Abstract：
Background:Chimeric antigen receptors (CARs) represent a novel facet of modern day synthetic biology that exemplifies personalized medicine at work through their ability to harness and redirect a patient's immune system to fight cancer. Body:By combining the target-specificity of antibodies to the effector capabilities of T cells, CARs have yielded high remission rates for many late staged and relapsed/refractory (r/r) hematological malignancies, including acute lymphoblastic leukemias (ALL) and Non-Hodgkin's lymphomas. Despite toxicities of cytokine release syndrome and neurotoxicity, recent studies have uncovered their underlying mechanisms and devised effective therapies to manage and possibly prevent them. In 2017, CAR T cell therapy became a reality for the general public despite the high costs, when Novartis's Kymriah, became the first product to receive FDA approval for pediatric r/r B cell ALL with Gilead's Yescarta following several months later. Although effective in hematological malignancies, CAR response has been limited in solid tumors largely attributed to the heterogeneous and immunosuppressive tumor microenvironment along tumor defense mechanisms, such as antigenic escape. Conclusion:Despite the current challenges of CAR T therapy, this technology is still in its infancy and its promise will continue to grow as scientists continue to develop novel approaches to enhance its efficacy. As its prevalence continues to increase, institutions and pharmaceuticals worldwide are investing in this technology in hopes of driving therapeutic innovation, while providing greater access to their respective populations through clinical trials.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Leyfman Ydoi
10.1186/s12935-018-0685-xsubject
Has Abstractpub_date
2018-11-14 00:00:00pages
182issn
1475-2867pii
685journal_volume
18pub_type
杂志文章,评审abstract：BACKGROUND:Epithelial mesenchymal transition (EMT) mediated by TGF-β pays an important role in malignant tumor acquired abilities of migration and invasion. Our previous study showed that the extract of Stellera chamaejasme L. (ESC) was against proliferation of a variety of tumor cells, but there were no studies in the...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-015-0265-2
更新日期：2015-12-10 00:00:00
abstract：Background:T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood. In this study, we tried to explore the physiological role of CD59 in T-ALL. Methods:In this study, we collected the bone marrow samples from 17 T-A...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-018-0714-9
更新日期：2019-01-08 00:00:00
abstract：Background:Melanoma as a type of skin cancer, is associated with a high mortality rate. Therefore, early diagnosis and efficient surgical treatment of this disease is very important. Photodynamic therapy (PDT) involves the activation of a photosensitizer by light at specific wavelength that interacts with oxygen and cr...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01616-x
更新日期：2020-10-29 00:00:00
abstract：Background:Acute myeloid leukemia (AML) is a clinically and biologically heterogeneous disease. The survival of older patients is generally poor. In the current study, we sought to investigate the differences in molecular gene mutations between younger and older AML patients, and to identify those newly diagnosed AML p...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-018-0716-7
更新日期：2018-12-22 00:00:00
abstract：Background:Melanoma is an extremely aggressive malignant skin tumor with high mortality. Many types of long noncoding RNAs and microRNAs have been reported to be associated with the oncogenesis of melanoma. However, a novel lncRNA-NEAT has not been thoroughly investigated in melanoma cancer. The purposes of this study ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0927-6
更新日期：2019-08-22 00:00:00
abstract：Background:Although major driver gene have been identified, the complex molecular heterogeneity of renal cell cancer (RCC) remains unclear. Therefore, more relevant genes need to be identified to explain the pathogenesis of renal cancer. Methods:Microarray datasets GSE781, GSE6344, GSE53000 and GSE68417 were downloade...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01405-6
