The role of A20 in the pathogenesis of lymphocytic malignancy.

abstract：Background:Dysregulation of lncRNAs is frequent in glioma and has emerged as an important mechanism involved in tumorigenesis. Previous analysis of Chinese Glioma Genome Atlas (CGGA) database indicated that LBX2-AS1 expression is one of differentially expression lncRNA between lower grade glioma (LGG) (grade II and III...

journal_title：Cancer cell international

authors： Chen Q,Gao J,Zhao Y,Hou R

更新日期：2020-08-26 00:00:00

abstract：BACKGROUND:Chemoresistance is a major obstacle to successful chemotherapy for colorectal cancer. Eukaryotic translation initiation factor 5A2 (eIF5A2), one of the two isoforms in the eIF5A family, has been reported to be a new oncogene in many types of human cancer. In the present study, we aimed to investigate whether...

journal_title：Cancer cell international

authors： Bao Y,Lu Y,Wang X,Feng W,Sun X,Guo H,Tang C,Zhang X,Shi Q,Yu H

更新日期：2015-11-17 00:00:00

abstract：Background:Chimeric antigen receptors (CARs) represent a novel facet of modern day synthetic biology that exemplifies personalized medicine at work through their ability to harness and redirect a patient's immune system to fight cancer. Body:By combining the target-specificity of antibodies to the effector capabilitie...

journal_title：Cancer cell international

authors： Leyfman Y

更新日期：2018-11-14 00:00:00

abstract：BACKGROUND:Alterations in the processing of the genetic information in carcinogenesis result from stable genetic mutations or epigenetic modifications. It is becoming clear that nucleosomal histones are central to proper gene expression and that aberrant DNA methylation of genes and histone methylation plays important ...

journal_title：Cancer cell international

authors： Watanabe H,Soejima K,Yasuda H,Kawada I,Nakachi I,Yoda S,Naoki K,Ishizaka A

更新日期：2008-11-03 00:00:00

abstract：BACKGROUND:Resistance to drug therapy is a major impediment for successful treatment of patients suffering from breast cancer (BC). Tamoxifen (TAM) is an extensively used therapeutic agent, which substantially reduces the risk of recurrence and associated mortality in BC. This study demonstrated that exosomal transfer ...

journal_title：Cancer cell international

authors： Liu J,Zhu S,Tang W,Huang Q,Mei Y,Yang H

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND:The digallic acid (DGA) purified from Pistacia lentiscus. L fruits was investigated for its antiproliferative and apoptotic activities on human lymphoblastoid TK6 cells. METHODS:We attempt to characterize the apoptotic pathway activated by DGA. Apoptosis was detected by DNA fragmentation, PARP cleavage and ...

journal_title：Cancer cell international

authors： Bhouri W,Boubaker J,Skandrani I,Ghedira K,Chekir Ghedira L

更新日期：2012-06-11 00:00:00

abstract：Background:Retinoblastoma (RB) is acknowledged to be the commonest intraocular malignancy in infants and children and the outcome of RB patients is unfavorable due to limited early diagnosis and effective therapy. SMAD family member 6 (SMAD6) has been reported in the initiation and progression of human cancers by actin...

journal_title：Cancer cell international

authors： Wang H,Ji X

更新日期：2020-01-22 00:00:00

abstract：BACKGROUND:Gastric cancer is one of the common cancers seen in south India. Unfortunately more than 90% are advanced by the time they report to a tertiary centre in the country. There is an urgent need to characterize these cancers and try to identify potential biomarkers and novel therapeutic targets. MATERIALS AND M...

journal_title：Cancer cell international

authors： Rajkumar T,Vijayalakshmi N,Gopal G,Sabitha K,Shirley S,Raja UM,Ramakrishnan SA

更新日期：2010-11-24 00:00:00

abstract：Background:In addition to morphological and cytogenetic features, acute myeloid leukemias are characterized by mutations that can be used for target-therapy; also the minimal/measurable residual disease (MRD) could be an important prognostic factor. The purpose of this retrospective study was to investigate if somatic ...

journal_title：Cancer cell international

authors： Salehzadeh S,Guerrini F,Pizzano U,Grassi S,Ciabatti E,Iovino L,Buda G,Caracciolo F,Benedetti E,Orciuolo E,Pelosini M,Consani G,Carulli G,Metelli MR,Martini F,Mazziotta F,Mazzantini E,Rossi P,Tavarozzi R,Ricci F,Pe

更新日期：2019-04-04 00:00:00

abstract：OBJECTIVES:Bladder transitional cell carcinoma (TCC) is one of the most common solid malignancies in China. This study examined the antitumor effect and underlying mechanism of action of sunitinib malate in human bladder TCC in vitro. METHODS:Bladder TCC cell lines 5637 and BIU87 were maintained in 1640 medium and T24...

