Downregulation of long non-coding RNA MAFG-AS1 represses tumorigenesis of colorectal cancer cells through the microRNA-149-3p-dependent inhibition of HOXB8.

abstract：BACKGROUND:Cancer cells, even in the presence of available oxygen, have a glycolysis enhancement. The "aerobic glycolysis" is known as the Warburg effect and it is considered one of the fundamental hallmarks of metabolic alteration during malignant transformation. A feature of many tumors is also a change into ions equ...

journal_title：Cancer cell international

authors： Bruni L,Babarinde AA,Ortalli I,Croci S

更新日期：2014-08-12 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the anti-tumor effects of Ad/gTRAIL (an adenoviral vector in which expression of GFP and TRAIL is driven by a human telomerase reverse transcriptase promoter, hTERT) on malignant meningiomas and gliomas. BACKGROUND:Gliomas and meningiomas are the two most common ty...

journal_title：Cancer cell international

authors： Li JT,Bian K,Zhang AL,Kim DH,Ashley WW,Nath R,McCutcheon I,Fang B,Murad F

更新日期：2011-10-28 00:00:00

abstract：BACKGROUND:LncRNA HOXA-AS2 has been found in the literature to deteriorate glioblastoma. However, its regulatory mechanism is yet to be fully investigated. Our study focused chiefly on the interaction and role of the HOXA-AS2/miR-885-5p/RBBP4 axis in the development of glioblastoma. METHODS:qRT-PCR analysis was perfor...

journal_title：Cancer cell international

authors： Shou J,Gao H,Cheng S,Wang B,Guan H

更新日期：2021-01-11 00:00:00

abstract：Background:Kinesin superfamily (KIFs) has a long-reported significant influence on the initiation, development, and progress of breast cancer. However, the prognostic value of whole family members was poorly done. Our study intends to demonstrate the value of kinesin superfamily members as prognostic biomarkers as well...

journal_title：Cancer cell international

authors： Li TF,Zeng HJ,Shan Z,Ye RY,Cheang TY,Zhang YJ,Lu SH,Zhang Q,Shao N,Lin Y

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:We have previously shown that ultraviolet-A (UVA) radiation enhances metastatic lung colonization capacity of B16-F1 melanoma cells. The aim of this study was to examine changes in expression profile of genes in mouse melanoma B16-F1 cells exposed to UVA radiation. RESULTS:B16-F1 melanoma cells were exposed...

journal_title：Cancer cell international

authors： Pastila R,Leszczynski D

更新日期：2007-05-02 00:00:00

abstract：Background:Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies and a major cause of cancer related death worldwide, especially in China. Cell lines are widely used disease models for basic medical research, however, well characterized ESCC cell models from China were seldom reported. Mis...

journal_title：Cancer cell international

authors： Li X,Tian D,Guo Y,Qiu S,Xu Z,Deng W,Su M

更新日期：2020-05-24 00:00:00

abstract：Background:Cutaneous melanoma is one of the most aggressive and lethal skin cancers. It is greatly important to identify prognostic biomarkers to guide the clinical management. However, it is technically challenging for untrained researchers to process high dimensional profiling data and identify potential prognostic g...

journal_title：Cancer cell international

authors： Zhang L,Wang Q,Wang L,Xie L,An Y,Zhang G,Zhu W,Li Y,Liu Z,Zhang X,Tang P,Huo X,Guo X

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:Resistance to drug therapy is a major impediment for successful treatment of patients suffering from breast cancer (BC). Tamoxifen (TAM) is an extensively used therapeutic agent, which substantially reduces the risk of recurrence and associated mortality in BC. This study demonstrated that exosomal transfer ...

journal_title：Cancer cell international

authors： Liu J,Zhu S,Tang W,Huang Q,Mei Y,Yang H

更新日期：2021-01-15 00:00:00

abstract：: Autoimmune phenomena were identified in many different cases of hematological diseases and solid tumors, which may be due to alterations in the expression and function of the NF-κB signaling pathway. Recently, a number of studies have shown that the deletion or mutation of A20, a negative regulator of NF-κB, is frequ...

journal_title：Cancer cell international

authors： Zhang F,Yang L,Li Y

更新日期：2012-11-07 00:00:00

abstract：BACKGROUND:Increased expression of voltage-gated sodium channels (VGSCs) have been implicated with strong metastatic potential of human breast cancer in vitro and in vivo where the main culprits are cardiac isoform Nav1.5 and its 'neonatal' splice variant, nNav1.5. Several factors have been associated with Nav1.5 and n...

