Abstract:
:Sineoculis homeobox homolog 1 (Six1), normally a developmentally restricted transcriptional regulator, is frequently dysregulated in mutiple cancers. Increasing evidences show that overexpression of Six1 plays a key role in tumorigenesis. However, the Six1 expression status and its relationship with the clinicopathological characteristics in prostate cancer were unclear. In this study, the mRNA and protein levels of Six1 in prostate cancer tissues and normal prostate tissues were evaluated. The clinicopathological significance of Six1 was investigated by immunohistochemistry (IHC) on a prostate cancer tissue microarray. The cut-off score for high expression of Six1 was determined by the receiver-operating characteristic (ROC) analysis. The correlation between Six1 protein expression and clinicopathological characteristics of prostate cancer was analyzed by Chi-square test. Increased expression of Six1 protein was observed in the majority of prostate cancer, compared with their paired adjacent normal prostate tissues. When Six1 high expression percentage was determined to be above 55 % (area under ROC curve = 0.881, P = 0.000), high expression of Six1 was observed in 55.6 % (80/144) of prostate cancer tissues and low expression of Six1 was observed in all normal prostate tissues by IHC. Increased expression of Six1 in patients was correlated with high histological grade (χ2 = 58.651, P = 0.00), advanced clinical stage (χ2 = 57.330, P = 0.000), high Gleason score (χ2 = 63.480, P = 0.000), high primary tumor grade (χ2 = 57.330, P = 0.000) and positive regional lymph node metastasis (χ2 = 19.294, P = 0.000). Furthermore, univariate and multivariate survival analysis suggested that Six1 was an independent prognostic indicator for overall survival (P < 0.05). This study suggests that Six1 could be served as an additional biomarker in identifying prostate cancer patients at risk of tumor progression, might potentially be used for predicting survival outcome of patients with prostate cancer.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Zeng J,Shi R,Cai CX,Liu XR,Song YB,Wei M,Ma WLdoi
10.1186/s12935-015-0215-zsubject
Has Abstractpub_date
2015-06-20 00:00:00pages
63issn
1475-2867pii
215journal_volume
15pub_type
杂志文章abstract:BACKGROUND:Mononuclear platinum anticancer agents hold a pivotal place in the treatment of many forms of cancers, however, there is a potential to improve response to evade resistance development and toxic side effects. BBR3464 is a promising trinuclear platinum anticancer agent, which is a polyamine mimic. The aim was...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-12-20
更新日期:2012-05-28 00:00:00
abstract:Background:Drug resistance to 5-fluorouracil (5-FU) and recurrence after chemotherapy in colorectal cancer remain a challenge to be resolved for the improvement of patient outcomes. It is recognized that a variety of secretory proteins released from the tumor cells exposed to chemo-drugs into the tumor microenvironment...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01541-z
更新日期:2020-09-14 00:00:00
abstract:BACKGROUND:While some risk factors for breast cancer are well-known, the influence of other factors, particularly virus infection, remains unclear. Human cytomegalovirus (HCMV) is widespread in the general population, and both molecular and epidemiological evidence has indicated links between HCMV and breast cancer. Th...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0399-5
更新日期:2017-02-13 00:00:00
abstract:Background:Melanoma as a type of skin cancer, is associated with a high mortality rate. Therefore, early diagnosis and efficient surgical treatment of this disease is very important. Photodynamic therapy (PDT) involves the activation of a photosensitizer by light at specific wavelength that interacts with oxygen and cr...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01616-x
更新日期:2020-10-29 00:00:00
abstract:BACKGROUND:The aim of this study was to determine whether brain abundant membrane attached signal protein 1 (BASP1) is a valuable prognostic biomarker for cervical cancer and whether BASP1 regulates the progression of cervical cancer. METHODS:Quantitative real-time PCR, western blotting, and immunohistochemistry were ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0452-4
更新日期:2017-10-24 00:00:00
abstract:BACKGROUND:CircRNAs play crucial roles in multiple tumours. However, the functions of most circRNAs in cervical cancer remain unclear. METHODS:This study collected GSE113696 data from the GEO database to search for differentially expressed circRNAs in cervical cancer. Quantitative reverse transcription PCR was used to...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01736-4
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:This last decade, a lot of emphasis has been placed on developing new cancer cell culture models, closer to in vivo condition, in order to test new drugs and therapies. In the case of colorectal cancer, the use of patient biopsies to seed 3D primary cultures and mimic tumor initiation necessitates the use of...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-016-0277-6
更新日期:2016-02-12 00:00:00
abstract:Background:Gastric cancer (GC) is a common cause of cancer-related mortality worldwide, and microRNAs (miRNAs) have been shown to play an important role in GC development. This study aims to explore the effect of microRNA-93-5p (miR-93-5p) on the epithelial-mesenchymal transition (EMT) in GC, via AHNAK and the Wnt sign...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-1092-7
