Abstract:
BACKGROUND:Cyclooxygenase (COX) is a rate-limiting enzyme in prostaglandins synthesis which exists in two isoforms, COX-1 and COX-2. Over-expression of COX-2 was considered to increase the proliferation and enhance the invasiveness of breast cancer cells. It was suggested that genetic variations in COX-2 could influence its expression. Herein, the present study was aimed to investigate the associations between two mostly studied functional polymorphisms (-765 G > C and 8473 C > T) in COX-2 and breast cancer risk in Chinese Han women. METHODS:In the hospital-based case-control study, 465 breast cancer patients and 799 cancer-free controls were genotyped for the COX-2 -765 G > C and 8473 C > T polymorphisms using TaqMan assay. We estimated odds ratios (ORs) and 95% confidence intervals (95% CIs) using the logistic regression. RESULTS:Compared with the wild genotype of -765 G > C, we found a statistically significant increased risk of breast cancer associated with the variant genotypes [GC/CC vs. GG: OR = 1.56, 95% CI = 1.11-2.21]. In the stratified analysis, the increased risk was more predominant among the subgroups of younger subjects (OR = 1.61, 95% CI = 1.00-2.61). Furthermore, the variant genotypes were associated with large tumor size (OR = 3.01, 95% CI = 1.47-6.12). No significant association was observed for the 8473 C > T polymorphism. CONCLUSIONS:Our results suggest that the functional -765 G > C polymorphism in the promoter of COX-2 may influence the susceptibility and progression of breast cancer in the Chinese Han population.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Gao J,Kang HF,Ma XB,Tang W,Liu D,Zhao Y,Zhang SQ,Guan HT,Lin S,Ren HT,Wang XJ,Dai ZJdoi
10.1186/1475-2867-14-38subject
Has Abstractpub_date
2014-05-06 00:00:00pages
38issn
1475-2867pii
1475-2867-14-38journal_volume
14pub_type
杂志文章abstract:Background:Some studies have investigated the prognostic value exhibited by the Prognostic Nutritional Index (PNI) in patients suffering diffuse large B-cell lymphoma (DLBCL), but varying results were obtained. In order to determine the specific prognostic value more accurately, a meta-analysis was conducted in this st...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-020-01535-x
更新日期:2020-09-15 00:00:00
abstract:BACKGROUND:Human umbilical cord blood derived-mesenchymal stem cells (hUCMSCs) offer an attractive alternative to bone marrow-derived MSCs (BMMSCs) for cell-based therapy as it is a less invasive source of biological material. However, limited studies have been conducted with hUCMSCs as compared to BMMSCs. The present ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-014-0093-9
更新日期:2014-09-24 00:00:00
abstract::[This corrects the article DOI: 10.1186/s12935-020-01426-1.]. ...
journal_title:Cancer cell international
pub_type: 已发布勘误
doi:10.1186/s12935-020-01482-7
更新日期:2020-08-18 00:00:00
abstract::Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha (HIF-1α) is a major regulator of cellular response to changes in oxygen concentration, supporting the adaptation of tumor cells to hypoxia in...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-020-01370-0
更新日期:2020-06-24 00:00:00
abstract:BACKGROUND:Hepatocellular carcinoma is a common cancer, ranking third in cancer-associated deaths. An important cause of cancer patients' mortality is metastasis. At the start of metastasis progression, there is an epithelial-mesenchymal transition, characterized by matrix degradation, junction reductions and vessels f...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-016-0370-x
更新日期:2017-01-04 00:00:00
abstract:Background:The staging system of nasopharyngeal carcinoma (NPC) has close relationship with the degree of cell differentiation, but most NPC patients remain undiagnosed until advanced phases. Novel metabolic markers need to be characterized to support diagnose at an early stage. Methods:Metabolic characteristics of na...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0759-4
更新日期:2019-02-18 00:00:00
abstract:Background:Despite improvements in nasopharyngeal carcinoma (NPC) treatment, patients with recurrence and metastasis still have a poor prognosis. Thus, the identification of novel biomarkers is urgently needed to predict outcomes and tailor treatment for NPC. Methods:Four data sets were downloaded from Gene Expression...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01587-z
更新日期:2020-10-12 00:00:00
