Emerging roles of RNA methylation in gastrointestinal cancers.

abstract：Background:Lung adenocarcinoma (LUAD) patients experiencing lymph node metastasis (LNM) always exhibit poor clinical outcomes. A biomarker or gene signature that could predict survival in these patients would have a substantial clinical impact, allowing for earlier detection of mortality risk and for individualized the...

journal_title：Cancer cell international

authors： Wang Y,Zhang Q,Gao Z,Xin S,Zhao Y,Zhang K,Shi R,Bao X

更新日期：2019-04-16 00:00:00

abstract：BACKGROUND:Without doubt, natural products have been, and still are, the cornerstone of the health care armamentarium. Of all natural sources, the marine environment is clearly the last great frontier for pharmaceutical and medical research. METHODS:This work progresses in the direction of identifying component(s) fro...

journal_title：Cancer cell international

authors： Dellai A,Deghrigue M,Laroche-Clary A,Masour HB,Chouchane N,Robert J,Bouraoui A

更新日期：2012-05-15 00:00:00

abstract：BACKGROUND:Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant and adjuvant chemotherapy; however, drug resistance often hinders therapy in OS patients. Also, the post-relapse survival of OS patients is as low as 20%. We the...

journal_title：Cancer cell international

authors： Saini H,Sharma H,Mukherjee S,Chowdhury S,Chowdhury R

更新日期：2021-01-14 00:00:00

abstract：BACKGROUND:Apigenin (4',5,7-trihydroxyflavone) was recently shown effective in inhibiting several cancers. The aim of this study was to investigate the effect and mechanism of apigenin in the human bladder cancer cell line T24 for the first time. METHODS:T24 cells were treated with varying concentrations and time of a...

journal_title：Cancer cell international

authors： Zhu Y,Mao Y,Chen H,Lin Y,Hu Z,Wu J,Xu X,Xu X,Qin J,Xie L

更新日期：2013-06-01 00:00:00

abstract：Background:The staging system of nasopharyngeal carcinoma (NPC) has close relationship with the degree of cell differentiation, but most NPC patients remain undiagnosed until advanced phases. Novel metabolic markers need to be characterized to support diagnose at an early stage. Methods:Metabolic characteristics of na...

journal_title：Cancer cell international

authors： Chen Y,Chen Z,Su Y,Lin D,Chen M,Feng S,Zou C

更新日期：2019-02-18 00:00:00

abstract：BACKGROUND:Urokinase-type Plasminogen Activator (uPA), a serine protease, plays a pivotal role in human breast cancer metastasis by mediating the degradation of extracellular matrix proteins and promoting cell motility. In more advanced breast cancers, uPA activity is significantly up regulated and serves as a prognost...

journal_title：Cancer cell international

authors： Candia BJ,Hines WC,Heaphy CM,Griffith JK,Orlando RA

更新日期：2006-05-31 00:00:00

abstract：BACKGROUND:Pancreatic cancer is currently one of the leading causes of cancer deaths without any effective therapies. Mir-145 has been found to be tumor-suppressive in various types of cancers. The aim of this study is to investigate the role of miR-145 in pancreatic cancer cells and explore its underlying mechanism. ...

journal_title：Cancer cell international

authors： Wang H,Hang C,Ou XL,Nie JS,Ding YT,Xue SG,Gao H,Zhu JX

更新日期：2016-08-25 00:00:00

abstract：BACKGROUND:Expression of P-glycoprotein (P-gp), the multidrug resistance (MDR) 1 gene product, can lead to multidrug resistance in tumours. However, the physiological role of P-gp in tumours growing as multicellular spheroids is not well understood. Recent evidence suggests that P-gp activity may be modulated by cellul...

journal_title：Cancer cell international

authors： Ponce de León V,Barrera-Rodríguez R

更新日期：2005-07-07 00:00:00

abstract：BACKGROUND:SATB1 is a nuclear protein that has been recently reported to be a 'genome organizer' which delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. In this study, the level of mRNA expression of SATB1 a...

journal_title：Cancer cell international

authors： Patani N,Jiang W,Mansel R,Newbold R,Mokbel K

更新日期：2009-07-30 00:00:00

abstract：BACKGROUND:Castration-resistance in prostate cancer (PC) is a critical event hallmarking a switch to a more aggressive phenotype. Neuroendocrine differentiation and upregulation of NFκB transcriptional activity are two mechanisms that have been independently linked to this process. METHODS:We investigated these two pa...

journal_title：Cancer cell international

authors： Patrikidou A,Vlachostergios PJ,Voutsadakis IA,Hatzidaki E,Valeri RM,Destouni C,Apostolou E,Daliani D,Papandreou CN

更新日期：2011-05-15 00:00:00

abstract：Background:Cutaneous melanoma is one of the most aggressive and lethal skin cancers. It is greatly important to identify prognostic biomarkers to guide the clinical management. However, it is technically challenging for untrained researchers to process high dimensional profiling data and identify potential prognostic g...

