Epigenetic silencing of long non-coding RNA BM742401 in multiple myeloma: impact on prognosis and myeloma dissemination.

abstract：Background:Abnormally expressed circular RNAs (circRNAs) are implicated in the development and treatment of gastric cancer (GC). Previous study has reported that hsa_circ_0003159 is expressed in GC. However, the role and mechanism of hsa_circ_0003159 in GC progression remain unclear. Methods:GC tissues and normal tiss...

journal_title：Cancer cell international

authors： Wang J,Lv W,Lin Z,Wang X,Bu J,Su Y

更新日期：2020-02-19 00:00:00

abstract：BACKGROUND:Circular RNAs (circRNAs) is a newly discovered type of non-coding RNA, the abnormal expression of which has been demonstrated in many types of human tumors. So they have been considered as promising candidates as diagnostic and therapeutic targets in cancer. This research aimed to screen the profile of circR...

journal_title：Cancer cell international

authors： Han J,Han N,Xu Z,Zhang C,Liu J,Ruan M

更新日期：2021-01-07 00:00:00

abstract：Background:Kinesin superfamily (KIFs) has a long-reported significant influence on the initiation, development, and progress of breast cancer. However, the prognostic value of whole family members was poorly done. Our study intends to demonstrate the value of kinesin superfamily members as prognostic biomarkers as well...

journal_title：Cancer cell international

authors： Li TF,Zeng HJ,Shan Z,Ye RY,Cheang TY,Zhang YJ,Lu SH,Zhang Q,Shao N,Lin Y

更新日期：2020-04-15 00:00:00

abstract：BACKGROUND:The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death. The role of these channels in the onset and progression of ovarian cancer is unknown. An understanding of mechanism by whi...

journal_title：Cancer cell international

authors： Asher V,Warren A,Shaw R,Sowter H,Bali A,Khan R

更新日期：2011-03-10 00:00:00

abstract：Objective:This study aimed to investigate the relationship among miR-145-5p, ANGPT2 and the NOD_LIKE_RECEPTOR pathway, thereby revealing the molecular mechanism of these three factors underlying the proliferation, migration and invasion of gastric cancer (GC) epithelial cells. Methods:qRT-PCR was carried out to detect...

journal_title：Cancer cell international

authors： Zhou K,Song B,Wei M,Fang J,Xu Y

更新日期：2020-08-28 00:00:00

abstract：BACKGROUND:Without doubt, natural products have been, and still are, the cornerstone of the health care armamentarium. Of all natural sources, the marine environment is clearly the last great frontier for pharmaceutical and medical research. METHODS:This work progresses in the direction of identifying component(s) fro...

journal_title：Cancer cell international

authors： Dellai A,Deghrigue M,Laroche-Clary A,Masour HB,Chouchane N,Robert J,Bouraoui A

更新日期：2012-05-15 00:00:00

abstract：Background:Many epidemiological studies have investigated association of AXIN2 variants on overall cancer risks; however, the available results remain inconsistent. Methods:An updated analysis was conducted to ascertain a more accurate estimation of the correlation between AXIN2 148 C/T, 1365 C/T, and rs4791171 A/G po...

journal_title：Cancer cell international

authors： Xu B,Yuan W,Shi L,Zuo L,Wu XY,Zhang W,Wen Q

更新日期：2019-05-06 00:00:00

abstract：Background:Estrogen sulfotransferase catalyzes conjugation of sulfuryl-group to estradiol/estrone and regulates E2 availability/activity via estrogen-receptor or non-receptor mediated pathways. Sulfoconjugated estrogen fails to bind estrogen-receptor (ER). High estrogen is a known carcinogen in postmenopausal women. Re...

journal_title：Cancer cell international

authors： Nazmeen A,Chen G,Ghosh TK,Maiti S

更新日期：2020-03-04 00:00:00

abstract：:An area of research that has been recently gaining attention is the relationship between cancer stem cell (CSC) biology and chemo-resistance in colon cancer patients. It is well recognized that tumor initiation, growth, invasion and metastasis are promoted by CSCs. An important reason for the widespread interest in th...

journal_title：Cancer cell international

authors： Garza-Treviño EN,Said-Fernández SL,Martínez-Rodríguez HG

更新日期：2015-01-28 00:00:00

abstract：Background:SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, over-expressed in human tumor tissues and embryonic cells. Evidences support its function in the cell cycle; however there is no clear mechanism explaining its function in cell proliferation regulation. Here we investigated cancer cell response t...

