当前位置： SCI文献检索 > Cancer Cell International期刊下所有文献 > Dual EGFR and BRAF blockade overcomes resistance to vemurafenib in BRAF mutated thyroid carcinoma cells.

Dual EGFR and BRAF blockade overcomes resistance to vemurafenib in BRAF mutated thyroid carcinoma cells.

Abstract：

BACKGROUND:BRAF inhibitors are effective anticancer agents in BRAF-mutated melanomas. By contrast, evidences about sensitivity of thyroid carcinomas to BRAF inhibition are conflicting and it has been proposed that BRAF V600E thyroid carcinoma cells are less sensitive to BRAF inhibitors due to activation of parallel signaling pathways. This study evaluated the hypothesis that feedback activation of EGFR signaling counteracts the cytostatic activity of vemurafenib (PLX4032) in BRAF V600E thyroid carcinoma cells. METHODS:Cell proliferation, cell cycle distribution, induction of apoptosis and EGFR and AKT signaling were evaluated in thyroid carcinoma cell lines bearing the BRAF V600E mutation in response to PLX4032. RESULTS:A partial and transient cytostatic response to PLX4032 was observed in thyroid carcinoma cell lines bearing the BRAF V600E mutation, with lack of full inhibition of ERK pathway. Interestingly, the exposure of thyroid carcinoma cells to PLX4032 resulted in a rapid feedback activation of EGFR signaling with parallel activation of AKT phosphorylation. Consistently, the dual inhibition of EGFR and BRAF, through combination therapy with PLX4032 and gefitinib, resulted in prevention of EGFR phosphorylation and sustained inhibition of ERK and AKT signaling and cell proliferation. Of note, the combined treatment with gefitinib and vemurafenib or the exposure of EGFR-silenced thyroid carcinoma cells to vemurafenib induced synthetic lethality compared to single agents. CONCLUSIONS:These data suggest that the dual EGFR and BRAF blockade represents a strategy to by-pass resistance to BRAF inhibitors in thyroid carcinoma cells.

journal_name

Cancer Cell Int

journal_title

Cancer cell international

authors

Notarangelo T,Sisinni L,Condelli V,Landriscina M

doi

10.1186/s12935-017-0457-z

subject

Has Abstract

pub_date

2017-10-04 00:00:00

pages

86

issn

1475-2867

pii

457

journal_volume

17

pub_type

杂志文章

相关文献

Cancer Cell International文献大全
  • microRNA-30b inhibits cell invasion and migration through targeting collagen triple helix repeat containing 1 in non-small cell lung cancer.

    abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) is the largest histological subgroup of lung cancer and has increased in prevalence in China over the past 5 years. The 5-year survival rate has remained at 15-20 %, with a median survival of 8-12 months. The tumorigenesis and progression of NSCLC is orchestrated by numerou...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-015-0236-7

    authors： Chen S,Li P,Yang R,Cheng R,Zhang F,Wang Y,Chen X,Sun Q,Zang W,Du Y,Zhao G,Zhang G

    更新日期：2015-09-17 00:00:00

  • HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation.

    abstract：BACKGROUND:Mutational inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene has been linked to hereditary as well as sporadic clear cell renal carcinomas. The product of the VHL gene, pVHL, acts to target hypoxia-inducible factor alpha (HIF-alpha) subunits for ubiquitination and subsequent degradation. Usin...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-7-13

    authors： Hughes MD,Kapllani E,Alexander AE,Burk RD,Schoenfeld AR

    更新日期：2007-06-28 00:00:00

  • Role of microRNA-92a in metastasis of osteosarcoma cells in vivo and in vitro by inhibiting expression of TCF21 with the transmission of bone marrow derived mesenchymal stem cells.

    abstract：Background:This study aims to investigate the role of microRNA-92a (miR-92a) in metastasis of osteosarcoma (OS) cells in vivo and in vitro by regulatingTCF21 with the transmission of bone marrow derived mesenchymal stem cells (BMSCs). Methods:BMSCs were isolated, purified and cultured from healthy adult bone marrow ti...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0741-1

    authors： Cao S,Jiang L,Shen L,Xiong Z

    更新日期：2019-02-12 00:00:00

  • Is systems biology a promising approach to resolve controversies in cancer research?