journal_title：Cancer cell international

authors： Zhang L,Wang Q,Wang L,Xie L,An Y,Zhang G,Zhu W,Li Y,Liu Z,Zhang X,Tang P,Huo X,Guo X

更新日期：2020-05-19 00:00:00

abstract：Background:Sarcomas are malignant heterogeneous tumors of mesenchymal derivation. Dedifferentiated liposarcoma (DDLPS) is aggressive with recurrence in 80% and metastasis in 20% of patients. We previously found that miR-133a was significantly underexpressed in liposarcoma tissues. As this miRNA has recently been shown ...

journal_title：Cancer cell international

authors： Yu PY,Lopez G,Braggio D,Koller D,Bill KLJ,Prudner BC,Zewdu A,Chen JL,Iwenofu OH,Lev D,Strohecker AM,Fenger JM,Pollock RE,Guttridge DC

更新日期：2018-06-26 00:00:00

abstract：Background:Oxidative stress is responsible for some alterations in the chemical structure and, consequently, in the function of proteins, lipids, and DNA. Recent studies have linked oxidative stress to cancers, particularly thyroid cancer, but the mechanisms remain unclear. Here, we further characterize the role of oxi...

journal_title：Cancer cell international

authors： Metere A,Frezzotti F,Graves CE,Vergine M,De Luca A,Pietraforte D,Giacomelli L

更新日期：2018-01-15 00:00:00

abstract：BACKGROUND:The aim of this study is to explore the expression of alpha-synuclein (α-synuclein) in benign, atypical, and anaplastic meningiomas and determine its role in the malignant progression of meningiomas. METHODS:Expression of α-synuclein was measured in 44 meningioma samples by real-time PCR analysis. The effec...

journal_title：Cancer cell international

authors： Ge Y,Xu K

更新日期：2016-11-15 00:00:00

abstract：Background:The hypoxic tumor microenvironment accelerates the invasion and migration of colorectal cancer (CRC) cells. The aim of this study was to develop and validate a hypoxia gene signature for predicting the outcome in stage I/II CRC patients that have limited therapeutic options. Methods:The hypoxic gene signatu...

journal_title：Cancer cell international

authors： Zou YF,Rong YM,Tan YX,Xiao J,Yu ZL,Chen YF,Ke J,Li CH,Chen X,Wu XJ,Lan P,Lin XT,Gao F

更新日期：2019-09-23 00:00:00

abstract：Background:In addition to morphological and cytogenetic features, acute myeloid leukemias are characterized by mutations that can be used for target-therapy; also the minimal/measurable residual disease (MRD) could be an important prognostic factor. The purpose of this retrospective study was to investigate if somatic ...

journal_title：Cancer cell international

authors： Salehzadeh S,Guerrini F,Pizzano U,Grassi S,Ciabatti E,Iovino L,Buda G,Caracciolo F,Benedetti E,Orciuolo E,Pelosini M,Consani G,Carulli G,Metelli MR,Martini F,Mazziotta F,Mazzantini E,Rossi P,Tavarozzi R,Ricci F,Pe

更新日期：2019-04-04 00:00:00

abstract：:BACKGROUND: The aim of this work was to investigate in vitro the putative role of EGR-1 in the growth of glioma cells. EGR-1 expression was examined during the early passages in vitro of 17 primary cell lines grown from 3 grade III and from 14 grade IV malignant astrocytoma explants. The explanted tumors were genetica...

journal_title：Cancer cell international

authors： Calogero A,Lombari V,De Gregorio G,Porcellini A,Ucci S,Arcella A,Caruso R,Gagliardi FM,Gulino A,Lanzetta G,Frati L,Mercola D,Ragona G

更新日期：2004-01-07 00:00:00

abstract：Background:To investigate the expression of RASSF-1A in oral squamous cell carcinoma (OSCC) and adjacent tissues, and to explore its mechanism of action in the development of OSCC. Methods:RASSF-1A and proliferation-related protein expression in clinical and OSCC mouse models were detected by qPCR and western blot. In...

journal_title：Cancer cell international

authors： Sun J

更新日期：2019-08-13 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) is the largest histological subgroup of lung cancer and has increased in prevalence in China over the past 5 years. The 5-year survival rate has remained at 15-20 %, with a median survival of 8-12 months. The tumorigenesis and progression of NSCLC is orchestrated by numerou...

journal_title：Cancer cell international

authors： Chen S,Li P,Yang R,Cheng R,Zhang F,Wang Y,Chen X,Sun Q,Zang W,Du Y,Zhao G,Zhang G

更新日期：2015-09-17 00:00:00

abstract：BACKGROUND:The incidence and mortalities from cancers remain on the rise worldwide. Despite significant efforts to discover and develop novel anticancer agents, many cancers remain in the unmet need category. As such, efforts to discover and develop new and more effective and less toxic agents against cancer remain a t...