journal_title：Cancer cell international

authors： Kamarulzaman NS,Dewadas HD,Leow CY,Yaacob NS,Mokhtar NF

更新日期：2017-08-01 00:00:00

abstract：Background:Accumulating studies showed that long noncoding RNAs (lncRNAs) played vital roles in cancer progression. LncRNA MIR4435-2HG was proved to act as an oncogene in various tumors. However, the underlying function of MIR4435-2HG in ovarian cancer (OC) remains unclear. Methods:The expression levels of MIR4435-2HG...

journal_title：Cancer cell international

authors： Zhu L,Wang A,Gao M,Duan X,Li Z

更新日期：2020-05-01 00:00:00

abstract：Background:Programmed cell death 1 (PD-1) functions as an immune checkpoint in the process of anti-tumor immune response. The PD-1 blockade is now becoming a fundamental part in cancer immunotherapy. So it's essential to elicit the PD-1 related immune process in different types of cancer. Methods:The Cancer Genome Atl...

journal_title：Cancer cell international

authors： Shang J,Song Q,Yang Z,Sun X,Xue M,Chen W,Yang J,Wang S

更新日期：2018-12-27 00:00:00

abstract：Background:T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood. In this study, we tried to explore the physiological role of CD59 in T-ALL. Methods:In this study, we collected the bone marrow samples from 17 T-A...

journal_title：Cancer cell international

authors： Jia Y,Qi Y,Wang Y,Ma X,Xu Y,Wang J,Zhang X,Gao M,Cong B,Han S

更新日期：2019-01-08 00:00:00

abstract：Background:Tumor necrosis factor-α (TNF-α) immunotherapy controls the progression of human cervical cancer. Here, we explored the detailed molecular mechanisms played by melatonin in human cervical cancer (HeLa cells) death in the presence of TNF-α injury, with a particular attention to the mitochondrial homeostasis. ...

journal_title：Cancer cell international

authors： Zhao Q,Wang W,Cui J

更新日期：2019-03-14 00:00:00

abstract：Background:Lung cancer is the most common malignant tumor in the world. The Whole-proteome microarray showed that ubiquitin ligase chromatin assembly factor 1 subunit B (CHAF1B) expression in A549/DDP cells is higher than in A549 cells. Our study explored the molecular mechanism of CHAF1B affecting cisplatin resistance...

journal_title：Cancer cell international

authors： Gong L,Hu Y,He D,Zhu Y,Xiang L,Xiao M,Bao Y,Liu X,Zeng Q,Liu J,Zhou M,Zhou Y,Cheng Y,Zhang Y,Deng L,Zhu R,Lan H,Cao K

更新日期：2020-05-25 00:00:00

abstract：BACKGROUND:Pancreatic cancer is currently one of the leading causes of cancer deaths without any effective therapies. Mir-145 has been found to be tumor-suppressive in various types of cancers. The aim of this study is to investigate the role of miR-145 in pancreatic cancer cells and explore its underlying mechanism. ...

journal_title：Cancer cell international

authors： Wang H,Hang C,Ou XL,Nie JS,Ding YT,Xue SG,Gao H,Zhu JX

更新日期：2016-08-25 00:00:00

abstract：Background:The crucial role of long non-coding RNAs (lncRNAs) has been certified in human cancers. The lncRNAs with abnormal expressions could act as tumor inhibitors or oncogenes in the advancement of tumors. LBX2-AS1 was once reported to accelerate esophageal squamous cell carcinoma. Nonetheless, its function in gast...

journal_title：Cancer cell international

authors： Xu G,Zhang Y,Li N,Wu Y,Zhang J,Xu R,Ming H

更新日期：2020-04-26 00:00:00

abstract：BACKGROUND:MicroRNAs are 22-24 nt non-coding RNAs that bind to the 3' UTR of target mRNAs, thereby inducing mRNA degradation or inhibiting mRNA translation. Due to their implication in the regulation of post-transcriptional processes, the role of miRNAs in hepatocellular carcinoma (HCC) has been extensively studied. Ho...

journal_title：Cancer cell international

authors： Wu W,Liu S,Liang Y,Zhou Z,Liu X

更新日期：2017-02-21 00:00:00

abstract：:BACKGROUND: The aim of this work was to investigate in vitro the putative role of EGR-1 in the growth of glioma cells. EGR-1 expression was examined during the early passages in vitro of 17 primary cell lines grown from 3 grade III and from 14 grade IV malignant astrocytoma explants. The explanted tumors were genetica...

journal_title：Cancer cell international

authors： Calogero A,Lombari V,De Gregorio G,Porcellini A,Ucci S,Arcella A,Caruso R,Gagliardi FM,Gulino A,Lanzetta G,Frati L,Mercola D,Ragona G

