Breast cancer pathogenesis is linked to the intra-tumoral estrogen sulfotransferase (hSULT1E1) expressions regulated by cellular redox dependent Nrf-2/NFκβ interplay.

abstract：Background:A number of JmjC domain-containing histone demethylases have been identified and biochemically characterized in mammalian models and humans. JMJD2A is a transcriptional co-factor and enzyme that catalyzes the demethylation of histone H3 lysine 9 and 36 (H3K9 and H3K36). Here in this study, we reported the ro...

journal_title：Cancer cell international

authors： Li M,Cheng J,Ma Y,Guo H,Shu H,Huang H,Kuang Y,Yang T

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:The expression of major histocompatibility complex class II (MHCII) antigens in both mouse and human tumors is rare, and these antigens are not easily inducible by IFN-gamma (IFNg). Since MHCII may play an important role in the development of host antitumor immune response, we explored the possibility of res...

journal_title：Cancer cell international

authors： Kudinov Y,Wiseman CL,Kharazi AI

更新日期：2003-03-25 00:00:00

abstract：BACKGROUND:Gastric cancer is one of the common cancers seen in south India. Unfortunately more than 90% are advanced by the time they report to a tertiary centre in the country. There is an urgent need to characterize these cancers and try to identify potential biomarkers and novel therapeutic targets. MATERIALS AND M...

journal_title：Cancer cell international

authors： Rajkumar T,Vijayalakshmi N,Gopal G,Sabitha K,Shirley S,Raja UM,Ramakrishnan SA

更新日期：2010-11-24 00:00:00

abstract：Background:Melanoma as a type of skin cancer, is associated with a high mortality rate. Therefore, early diagnosis and efficient surgical treatment of this disease is very important. Photodynamic therapy (PDT) involves the activation of a photosensitizer by light at specific wavelength that interacts with oxygen and cr...

journal_title：Cancer cell international

authors： Khorsandi K,Hosseinzadeh R,Chamani E

更新日期：2020-10-29 00:00:00

abstract：:Colorectal cancer (CRC) is a complex and molecularly heterogeneous disease representing one of the most frequent causes of cancer-related death worldwide. About 8-15% of CRCs harbor a mutation in BRAF gene, a proto-oncogene involved in cell proliferation, differentiation and survival through the MAPK signaling cascade...

journal_title：Cancer cell international

authors： Fanelli GN,Dal Pozzo CA,Depetris I,Schirripa M,Brignola S,Biason P,Balistreri M,Dal Santo L,Lonardi S,Munari G,Loupakis F,Fassan M

更新日期：2020-01-29 00:00:00

abstract：Background:Recent studies have emphasized the important prognostic role of long noncoding RNAs (lncRNAs) in various types of cancers. Here we conducted a meta-analysis to investigate whether lncRNA HOXA11-AS can be served as a prognostic biomarker in human cancers. Patients/methods:We systematically searched PubMed, E...

journal_title：Cancer cell international

authors： Mu S,Ai L,Fan F,Sun C,Hu Y

更新日期：2018-01-03 00:00:00

abstract：Background:Alternative splicing (AS) is a key factor in protein-coding gene diversity, and is associated with the development and progression of malignant tumours. However, the role of AS in cervical cancer is unclear. Methods:The AS data for cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) were...

journal_title：Cancer cell international

authors： Ouyang D,Yang P,Cai J,Sun S,Wang Z

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Cyclooxygenase (COX) is a rate-limiting enzyme in prostaglandins synthesis which exists in two isoforms, COX-1 and COX-2. Over-expression of COX-2 was considered to increase the proliferation and enhance the invasiveness of breast cancer cells. It was suggested that genetic variations in COX-2 could influenc...

journal_title：Cancer cell international

authors： Gao J,Kang HF,Ma XB,Tang W,Liu D,Zhao Y,Zhang SQ,Guan HT,Lin S,Ren HT,Wang XJ,Dai ZJ

更新日期：2014-05-06 00:00:00

abstract：BACKGROUND:Celecoxib is a selective cyclooxygenase (COX)-2 inhibitor that has been reported to reduce the risk of breast cancer. In our previous study, celecoxib induced apoptosis and caused cell cycle arrest at the G0/G1 phase in the breast cancer cell line MDA-MB-231, and its effects were mediated by downregulation o...

journal_title：Cancer cell international

authors： Wang L,Kang F,Li J,Zhang J,Shan B

更新日期：2013-02-12 00:00:00

abstract：Background:The staging system of nasopharyngeal carcinoma (NPC) has close relationship with the degree of cell differentiation, but most NPC patients remain undiagnosed until advanced phases. Novel metabolic markers need to be characterized to support diagnose at an early stage. Methods:Metabolic characteristics of na...