journal_title：Cancer cell international

authors： Saghaeian Jazi M,Samaei NM,Mowla SJ,Arefnezhad B,Kouhsar M

更新日期：2018-09-05 00:00:00

abstract：Background:Colorectal cancer (CRC) is considered as the second common death-induced cancer. More recently, association of long non-coding RNAs (lncRNAs) with CRC has been extensively investigated. Therefore, the present study was performed to determine whether lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAF...

journal_title：Cancer cell international

authors： Ruan Z,Deng H,Liang M,Xu Z,Lai M,Ren H,Deng X,Su X

更新日期：2020-10-19 00:00:00

abstract：Objective:To study the potential role of miR-544 in the immune escape mechanism of hepatoma cells. Methods:Natural killer (NK) cells were collected from healthy volunteers and patients with liver cancer. Interleukin (IL)-2 activated-NK-92 cells were transfected with miR-544 inhibitor/mimic or NC/pre-NC in HepG2 co-cul...

journal_title：Cancer cell international

authors： Pan C,Xiang L,Pan Z,Wang X,Li J,Zhuge L,Fang P,Xie Q,Hu X

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:SATB1 is a nuclear protein that has been recently reported to be a 'genome organizer' which delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. In this study, the level of mRNA expression of SATB1 a...

journal_title：Cancer cell international

authors： Patani N,Jiang W,Mansel R,Newbold R,Mokbel K

更新日期：2009-07-30 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) is a type of malignancy with progressive metastasis having poor prognosis and lowered survival resulting from late diagnosis. The therapeutic approaches for the treatment of this incurable cancer are chemo- and radiotherapy. Since current treatments are insufficient and because of dr...

journal_title：Cancer cell international

authors： Pourhanifeh MH,Sharifi M,Reiter RJ,Davoodabadi A,Asemi Z

更新日期：2019-05-16 00:00:00

abstract：BACKGROUND:Cyclooxygenase (COX) is a rate-limiting enzyme in prostaglandins synthesis which exists in two isoforms, COX-1 and COX-2. Over-expression of COX-2 was considered to increase the proliferation and enhance the invasiveness of breast cancer cells. It was suggested that genetic variations in COX-2 could influenc...

journal_title：Cancer cell international

authors： Gao J,Kang HF,Ma XB,Tang W,Liu D,Zhao Y,Zhang SQ,Guan HT,Lin S,Ren HT,Wang XJ,Dai ZJ

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:Apigenin (4',5,7-trihydroxyflavone) was recently shown effective in inhibiting several cancers. The aim of this study was to investigate the effect and mechanism of apigenin in the human bladder cancer cell line T24 for the first time. METHODS:T24 cells were treated with varying concentrations and time of a...

journal_title：Cancer cell international

authors： Zhu Y,Mao Y,Chen H,Lin Y,Hu Z,Wu J,Xu X,Xu X,Qin J,Xie L

更新日期：2013-06-01 00:00:00

abstract：BACKGROUND:Compounds of plant origin and food components have attracted scientific attention for use as agents for cancer prevention and treatment. Wine contains polyphenols that were shown to have anti-cancer and other health benefits. The survival pathways of Akt and extracellular signal-regulated kinase (Erk), and t...

journal_title：Cancer cell international

authors： Barron CC,Moore J,Tsakiridis T,Pickering G,Tsiani E

更新日期：2014-01-23 00:00:00

abstract：Background:Newly identified lncRNA zinc finger protein, FOG family member 2 antisense RNA 1 (ZFPM2-AS1) is identified as an oncogenic gene. However, the role of ZFPM2-AS1 in small cell lung cancer (SCLC) is poorly comprehended. Methods:The expression of genes in SCLC tissues and cells was measured by qRT-PCR. Colony f...

journal_title：Cancer cell international

authors： Yan Z,Yang Q,Xue M,Wang S,Hong W,Gao X

更新日期：2020-04-03 00:00:00

abstract：:Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of proteins, involved in inhibition of apoptosis and regulation of cell cycle. These functional attributes make Survivin a unique protein exhibiting divergent functions i.e. regulating cell proliferation and cell death. Expression pattern of Su...

journal_title：Cancer cell international

authors： Garg H,Suri P,Gupta JC,Talwar GP,Dubey S

更新日期：2016-06-23 00:00:00

abstract：Background:The ubiquitin-specific protease 28 (USP28) is an oncogenic deubiquitinase, which plays a critical role in tumorigenesis via antagonizing the ubiquitination and degradation of tumor suppressor protein FBXW7-mediated oncogenic substrates. USP28 controls hypoxia-dependent angiogenesis and metastasis by preventi...