更新日期：2004-01-07 00:00:00

abstract：Background:Thyroid cancer (TC) is the most frequent endocrine malignancy. Long noncoding RNAs (lncRNAs) have been confirmed to act as significant roles in tumor development. The role of lncRNA TMPO-AS1 in TC is still unclear, so it remains to be explored. The aim of the research is to investigate the role and regulator...

journal_title：Cancer cell international

authors： Li Z,Feng Y,Zhang Z,Cao X,Lu X

更新日期：2020-07-08 00:00:00

abstract：:N6-methyl-adenosine(m6A) modification emerges as an abundant and dynamic regulation throughout the Eukaryotic transcriptome. Dysregulation of the m6A regulators has increasingly been found in many neoplasms. It is reasonable to believe that m6A changes the fate of cancer cells and subsequently affected all aspects of ...

journal_title：Cancer cell international

authors： Yang G,Sun Z,Zhang N

更新日期：2020-07-29 00:00:00

abstract：Background:Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case-control study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) in TNFAIP8 on...

journal_title：Cancer cell international

authors： Liu T,Jiang L,Yu L,Ge T,Wang J,Gao H

更新日期：2019-04-23 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma is a common cancer, ranking third in cancer-associated deaths. An important cause of cancer patients' mortality is metastasis. At the start of metastasis progression, there is an epithelial-mesenchymal transition, characterized by matrix degradation, junction reductions and vessels f...

journal_title：Cancer cell international

authors： Angiolini VA,Cruz CU,López ML,Simon L,Matte U

更新日期：2017-01-04 00:00:00

abstract：Background:MicroRNAs (miRNAs) play key roles in tumorigenesis and progression of gastric cancer (GC). miR-1269 has been reported to be upregulated in several cancers and plays a crucial role in carcinogenesis and cancer progression. However, the biological function of miR-1269 in human GC and its mechanism remain uncle...

journal_title：Cancer cell international

authors： Liu WL,Wang HX,Shi CX,Shi FY,Zhao LY,Zhao W,Wang GH

更新日期：2019-11-21 00:00:00

abstract：BACKGROUND:Mutational inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene has been linked to hereditary as well as sporadic clear cell renal carcinomas. The product of the VHL gene, pVHL, acts to target hypoxia-inducible factor alpha (HIF-alpha) subunits for ubiquitination and subsequent degradation. Usin...

journal_title：Cancer cell international

authors： Hughes MD,Kapllani E,Alexander AE,Burk RD,Schoenfeld AR

更新日期：2007-06-28 00:00:00

abstract：BACKGROUND:In this report the phytochemical profile of Nitraria. Retusa (N. Retusa) leaf extracts were identified and their ability to induce apoptosis in human chronic myelogenous erythroleukaemia (K562) was evaluated. METHODS:Apoptosis of the human chronic myelogenous erythroleukaemia (K562) was evidenced by investi...

journal_title：Cancer cell international

authors： Boubaker J,Bhouri W,Sghaier MB,Bouhlel I,Skandrani I,Ghedira K,Chekir-Ghedira L

更新日期：2011-10-31 00:00:00

abstract：:miRNAs, a major class of small noncoding RNAs approximately 18-25 nucleotides in length, function by repressing the expression of target genes through binding to complementary sequences in the 3'-UTRs of target genes. Emerging evidence has highlighted their important roles in numerous diseases, including human cancers...

journal_title：Cancer cell international

authors： Yu Y,Cao XC

更新日期：2019-10-07 00:00:00

abstract：BACKGROUND:The expression of major histocompatibility complex class II (MHCII) antigens in both mouse and human tumors is rare, and these antigens are not easily inducible by IFN-gamma (IFNg). Since MHCII may play an important role in the development of host antitumor immune response, we explored the possibility of res...

journal_title：Cancer cell international

authors： Kudinov Y,Wiseman CL,Kharazi AI

更新日期：2003-03-25 00:00:00

abstract：BACKGROUND:Ca2+ is known to be involved in a number of metastatic processes including motility and proliferation which can result in store-depletion of Ca2+. Up regulation of genes which contribute to store operated channel (SOC) activity may plausibly be necessary for these processes to take place efficiently. TRPC pr...

journal_title：Cancer cell international

authors： Aydar E,Yeo S,Djamgoz M,Palmer C

更新日期：2009-08-18 00:00:00

abstract：BACKGROUND:Mononuclear platinum anticancer agents hold a pivotal place in the treatment of many forms of cancers, however, there is a potential to improve response to evade resistance development and toxic side effects. BBR3464 is a promising trinuclear platinum anticancer agent, which is a polyamine mimic. The aim was...

journal_title：Cancer cell international

authors： Kjellström J,Oredsson SM,Wennerberg J

更新日期：2012-05-28 00:00:00