journal_title：Cancer cell international

authors： Chen Y,Chen Z,Su Y,Lin D,Chen M,Feng S,Zou C

更新日期：2019-02-18 00:00:00

abstract：Background:Fyn has been documented to have oncogenic features in multiple tumors, which might be a potential therapeutic target, however, few studies on the function role of Fyn and its specific inhibitors in melanoma. Methods:We investigated the impacts of Fyn and its inhibitor Lj-1-60 on melanoma through bioinformat...

journal_title：Cancer cell international

authors： Tang L,Long J,Li K,Zhang X,Chen X,Peng C

更新日期：2020-06-18 00:00:00

abstract：Background:Programmed cell death 1 (PD-1) functions as an immune checkpoint in the process of anti-tumor immune response. The PD-1 blockade is now becoming a fundamental part in cancer immunotherapy. So it's essential to elicit the PD-1 related immune process in different types of cancer. Methods:The Cancer Genome Atl...

journal_title：Cancer cell international

authors： Shang J,Song Q,Yang Z,Sun X,Xue M,Chen W,Yang J,Wang S

更新日期：2018-12-27 00:00:00

abstract：Background:Extracellular ATP (eATP) was shown to induce epithelial-mesenchymal transition (EMT), a very important early process in metastasis, in cancer cells via purinergic receptor signaling. However, the exact induction mechanisms are far from fully known. We previously described that eATP is internalized by cancer ...

journal_title：Cancer cell international

authors： Cao Y,Wang X,Li Y,Evers M,Zhang H,Chen X

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:G protein-coupled receptor family C group 5 member A (GPRC5A), a retinoic acid-inducible gene, is a lung tumor suppressor. Previously, we showed that repression of GPRC5A expression was associated with pathologic differentiation grade of oral squamous cell carcinomas (OSCC) and overexpression of GPRC5A gene ...

journal_title：Cancer cell international

authors： Liu S,Ye D,Wang T,Guo W,Song H,Liao Y,Xu D,Zhu H,Zhang Z,Deng J

更新日期：2017-03-02 00:00:00

abstract：BACKGROUND:Compounds of plant origin and food components have attracted scientific attention for use as agents for cancer prevention and treatment. Wine contains polyphenols that were shown to have anti-cancer and other health benefits. The survival pathways of Akt and extracellular signal-regulated kinase (Erk), and t...

journal_title：Cancer cell international

authors： Barron CC,Moore J,Tsakiridis T,Pickering G,Tsiani E

更新日期：2014-01-23 00:00:00

abstract：BACKGROUND:Several reports have revealed that cancer stem cells (CSCs) exist in many types of solid tumors. Some studies have demonstrated that side population (SP) cells isolated from diverse cancer lines harbor cancer stem-like properties, but there are few reports examining the characteristic of SP cells in human ce...

journal_title：Cancer cell international

authors： Qi W,Zhao C,Zhao L,Liu N,Li X,Yu W,Wei L

更新日期：2014-01-13 00:00:00

abstract：:Prostate cancer is a gland tumor in the male reproductive system. It is a multifaceted and genomically complex disease. Transmembrane protease, serine 2 and v-ets erythroblastosis virus E26 homolog (TMPRSS2-ERG) gene fusions are the common molecular signature of prostate cancer. Although tremendous advances have been ...

journal_title：Cancer cell international

authors： Farooqi AA,Hou MF,Chen CC,Wang CL,Chang HW

更新日期：2014-04-17 00:00:00

abstract：:[This corrects the article DOI: 10.1186/s12935-020-01426-1.]. ...

journal_title：Cancer cell international

authors： Li T,Liu Q,Zhang R,Liao Q,Zhao Y

更新日期：2020-08-18 00:00:00

abstract：Background:Acute lymphoblastic leukemia (ALL) is an aggressive hematopoietic malignancy that is most commonly observed in children. Alantolactone (ALT) has been reported to exhibit anti-tumor activity in different types of cancer. The aim of the present study was to investigate the anti-tumor activity and molecular mec...

journal_title：Cancer cell international

authors： Shi C,Lan W,Wang Z,Yang D,Wei J,Liu Z,Teng Y,Gu M,Yuan T,Cao F,Zhou J,Li Y

更新日期：2020-09-09 00:00:00

abstract：Background:Newly identified lncRNA zinc finger protein, FOG family member 2 antisense RNA 1 (ZFPM2-AS1) is identified as an oncogenic gene. However, the role of ZFPM2-AS1 in small cell lung cancer (SCLC) is poorly comprehended. Methods:The expression of genes in SCLC tissues and cells was measured by qRT-PCR. Colony f...

journal_title：Cancer cell international

authors： Yan Z,Yang Q,Xue M,Wang S,Hong W,Gao X

更新日期：2020-04-03 00:00:00

abstract：Background:MicroRNAs have been involved in regulating crucial biological function in some tumors. However, the clinical role and functional effects of miR-591 in breast cancer remain unknown. Methods:The expression of miR-591 was detected in breast cancer tissues and their paired normal tissues by qRT-PCR. Functional ...

