Abstract：
Background:Cutaneous melanoma is one of the most aggressive and lethal skin cancers. It is greatly important to identify prognostic biomarkers to guide the clinical management. However, it is technically challenging for untrained researchers to process high dimensional profiling data and identify potential prognostic genes in profiling datasets. Methods:In this study, we developed a webserver to analyze the prognostic values of genes in cutaneous melanoma using data from TCGA and GEO databases. The webserver is named Online consensus Survival webserver for Skin Cutaneous Melanoma (OSskcm) which includes 1085 clinical melanoma samples. The OSskcm is hosted in a windows tomcat server. Server-side scripts were developed in Java script. The database system is managed by a SQL Server, which integrates gene expression data and clinical data. The Kaplan-Meier (KM) survival curves, Hazard ratio (HR) and 95% confidence interval (95%CI) were calculated in a univariate Cox regression analysis. Results:In OSskcm, by inputting official gene symbol and selecting proper options, users could obtain KM survival plot with log-rank P value and HR on the output web page. In addition, clinical characters including race, stage, gender, age and type of therapy could also be included in the prognosis analysis as confounding factors to constrain the analysis in a subgroup of melanoma patients. Conclusion:The OSskcm is highly valuable for biologists and clinicians to perform the assessment and validation of new or interested prognostic biomarkers for melanoma. OSskcm can be accessed online at: http://bioinfo.henu.edu.cn/Melanoma/MelanomaList.jsp.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Zhang L,Wang Q,Wang L,Xie L,An Y,Zhang G,Zhu W,Li Y,Liu Z,Zhang X,Tang P,Huo X,Guo Xdoi
10.1186/s12935-020-01262-3subject
Has Abstractpub_date
2020-05-19 00:00:00pages
176issn
1475-2867pii
1262journal_volume
20pub_type
杂志文章abstract：Background:Melanoma is an extremely aggressive malignant skin tumor with high mortality. Many types of long noncoding RNAs and microRNAs have been reported to be associated with the oncogenesis of melanoma. However, a novel lncRNA-NEAT has not been thoroughly investigated in melanoma cancer. The purposes of this study ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0927-6
更新日期：2019-08-22 00:00:00
abstract：Background:Colorectal cancer (CRC) is considered as the second common death-induced cancer. More recently, association of long non-coding RNAs (lncRNAs) with CRC has been extensively investigated. Therefore, the present study was performed to determine whether lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAF...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01485-4
更新日期：2020-10-19 00:00:00
abstract：BACKGROUND:G protein-coupled receptor family C group 5 member A (GPRC5A), a retinoic acid-inducible gene, is a lung tumor suppressor. Previously, we showed that repression of GPRC5A expression was associated with pathologic differentiation grade of oral squamous cell carcinomas (OSCC) and overexpression of GPRC5A gene ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-017-0406-x
更新日期：2017-03-02 00:00:00
abstract：Background:Lung adenocarcinoma (LUAD) patients experiencing lymph node metastasis (LNM) always exhibit poor clinical outcomes. A biomarker or gene signature that could predict survival in these patients would have a substantial clinical impact, allowing for earlier detection of mortality risk and for individualized the...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0822-1
更新日期：2019-04-16 00:00:00
abstract：Background:Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property. Cytosine deaminase (CD), which is derived from bacteria or yeast, can convert a relatively nontoxic prodrug 5-fluorocytosine (5-FC) into the active an...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01340-6
更新日期：2020-06-15 00:00:00
abstract：:Sineoculis homeobox homolog 1 (Six1), normally a developmentally restricted transcriptional regulator, is frequently dysregulated in mutiple cancers. Increasing evidences show that overexpression of Six1 plays a key role in tumorigenesis. However, the Six1 expression status and its relationship with the clinicopatholo...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-015-0215-z
更新日期：2015-06-20 00:00:00
abstract：Background:Hepatocellular carcinoma (HCC) is one of the most common malignancies with a high morbidity and mortality worldwide. MicroRNAs are key regulators of HCC genesis. However, the regulatory role and underlying mechanisms of microRNA in HCC is still limited. Methods:Cyclin B1 (CCNB1) mRNA levels were examined in...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0729-x
更新日期：2019-01-14 00:00:00
abstract：BACKGROUND:The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death. The role of these channels in the onset and progression of ovarian cancer is unknown. An understanding of mechanism by whi...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-11-6
更新日期：2011-03-10 00:00:00
abstract：Background:Programmed cell death 1 (PD-1) functions as an immune checkpoint in the process of anti-tumor immune response. The PD-1 blockade is now becoming a fundamental part in cancer immunotherapy. So it's essential to elicit the PD-1 related immune process in different types of cancer. Methods:The Cancer Genome Atl...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-018-0712-y
更新日期：2018-12-27 00:00:00
abstract：:Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha (HIF-1α) is a major regulator of cellular response to changes in oxygen concentration, supporting the adaptation of tumor cells to hypoxia in...
