BTG1 inhibits malignancy as a novel prognosis signature in endometrial carcinoma.

abstract：BACKGROUND:This last decade, a lot of emphasis has been placed on developing new cancer cell culture models, closer to in vivo condition, in order to test new drugs and therapies. In the case of colorectal cancer, the use of patient biopsies to seed 3D primary cultures and mimic tumor initiation necessitates the use of...

journal_title：Cancer cell international

authors： Relier S,Yazdani L,Ayad O,Choquet A,Bourgaux JF,Prudhomme M,Pannequin J,Macari F,David A

更新日期：2016-02-12 00:00:00

abstract：:[This retracts the article DOI: 10.1186/s12935-015-0237-6.]. ...

journal_title：Cancer cell international

authors： Mirghasemi A,Taheriazam A,Karbasy SH,Torkaman A,Shakeri M,Yahaghi E,Mokarizadeh A

更新日期：2016-11-04 00:00:00

abstract：Background:The ubiquitin-specific protease 28 (USP28) is an oncogenic deubiquitinase, which plays a critical role in tumorigenesis via antagonizing the ubiquitination and degradation of tumor suppressor protein FBXW7-mediated oncogenic substrates. USP28 controls hypoxia-dependent angiogenesis and metastasis by preventi...

journal_title：Cancer cell international

authors： Du SC,Zhu L,Wang YX,Liu J,Zhang D,Chen YL,Peng Q,Liu W,Liu B

更新日期：2019-01-03 00:00:00

abstract：Background:Angiogenesis plays critical roles in the progression and metastasis of malignant tumors. Gastric neuroendocrine carcinoma is an uncommon stomach cancer that is rich in blood vessels and exhibits highly malignant biological behavior with a poor prognosis. The role of CDK5RAP3 in GNEC has not been reported to ...

journal_title：Cancer cell international

authors： Lin JX,Weng XF,Xie XS,Lian NZ,Qiu SL,Wang JB,Lu J,Chen QY,Cao LL,Lin M,Tu RH,Yang YH,Liu SJ,Hu M,Lin YK,Huang CM,Zheng CH,Li P,Xie JW

更新日期：2019-11-07 00:00:00

abstract：Background:Melanoma is the most aggressive type of skin cancer with high mortality rate and poor prognosis. lncRNA MEG3, a tumor suppressor, is closely related to the development of various cancers. However, the role of lncRNA MEG3 in melanoma has seldom been studied. Methods:RT-PCR was used to examine the expressions...

journal_title：Cancer cell international

authors： Wu L,Zhu L,Li Y,Zheng Z,Lin X,Yang C

更新日期：2020-01-10 00:00:00

abstract：BACKGROUND:Advanced cancer and chemotherapy are both associated with immune system suppression. We initiated a clinical trial in patients receiving chemotherapy for metastatic colorectal cancer to determine if administration of GM-CSF in this setting was immunostimulatory. METHODS:Between June, 2003 and January, 2007,...

journal_title：Cancer cell international

authors： Martinez M,Ono N,Planutiene M,Planutis K,Nelson EL,Holcombe RF

更新日期：2012-01-23 00:00:00

abstract：BACKGROUND:Patients with dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine are resistant to chemotherapeutic treatment and external irradiation and thus are difficult to treat. Direct induction of apoptosis is a promising approach in these apoptosis-resistant tumor cells. The BH3 mimeti...

journal_title：Cancer cell international

authors： Broecker-Preuss M,Becher-Boveleth N,Müller S,Mann K

更新日期：2016-04-02 00:00:00

abstract：Background:Thyroid cancer (TC) is the most frequent endocrine malignancy. Long noncoding RNAs (lncRNAs) have been confirmed to act as significant roles in tumor development. The role of lncRNA TMPO-AS1 in TC is still unclear, so it remains to be explored. The aim of the research is to investigate the role and regulator...

journal_title：Cancer cell international

authors： Li Z,Feng Y,Zhang Z,Cao X,Lu X

更新日期：2020-07-08 00:00:00

abstract：Background:SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, over-expressed in human tumor tissues and embryonic cells. Evidences support its function in the cell cycle; however there is no clear mechanism explaining its function in cell proliferation regulation. Here we investigated cancer cell response t...

journal_title：Cancer cell international

authors： Saghaeian Jazi M,Samaei NM,Mowla SJ,Arefnezhad B,Kouhsar M

更新日期：2018-09-05 00:00:00

abstract：BACKGROUND:Avenanthramides (AVN) are a relatively unstudied family of phytochemicals that could be novel chemotherapeutics. These compounds, found in oats, are non-toxic to healthy cells and have been shown to reduce viability of human colon and liver cancers in vitro. However, these studies do not elucidate a molecula...