更新日期:2020-03-12 00:00:00
abstract:Background:Glioma is the most common highly aggressive, primary adult brain tumour. Clinical data show that therapeutic approaches cannot reach the expectations in patients, thus gliomas are mainly incurable diseases. Tumour cells can adapt rapidly to alterations during therapeutic treatments related to their metabolic...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0710-0
更新日期:2018-12-19 00:00:00
abstract::Circular RNAs (circRNAs) are small non-coding RNAs with a unique ring structure and play important roles as gene regulators. Disturbed expressions of circRNAs is closely related to varieties of pathological processes. The roles of circRNAs in cancers have gained increasing concerns. The communications between the canc...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-020-01301-z
更新日期:2020-06-03 00:00:00
abstract:Background:Neuroblastoma (NB) is the most common malignant tumor originating from the extracranial sympathetic nervous system in children. The molecular mechanisms underlying this disease are complex, and not completely understood. Methods:Quantitative real-time PCR (qRT-PCR) was applied to quantify the expression of ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0499-2
更新日期:2018-01-04 00:00:00
abstract:BACKGROUND:Liver cancer is one of the most frequent cancers in the world. Targeted therapy of cancer with specific inhibitors is developing and has shown promising antitumor efficacy. CCI-779 (temsirolimus), a specific inhibitor of mTOR (mammalian target of rapamycin), can block the mTOR signaling pathway. Here, we sys...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-13-30
更新日期:2013-03-28 00:00:00
abstract:Background:Acute lymphoblastic leukemia (ALL) is an aggressive hematopoietic malignancy that is most commonly observed in children. Alantolactone (ALT) has been reported to exhibit anti-tumor activity in different types of cancer. The aim of the present study was to investigate the anti-tumor activity and molecular mec...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01537-9
更新日期:2020-09-09 00:00:00
abstract:Background:Angiogenesis plays critical roles in the progression and metastasis of malignant tumors. Gastric neuroendocrine carcinoma is an uncommon stomach cancer that is rich in blood vessels and exhibits highly malignant biological behavior with a poor prognosis. The role of CDK5RAP3 in GNEC has not been reported to ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0997-5
更新日期:2019-11-07 00:00:00
abstract:BACKGROUND:Bladder cancer (BCa) is a malignant tumor that occurs on the mucosa of the bladder, in which dysregulated long non-coding RNAs (lncRNAs) are involved. This study investigated the effect of lncRNA small nucleolar RNA host gene 1 (SNHG14) on the biological characteristics of BCa cells from microRNA (miR)-211-3...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01717-7
更新日期:2021-01-22 00:00:00
abstract:BACKGROUND:Gastric carcinoma (GC) is currently one of the most common malignant tumors of the digestive system, and gastric precancerous lesions play a vital role in studying the mechanism of GC. Multiple microRNAs (miRNAs) have been documented to be potential biomarkers to indicate progression of gastric precancerous ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01578-0
更新日期:2020-11-13 00:00:00
abstract:BACKGROUND:Compounds of plant origin and food components have attracted scientific attention for use as agents for cancer prevention and treatment. Wine contains polyphenols that were shown to have anti-cancer and other health benefits. The survival pathways of Akt and extracellular signal-regulated kinase (Erk), and t...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-14-6
更新日期:2014-01-23 00:00:00
abstract:BACKGROUND:Drug resistance is a major obstacle to successful chemotherapy for epithelial ovarian cancer (EOC). We found a subset of miRNAs associated with the response to first-line platinum-based chemotherapy in EOC by microarray, and miR-206 was one of the most significant miRNAs. The purposes of this study were to e...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01623-y
更新日期:2020-11-03 00:00:00
abstract:Objective:This study aimed to investigate the relationship among miR-145-5p, ANGPT2 and the NOD_LIKE_RECEPTOR pathway, thereby revealing the molecular mechanism of these three factors underlying the proliferation, migration and invasion of gastric cancer (GC) epithelial cells. Methods:qRT-PCR was carried out to detect...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01483-6
更新日期:2020-08-28 00:00:00
abstract:Background:LncRNAs are key regulators in cancer. The current study explored the role of lncRNA LINC00261 (LINC00261) in lung cancer (LC). Methods:Expression of LINC00261 in LC tissues and cells was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Pearson's Chi square test and Kaplan-Meier anal...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01332-6
更新日期:2020-06-26 00:00:00
abstract:BACKGROUND:The present study mainly aimed to investigate the direct effects of Endostar (ES) on the proliferation and radiosensitivity of human lung squamous cancer cell line H-520. RESULTS:ES significantly inhibited H-520 cell proliferation in a time- and dose-dependent manner. According to the colony-forming assays,...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-10-17
更新日期:2010-05-24 00:00:00
abstract::[This corrects the article DOI: 10.1186/s12935-017-0407-9.]. ...