    abstract：: At the beginning of the 21st century cancer research has reached an impasse similar to that experienced in developmental biology in the first decades of the 20th century when conflicting results and interpretations co-existed for a long time until these differences were resolved and contradictions were eliminated. In...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-12-12

    authors： Soto AM,Sonnenschein C

    更新日期：2012-03-26 00:00:00

  • The mRNA expression of SATB1 and SATB2 in human breast cancer.

    abstract：BACKGROUND:SATB1 is a nuclear protein that has been recently reported to be a 'genome organizer' which delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. In this study, the level of mRNA expression of SATB1 a...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-9-18

    authors： Patani N,Jiang W,Mansel R,Newbold R,Mokbel K

    更新日期：2009-07-30 00:00:00

  • Differential effects of HIF-α isoforms on apoptosis in renal carcinoma cell lines.

    abstract：BACKGROUND:Germline mutations in the von Hippel-Lindau (VHL) tumor suppressor gene predispose individuals to clear cell renal carcinomas, hemangioblastomas, and pheochromocytomas. The VHL gene product forms an ubiquitin E3 ligase complex, with regulation of hypoxia-inducible factor alpha (HIF-α) as its best known funct...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-015-0175-3

    authors： Doonachar A,Gallo MD,Doukas D,Pasricha R,Lantsberg I,Schoenfeld AR

    更新日期：2015-02-22 00:00:00

  • Prognostic values, ceRNA network, and immune regulation function of SDPR in KRAS-mutant lung cancer.

    abstract：BACKGROUND:Serum Deprivation Protein Response (SDPR) plays an important role in formation of pulmonary alveoli. However, the functions and values of SDPR in lung cancer remain unknown. We explored prognostic value, expression pattern, and biological function of SDPR in non-small cell lung cancer (NSCLC) and KRAS-mutant...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-021-01756-8

    authors： Luo X,Peng S,Ding S,Zeng Q,Wang R,Ma Y,Chen S,Wang Y,Wang W

    更新日期：2021-01-12 00:00:00

  • Long non-coding RNA LBX2-AS1 enhances glioma proliferation through downregulating microRNA-491-5p.

    abstract：Background:Dysregulation of lncRNAs is frequent in glioma and has emerged as an important mechanism involved in tumorigenesis. Previous analysis of Chinese Glioma Genome Atlas (CGGA) database indicated that LBX2-AS1 expression is one of differentially expression lncRNA between lower grade glioma (LGG) (grade II and III...

    journal_title：Cancer cell international

    pub_type： 杂志文章,收录出版

    doi：10.1186/s12935-020-01433-2

    authors： Chen Q,Gao J,Zhao Y,Hou R

    更新日期：2020-08-26 00:00:00

  • Mitochondrial structure alteration in human prostate cancer cells upon initial interaction with a chemopreventive agent phenethyl isothiocyanate.

    abstract：BACKGROUND:Phenethyl isothiocyanate (PEITC), present naturally in cruciferous vegetables, is a chemopreventive agent. It blocks initiation and post-initiation progression of carcinogenesis. Mechanism study in human prostate cancer cells revealed that PEITC is a dual inhibitor of aberrant DNA hypermethylation and histon...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-14-30

    authors： Xue C,Pasolli HA,Piscopo I,Gros DJ,Liu C,Chen Y,Chiao JW

    更新日期：2014-03-31 00:00:00

  • BTG1 inhibits malignancy as a novel prognosis signature in endometrial carcinoma.

    abstract：Background:Endometrial carcinoma (EC) is one of the three major malignant tumors of the female reproductive system. In recent years, the incidence and mortality rate of EC have increased. B-cell translocation gene 1 (BTG1) is an anti-proliferation gene that regulates the occurrence and development of a variety of tumor...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01591-3

    authors： Li Y,Huo J,He J,Zhang Y,Ma X

    更新日期：2020-10-07 00:00:00

  • The heterogeneity of cancer stem-like cells at the invasive front.