journal_title：Cancer cell international
pub_type： 杂志文章,评审
doi：10.1186/s12935-020-01370-0
更新日期：2020-06-24 00:00:00
abstract：Background:Despite improvements in nasopharyngeal carcinoma (NPC) treatment, patients with recurrence and metastasis still have a poor prognosis. Thus, the identification of novel biomarkers is urgently needed to predict outcomes and tailor treatment for NPC. Methods:Four data sets were downloaded from Gene Expression...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01587-z
更新日期：2020-10-12 00:00:00
abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is an aggressive cancer with high mortality and morbidity worldwide. The limited clinically relevant model has impeded the development of effective HCC treatment strategy. Patient-derived xenograft (PDX) models retain most of the characteristics of original tumors and were show...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-016-0322-5
更新日期：2016-06-08 00:00:00
abstract：Background:T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood. In this study, we tried to explore the physiological role of CD59 in T-ALL. Methods:In this study, we collected the bone marrow samples from 17 T-A...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-018-0714-9
更新日期：2019-01-08 00:00:00
abstract：Background:Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case-control study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) in TNFAIP8 on...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0827-9
更新日期：2019-04-23 00:00:00
abstract：Background:Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies and a major cause of cancer related death worldwide, especially in China. Cell lines are widely used disease models for basic medical research, however, well characterized ESCC cell models from China were seldom reported. Mis...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01268-x
更新日期：2020-05-24 00:00:00
abstract：Background:MicroRNA (MiRNA) is a small non-coding RNA which is implicated in a cohort of biological function in cancer, including proliferation, metastasis, apoptosis and invasion. MiR-96 has been reported to be involved in many cancers, including papillary thyroid cancer. However, the role of miR-96-3p in papillary th...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-1003-y
更新日期：2019-11-12 00:00:00
abstract：BACKGROUND:The incidence and mortalities from cancers remain on the rise worldwide. Despite significant efforts to discover and develop novel anticancer agents, many cancers remain in the unmet need category. As such, efforts to discover and develop new and more effective and less toxic agents against cancer remain a t...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-017-0404-z
更新日期：2017-03-07 00:00:00
abstract：Background:Recent studies have emphasized the important prognostic role of long noncoding RNAs (lncRNAs) in various types of cancers. Here we conducted a meta-analysis to investigate whether lncRNA HOXA11-AS can be served as a prognostic biomarker in human cancers. Patients/methods:We systematically searched PubMed, E...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-017-0498-3
更新日期：2018-01-03 00:00:00
abstract：BACKGROUND:Alterations in the processing of the genetic information in carcinogenesis result from stable genetic mutations or epigenetic modifications. It is becoming clear that nucleosomal histones are central to proper gene expression and that aberrant DNA methylation of genes and histone methylation plays important ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-8-15
更新日期：2008-11-03 00:00:00
abstract：Background:Retinoblastoma (RB) is acknowledged to be the commonest intraocular malignancy in infants and children and the outcome of RB patients is unfavorable due to limited early diagnosis and effective therapy. SMAD family member 6 (SMAD6) has been reported in the initiation and progression of human cancers by actin...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-1103-8
更新日期：2020-01-22 00:00:00
abstract：Background:Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Siah E3 ubiquitin protein ligase 1 (Siah1) has been identified as a tumor suppressor gene and plays an important role in the development of malignant tumors. However, the potential role and molecular mechanism of Siah1 in the de...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-1124-3
更新日期：2020-02-13 00:00:00
abstract：:Prostate cancer is a gland tumor in the male reproductive system. It is a multifaceted and genomically complex disease. Transmembrane protease, serine 2 and v-ets erythroblastosis virus E26 homolog (TMPRSS2-ERG) gene fusions are the common molecular signature of prostate cancer. Although tremendous advances have been ...
