The role of A20 in the pathogenesis of lymphocytic malignancy.


: Autoimmune phenomena were identified in many different cases of hematological diseases and solid tumors, which may be due to alterations in the expression and function of the NF-κB signaling pathway. Recently, a number of studies have shown that the deletion or mutation of A20, a negative regulator of NF-κB, is frequently found in lymphomas, suggesting that it may be a linker between the altered immune response and leukemogenesis. The aim of this review is to summarize current findings of the A20 biological functions and its molecular mechanism as a tumor suppressor and immune regulator. The identification of A20 mutations and deletions in lymphocytic malignancy and the predictive significance of these aberrations are also reviewed.


Cancer Cell Int


Zhang F,Yang L,Li Y




Has Abstract


2012-11-07 00:00:00












  • Functional polymorphisms in LncRNA HOTAIR contribute to susceptibility of pancreatic cancer.

    abstract:Background:Pancreatic cancer (PC) remains one of the most aggressive cancers worldwide. However, genetic factors underlying PC susceptibility remain largely unclear. Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) acts as an oncogene and its genetic variation has been linked to many cancers. However, ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Jiang D,Xu L,Ni J,Zhang J,Cai M,Shen L

    更新日期:2019-02-28 00:00:00

  • Curcumin reduces mitomycin C resistance in breast cancer stem cells by regulating Bcl-2 family-mediated apoptosis.

    abstract:BACKGROUND:Curcumin, a natural compound derived from the turmeric rhizome Curcuma longa Linn, has anticancer and chemoresistance reduction biological activities. We evaluated the efficacy of curcumin in sensitizing chemotherapy drugs through regulation of Bcl-2-mediated apoptosis in breast cancer stem-like cells (BCSCs...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Zhou QM,Sun Y,Lu YY,Zhang H,Chen QL,Su SB

    更新日期:2017-09-26 00:00:00

  • CDK5 neutralizes the tumor suppressing effect of BIN1 via mediating phosphorylation of c-MYC at Ser-62 site in NSCLC.

    abstract:Background:Bridging integrator 1 (BIN1) has showed outstanding tumor-suppressive potential via inhibiting c-MYC-mediated tumorigenesis. However, a frequent phosphorylation of c-MYC at Ser-62 site could block the BIN1/c-MYC interaction and limits the tumor-suppressive effect of BIN1. Cyclin-dependent kinase 5 (CDK5), a ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Zhang X,Wang J,Jia Y,Liu T,Wang M,Lv W,Zhang R,Shi J,Liu L

    更新日期:2019-09-02 00:00:00

  • MicroRNA-4316 inhibits gastric cancer proliferation and migration via directly targeting VEGF-A.

    abstract:Background and aims:microRNAs (miRNAs) have been reported to regulate proliferation and migration by down-regulating the expression of target genes. The aims of this study were to investigate whether miR-4316 inhibited proliferation and migration by downregulating vascular endothelial growth factor A (VEGF-A) and its c...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Mousa H,Yuan M,Zhang X,Li X,Shopit A,Almoiliqy M,Alshwmi M,Al-Dherasi A,Xu Y,Zuo Y

    更新日期:2020-02-22 00:00:00

  • SENP1-mediated deSUMOylation of USP28 regulated HIF-1α accumulation and activation during hypoxia response.

    abstract:Background:The ubiquitin-specific protease 28 (USP28) is an oncogenic deubiquitinase, which plays a critical role in tumorigenesis via antagonizing the ubiquitination and degradation of tumor suppressor protein FBXW7-mediated oncogenic substrates. USP28 controls hypoxia-dependent angiogenesis and metastasis by preventi...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Du SC,Zhu L,Wang YX,Liu J,Zhang D,Chen YL,Peng Q,Liu W,Liu B

    更新日期:2019-01-03 00:00:00

  • LncRNA NEAT1 promotes proliferation, migration, invasion and epithelial-mesenchymal transition process in TGF-β2-stimulated lens epithelial cells through regulating the miR-486-5p/SMAD4 axis.

    abstract:BACKGROUND:Abnormal proliferation, metastasis and epithelial-mesenchymal transformation (EMT) of lens epithelial cells (LECs) are direct factors of posterior capsular opacification (PCO). Nuclear enriched abundant transcript 1 (NEAT1) has been shown to promote cell proliferation, metastasis and EMT, but whether it affe...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Wang H,Zheng G