    abstract：:Cancer stem-like cells exhibit the multi-functional roles to survive and persist for a long period in the minimal residual disease after the conventional anti-cancer treatments. Cancer stem-like cells of solid malignant tumors which highly express CD44v8-10, the variant isoform of CD44 generated by alternative splicin...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-017-0393-y

    authors： Yoshida GJ

    更新日期：2017-02-13 00:00:00

  • Silenced lncRNA SNHG14 restrains the biological behaviors of bladder cancer cells via regulating microRNA-211-3p/ESM1 axis.

    abstract：BACKGROUND:Bladder cancer (BCa) is a malignant tumor that occurs on the mucosa of the bladder, in which dysregulated long non-coding RNAs (lncRNAs) are involved. This study investigated the effect of lncRNA small nucleolar RNA host gene 1 (SNHG14) on the biological characteristics of BCa cells from microRNA (miR)-211-3...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01717-7

    authors： Feng R,Li Z,Wang X,Ge G,Jia Y,Wu D,Ji Y,Wang C

    更新日期：2021-01-22 00:00:00

  • MiR-7 inhibits progression of hepatocarcinoma by targeting KLF-4 and promises a novel diagnostic biomarker.

    abstract：BACKGROUND:MicroRNAs are 22-24 nt non-coding RNAs that bind to the 3' UTR of target mRNAs, thereby inducing mRNA degradation or inhibiting mRNA translation. Due to their implication in the regulation of post-transcriptional processes, the role of miRNAs in hepatocellular carcinoma (HCC) has been extensively studied. Ho...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-017-0386-x

    authors： Wu W,Liu S,Liang Y,Zhou Z,Liu X

    更新日期：2017-02-21 00:00:00

  • Increase of IFN-γ and TNF-α production in CD107a + NK-92 cells co-cultured with cervical cancer cell lines pre-treated with the HO-1 inhibitor.

    abstract：BACKGROUND:Natural killer (NK) cells eliminate virus-infected and tumor cells through the release of perforins and granzymes; they also produce Interferon gamma (IFN-γ) and Tumor necrosis factor alpha (TNF-α), which induce apoptosis in target cells. Many tumors express Heme oxygenase 1 (HO-1), and this expression has b...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-014-0100-1

    authors： Gómez-Lomelí P,Bravo-Cuellar A,Hernández-Flores G,Jave-Suárez LF,Aguilar-Lemarroy A,Lerma-Díaz JM,Domínguez-Rodríguez JR,Sánchez-Reyes K,Ortiz-Lazareno PC

    更新日期：2014-10-01 00:00:00

  • Chimeric antigen receptors: unleashing a new age of anti-cancer therapy.

    abstract：Background:Chimeric antigen receptors (CARs) represent a novel facet of modern day synthetic biology that exemplifies personalized medicine at work through their ability to harness and redirect a patient's immune system to fight cancer. Body:By combining the target-specificity of antibodies to the effector capabilitie...

    journal_title：Cancer cell international

    pub_type： 杂志文章,评审

    doi：10.1186/s12935-018-0685-x

    authors： Leyfman Y

    更新日期：2018-11-14 00:00:00

  • Human colorectal cancer-derived carcinoma associated fibroblasts promote CD44-mediated adhesion of colorectal cancer cells to endothelial cells by secretion of HGF.

    abstract：Background:Carcinoma-associated fibroblasts (CAFs) are dominant components of tumor microenvironment, which has been reported to promote development, progression, and metastasis of cancer. However, the role of CAFs during adhesion process remains unknown. It has been hypothesized that CAFs contribute to adhesion to end...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0914-y

    authors： Zhang R,Qi F,Shao S,Li G,Feng Y

    更新日期：2019-07-24 00:00:00

  • Phorbol myristate acetate and Bryostatin 1 rescue IFN-gamma inducibility of MHC class II molecules in LS1034 colorectal carcinoma cell line.