abstract:Background:Extracellular ATP (eATP) was shown to induce epithelial-mesenchymal transition (EMT), a very important early process in metastasis, in cancer cells via purinergic receptor signaling. However, the exact induction mechanisms are far from fully known. We previously described that eATP is internalized by cancer ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0973-0
更新日期:2019-10-01 00:00:00
abstract::Application of novel methods in cancer therapy is important in terms of management and treatment of the life-threatening disorder. It appears that autophagy is a potential target in cancer therapy, as a variety of drugs targeting autophagy have shown great potential in reducing the viability and proliferation of cance...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-020-01634-9
更新日期:2020-11-04 00:00:00
abstract:Background:miR-429 and TLN1 have been shown to affect the biological behaviours of many carcinomas. However, their effects in nasopharyngeal carcinoma (NPC) are not yet clear. Here, we investigated their regulatory relationships and effects on NPC cells. Methods:TargetScan was used to predict the regulatory relationsh...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0831-0
更新日期:2019-04-30 00:00:00
abstract:BACKGROUND:BRAF inhibitors are effective anticancer agents in BRAF-mutated melanomas. By contrast, evidences about sensitivity of thyroid carcinomas to BRAF inhibition are conflicting and it has been proposed that BRAF V600E thyroid carcinoma cells are less sensitive to BRAF inhibitors due to activation of parallel sig...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0457-z
更新日期:2017-10-04 00:00:00
abstract:BACKGROUND:Resistance to drug therapy is a major impediment for successful treatment of patients suffering from breast cancer (BC). Tamoxifen (TAM) is an extensively used therapeutic agent, which substantially reduces the risk of recurrence and associated mortality in BC. This study demonstrated that exosomal transfer ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01659-0
更新日期:2021-01-15 00:00:00
abstract:Background:Immunotherapies that targeting programmed cell death 1 (PD-1) and programmed death-ligand 1 (PD-L1) have obtained prominent success in breast cancer (BC). However, not all the patients benefit from the antibody therapy. This study aimed to identify PD-1/PD-L1 correlated genes and pathways as well as investig...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0955-2
更新日期:2019-09-09 00:00:00
abstract::[This corrects the article DOI: 10.1186/s12935-019-0742-0.]. ...
journal_title:Cancer cell international
pub_type: 杂志文章,已发布勘误
doi:10.1186/s12935-019-0797-y
更新日期:2019-04-11 00:00:00
abstract:BACKGROUND:Gastric cancer is one of the common cancers seen in south India. Unfortunately more than 90% are advanced by the time they report to a tertiary centre in the country. There is an urgent need to characterize these cancers and try to identify potential biomarkers and novel therapeutic targets. MATERIALS AND M...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-10-45
更新日期:2010-11-24 00:00:00
abstract:Background:Breast cancer has been the first death cause of cancer in women all over the world. Metastasis is believed to be the most important process for treating breast cancer. There is evidence that lncRNA MEG3 functions as a tumor suppressor in breast cancer metastasis. However, upstream regulation of MEG3 in breas...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0642-8
更新日期:2018-10-25 00:00:00
abstract:Objective:To study the potential role of miR-544 in the immune escape mechanism of hepatoma cells. Methods:Natural killer (NK) cells were collected from healthy volunteers and patients with liver cancer. Interleukin (IL)-2 activated-NK-92 cells were transfected with miR-544 inhibitor/mimic or NC/pre-NC in HepG2 co-cul...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0542-y
更新日期:2018-04-03 00:00:00
abstract:BACKGROUND:The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death. The role of these channels in the onset and progression of ovarian cancer is unknown. An understanding of mechanism by whi...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-11-6
更新日期:2011-03-10 00:00:00
abstract:BACKGROUND:Apigenin (4',5,7-trihydroxyflavone) was recently shown effective in inhibiting several cancers. The aim of this study was to investigate the effect and mechanism of apigenin in the human bladder cancer cell line T24 for the first time. METHODS:T24 cells were treated with varying concentrations and time of a...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-13-54