journal_title：Cancer cell international
pub_type： 杂志文章,评审
doi：10.1186/1475-2867-14-34
更新日期：2014-04-17 00:00:00
abstract：BACKGROUND:While some risk factors for breast cancer are well-known, the influence of other factors, particularly virus infection, remains unclear. Human cytomegalovirus (HCMV) is widespread in the general population, and both molecular and epidemiological evidence has indicated links between HCMV and breast cancer. Th...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-017-0399-5
更新日期：2017-02-13 00:00:00
abstract：Background:Endometrial cancer (EC) is the fourth most common malignancy of the female genital tract worldwide. MicroRNAs are important gene regulators with critical roles in diverse biological processes, including tumorigenesis. Several study's show that miR-139-5p is involved in the tumorigenesis and metastasis of var...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-018-0545-8
更新日期：2018-04-02 00:00:00
abstract：Background:The hypoxic tumor microenvironment accelerates the invasion and migration of colorectal cancer (CRC) cells. The aim of this study was to develop and validate a hypoxia gene signature for predicting the outcome in stage I/II CRC patients that have limited therapeutic options. Methods:The hypoxic gene signatu...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0964-1
更新日期：2019-09-23 00:00:00
abstract：Background:Estrogen sulfotransferase catalyzes conjugation of sulfuryl-group to estradiol/estrone and regulates E2 availability/activity via estrogen-receptor or non-receptor mediated pathways. Sulfoconjugated estrogen fails to bind estrogen-receptor (ER). High estrogen is a known carcinogen in postmenopausal women. Re...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-1153-y
更新日期：2020-03-04 00:00:00
abstract：BACKGROUND:Tumor tissue resembles chronically inflamed tissue. Since chronic inflammatory conditions are a strong stimulus for bone marrow-derived cells (BMDCs) it can be assumed that recruitment of BMDCs into cancer tissue should be a common phenomenon. Several data have outlined that BMDC can influence tumor growth a...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-11-21
更新日期：2011-06-28 00:00:00
abstract：Background:Helicobacter pylori (H. pylori)-induced gastric cancer is an intricate progression of immune response against H. pylori infection. IL-16, TGF-β1 and TLR4 pathways were the mediators involved in the immune response. We hypothesized that genetic variations in genes of these pathways have potential susceptibili...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-018-0682-0
更新日期：2018-11-20 00:00:00
abstract：Background:Osteosarcoma (OS) is still a disease with high mortality from malignant tumors in children and adolescents. Due to its poor treatment, this study explored the involvement of lncRNA ZFAS1/microRNA-135a (miR-135a)/apurinic/apyrimidinic exonuclease 1 (APEX1) axis in the regulation of OS growth and metastasis. ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-1049-x
更新日期：2019-12-03 00:00:00
abstract：BACKGROUND:Natural killer (NK) cells eliminate virus-infected and tumor cells through the release of perforins and granzymes; they also produce Interferon gamma (IFN-γ) and Tumor necrosis factor alpha (TNF-α), which induce apoptosis in target cells. Many tumors express Heme oxygenase 1 (HO-1), and this expression has b...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-014-0100-1
更新日期：2014-10-01 00:00:00