    更新日期:2020-10-31 00:00:00

  • Long non-coding RNA CTBP1-AS2 enhances cervical cancer progression via up-regulation of ZNF217 through sponging miR-3163.

    abstract:Background:Long non-coding RNAs (lncRNAs) play significant roles in tumorigenesis and can contribute to identification of novel therapeutic targets for cancers. This paper was aimed at exploring the role of CTBP1 divergent transcript (CTBP1-AS2) in cervical cancer (CC) progression. Methods:qRT-PCR and western blot ass...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Yang S,Shi F,Du Y,Wang Z,Feng Y,Song J,Liu Y,Xiao M

    更新日期:2020-07-28 00:00:00

  • MiR-384 inhibits the proliferation of colorectal cancer by targeting AKT3.

    abstract:Background:Growing evidence suggests that MiRNAs play essential roles in the initiation and progression of colorectal cancer (CRC). The aberrant expression of miR-384 has been reported in some cancers. However, the role and mechanism of miR-384 in CRC proliferation remains unknown. Methods:The expression of miR-384 wa...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Wang YX,Zhu HF,Zhang ZY,Ren F,Hu YH

    更新日期:2018-09-03 00:00:00

  • Comprehensive characterization of the patient-derived xenograft and the paralleled primary hepatocellular carcinoma cell line.

    abstract:BACKGROUND:Hepatocellular carcinoma (HCC) is an aggressive cancer with high mortality and morbidity worldwide. The limited clinically relevant model has impeded the development of effective HCC treatment strategy. Patient-derived xenograft (PDX) models retain most of the characteristics of original tumors and were show...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Cheung PF,Yip CW,Ng LW,Lo KW,Chow C,Chan KF,Cheung TT,Cheung ST

    更新日期:2016-06-08 00:00:00

  • Silencing lncRNA ZFAS1 or elevated microRNA-135a represses proliferation, migration, invasion and resistance to apoptosis of osteosarcoma cells.

    abstract:Background:Osteosarcoma (OS) is still a disease with high mortality from malignant tumors in children and adolescents. Due to its poor treatment, this study explored the involvement of lncRNA ZFAS1/microRNA-135a (miR-135a)/apurinic/apyrimidinic exonuclease 1 (APEX1) axis in the regulation of OS growth and metastasis. ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Zhao Z,Lin X,Tong Y,Li W

    更新日期:2019-12-03 00:00:00

  • Targeting the angiotensin II type 2 receptor (AT2R) in colorectal liver metastases.

    abstract:BACKGROUND:Blockade of the angiotensin (ANG) II type 1 receptor (AT1R) inhibits tumour growth in several cancers, including colorectal cancer (CRC) liver metastases. While AT1R blockade has been extensively studied, the potential of targeting the antagonistically acting AT2R in cancer has not been investigated. This st...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Ager EI,Chong WW,Wen SW,Christophi C

    更新日期:2010-06-28 00:00:00

  • The BH3 mimetic drug ABT-737 induces apoptosis and acts synergistically with chemotherapeutic drugs in thyroid carcinoma cells.

    abstract:BACKGROUND:Patients with dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine are resistant to chemotherapeutic treatment and external irradiation and thus are difficult to treat. Direct induction of apoptosis is a promising approach in these apoptosis-resistant tumor cells. The BH3 mimeti...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Broecker-Preuss M,Becher-Boveleth N,Müller S,Mann K

    更新日期:2016-04-02 00:00:00

  • Caspase-2 is involved in cell death induction by taxanes in breast cancer cells.

    abstract:BACKGROUND:We studied the role of caspase-2 in apoptosis induction by taxanes (paclitaxel, novel taxane SB-T-1216) in breast cancer cells using SK-BR-3 (nonfunctional p53, functional caspase-3) and MCF-7 (functional p53, nonfunctional caspase-3) cell lines. RESULTS:Both taxanes induced apoptosis in SK-BR-3 as well as ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Jelínek M,Balušíková K,Kopperová D,Nĕmcová-Fürstová V,Šrámek J,Fidlerová J,Zanardi I,Ojima I,Kovář J

    更新日期:2013-05-15 00:00:00

  • Emerging roles of RNA methylation in gastrointestinal cancers.

    abstract::RNA methylation has emerged as a fundamental process in epigenetic regulation. Accumulating evidences indicate that RNA methylation is essential for many biological functions, and its dysregulation is associated with human cancer progression, particularly in gastrointestinal cancers. RNA methylation has a variety of b...