journal_title：Cancer cell international

authors： Huang X,Tang F,Weng Z,Zhou M,Zhang Q

更新日期：2019-04-24 00:00:00

abstract：Background:The ubiquitin-specific protease 28 (USP28) is an oncogenic deubiquitinase, which plays a critical role in tumorigenesis via antagonizing the ubiquitination and degradation of tumor suppressor protein FBXW7-mediated oncogenic substrates. USP28 controls hypoxia-dependent angiogenesis and metastasis by preventi...

journal_title：Cancer cell international

authors： Du SC,Zhu L,Wang YX,Liu J,Zhang D,Chen YL,Peng Q,Liu W,Liu B

更新日期：2019-01-03 00:00:00

abstract：BACKGROUND:We previously observed that the TGFbeta-Par6 pathway mediates loss of polarity and apoptosis in NMuMG cells. Here we investigate the contribution of Par6 versus TGFbeta receptor I activation to TGFbeta-induced apoptosis in association with changes in apico-basal polarity. We focus on the effect of Par6 activ...

journal_title：Cancer cell international

authors： Avery-Cooper G,Doerr M,Gilbert RW,Youssef M,Richard A,Huether P,Viloria-Petit AM

更新日期：2014-03-01 00:00:00

abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) is the largest histological subgroup of lung cancer and has increased in prevalence in China over the past 5 years. The 5-year survival rate has remained at 15-20 %, with a median survival of 8-12 months. The tumorigenesis and progression of NSCLC is orchestrated by numerou...

journal_title：Cancer cell international

authors： Chen S,Li P,Yang R,Cheng R,Zhang F,Wang Y,Chen X,Sun Q,Zang W,Du Y,Zhao G,Zhang G

更新日期：2015-09-17 00:00:00

abstract：BACKGROUND:miR-222 has been reported to be overexpressed in colorectal cancer and it influences cancer cell proliferation, drug resistance and metastasis. However, the underlying molecular mechanism of miR-222 in colorectal cancer cell invasion and migration has not been thoroughly elucidated to date. METHODS:The cell...

journal_title：Cancer cell international

authors： Gao H,Cong X,Zhou J,Guan M

更新日期：2017-08-29 00:00:00

abstract：Background:Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property. Cytosine deaminase (CD), which is derived from bacteria or yeast, can convert a relatively nontoxic prodrug 5-fluorocytosine (5-FC) into the active an...

journal_title：Cancer cell international

authors： Ding Y,Fan J,Deng L,Huang B,Zhou B

更新日期：2020-06-15 00:00:00

abstract：Background:Transgelin, an actin-binding protein, is associated with cytoskeleton remodeling. Findings from our previous studies demonstrated that transgelin was up-regulated in node-positive colorectal cancer (CRC) versus node-negative disease. Over-expression of TAGLN affected the expression of 256 downstream transcri...

journal_title：Cancer cell international

authors： Lew ZX,Zhou HM,Fang YY,Ye Z,Zhong W,Yang XY,Yu Z,Chen DY,Luo SM,Chen LF,Lin Y

更新日期：2020-08-03 00:00:00

abstract：Background:Cutaneous melanoma is one of the most aggressive and lethal skin cancers. It is greatly important to identify prognostic biomarkers to guide the clinical management. However, it is technically challenging for untrained researchers to process high dimensional profiling data and identify potential prognostic g...

journal_title：Cancer cell international

authors： Zhang L,Wang Q,Wang L,Xie L,An Y,Zhang G,Zhu W,Li Y,Liu Z,Zhang X,Tang P,Huo X,Guo X

更新日期：2020-05-19 00:00:00

abstract：BACKGROUND:Resistance to drug therapy is a major impediment for successful treatment of patients suffering from breast cancer (BC). Tamoxifen (TAM) is an extensively used therapeutic agent, which substantially reduces the risk of recurrence and associated mortality in BC. This study demonstrated that exosomal transfer ...

journal_title：Cancer cell international

authors： Liu J,Zhu S,Tang W,Huang Q,Mei Y,Yang H

更新日期：2021-01-15 00:00:00

abstract：BACKGROUND:Gastric carcinoma (GC) is currently one of the most common malignant tumors of the digestive system, and gastric precancerous lesions play a vital role in studying the mechanism of GC. Multiple microRNAs (miRNAs) have been documented to be potential biomarkers to indicate progression of gastric precancerous ...

journal_title：Cancer cell international

authors： Zhang T,Zhang K,Ji K,Zhang C,Jiang Y,Zhang Q,Tian Z,Wang X,Zhang M,Li X

更新日期：2020-11-13 00:00:00