更新日期：2020-07-21 00:00:00
abstract：Background:Recent studies have demonstrated that the kallikrein and kallikrein-related peptidases (KLKs) exhibit aberrant expression in patients with colorectal cancer (CRC) and might be considered as potential prognostic biomarkers of CRC. However, inconsistent findings have been reported, which promote us to summariz...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01350-4
更新日期：2020-06-22 00:00:00
abstract：BACKGROUND:G protein-coupled receptor family C group 5 member A (GPRC5A), a retinoic acid-inducible gene, is a lung tumor suppressor. Previously, we showed that repression of GPRC5A expression was associated with pathologic differentiation grade of oral squamous cell carcinomas (OSCC) and overexpression of GPRC5A gene ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-017-0406-x
更新日期：2017-03-02 00:00:00
abstract：BACKGROUND:We have previously shown that ultraviolet-A (UVA) radiation enhances metastatic lung colonization capacity of B16-F1 melanoma cells. The aim of this study was to examine changes in expression profile of genes in mouse melanoma B16-F1 cells exposed to UVA radiation. RESULTS:B16-F1 melanoma cells were exposed...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-7-7
更新日期：2007-05-02 00:00:00
abstract：Background:Long noncoding RNAs (lncRNAs) play essential roles in tumor progression. However, the functions and targets of lncRNAs in neuroblastoma (NB) progression still remain to be determined. In this study, we aimed to investigate the effect of lncRNA DLX6 antisense RNA 1 (DLX6-AS1) on NB and the underlying mechanis...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0968-x
更新日期：2019-11-27 00:00:00
abstract：Background:Breast cancer has been the first death cause of cancer in women all over the world. Metastasis is believed to be the most important process for treating breast cancer. There is evidence that lncRNA MEG3 functions as a tumor suppressor in breast cancer metastasis. However, upstream regulation of MEG3 in breas...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-018-0642-8
更新日期：2018-10-25 00:00:00
abstract：BACKGROUND:Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant and adjuvant chemotherapy; however, drug resistance often hinders therapy in OS patients. Also, the post-relapse survival of OS patients is as low as 20%. We the...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01720-y
更新日期：2021-01-14 00:00:00
abstract：BACKGROUND:The thieno[2,3-b]pyridines were discovered by virtual high throughput screening as potential inhibitors of phospholipase C (PLC) isoforms and showed potent growth inhibitory effects in National Cancer Institute's human tumour cell line panel (NCI60). The mechanism of the anti-proliferative activity of thieno...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-016-0293-6
更新日期：2016-03-10 00:00:00
abstract：Background:Gastric cancer (GC) is a common cause of cancer-related mortality worldwide, and microRNAs (miRNAs) have been shown to play an important role in GC development. This study aims to explore the effect of microRNA-93-5p (miR-93-5p) on the epithelial-mesenchymal transition (EMT) in GC, via AHNAK and the Wnt sign...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-1092-7
更新日期：2020-03-12 00:00:00
abstract：Background:Transgelin, an actin-binding protein, is associated with cytoskeleton remodeling. Findings from our previous studies demonstrated that transgelin was up-regulated in node-positive colorectal cancer (CRC) versus node-negative disease. Over-expression of TAGLN affected the expression of 256 downstream transcri...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01461-y
更新日期：2020-08-03 00:00:00
abstract：:Amongst males, leukaemia is the most common cause of cancer-related death in individuals younger than 40 years of age whereas in female children and adolescents, leukaemia is the most common cause of cancer-related death. Chronic myeloid leukaemia (CML) is a chronic leukaemia of the haematopoietic stem cells affecting...
