Antitumor efficacy of cytosine deaminase-armed vaccinia virus plus 5-fluorocytosine in colorectal cancers.

abstract：BACKGROUND:Circular RNAs (circRNAs) is a newly discovered type of non-coding RNA, the abnormal expression of which has been demonstrated in many types of human tumors. So they have been considered as promising candidates as diagnostic and therapeutic targets in cancer. This research aimed to screen the profile of circR...

journal_title：Cancer cell international

authors： Han J,Han N,Xu Z,Zhang C,Liu J,Ruan M

更新日期：2021-01-07 00:00:00

abstract：Background:Cancer-associated fibroblasts (CAFs) play important roles in tumor progression. However, the behaviors of activated CAFs in gastric cancer remain to be determined. The aim of the present study was to investigate the correlations between activated gastric CAFs and the prognosis of patients with gastric cancer...

journal_title：Cancer cell international

authors： Ma Y,Zhu J,Chen S,Li T,Ma J,Guo S,Hu J,Yue T,Zhang J,Wang P,Wang X,Chen G,Liu Y

更新日期：2018-07-20 00:00:00

abstract：BACKGROUND:Advanced cancer and chemotherapy are both associated with immune system suppression. We initiated a clinical trial in patients receiving chemotherapy for metastatic colorectal cancer to determine if administration of GM-CSF in this setting was immunostimulatory. METHODS:Between June, 2003 and January, 2007,...

journal_title：Cancer cell international

authors： Martinez M,Ono N,Planutiene M,Planutis K,Nelson EL,Holcombe RF

更新日期：2012-01-23 00:00:00

abstract：Background:Gastric cancer (GC) is a common cause of cancer-related mortality worldwide, and microRNAs (miRNAs) have been shown to play an important role in GC development. This study aims to explore the effect of microRNA-93-5p (miR-93-5p) on the epithelial-mesenchymal transition (EMT) in GC, via AHNAK and the Wnt sign...

journal_title：Cancer cell international

authors： Shen E,Wang X,Liu X,Lv M,Zhang L,Zhu G,Sun Z

更新日期：2020-03-12 00:00:00

abstract：BACKGROUND:Germline mutations in the von Hippel-Lindau (VHL) tumor suppressor gene predispose individuals to clear cell renal carcinomas, hemangioblastomas, and pheochromocytomas. The VHL gene product forms an ubiquitin E3 ligase complex, with regulation of hypoxia-inducible factor alpha (HIF-α) as its best known funct...

journal_title：Cancer cell international

authors： Doonachar A,Gallo MD,Doukas D,Pasricha R,Lantsberg I,Schoenfeld AR

更新日期：2015-02-22 00:00:00

abstract：BACKGROUND:Castration-resistance in prostate cancer (PC) is a critical event hallmarking a switch to a more aggressive phenotype. Neuroendocrine differentiation and upregulation of NFκB transcriptional activity are two mechanisms that have been independently linked to this process. METHODS:We investigated these two pa...

journal_title：Cancer cell international

authors： Patrikidou A,Vlachostergios PJ,Voutsadakis IA,Hatzidaki E,Valeri RM,Destouni C,Apostolou E,Daliani D,Papandreou CN

更新日期：2011-05-15 00:00:00

abstract：:BACKGROUND: The aim of this work was to investigate in vitro the putative role of EGR-1 in the growth of glioma cells. EGR-1 expression was examined during the early passages in vitro of 17 primary cell lines grown from 3 grade III and from 14 grade IV malignant astrocytoma explants. The explanted tumors were genetica...

journal_title：Cancer cell international

authors： Calogero A,Lombari V,De Gregorio G,Porcellini A,Ucci S,Arcella A,Caruso R,Gagliardi FM,Gulino A,Lanzetta G,Frati L,Mercola D,Ragona G

更新日期：2004-01-07 00:00:00

abstract：BACKGROUND:In vivo, the transforming growth factor-beta1 (TGF-β1)-induced epithelial to mesenchymal transition (EMT) occurs in seconds during cancer cells intravasation and extravasation. Although it has been established that cellular stiffness can change as a cancer cell transformed, the precise relationship between T...

journal_title：Cancer cell international

authors： Wu TH,Chou YW,Chiu PH,Tang MJ,Hu CW,Yeh ML

更新日期：2014-03-03 00:00:00

abstract：Background:Emergence of resistance to molecular targeted therapy constitutes a limitation to clinical benefits in cancer treatment. Cross-resistance commonly happens with chemotherapeutic agents but might not with targeted agents. Methods:In the current study, TP53 wild-type cell lines with druggable MAPK pathway muta...

journal_title：Cancer cell international

authors： Wu CE,Koay TS,Ho YH,Lovat P,Lunec J

更新日期：2019-03-07 00:00:00

abstract：Background:MicroRNA (MiRNA) is a small non-coding RNA which is implicated in a cohort of biological function in cancer, including proliferation, metastasis, apoptosis and invasion. MiR-96 has been reported to be involved in many cancers, including papillary thyroid cancer. However, the role of miR-96-3p in papillary th...