journal_title：Cancer cell international

authors： Wen J,Li HZ,Ji ZG,Jin J

更新日期：2015-02-28 00:00:00

abstract：Background:Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case-control study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) in TNFAIP8 on...

journal_title：Cancer cell international

authors： Liu T,Jiang L,Yu L,Ge T,Wang J,Gao H

更新日期：2019-04-23 00:00:00

abstract：BACKGROUND:The thieno[2,3-b]pyridines were discovered by virtual high throughput screening as potential inhibitors of phospholipase C (PLC) isoforms and showed potent growth inhibitory effects in National Cancer Institute's human tumour cell line panel (NCI60). The mechanism of the anti-proliferative activity of thieno...

journal_title：Cancer cell international

authors： Reynisson J,Jaiswal JK,Barker D,D'mello SA,Denny WA,Baguley BC,Leung EY

更新日期：2016-03-10 00:00:00

abstract：BACKGROUND:SATB1 is a nuclear protein that has been recently reported to be a 'genome organizer' which delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. In this study, the level of mRNA expression of SATB1 a...

journal_title：Cancer cell international

authors： Patani N,Jiang W,Mansel R,Newbold R,Mokbel K

更新日期：2009-07-30 00:00:00

abstract：Background:Colorectal cancer (CRC) is considered as the second common death-induced cancer. More recently, association of long non-coding RNAs (lncRNAs) with CRC has been extensively investigated. Therefore, the present study was performed to determine whether lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAF...

journal_title：Cancer cell international

authors： Ruan Z,Deng H,Liang M,Xu Z,Lai M,Ren H,Deng X,Su X

更新日期：2020-10-19 00:00:00

abstract：Background:Long non-coding RNAs (lncRNAs) play significant roles in tumorigenesis and can contribute to identification of novel therapeutic targets for cancers. This paper was aimed at exploring the role of CTBP1 divergent transcript (CTBP1-AS2) in cervical cancer (CC) progression. Methods:qRT-PCR and western blot ass...

journal_title：Cancer cell international

authors： Yang S,Shi F,Du Y,Wang Z,Feng Y,Song J,Liu Y,Xiao M

更新日期：2020-07-28 00:00:00

abstract：Background:Cholangiocarcinoma (CCA) is an invasive malignancy arising from biliary epithelial cells; it is the most common primary tumour of the bile tract and has a poor prognosis. The aim of this study was to screen prognostic biomarkers for CCA by integrated multiomics analysis. Methods:The GSE32225 dataset was der...

journal_title：Cancer cell international

authors： Da Z,Gao L,Su G,Yao J,Fu W,Zhang J,Zhang X,Pei Z,Yue P,Bai B,Lin Y,Meng W,Li X

更新日期：2020-04-22 00:00:00

abstract：Background:Recent studies have emphasized the important prognostic role of long noncoding RNAs (lncRNAs) in various types of cancers. Here we conducted a meta-analysis to investigate whether lncRNA HOXA11-AS can be served as a prognostic biomarker in human cancers. Patients/methods:We systematically searched PubMed, E...

journal_title：Cancer cell international

authors： Mu S,Ai L,Fan F,Sun C,Hu Y

更新日期：2018-01-03 00:00:00

abstract：:Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of proteins, involved in inhibition of apoptosis and regulation of cell cycle. These functional attributes make Survivin a unique protein exhibiting divergent functions i.e. regulating cell proliferation and cell death. Expression pattern of Su...

journal_title：Cancer cell international

authors： Garg H,Suri P,Gupta JC,Talwar GP,Dubey S

更新日期：2016-06-23 00:00:00

abstract：Background:Cutaneous melanoma is one of the most aggressive and lethal skin cancers. It is greatly important to identify prognostic biomarkers to guide the clinical management. However, it is technically challenging for untrained researchers to process high dimensional profiling data and identify potential prognostic g...

journal_title：Cancer cell international

authors： Zhang L,Wang Q,Wang L,Xie L,An Y,Zhang G,Zhu W,Li Y,Liu Z,Zhang X,Tang P,Huo X,Guo X

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:Natural killer (NK) cells eliminate virus-infected and tumor cells through the release of perforins and granzymes; they also produce Interferon gamma (IFN-γ) and Tumor necrosis factor alpha (TNF-α), which induce apoptosis in target cells. Many tumors express Heme oxygenase 1 (HO-1), and this expression has b...

journal_title：Cancer cell international

authors： Gómez-Lomelí P,Bravo-Cuellar A,Hernández-Flores G,Jave-Suárez LF,Aguilar-Lemarroy A,Lerma-Díaz JM,Domínguez-Rodríguez JR,Sánchez-Reyes K,Ortiz-Lazareno PC