journal_title：Cancer cell international
pub_type： 杂志文章,评审
doi：10.1186/s12935-017-0460-4
更新日期：2017-10-30 00:00:00
abstract：Background and aims:microRNAs (miRNAs) have been reported to regulate proliferation and migration by down-regulating the expression of target genes. The aims of this study were to investigate whether miR-4316 inhibited proliferation and migration by downregulating vascular endothelial growth factor A (VEGF-A) and its c...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-1132-3
更新日期：2020-02-22 00:00:00
abstract：BACKGROUND:Prostate cancer is a leading cause of male cancer specific mortality. When cure by radical prostatectomy is not possible the next line of prostate cancer treatment is androgen deprivation. However prolonged androgen deprivation often results in relapse and androgen-independent prostate cancer that is inevita...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-8-3
更新日期：2008-03-18 00:00:00
abstract：BACKGROUND:Patients with dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine are resistant to chemotherapeutic treatment and external irradiation and thus are difficult to treat. Direct induction of apoptosis is a promising approach in these apoptosis-resistant tumor cells. The BH3 mimeti...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-016-0303-8
更新日期：2016-04-02 00:00:00
abstract：BACKGROUND:Non-small cell lung cancer comprises the majority of lung cancer cases and is insensitive to chemotherapy. Most patients develop drug resistance. Recently, tetrandrine (TET), a bis-benzylisoquinoline alkaloid, was identified as a novel anti-cancer agent. However, the effect of tetrandrine combined with cispl...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-017-0410-1
更新日期：2017-03-27 00:00:00
abstract：BACKGROUND:The goal of this study was to identify the nature of the inclusion bodies that have been found in HeLa cells (cervical cancer immortal cell line) by electron microscope and to determine whether the major capsid protein (L1) of human papillomavirus (HPV) can be expressed in HPV-positive uterine cervix cancer ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-015-0206-0
更新日期：2015-05-23 00:00:00
abstract：Background:Thyroid cancer (TC) is the most frequent endocrine malignancy. Long noncoding RNAs (lncRNAs) have been confirmed to act as significant roles in tumor development. The role of lncRNA TMPO-AS1 in TC is still unclear, so it remains to be explored. The aim of the research is to investigate the role and regulator...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01334-4
更新日期：2020-07-08 00:00:00
abstract：Background:Long non-coding RNA (lncRNA) BM742401 is a tumor suppressor in gastric cancer and chronic lymphocytic leukemia. As the promoter and coding region of BM742401 are fully embedded in a CpG island, we hypothesized that BM742401 is a tumor suppressor lncRNA epigenetically silenced by promoter DNA methylation in m...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01504-4
更新日期：2020-08-25 00:00:00
abstract：:miRNAs, a major class of small noncoding RNAs approximately 18-25 nucleotides in length, function by repressing the expression of target genes through binding to complementary sequences in the 3'-UTRs of target genes. Emerging evidence has highlighted their important roles in numerous diseases, including human cancers...
journal_title：Cancer cell international
pub_type： 杂志文章,评审
doi：10.1186/s12935-019-0984-x
更新日期：2019-10-07 00:00:00
abstract：BACKGROUND:Compounds of plant origin and food components have attracted scientific attention for use as agents for cancer prevention and treatment. Wine contains polyphenols that were shown to have anti-cancer and other health benefits. The survival pathways of Akt and extracellular signal-regulated kinase (Erk), and t...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-14-6
更新日期：2014-01-23 00:00:00
abstract：:[This corrects the article DOI: 10.1186/s12935-019-0742-0.]. ...
journal_title：Cancer cell international
pub_type： 杂志文章,已发布勘误
doi：10.1186/s12935-019-0797-y
更新日期：2019-04-11 00:00:00
abstract：: Cancer-initiating cells display aberrant functional and phenotypic characteristics of normal stem cells from which they evolved by accumulation of multiple cytogenetic and/or epigenetic alterations. Signal transduction pathways which are essential for normal stem cell function are abnormally expressed by cancer cells...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-12-24
更新日期：2012-06-07 00:00:00
abstract：BACKGROUND:The present study mainly aimed to investigate the direct effects of Endostar (ES) on the proliferation and radiosensitivity of human lung squamous cancer cell line H-520. RESULTS:ES significantly inhibited H-520 cell proliferation in a time- and dose-dependent manner. According to the colony-forming assays,...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-10-17
更新日期：2010-05-24 00:00:00
abstract：BACKGROUND:The incidence and mortalities from cancers remain on the rise worldwide. Despite significant efforts to discover and develop novel anticancer agents, many cancers remain in the unmet need category. As such, efforts to discover and develop new and more effective and less toxic agents against cancer remain a t...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-017-0404-z
更新日期：2017-03-07 00:00:00
abstract：Background:Colorectal cancer (CRC) is considered as the second common death-induced cancer. More recently, association of long non-coding RNAs (lncRNAs) with CRC has been extensively investigated. Therefore, the present study was performed to determine whether lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAF...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01485-4
更新日期：2020-10-19 00:00:00