    abstract：BACKGROUND:The expression of major histocompatibility complex class II (MHCII) antigens in both mouse and human tumors is rare, and these antigens are not easily inducible by IFN-gamma (IFNg). Since MHCII may play an important role in the development of host antitumor immune response, we explored the possibility of res...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-3-4

    authors： Kudinov Y,Wiseman CL,Kharazi AI

    更新日期：2003-03-25 00:00:00

  • Granulocyte-macrophage stimulating factor (GM-CSF) increases circulating dendritic cells but does not abrogate suppression of adaptive cellular immunity in patients with metastatic colorectal cancer receiving chemotherapy.

    abstract：BACKGROUND:Advanced cancer and chemotherapy are both associated with immune system suppression. We initiated a clinical trial in patients receiving chemotherapy for metastatic colorectal cancer to determine if administration of GM-CSF in this setting was immunostimulatory. METHODS:Between June, 2003 and January, 2007,...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-12-2

    authors： Martinez M,Ono N,Planutiene M,Planutis K,Nelson EL,Holcombe RF

    更新日期：2012-01-23 00:00:00

  • MiR-145-5p suppresses the proliferation, migration and invasion of gastric cancer epithelial cells via the ANGPT2/NOD_LIKE_RECEPTOR axis.

    abstract：Objective:This study aimed to investigate the relationship among miR-145-5p, ANGPT2 and the NOD_LIKE_RECEPTOR pathway, thereby revealing the molecular mechanism of these three factors underlying the proliferation, migration and invasion of gastric cancer (GC) epithelial cells. Methods:qRT-PCR was carried out to detect...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01483-6

    authors： Zhou K,Song B,Wei M,Fang J,Xu Y

    更新日期：2020-08-28 00:00:00

  • Identifying the novel key genes in renal cell carcinoma by bioinformatics analysis and cell experiments.

    abstract：Background:Although major driver gene have been identified, the complex molecular heterogeneity of renal cell cancer (RCC) remains unclear. Therefore, more relevant genes need to be identified to explain the pathogenesis of renal cancer. Methods:Microarray datasets GSE781, GSE6344, GSE53000 and GSE68417 were downloade...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01405-6

    authors： Chen Y,Gu D,Wen Y,Yang S,Duan X,Lai Y,Yang J,Yuan D,Khan A,Wu W,Zeng G

    更新日期：2020-07-21 00:00:00

  • p62 acts as an oncogene and is targeted by miR-124-3p in glioma.

    abstract：Background:Glioma is the most common central nervous system (CNS) tumour. p62, an important autophagy adaptor, plays a crucial role in cancer. However, the role of p62 in the progression of glioma is poorly characterized. Methods:We examined the expression of p62 in glioma tissues and cell lines. Then we investigated ...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-1004-x

    authors： Deng D,Luo K,Liu H,Nie X,Xue L,Wang R,Xu Y,Cui J,Shao N,Zhi F

    更新日期：2019-11-06 00:00:00

  • ESC reverses epithelial mesenchymal transition induced by transforming growth factor-β via inhibition of Smad signal pathway in HepG2 liver cancer cells.

    abstract：BACKGROUND:Epithelial mesenchymal transition (EMT) mediated by TGF-β pays an important role in malignant tumor acquired abilities of migration and invasion. Our previous study showed that the extract of Stellera chamaejasme L. (ESC) was against proliferation of a variety of tumor cells, but there were no studies in the...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-015-0265-2

    authors： Liu XN,Wang S,Yang Q,Wang YJ,Chen DX,Zhu XX

    更新日期：2015-12-10 00:00:00

  • LncRNA MIR4435-2HG triggers ovarian cancer progression by regulating miR-128-3p/CKD14 axis.

    abstract：Background:Accumulating studies showed that long noncoding RNAs (lncRNAs) played vital roles in cancer progression. LncRNA MIR4435-2HG was proved to act as an oncogene in various tumors. However, the underlying function of MIR4435-2HG in ovarian cancer (OC) remains unclear. Methods:The expression levels of MIR4435-2HG...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01227-6

    authors： Zhu L,Wang A,Gao M,Duan X,Li Z

    更新日期：2020-05-01 00:00:00

  • Hsa_circ_0003159 inhibits gastric cancer progression by regulating miR-223-3p/NDRG1 axis.