更新日期：2014-10-01 00:00:00

abstract：:[This retracts the article DOI: 10.1186/s12935-015-0237-6.]. ...

journal_title：Cancer cell international

authors： Mirghasemi A,Taheriazam A,Karbasy SH,Torkaman A,Shakeri M,Yahaghi E,Mokarizadeh A

更新日期：2016-11-04 00:00:00

abstract：Background:In recent years, the B cell receptor (BCR) signaling pathway has become a "hot point" because it plays a critical role in B-cell proliferation and function. Bruton's tyrosine kinase (BTK) is overexpressed in many subtypes of B-cell lymphoma as a downstream kinase in the BCR signaling pathway. Ibrutinib, the ...

journal_title：Cancer cell international

authors： Xue C,Wang X,Zhang L,Qu Q,Zhang Q,Jiang Y

更新日期：2020-09-29 00:00:00

abstract：Background:Casticin, an isoflavone compound extracted from the herb Fructus Viticis, has demonstrated anti-inflammatory and anticancer activities and properties. The aim of this study was to investigate the effects and mechanisms of casticin in nasopharyngeal carcinoma (NPC) cells and to determine its potential for tar...

journal_title：Cancer cell international

authors： Liu J,Yang J,Hou Y,Zhu Z,He J,Zhao H,Ye X,Li D,Wu Z,Huang Z,Hao B,Yao K

更新日期：2019-12-21 00:00:00

abstract：Background:Thyroid cancer (TC) is the most frequent endocrine malignancy. Long noncoding RNAs (lncRNAs) have been confirmed to act as significant roles in tumor development. The role of lncRNA TMPO-AS1 in TC is still unclear, so it remains to be explored. The aim of the research is to investigate the role and regulator...

journal_title：Cancer cell international

authors： Li Z,Feng Y,Zhang Z,Cao X,Lu X

更新日期：2020-07-08 00:00:00

abstract：BACKGROUND:The incidence and mortalities from cancers remain on the rise worldwide. Despite significant efforts to discover and develop novel anticancer agents, many cancers remain in the unmet need category. As such, efforts to discover and develop new and more effective and less toxic agents against cancer remain a t...

journal_title：Cancer cell international

authors： Lowe HIC,Toyang NJ,Watson CT,Ayeah KN,Bryant J

更新日期：2017-03-07 00:00:00

abstract：Background:miR-429 and TLN1 have been shown to affect the biological behaviours of many carcinomas. However, their effects in nasopharyngeal carcinoma (NPC) are not yet clear. Here, we investigated their regulatory relationships and effects on NPC cells. Methods:TargetScan was used to predict the regulatory relationsh...

journal_title：Cancer cell international

authors： Wang Z,Zhu Z,Lin Z,Luo Y,Liang Z,Zhang C,Chen J,Peng P

更新日期：2019-04-30 00:00:00

abstract：Background:A number of JmjC domain-containing histone demethylases have been identified and biochemically characterized in mammalian models and humans. JMJD2A is a transcriptional co-factor and enzyme that catalyzes the demethylation of histone H3 lysine 9 and 36 (H3K9 and H3K36). Here in this study, we reported the ro...

journal_title：Cancer cell international

authors： Li M,Cheng J,Ma Y,Guo H,Shu H,Huang H,Kuang Y,Yang T

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma is a common cancer, ranking third in cancer-associated deaths. An important cause of cancer patients' mortality is metastasis. At the start of metastasis progression, there is an epithelial-mesenchymal transition, characterized by matrix degradation, junction reductions and vessels f...

journal_title：Cancer cell international

authors： Angiolini VA,Cruz CU,López ML,Simon L,Matte U

更新日期：2017-01-04 00:00:00

abstract：Background:Endometrial carcinoma (EC) is one of the three major malignant tumors of the female reproductive system. In recent years, the incidence and mortality rate of EC have increased. B-cell translocation gene 1 (BTG1) is an anti-proliferation gene that regulates the occurrence and development of a variety of tumor...

journal_title：Cancer cell international

authors： Li Y,Huo J,He J,Zhang Y,Ma X

更新日期：2020-10-07 00:00:00

abstract：Background:Nuclear transcription factor kappa B (NF-κB) subunits exhibit crucial roles in tumorigenesis and chemo-sensitivity. Recent studies suggest that RelB, the key subunit of the alternative NF-κB pathway, plays a critical role in the progression of diverse human malignancies. However, the significance of RelB in ...

journal_title：Cancer cell international

authors： Zhou X,Shan Z,Yang H,Xu J,Li W,Guo F

更新日期：2018-11-13 00:00:00