journal_title：Cancer cell international

authors： Du SC,Zhu L,Wang YX,Liu J,Zhang D,Chen YL,Peng Q,Liu W,Liu B

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:MicroRNAs are 22-24 nt non-coding RNAs that bind to the 3' UTR of target mRNAs, thereby inducing mRNA degradation or inhibiting mRNA translation. Due to their implication in the regulation of post-transcriptional processes, the role of miRNAs in hepatocellular carcinoma (HCC) has been extensively studied. Ho...

journal_title：Cancer cell international

authors： Wu W,Liu S,Liang Y,Zhou Z,Liu X

更新日期：2017-02-21 00:00:00

abstract：BACKGROUND:Drug resistance is a major obstacle to successful chemotherapy for epithelial ovarian cancer (EOC). We found a subset of miRNAs associated with the response to first-line platinum-based chemotherapy in EOC by microarray, and miR-206 was one of the most significant miRNAs. The purposes of this study were to e...

journal_title：Cancer cell international

authors： Yu X,Zhang X,Wang G,Wang B,Ding Y,Zhao J,Liu H,Cui S

更新日期：2020-11-03 00:00:00

abstract：Background:Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property. Cytosine deaminase (CD), which is derived from bacteria or yeast, can convert a relatively nontoxic prodrug 5-fluorocytosine (5-FC) into the active an...

journal_title：Cancer cell international

authors： Ding Y,Fan J,Deng L,Huang B,Zhou B

更新日期：2020-06-15 00:00:00

abstract：BACKGROUND:Patients with dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine are resistant to chemotherapeutic treatment and external irradiation and thus are difficult to treat. Direct induction of apoptosis is a promising approach in these apoptosis-resistant tumor cells. The BH3 mimeti...

journal_title：Cancer cell international

authors： Broecker-Preuss M,Becher-Boveleth N,Müller S,Mann K

更新日期：2016-04-02 00:00:00

abstract：Background:Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies and a major cause of cancer related death worldwide, especially in China. Cell lines are widely used disease models for basic medical research, however, well characterized ESCC cell models from China were seldom reported. Mis...

journal_title：Cancer cell international

authors： Li X,Tian D,Guo Y,Qiu S,Xu Z,Deng W,Su M

更新日期：2020-05-24 00:00:00

abstract：Background:T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood. In this study, we tried to explore the physiological role of CD59 in T-ALL. Methods:In this study, we collected the bone marrow samples from 17 T-A...

journal_title：Cancer cell international

authors： Jia Y,Qi Y,Wang Y,Ma X,Xu Y,Wang J,Zhang X,Gao M,Cong B,Han S

更新日期：2019-01-08 00:00:00

abstract：BACKGROUND:Gastric cancer is one of the common cancers seen in south India. Unfortunately more than 90% are advanced by the time they report to a tertiary centre in the country. There is an urgent need to characterize these cancers and try to identify potential biomarkers and novel therapeutic targets. MATERIALS AND M...

journal_title：Cancer cell international

authors： Rajkumar T,Vijayalakshmi N,Gopal G,Sabitha K,Shirley S,Raja UM,Ramakrishnan SA

更新日期：2010-11-24 00:00:00

abstract：BACKGROUND:Expression of P-glycoprotein (P-gp), the multidrug resistance (MDR) 1 gene product, can lead to multidrug resistance in tumours. However, the physiological role of P-gp in tumours growing as multicellular spheroids is not well understood. Recent evidence suggests that P-gp activity may be modulated by cellul...

journal_title：Cancer cell international

authors： Ponce de León V,Barrera-Rodríguez R

更新日期：2005-07-07 00:00:00

abstract：:N6-methyl-adenosine(m6A) modification emerges as an abundant and dynamic regulation throughout the Eukaryotic transcriptome. Dysregulation of the m6A regulators has increasingly been found in many neoplasms. It is reasonable to believe that m6A changes the fate of cancer cells and subsequently affected all aspects of ...

journal_title：Cancer cell international

authors： Yang G,Sun Z,Zhang N

更新日期：2020-07-29 00:00:00

abstract：BACKGROUND:ErbB3-binding protein 1 (Ebp1) is a member of the PA2G4 family of proliferation-regulated proteins that is expressed in multiple malignant and non-malignant cells. ErbB3 and other members of the EGFR family have been implicated in cancer progression, it however remains unknown whether Ebp1 participate in pro...

journal_title：Cancer cell international

authors： Gannon PO,Koumakpayi IH,Le Page C,Karakiewicz PI,Mes-Masson AM,Saad F

更新日期：2008-11-24 00:00:00