    journal_title:Cancer cell international

    pub_type: 杂志文章,评审


    authors: Xie S,Chen W,Chen K,Chang Y,Yang F,Lin A,Shu Q,Zhou T,Yan X

    更新日期:2020-12-07 00:00:00

  • The novel mTOR inhibitor CCI-779 (temsirolimus) induces antiproliferative effects through inhibition of mTOR in Bel-7402 liver cancer cells.

    abstract:BACKGROUND:Liver cancer is one of the most frequent cancers in the world. Targeted therapy of cancer with specific inhibitors is developing and has shown promising antitumor efficacy. CCI-779 (temsirolimus), a specific inhibitor of mTOR (mammalian target of rapamycin), can block the mTOR signaling pathway. Here, we sys...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Li S,Liang Y,Wu M,Wang X,Fu H,Chen Y,Wang Z

    更新日期:2013-03-28 00:00:00

  • Evidence that phospholipase C is involved in the antitumour action of NSC768313, a new thieno[2,3-b]pyridine derivative.

    abstract:BACKGROUND:The thieno[2,3-b]pyridines were discovered by virtual high throughput screening as potential inhibitors of phospholipase C (PLC) isoforms and showed potent growth inhibitory effects in National Cancer Institute's human tumour cell line panel (NCI60). The mechanism of the anti-proliferative activity of thieno...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Reynisson J,Jaiswal JK,Barker D,D'mello SA,Denny WA,Baguley BC,Leung EY

    更新日期:2016-03-10 00:00:00

  • Observations on the expression of human papillomavirus major capsid protein in HeLa cells.

    abstract:BACKGROUND:The goal of this study was to identify the nature of the inclusion bodies that have been found in HeLa cells (cervical cancer immortal cell line) by electron microscope and to determine whether the major capsid protein (L1) of human papillomavirus (HPV) can be expressed in HPV-positive uterine cervix cancer ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Xiao CY,Fu BB,Li ZY,Mushtaq G,Kamal MA,Li JH,Tang GC,Xiao SS

    更新日期:2015-05-23 00:00:00

  • Prognostic value of CD44 expression in patients with hepatocellular carcinoma: meta-analysis.

    abstract:BACKGROUND:CD44 has been reported to be involved with tumor growth and metastasis and has also been implicated as a CSC marker in hepatocellular carcinoma (HCC). However, the prognostic value of CD44 still remains controversial; hence, we investigated the correlation between CD44 and the clinicopathological features of...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Luo Y,Tan Y

    更新日期:2016-06-17 00:00:00

  • TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response.

    abstract:Background:Emergence of resistance to molecular targeted therapy constitutes a limitation to clinical benefits in cancer treatment. Cross-resistance commonly happens with chemotherapeutic agents but might not with targeted agents. Methods:In the current study, TP53 wild-type cell lines with druggable MAPK pathway muta...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Wu CE,Koay TS,Ho YH,Lovat P,Lunec J

    更新日期:2019-03-07 00:00:00

  • Co-cultivation of murine BMDCs with 67NR mouse mammary carcinoma cells give rise to highly drug resistant cells.

    abstract:BACKGROUND:Tumor tissue resembles chronically inflamed tissue. Since chronic inflammatory conditions are a strong stimulus for bone marrow-derived cells (BMDCs) it can be assumed that recruitment of BMDCs into cancer tissue should be a common phenomenon. Several data have outlined that BMDC can influence tumor growth a...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Nagler C,Hardt C,Zänker KS,Dittmar T

    更新日期:2011-06-28 00:00:00

  • Epigenetic silencing of long non-coding RNA BM742401 in multiple myeloma: impact on prognosis and myeloma dissemination.

    abstract:Background:Long non-coding RNA (lncRNA) BM742401 is a tumor suppressor in gastric cancer and chronic lymphocytic leukemia. As the promoter and coding region of BM742401 are fully embedded in a CpG island, we hypothesized that BM742401 is a tumor suppressor lncRNA epigenetically silenced by promoter DNA methylation in m...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Li Z,Kumar S,Jin DY,Calin GA,Chng WJ,Siu KL,Poon MW,Chim CS

    更新日期:2020-08-25 00:00:00

  • Prognostic and clinicopathological significance of long noncoding RNA HOXA11-AS expression in human solid tumors: a meta-analysis.