journal_title：Cancer cell international

authors： Hastings J,Kenealey J

更新日期：2017-10-18 00:00:00

abstract：BACKGROUND:Expression of P-glycoprotein (P-gp), the multidrug resistance (MDR) 1 gene product, can lead to multidrug resistance in tumours. However, the physiological role of P-gp in tumours growing as multicellular spheroids is not well understood. Recent evidence suggests that P-gp activity may be modulated by cellul...

journal_title：Cancer cell international

authors： Ponce de León V,Barrera-Rodríguez R

更新日期：2005-07-07 00:00:00

abstract：BACKGROUND:Prostate cancer progression to androgen independence is the primary cause of mortality by this tumor type. The IGF-1/IGF-1R axis is well known to contribute to prostate cancer initiation, but its contribution to invasiveness and the downstream signalling mechanisms that are involved are unclear at present. ...

journal_title：Cancer cell international

authors： Saikali Z,Setya H,Singh G,Persad S

更新日期：2008-07-03 00:00:00

abstract：Background:Estrogen sulfotransferase catalyzes conjugation of sulfuryl-group to estradiol/estrone and regulates E2 availability/activity via estrogen-receptor or non-receptor mediated pathways. Sulfoconjugated estrogen fails to bind estrogen-receptor (ER). High estrogen is a known carcinogen in postmenopausal women. Re...

journal_title：Cancer cell international

authors： Nazmeen A,Chen G,Ghosh TK,Maiti S

更新日期：2020-03-04 00:00:00

abstract：Background:At the present time, colorectal cancer (CRC) is still known as a disease with a high mortality rate. Theranostics are flawless scenarios that link diagnosis with therapy, including precision medicine as a critical platform that relies on the development of biomarkers particularly "liquid biopsy". Circulating...

journal_title：Cancer cell international

authors： Vafaei S,Roudi R,Madjd Z,Aref AR,Ebrahimi M

更新日期：2020-07-06 00:00:00

abstract：: Autoimmune phenomena were identified in many different cases of hematological diseases and solid tumors, which may be due to alterations in the expression and function of the NF-κB signaling pathway. Recently, a number of studies have shown that the deletion or mutation of A20, a negative regulator of NF-κB, is frequ...

journal_title：Cancer cell international

authors： Zhang F,Yang L,Li Y

更新日期：2012-11-07 00:00:00

abstract：BACKGROUND:The goal of this study was to identify the nature of the inclusion bodies that have been found in HeLa cells (cervical cancer immortal cell line) by electron microscope and to determine whether the major capsid protein (L1) of human papillomavirus (HPV) can be expressed in HPV-positive uterine cervix cancer ...

journal_title：Cancer cell international

authors： Xiao CY,Fu BB,Li ZY,Mushtaq G,Kamal MA,Li JH,Tang GC,Xiao SS

更新日期：2015-05-23 00:00:00

abstract：:[This corrects the article DOI: 10.1186/s12935-017-0407-9.]. ...

journal_title：Cancer cell international

authors： Hu Y,Xie H,Liu Y,Liu W,Liu M,Tang H

更新日期：2020-07-17 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) is a type of malignancy with progressive metastasis having poor prognosis and lowered survival resulting from late diagnosis. The therapeutic approaches for the treatment of this incurable cancer are chemo- and radiotherapy. Since current treatments are insufficient and because of dr...

journal_title：Cancer cell international

authors： Pourhanifeh MH,Sharifi M,Reiter RJ,Davoodabadi A,Asemi Z

更新日期：2019-05-16 00:00:00

abstract：Background:Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Siah E3 ubiquitin protein ligase 1 (Siah1) has been identified as a tumor suppressor gene and plays an important role in the development of malignant tumors. However, the potential role and molecular mechanism of Siah1 in the de...

journal_title：Cancer cell international

authors： Xiao Z,Wei Z,Deng D,Zheng Z,Zhao Y,Jiang S,Zhang D,Zhang LJ,Fan M,Chen S,Wang S,Ding Y,Ye Y,Jiao H

更新日期：2020-02-13 00:00:00

abstract：Background:Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case-control study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) in TNFAIP8 on...

journal_title：Cancer cell international

authors： Liu T,Jiang L,Yu L,Ge T,Wang J,Gao H

更新日期：2019-04-23 00:00:00

abstract：BACKGROUND:Mononuclear platinum anticancer agents hold a pivotal place in the treatment of many forms of cancers, however, there is a potential to improve response to evade resistance development and toxic side effects. BBR3464 is a promising trinuclear platinum anticancer agent, which is a polyamine mimic. The aim was...