journal_title：Cancer cell international

authors： Zhao X,Li Y,Zhou Y

更新日期：2019-11-12 00:00:00

abstract：Background:Breast cancer is one of the most common malignancy among females from the worldwide cancer incidence statistics. Peroxisome gamma coactivator-1β (PGC-1β) has long been identified to be involved in this type of tumorigenesis. However, the mechanisms of PGC-1β in human breast cancer have not been fully underst...

journal_title：Cancer cell international

authors： Cao J,Wang X,Wang D,Ma R,Li X,Feng H,Wang J,Liu S,Wang L

更新日期：2019-04-11 00:00:00

abstract：Background:Breast cancer has been the first death cause of cancer in women all over the world. Metastasis is believed to be the most important process for treating breast cancer. There is evidence that lncRNA MEG3 functions as a tumor suppressor in breast cancer metastasis. However, upstream regulation of MEG3 in breas...

journal_title：Cancer cell international

authors： Wang XX,Guo GC,Qian XK,Dou DW,Zhang Z,Xu XD,Duan X,Pei XH

更新日期：2018-10-25 00:00:00

abstract：Background:Renal cell carcinoma (RCC) is the most common kidney cancer and includes several molecular and histological subtypes with different clinical characteristics. The combination of DNA methylation and gene expression data can improve the classification of tumor heterogeneity, by incorporating differences at the ...

journal_title：Cancer cell international

authors： Chen W,Zhuang J,Wang PP,Jiang J,Lin C,Zeng P,Liang Y,Zhang X,Dai Y,Diao H

更新日期：2019-07-16 00:00:00

abstract：Background:A number of JmjC domain-containing histone demethylases have been identified and biochemically characterized in mammalian models and humans. JMJD2A is a transcriptional co-factor and enzyme that catalyzes the demethylation of histone H3 lysine 9 and 36 (H3K9 and H3K36). Here in this study, we reported the ro...

journal_title：Cancer cell international

authors： Li M,Cheng J,Ma Y,Guo H,Shu H,Huang H,Kuang Y,Yang T

更新日期：2020-03-30 00:00:00

abstract：Background:Despite improvements in nasopharyngeal carcinoma (NPC) treatment, patients with recurrence and metastasis still have a poor prognosis. Thus, the identification of novel biomarkers is urgently needed to predict outcomes and tailor treatment for NPC. Methods:Four data sets were downloaded from Gene Expression...

journal_title：Cancer cell international

authors： Huang D,Liu Q,Zhang W,Huang C,Zheng R,Xie G,Wang H,Jia B,Shi J,Yuan Y,Deng M

更新日期：2020-10-12 00:00:00

abstract：:Osteosarcoma (OS) is one of the most prevalent malignant cancers with lower survival and poor overall prognosis mainly in children and adolescents. Identifying the molecular mechanisms and OS stem cells (OSCs) as new concepts involved in disease pathogenesis and progression may potentially lead to new therapeutic targ...

journal_title：Cancer cell international

authors： Otoukesh B,Boddouhi B,Moghtadaei M,Kaghazian P,Kaghazian M

更新日期：2018-10-16 00:00:00

abstract：OBJECTIVES:Bladder transitional cell carcinoma (TCC) is one of the most common solid malignancies in China. This study examined the antitumor effect and underlying mechanism of action of sunitinib malate in human bladder TCC in vitro. METHODS:Bladder TCC cell lines 5637 and BIU87 were maintained in 1640 medium and T24...

journal_title：Cancer cell international

authors： Wen J,Li HZ,Ji ZG,Jin J

更新日期：2015-02-28 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is an aggressive cancer with high mortality and morbidity worldwide. The limited clinically relevant model has impeded the development of effective HCC treatment strategy. Patient-derived xenograft (PDX) models retain most of the characteristics of original tumors and were show...

journal_title：Cancer cell international

authors： Cheung PF,Yip CW,Ng LW,Lo KW,Chow C,Chan KF,Cheung TT,Cheung ST

更新日期：2016-06-08 00:00:00

abstract：Background:Accumulating studies showed that long noncoding RNAs (lncRNAs) played vital roles in cancer progression. LncRNA MIR4435-2HG was proved to act as an oncogene in various tumors. However, the underlying function of MIR4435-2HG in ovarian cancer (OC) remains unclear. Methods:The expression levels of MIR4435-2HG...

journal_title：Cancer cell international

authors： Zhu L,Wang A,Gao M,Duan X,Li Z

更新日期：2020-05-01 00:00:00

abstract：Background:Melanoma is an extremely aggressive malignant skin tumor with high mortality. Many types of long noncoding RNAs and microRNAs have been reported to be associated with the oncogenesis of melanoma. However, a novel lncRNA-NEAT has not been thoroughly investigated in melanoma cancer. The purposes of this study ...