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Several reports have revealed that cancer stem cells (CSCs) exist in many types of solid tumors. Some studies have demonstrated that side population (SP) cells isolated from diverse cancer lines harbor cancer stem-like properties, but there are few reports examining the characteristic of SP cells in human ce...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-14-3
更新日期:2014-01-13 00:00:00
abstract:BACKGROUND:Blockade of the angiotensin (ANG) II type 1 receptor (AT1R) inhibits tumour growth in several cancers, including colorectal cancer (CRC) liver metastases. While AT1R blockade has been extensively studied, the potential of targeting the antagonistically acting AT2R in cancer has not been investigated. This st...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-10-19
更新日期:2010-06-28 00:00:00
abstract:Background:Long noncoding RNAs (lncRNAs) play essential roles in tumor progression. However, the functions and targets of lncRNAs in neuroblastoma (NB) progression still remain to be determined. In this study, we aimed to investigate the effect of lncRNA DLX6 antisense RNA 1 (DLX6-AS1) on NB and the underlying mechanis...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0968-x
更新日期:2019-11-27 00:00:00
abstract:Background:Cancer-associated fibroblasts (CAFs) play important roles in tumor progression. However, the behaviors of activated CAFs in gastric cancer remain to be determined. The aim of the present study was to investigate the correlations between activated gastric CAFs and the prognosis of patients with gastric cancer...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0599-7
更新日期:2018-07-20 00:00:00
abstract::BACKGROUND: The aim of this work was to investigate in vitro the putative role of EGR-1 in the growth of glioma cells. EGR-1 expression was examined during the early passages in vitro of 17 primary cell lines grown from 3 grade III and from 14 grade IV malignant astrocytoma explants. The explanted tumors were genetica...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-4-1
更新日期:2004-01-07 00:00:00
abstract:OBJECTIVE:To explore the relationship between tumor necrosis factor receptor-associated factor 6 (TRAF6) and the clinicopathological features in HCC as well as its biological function. METHODS:Totally, 412 liver tissues were collected, including 171 hepatocellular carcinoma (HCC) and their corresponding non-tumor tiss...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-016-0352-z
更新日期:2016-09-29 00:00:00
abstract::Cancer stem-like cells exhibit the multi-functional roles to survive and persist for a long period in the minimal residual disease after the conventional anti-cancer treatments. Cancer stem-like cells of solid malignant tumors which highly express CD44v8-10, the variant isoform of CD44 generated by alternative splicin...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0393-y
更新日期:2017-02-13 00:00:00
abstract:BACKGROUND:Recent studies have reported the involvement of microRNA-29 (miR-29) family members in human cancers through their ability to regulate cellular functions. The present study investigated biological function of miR-29b in colorectal cancer (CRC). METHODS:CRC tissues and adjacent normal tissues were collected ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01700-2
更新日期:2021-01-06 00:00:00
abstract:Background:Abnormally expressed circular RNAs (circRNAs) are implicated in the development and treatment of gastric cancer (GC). Previous study has reported that hsa_circ_0003159 is expressed in GC. However, the role and mechanism of hsa_circ_0003159 in GC progression remain unclear. Methods:GC tissues and normal tiss...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1119-0
更新日期:2020-02-19 00:00:00
abstract:BACKGROUND:Breast cancer (BrCa) is the most common female malignancy worldwide and has the highest morbidity among all cancers in females. Unfortunately, the mechanisms of BrCa growth and metastasis, which lead to a poor prognosis in BrCa patients, have not been well characterized. METHODS:Immunohistochemistry (IHC) w...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01733-7
更新日期:2021-01-06 00:00:00
abstract:Background:Drug resistance to 5-fluorouracil (5-FU) and recurrence after chemotherapy in colorectal cancer remain a challenge to be resolved for the improvement of patient outcomes. It is recognized that a variety of secretory proteins released from the tumor cells exposed to chemo-drugs into the tumor microenvironment...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01541-z
更新日期:2020-09-14 00:00:00