journal_title：Cancer cell international

authors： Lowe HIC,Toyang NJ,Watson CT,Ayeah KN,Bryant J

更新日期：2017-03-07 00:00:00

abstract：Background:Programmed cell death 1 (PD-1) functions as an immune checkpoint in the process of anti-tumor immune response. The PD-1 blockade is now becoming a fundamental part in cancer immunotherapy. So it's essential to elicit the PD-1 related immune process in different types of cancer. Methods:The Cancer Genome Atl...

journal_title：Cancer cell international

authors： Shang J,Song Q,Yang Z,Sun X,Xue M,Chen W,Yang J,Wang S

更新日期：2018-12-27 00:00:00

abstract：BACKGROUND:miR-222 has been reported to be overexpressed in colorectal cancer and it influences cancer cell proliferation, drug resistance and metastasis. However, the underlying molecular mechanism of miR-222 in colorectal cancer cell invasion and migration has not been thoroughly elucidated to date. METHODS:The cell...

journal_title：Cancer cell international

authors： Gao H,Cong X,Zhou J,Guan M

更新日期：2017-08-29 00:00:00

abstract：Background:miR-429 and TLN1 have been shown to affect the biological behaviours of many carcinomas. However, their effects in nasopharyngeal carcinoma (NPC) are not yet clear. Here, we investigated their regulatory relationships and effects on NPC cells. Methods:TargetScan was used to predict the regulatory relationsh...

journal_title：Cancer cell international

authors： Wang Z,Zhu Z,Lin Z,Luo Y,Liang Z,Zhang C,Chen J,Peng P

更新日期：2019-04-30 00:00:00

abstract：BACKGROUND:Gastric cancer is one of the common cancers seen in south India. Unfortunately more than 90% are advanced by the time they report to a tertiary centre in the country. There is an urgent need to characterize these cancers and try to identify potential biomarkers and novel therapeutic targets. MATERIALS AND M...

journal_title：Cancer cell international

authors： Rajkumar T,Vijayalakshmi N,Gopal G,Sabitha K,Shirley S,Raja UM,Ramakrishnan SA

更新日期：2010-11-24 00:00:00

abstract：:Application of novel methods in cancer therapy is important in terms of management and treatment of the life-threatening disorder. It appears that autophagy is a potential target in cancer therapy, as a variety of drugs targeting autophagy have shown great potential in reducing the viability and proliferation of cance...

journal_title：Cancer cell international

authors： Ashrafizadeh M,Ahmadi Z,Farkhondeh T,Samarghandian S

更新日期：2020-11-04 00:00:00

abstract：OBJECTIVE:To explore the relationship between tumor necrosis factor receptor-associated factor 6 (TRAF6) and the clinicopathological features in HCC as well as its biological function. METHODS:Totally, 412 liver tissues were collected, including 171 hepatocellular carcinoma (HCC) and their corresponding non-tumor tiss...

journal_title：Cancer cell international

authors： Li JJ,Luo J,Lu JN,Liang XN,Luo YH,Liu YR,Yang J,Ding H,Qin GH,Yang LH,Dang YW,Yang H,Chen G

更新日期：2016-09-29 00:00:00

abstract：Background:Casticin, an isoflavone compound extracted from the herb Fructus Viticis, has demonstrated anti-inflammatory and anticancer activities and properties. The aim of this study was to investigate the effects and mechanisms of casticin in nasopharyngeal carcinoma (NPC) cells and to determine its potential for tar...

journal_title：Cancer cell international

authors： Liu J,Yang J,Hou Y,Zhu Z,He J,Zhao H,Ye X,Li D,Wu Z,Huang Z,Hao B,Yao K

更新日期：2019-12-21 00:00:00

abstract：Background:This study aims to investigate the role of microRNA-92a (miR-92a) in metastasis of osteosarcoma (OS) cells in vivo and in vitro by regulatingTCF21 with the transmission of bone marrow derived mesenchymal stem cells (BMSCs). Methods:BMSCs were isolated, purified and cultured from healthy adult bone marrow ti...

journal_title：Cancer cell international

authors： Cao S,Jiang L,Shen L,Xiong Z

更新日期：2019-02-12 00:00:00

abstract：:BACKGROUND: Mast cells are known to accumulate at sites of inflammation and upon activation to release their granule content, e.g. histamine, cytokines and proteases. The secretory leukocyte protease inhibitor (SLPI) is produced in the respiratory mucous and plays a role in regulating the activity of the proteases. RE...

journal_title：Cancer cell international

authors： Hollander C,Nyström M,Janciauskiene S,Westin U

更新日期：2003-08-20 00:00:00

abstract：BACKGROUND:CircRNAs play crucial roles in multiple tumours. However, the functions of most circRNAs in cervical cancer remain unclear. METHODS:This study collected GSE113696 data from the GEO database to search for differentially expressed circRNAs in cervical cancer. Quantitative reverse transcription PCR was used to...

journal_title：Cancer cell international

authors： Chen Y,Geng Y,Huang J,Xi D,Xu G,Gu W,Shao Y

更新日期：2021-01-07 00:00:00