journal_title：Cancer cell international

authors： Ding F,Lai J,Gao Y,Wang G,Shang J,Zhang D,Zheng S

更新日期：2019-08-22 00:00:00

abstract：BACKGROUND:Breast cancer (BrCa) is the most common female malignancy worldwide and has the highest morbidity among all cancers in females. Unfortunately, the mechanisms of BrCa growth and metastasis, which lead to a poor prognosis in BrCa patients, have not been well characterized. METHODS:Immunohistochemistry (IHC) w...

journal_title：Cancer cell international

authors： Hang C,Zhao S,Wang T,Zhang Y

更新日期：2021-01-06 00:00:00

abstract：Background:Lung adenocarcinoma (LUAD) patients experiencing lymph node metastasis (LNM) always exhibit poor clinical outcomes. A biomarker or gene signature that could predict survival in these patients would have a substantial clinical impact, allowing for earlier detection of mortality risk and for individualized the...

journal_title：Cancer cell international

authors： Wang Y,Zhang Q,Gao Z,Xin S,Zhao Y,Zhang K,Shi R,Bao X

更新日期：2019-04-16 00:00:00

abstract：Background:Casticin, an isoflavone compound extracted from the herb Fructus Viticis, has demonstrated anti-inflammatory and anticancer activities and properties. The aim of this study was to investigate the effects and mechanisms of casticin in nasopharyngeal carcinoma (NPC) cells and to determine its potential for tar...

journal_title：Cancer cell international

authors： Liu J,Yang J,Hou Y,Zhu Z,He J,Zhao H,Ye X,Li D,Wu Z,Huang Z,Hao B,Yao K

更新日期：2019-12-21 00:00:00

abstract：BACKGROUND:Urokinase-type Plasminogen Activator (uPA), a serine protease, plays a pivotal role in human breast cancer metastasis by mediating the degradation of extracellular matrix proteins and promoting cell motility. In more advanced breast cancers, uPA activity is significantly up regulated and serves as a prognost...

journal_title：Cancer cell international

authors： Candia BJ,Hines WC,Heaphy CM,Griffith JK,Orlando RA

更新日期：2006-05-31 00:00:00

abstract：Background:Acute lymphoblastic leukemia (ALL) is an aggressive hematopoietic malignancy that is most commonly observed in children. Alantolactone (ALT) has been reported to exhibit anti-tumor activity in different types of cancer. The aim of the present study was to investigate the anti-tumor activity and molecular mec...

journal_title：Cancer cell international

authors： Shi C,Lan W,Wang Z,Yang D,Wei J,Liu Z,Teng Y,Gu M,Yuan T,Cao F,Zhou J,Li Y

更新日期：2020-09-09 00:00:00

abstract：:Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha (HIF-1α) is a major regulator of cellular response to changes in oxygen concentration, supporting the adaptation of tumor cells to hypoxia in...

journal_title：Cancer cell international

authors： Jin X,Dai L,Ma Y,Wang J,Liu Z

更新日期：2020-06-24 00:00:00

abstract：BACKGROUND:We previously observed that the TGFbeta-Par6 pathway mediates loss of polarity and apoptosis in NMuMG cells. Here we investigate the contribution of Par6 versus TGFbeta receptor I activation to TGFbeta-induced apoptosis in association with changes in apico-basal polarity. We focus on the effect of Par6 activ...

journal_title：Cancer cell international

authors： Avery-Cooper G,Doerr M,Gilbert RW,Youssef M,Richard A,Huether P,Viloria-Petit AM

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:BRAF inhibitors are effective anticancer agents in BRAF-mutated melanomas. By contrast, evidences about sensitivity of thyroid carcinomas to BRAF inhibition are conflicting and it has been proposed that BRAF V600E thyroid carcinoma cells are less sensitive to BRAF inhibitors due to activation of parallel sig...

journal_title：Cancer cell international

authors： Notarangelo T,Sisinni L,Condelli V,Landriscina M

更新日期：2017-10-04 00:00:00

abstract：BACKGROUND:While some risk factors for breast cancer are well-known, the influence of other factors, particularly virus infection, remains unclear. Human cytomegalovirus (HCMV) is widespread in the general population, and both molecular and epidemiological evidence has indicated links between HCMV and breast cancer. Th...

journal_title：Cancer cell international

authors： Valle Oseguera CA,Spencer JV

更新日期：2017-02-13 00:00:00

abstract：Background:Acute myeloid leukemia (AML) is a clinically and biologically heterogeneous disease. The survival of older patients is generally poor. In the current study, we sought to investigate the differences in molecular gene mutations between younger and older AML patients, and to identify those newly diagnosed AML p...

journal_title：Cancer cell international

authors： Cao XX,Cai H,Mao YY,Wu Q,Zhang L,Zhou DB,Li J

更新日期：2018-12-22 00:00:00