    abstract:Background:Recent studies have emphasized the important prognostic role of long noncoding RNAs (lncRNAs) in various types of cancers. Here we conducted a meta-analysis to investigate whether lncRNA HOXA11-AS can be served as a prognostic biomarker in human cancers. Patients/methods:We systematically searched PubMed, E...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Mu S,Ai L,Fan F,Sun C,Hu Y

    更新日期:2018-01-03 00:00:00

  • Potential Role of circPVT1 as a proliferative factor and treatment target in esophageal carcinoma.

    abstract:Background:Many circRNAs have been reported to play important roles in cancer development and have the potential to serve as a novel class of biomarkers for clinical diagnosis. However, the role of circRNAs in esophageal carcinoma (EC) remains unclear. In the current study, we investigated the potential role of circPVT...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Zhong R,Chen Z,Mo T,Li Z,Zhang P

    更新日期:2019-10-15 00:00:00

  • New insights into the association between AXIN2 148 C/T, 1365 C/T, and rs4791171 A/G variants and cancer risk.

    abstract:Background:Many epidemiological studies have investigated association of AXIN2 variants on overall cancer risks; however, the available results remain inconsistent. Methods:An updated analysis was conducted to ascertain a more accurate estimation of the correlation between AXIN2 148 C/T, 1365 C/T, and rs4791171 A/G po...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Xu B,Yuan W,Shi L,Zuo L,Wu XY,Zhang W,Wen Q

    更新日期:2019-05-06 00:00:00

  • Apigenin promotes apoptosis, inhibits invasion and induces cell cycle arrest of T24 human bladder cancer cells.

    abstract:BACKGROUND:Apigenin (4',5,7-trihydroxyflavone) was recently shown effective in inhibiting several cancers. The aim of this study was to investigate the effect and mechanism of apigenin in the human bladder cancer cell line T24 for the first time. METHODS:T24 cells were treated with varying concentrations and time of a...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Zhu Y,Mao Y,Chen H,Lin Y,Hu Z,Wu J,Xu X,Xu X,Qin J,Xie L

    更新日期:2013-06-01 00:00:00

  • Is systems biology a promising approach to resolve controversies in cancer research?

    abstract:: At the beginning of the 21st century cancer research has reached an impasse similar to that experienced in developmental biology in the first decades of the 20th century when conflicting results and interpretations co-existed for a long time until these differences were resolved and contradictions were eliminated. In...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Soto AM,Sonnenschein C

    更新日期:2012-03-26 00:00:00

  • MicroRNA-32 promotes cell proliferation, migration and suppresses apoptosis in breast cancer cells by targeting FBXW7.

    abstract:BACKGROUND:MicroRNAs are a class of small non-coding RNAs that are involved in many important physiological and pathological processes by regulating gene expression negatively. The purpose of this study was to investigate the effect of miR-32 on cell proliferation, migration and apoptosis and to determine the functiona...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Xia W,Zhou J,Luo H,Liu Y,Peng C,Zheng W,Ma W

    更新日期:2017-01-25 00:00:00

  • Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy.

    abstract:BACKGROUND:Ca2+ is known to be involved in a number of metastatic processes including motility and proliferation which can result in store-depletion of Ca2+. Up regulation of genes which contribute to store operated channel (SOC) activity may plausibly be necessary for these processes to take place efficiently. TRPC pr...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Aydar E,Yeo S,Djamgoz M,Palmer C

    更新日期:2009-08-18 00:00:00

  • Melatonin and non-small cell lung cancer: new insights into signaling pathways.

    abstract::Non-small-cell lung cancer (NSCLC) is a type of malignancy with progressive metastasis having poor prognosis and lowered survival resulting from late diagnosis. The therapeutic approaches for the treatment of this incurable cancer are chemo- and radiotherapy. Since current treatments are insufficient and because of dr...

    journal_title:Cancer cell international

    pub_type: 杂志文章,评审


    authors: Pourhanifeh MH,Sharifi M,Reiter RJ,Davoodabadi A,Asemi Z

    更新日期:2019-05-16 00:00:00

  • Human cytomegalovirus interleukin-10 enhances matrigel invasion of MDA-MB-231 breast cancer cells.

    abstract:BACKGROUND:While some risk factors for breast cancer are well-known, the influence of other factors, particularly virus infection, remains unclear. Human cytomegalovirus (HCMV) is widespread in the general population, and both molecular and epidemiological evidence has indicated links between HCMV and breast cancer. Th...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Valle Oseguera CA,Spencer JV

    更新日期:2017-02-13 00:00:00