journal_title：Cancer cell international

authors： Kjellström J,Oredsson SM,Wennerberg J

更新日期：2012-05-28 00:00:00

abstract：BACKGROUND:Gastric carcinoma (GC) is currently one of the most common malignant tumors of the digestive system, and gastric precancerous lesions play a vital role in studying the mechanism of GC. Multiple microRNAs (miRNAs) have been documented to be potential biomarkers to indicate progression of gastric precancerous ...

journal_title：Cancer cell international

authors： Zhang T,Zhang K,Ji K,Zhang C,Jiang Y,Zhang Q,Tian Z,Wang X,Zhang M,Li X

更新日期：2020-11-13 00:00:00

abstract：Background:Cholangiocarcinoma (CCA) is an invasive malignancy arising from biliary epithelial cells; it is the most common primary tumour of the bile tract and has a poor prognosis. The aim of this study was to screen prognostic biomarkers for CCA by integrated multiomics analysis. Methods:The GSE32225 dataset was der...

journal_title：Cancer cell international

authors： Da Z,Gao L,Su G,Yao J,Fu W,Zhang J,Zhang X,Pei Z,Yue P,Bai B,Lin Y,Meng W,Li X

更新日期：2020-04-22 00:00:00

abstract：:An area of research that has been recently gaining attention is the relationship between cancer stem cell (CSC) biology and chemo-resistance in colon cancer patients. It is well recognized that tumor initiation, growth, invasion and metastasis are promoted by CSCs. An important reason for the widespread interest in th...

journal_title：Cancer cell international

authors： Garza-Treviño EN,Said-Fernández SL,Martínez-Rodríguez HG

更新日期：2015-01-28 00:00:00

abstract：BACKGROUND:Serum Deprivation Protein Response (SDPR) plays an important role in formation of pulmonary alveoli. However, the functions and values of SDPR in lung cancer remain unknown. We explored prognostic value, expression pattern, and biological function of SDPR in non-small cell lung cancer (NSCLC) and KRAS-mutant...

journal_title：Cancer cell international

authors： Luo X,Peng S,Ding S,Zeng Q,Wang R,Ma Y,Chen S,Wang Y,Wang W

更新日期：2021-01-12 00:00:00

abstract：Background:Lung cancer is the most common malignant tumor in the world. The Whole-proteome microarray showed that ubiquitin ligase chromatin assembly factor 1 subunit B (CHAF1B) expression in A549/DDP cells is higher than in A549 cells. Our study explored the molecular mechanism of CHAF1B affecting cisplatin resistance...

journal_title：Cancer cell international

authors： Gong L,Hu Y,He D,Zhu Y,Xiang L,Xiao M,Bao Y,Liu X,Zeng Q,Liu J,Zhou M,Zhou Y,Cheng Y,Zhang Y,Deng L,Zhu R,Lan H,Cao K

更新日期：2020-05-25 00:00:00

abstract：BACKGROUND:Endometrial cancer is an invasive gynecological cancer prevalent in the world. The pathogenesis of endometrial cancer is related to multiple levels of regulation, referring to oestrogen, tumor-suppressor gene (e.g. PTEN) or microRNAs (e.g. miR-23a and miR-29b). Metapristone is a hormone-related drug, which i...

journal_title：Cancer cell international

authors： Chang Y,Hao M,Jia R,Zhao Y,Cai Y,Liu Y

更新日期：2021-01-07 00:00:00

abstract：Background:The aim of the study was to explore the association between the SIRT1 single nucleotide polymorphism (SNP) rs3758391 and diffuse large B cell lymphoma (DLBCL) in a Chinese Han population. Methods:206 patients diagnosed with DLBCL and 219 healthy individuals were recruited in the present study. The genotypin...

journal_title：Cancer cell international

authors： Kan Y,Ge P,Wang X,Xiao G,Zhao H

更新日期：2018-10-22 00:00:00

abstract：Background:Tumor necrosis factor-α (TNF-α) immunotherapy controls the progression of human cervical cancer. Here, we explored the detailed molecular mechanisms played by melatonin in human cervical cancer (HeLa cells) death in the presence of TNF-α injury, with a particular attention to the mitochondrial homeostasis. ...

journal_title：Cancer cell international

authors： Zhao Q,Wang W,Cui J

更新日期：2019-03-14 00:00:00

abstract：BACKGROUND:While some risk factors for breast cancer are well-known, the influence of other factors, particularly virus infection, remains unclear. Human cytomegalovirus (HCMV) is widespread in the general population, and both molecular and epidemiological evidence has indicated links between HCMV and breast cancer. Th...

journal_title：Cancer cell international

authors： Valle Oseguera CA,Spencer JV

更新日期：2017-02-13 00:00:00