journal_title:Cancer cell international
pub_type: 已发布勘误
doi:10.1186/s12935-020-01375-9
更新日期:2020-07-17 00:00:00
abstract:Background:Dysregulation of lncRNAs is frequent in glioma and has emerged as an important mechanism involved in tumorigenesis. Previous analysis of Chinese Glioma Genome Atlas (CGGA) database indicated that LBX2-AS1 expression is one of differentially expression lncRNA between lower grade glioma (LGG) (grade II and III...
journal_title:Cancer cell international
pub_type: 杂志文章,收录出版
doi:10.1186/s12935-020-01433-2
更新日期:2020-08-26 00:00:00
abstract:BACKGROUND:Non-small cell lung cancer (NSCLC) is the largest histological subgroup of lung cancer and has increased in prevalence in China over the past 5 years. The 5-year survival rate has remained at 15-20 %, with a median survival of 8-12 months. The tumorigenesis and progression of NSCLC is orchestrated by numerou...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0236-7
更新日期:2015-09-17 00:00:00
abstract:Background:Pancreatic cancer is a common malignant tumor of the digestive tract. It has a high degree of malignancy and poor prognosis. Finding effective molecular markers has great significance for pancreatic cancer diagnosis and treatment. This study aimed to investigate DLGAP5 expression in pancreatic cancer and exp...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01474-7
更新日期:2020-08-08 00:00:00
abstract:BACKGROUND:Recent studies have reported the involvement of microRNA-29 (miR-29) family members in human cancers through their ability to regulate cellular functions. The present study investigated biological function of miR-29b in colorectal cancer (CRC). METHODS:CRC tissues and adjacent normal tissues were collected ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01700-2
更新日期:2021-01-06 00:00:00
abstract:Background:Long noncoding RNAs (lncRNAs) play essential roles in tumor progression. However, the functions and targets of lncRNAs in neuroblastoma (NB) progression still remain to be determined. In this study, we aimed to investigate the effect of lncRNA DLX6 antisense RNA 1 (DLX6-AS1) on NB and the underlying mechanis...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0968-x
更新日期:2019-11-27 00:00:00
abstract:BACKGROUND:Gastric cancer is one of the common cancers seen in south India. Unfortunately more than 90% are advanced by the time they report to a tertiary centre in the country. There is an urgent need to characterize these cancers and try to identify potential biomarkers and novel therapeutic targets. MATERIALS AND M...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-10-45
更新日期:2010-11-24 00:00:00
abstract:BACKGROUND:Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant and adjuvant chemotherapy; however, drug resistance often hinders therapy in OS patients. Also, the post-relapse survival of OS patients is as low as 20%. We the...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01720-y
更新日期:2021-01-14 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the anti-tumor effects of Ad/gTRAIL (an adenoviral vector in which expression of GFP and TRAIL is driven by a human telomerase reverse transcriptase promoter, hTERT) on malignant meningiomas and gliomas. BACKGROUND:Gliomas and meningiomas are the two most common ty...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-11-35
更新日期:2011-10-28 00:00:00