wine contains polyphenols that were shown to have anti-cancer and other health benefits. The survival pathways of Akt and extracellular signal-regulated kinase (Erk), and t...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-14-6
更新日期:2014-01-23 00:00:00
abstract:Background:Melanoma is an extremely aggressive malignant skin tumor with high mortality. Many types of long noncoding RNAs and microRNAs have been reported to be associated with the oncogenesis of melanoma. However, a novel lncRNA-NEAT has not been thoroughly investigated in melanoma cancer. The purposes of this study ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0927-6
更新日期:2019-08-22 00:00:00
abstract:Background:MicroRNA (MiRNA) is a small non-coding RNA which is implicated in a cohort of biological function in cancer, including proliferation, metastasis, apoptosis and invasion. MiR-96 has been reported to be involved in many cancers, including papillary thyroid cancer. However, the role of miR-96-3p in papillary th...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-1003-y
更新日期:2019-11-12 00:00:00
abstract:BACKGROUND:Prostate cancer progression to androgen independence is the primary cause of mortality by this tumor type. The IGF-1/IGF-1R axis is well known to contribute to prostate cancer initiation, but its contribution to invasiveness and the downstream signalling mechanisms that are involved are unclear at present. ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-8-10
更新日期:2008-07-03 00:00:00
abstract:Background:Estrogen sulfotransferase catalyzes conjugation of sulfuryl-group to estradiol/estrone and regulates E2 availability/activity via estrogen-receptor or non-receptor mediated pathways. Sulfoconjugated estrogen fails to bind estrogen-receptor (ER). High estrogen is a known carcinogen in postmenopausal women. Re...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1153-y
更新日期:2020-03-04 00:00:00
abstract:Background:SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, over-expressed in human tumor tissues and embryonic cells. Evidences support its function in the cell cycle; however there is no clear mechanism explaining its function in cell proliferation regulation. Here we investigated cancer cell response t...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0618-8
更新日期:2018-09-05 00:00:00
abstract:Background:Alternative splicing (AS) is a key factor in protein-coding gene diversity, and is associated with the development and progression of malignant tumours. However, the role of AS in cervical cancer is unclear. Methods:The AS data for cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) were...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01299-4
更新日期:2020-06-08 00:00:00
abstract:Background:Increasing evidences have underlined the importance of long non-coding RNAs (lncRNAs) in human malignancies. LINC00958 has been found involved in some cancers. However, the underlying mechanical performance of LINC00958 in lung adenocarcinoma (LAD) has not been explored yet. Methods:The expression of releva...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1099-0
更新日期:2020-01-23 00:00:00
abstract:BACKGROUND:The goal of this study was to identify the nature of the inclusion bodies that have been found in HeLa cells (cervical cancer immortal cell line) by electron microscope and to determine whether the major capsid protein (L1) of human papillomavirus (HPV) can be expressed in HPV-positive uterine cervix cancer ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0206-0
更新日期:2015-05-23 00:00:00
abstract:Background:Recent studies have emphasized the important prognostic role of long noncoding RNAs (lncRNAs) in various types of cancers. Here we conducted a meta-analysis to investigate whether lncRNA HOXA11-AS can be served as a prognostic biomarker in human cancers. Patients/methods:We systematically searched PubMed, E...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0498-3
更新日期:2018-01-03 00:00:00
abstract:Background:Melanoma as a type of skin cancer, is associated with a high mortality rate. Therefore, early diagnosis and efficient surgical treatment of this disease is very important. Photodynamic therapy (PDT) involves the activation of a photosensitizer by light at specific wavelength that interacts with oxygen and cr...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01616-x
更新日期:2020-10-29 00:00:00
abstract:Background:Angioimmunoblastic T cell lymphoma (AITL) is a distinct subtype of peripheral T cell lymphoma and associated with poor outcomes. The activation status of T cell receptor (TCR) signaling has recently become a focus of attention in terms of the therapeutic targets. However, the molecular pathogenesis mechanism...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0754-9
更新日期:2019-02-14 00:00:00
abstract::RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression, particularly in gastrointestinal cancers. RNA methylation has a variety of b...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-020-01679-w
更新日期:2020-12-07 00:00:00
abstract::[This corrects the article DOI: 10.1186/s12935-020-01426-1.]. ...
journal_title:Cancer cell international
pub_type: 已发布勘误
doi:10.1186/s12935-020-01482-7
更新日期:2020-08-18 00:00:00
abstract:Background:Oxidative stress is responsible for some alterations in the chemical structure and, consequently, in the function of proteins, lipids, and DNA. Recent studies have linked oxidative stress to cancers, particularly thyroid cancer, but the mechanisms remain unclear. Here, we further characterize the role of oxi...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0504-4
更新日期:2018-01-15 00:00:00
abstract:Background:Immunotherapies that targeting programmed cell death 1 (PD-1) and programmed death-ligand 1 (PD-L1) have obtained prominent success in breast cancer (BC). However, not all the patients benefit from the antibody therapy. This study aimed to identify PD-1/PD-L1 correlated genes and pathways as well as investig...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0955-2
更新日期:2019-09-09 00:00:00
abstract:BACKGROUND:Several reports have revealed that cancer stem cells (CSCs) exist in many types of solid tumors. Some studies have demonstrated that side population (SP) cells isolated from diverse cancer lines harbor cancer stem-like properties, but there are few reports examining the characteristic of SP cells in human ce...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-14-3
更新日期:2014-01-13 00:00:00
abstract:BACKGROUND:The present study mainly aimed to investigate the direct effects of Endostar (ES) on the proliferation and radiosensitivity of human lung squamous cancer cell line H-520. RESULTS:ES significantly inhibited H-520 cell proliferation in a time- and dose-dependent manner. According to the colony-forming assays,...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-10-17
更新日期:2010-05-24 00:00:00
abstract:UNLABELLED: BACKGROUND:Anticancer research resulted in the discovery of a promising antimitotic metabolite, 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate, a bis-sulphamoylated analogue exerts antiproliferative- and antimitotic activity. Investigating the anticancer potential of 2-methoxyestradiol-bis-sulphamat...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-12-37
更新日期:2012-08-20 00:00:00
abstract::Osteosarcoma (OS) is one of the most prevalent malignant cancers with lower survival and poor overall prognosis mainly in children and adolescents. Identifying the molecular mechanisms and OS stem cells (OSCs) as new concepts involved in disease pathogenesis and progression may potentially lead to new therapeutic targ...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-018-0654-4
更新日期:2018-10-16 00:00:00