Abstract:
BACKGROUND:Apigenin (4',5,7-trihydroxyflavone) was recently shown effective in inhibiting several cancers. The aim of this study was to investigate the effect and mechanism of apigenin in the human bladder cancer cell line T24 for the first time. METHODS:T24 cells were treated with varying concentrations and time of apigenin. Cell viability was evaluated by MTT assay. Cell motility and invasiveness were assayed by Matrigel migration and invasion assay. Flow cytometry and western blot analysis were used to detect cell apoptosis, cell cycle and signaling pathway. RESULTS:The results demonstrated that apigenin suppressed proliferation and inhibited the migration and invasion potential of T24 bladder cancer cells in a dose- and time-dependent manner, which was associated with induced G2/M Phase cell cycle arrest and apoptosis. The mechanism of action is like to involve PI3K/Akt pathway and Bcl-2 family proteins. Apigenin increased caspase-3 activity and PARP cleavage, indicating that apigenin induced apoptosis in a caspase-dependent way. CONCLUSIONS:These findings suggest that apigenin may be an effective way for treating human bladder cancer.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Zhu Y,Mao Y,Chen H,Lin Y,Hu Z,Wu J,Xu X,Xu X,Qin J,Xie Ldoi
10.1186/1475-2867-13-54subject
Has Abstractpub_date
2013-06-01 00:00:00pages
54issue
1issn
1475-2867pii
1475-2867-13-54journal_volume
13pub_type
杂志文章abstract:BACKGROUND:Circular RNAs (circRNAs) is a newly discovered type of non-coding RNA, the abnormal expression of which has been demonstrated in many types of human tumors. So they have been considered as promising candidates as diagnostic and therapeutic targets in cancer. This research aimed to screen the profile of circR...
journal_title:Cancer cell international
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abstract::[This corrects the article DOI: 10.1186/s12935-020-01426-1.]. ...
journal_title:Cancer cell international
pub_type: 已发布勘误
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journal_title:Cancer cell international
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journal_title:Cancer cell international
pub_type: 杂志文章,评审
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journal_title:Cancer cell international
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journal_title:Cancer cell international
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pub_type: 杂志文章
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journal_title:Cancer cell international
pub_type: 杂志文章
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journal_title:Cancer cell international
pub_type: 杂志文章,评审
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journal_title:Cancer cell international
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0642-8
更新日期:2018-10-25 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
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更新日期:2017-10-18 00:00:00
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journal_title:Cancer cell international
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journal_title:Cancer cell international
pub_type: 杂志文章
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更新日期:2018-07-20 00:00:00
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journal_title:Cancer cell international
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更新日期:2009-07-30 00:00:00