    abstract：Background:Abnormally expressed circular RNAs (circRNAs) are implicated in the development and treatment of gastric cancer (GC). Previous study has reported that hsa_circ_0003159 is expressed in GC. However, the role and mechanism of hsa_circ_0003159 in GC progression remain unclear. Methods:GC tissues and normal tiss...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-1119-0

    authors： Wang J,Lv W,Lin Z,Wang X,Bu J,Su Y

    更新日期：2020-02-19 00:00:00

  • Mammaglobin as a potential molecular target for breast cancer drug delivery.

    abstract：BACKGROUND:Mammaglobin (MAM) has been used as a specific molecular marker for breast cancer diagnosis. Recently, several groups of researchers proposed a number of therapeutic strategies targeting this molecule. Some of the strategies are based upon an essential but not demonstrated hypothesis - mammaglobin is associat...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-9-8

    authors： Zuo L,Li L,Wang Q,Fleming TP,You S

    更新日期：2009-03-23 00:00:00

  • MicroRNA-144 inhibits cell proliferation, migration and invasion in human hepatocellular carcinoma by targeting CCNB1.

    abstract：Background:Hepatocellular carcinoma (HCC) is one of the most common malignancies with a high morbidity and mortality worldwide. MicroRNAs are key regulators of HCC genesis. However, the regulatory role and underlying mechanisms of microRNA in HCC is still limited. Methods:Cyclin B1 (CCNB1) mRNA levels were examined in...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0729-x

    authors： Gu J,Liu X,Li J,He Y

    更新日期：2019-01-14 00:00:00

  • Long noncoding RNA SNHG4 promotes renal cell carcinoma tumorigenesis and invasion by acting as ceRNA to sponge miR-204-5p and upregulate RUNX2.

    abstract：Background:Long noncoding RNAs (lncRNAs) are involved in the tumorigenesis and progression of human cancers, including renal cell carcinoma (RCC). Small nucleolar RNA host gene 4 (SNHG4) is reported to play an essential role in tumor growth and progression. However, the molecular mechanisms and function of SNHG4 in RCC...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01606-z

    authors： Wu J,Liu T,Sun L,Zhang S,Dong G

    更新日期：2020-10-19 00:00:00

  • MicroRNA-1269 promotes cell proliferation via the AKT signaling pathway by targeting RASSF9 in human gastric cancer.

    abstract：Background:MicroRNAs (miRNAs) play key roles in tumorigenesis and progression of gastric cancer (GC). miR-1269 has been reported to be upregulated in several cancers and plays a crucial role in carcinogenesis and cancer progression. However, the biological function of miR-1269 in human GC and its mechanism remain uncle...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-1026-4

    authors： Liu WL,Wang HX,Shi CX,Shi FY,Zhao LY,Zhao W,Wang GH

    更新日期：2019-11-21 00:00:00

  • CircNEIL3 promotes cervical cancer cell proliferation by adsorbing miR-137 and upregulating KLF12.

    abstract：BACKGROUND:CircRNAs play crucial roles in multiple tumours. However, the functions of most circRNAs in cervical cancer remain unclear. METHODS:This study collected GSE113696 data from the GEO database to search for differentially expressed circRNAs in cervical cancer. Quantitative reverse transcription PCR was used to...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01736-4

    authors： Chen Y,Geng Y,Huang J,Xi D,Xu G,Gu W,Shao Y

    更新日期：2021-01-07 00:00:00

  • Alginate-embedded HuH-7 cells increase MMP-9 and reduce OCLN expression in vitro.

    abstract：BACKGROUND:Hepatocellular carcinoma is a common cancer, ranking third in cancer-associated deaths. An important cause of cancer patients' mortality is metastasis. At the start of metastasis progression, there is an epithelial-mesenchymal transition, characterized by matrix degradation, junction reductions and vessels f...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-016-0370-x

    authors： Angiolini VA,Cruz CU,López ML,Simon L,Matte U

    更新日期：2017-01-04 00:00:00