Prognostic nutritional index and the prognosis of diffuse large b-cell lymphoma: a meta-analysis.


Background:Some studies have investigated the prognostic value exhibited by the Prognostic Nutritional Index (PNI) in patients suffering diffuse large B-cell lymphoma (DLBCL), but varying results were obtained. In order to determine the specific prognostic value more accurately, a meta-analysis was conducted in this study. Methods:Literatures were searched from the China National Knowledge Infrastructure (CNKI), Wanfang, PubMed, Embase, the Cochrane Library, and Web of Science. Pooled hazard ratio (HR) and the 95% confidence interval (CI) were calculated to assess the association between PNI and the overall survival (OS) and the progression-free survival (PFS) of patients with DLBCL. Results:Based on seven studies with a total number of 1311 patients, our meta-analysis revealed that low PNI may meant poor OS (HR = 2.14, 95% CI 1.66-2.75, p < 0.001) and poor PFS (HR = 1.75, 95% CI 1.36-2.25, p = 0.438). Subgroup analysis showed that, in Asians, low PNI was correlated to poor OS (pooled HR = 2.06 95% CI 1.59-2.66) and poor PFS (pooled HR = 1.66, 95% CI 1.28-2.15). Similar results were obtained from one European study, which is the only study performed outside of Asia from our literature search. Conclusion:For patients with DLBCL, low PNI may be interpreted as adverse prognosis. More data from European patients are required in this study to avoid analysis bias.


Cancer Cell Int


Luan C,Wang F,Wei N,Chen B




Has Abstract


2020-09-15 00:00:00










  • LncRNA NEAT1 promotes proliferation, migration, invasion and epithelial-mesenchymal transition process in TGF-β2-stimulated lens epithelial cells through regulating the miR-486-5p/SMAD4 axis.

    abstract:BACKGROUND:Abnormal proliferation, metastasis and epithelial-mesenchymal transformation (EMT) of lens epithelial cells (LECs) are direct factors of posterior capsular opacification (PCO). Nuclear enriched abundant transcript 1 (NEAT1) has been shown to promote cell proliferation, metastasis and EMT, but whether it affe...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Wang H,Zheng G

    更新日期:2020-10-31 00:00:00

  • MiR-145 functions as a tumor suppressor via regulating angiopoietin-2 in pancreatic cancer cells.

    abstract:BACKGROUND:Pancreatic cancer is currently one of the leading causes of cancer deaths without any effective therapies. Mir-145 has been found to be tumor-suppressive in various types of cancers. The aim of this study is to investigate the role of miR-145 in pancreatic cancer cells and explore its underlying mechanism. ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Wang H,Hang C,Ou XL,Nie JS,Ding YT,Xue SG,Gao H,Zhu JX

    更新日期:2016-08-25 00:00:00

  • MiR-7 inhibits progression of hepatocarcinoma by targeting KLF-4 and promises a novel diagnostic biomarker.

    abstract:BACKGROUND:MicroRNAs are 22-24 nt non-coding RNAs that bind to the 3' UTR of target mRNAs, thereby inducing mRNA degradation or inhibiting mRNA translation. Due to their implication in the regulation of post-transcriptional processes, the role of miRNAs in hepatocellular carcinoma (HCC) has been extensively studied. Ho...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Wu W,Liu S,Liang Y,Zhou Z,Liu X

    更新日期:2017-02-21 00:00:00

  • PEG10 as an oncogene: expression regulatory mechanisms and role in tumor progression.

    abstract::Cancer is a major public health problem as one of the leading causes of death worldwide. Deciphering the molecular regulation mechanisms of tumor progression can make way for tumor diagnosis and therapy. Paternally expressed gene 10 (PEG10), located on human chromosome 7q21.3, has turned out to be an oncogene implicat...

    journal_title:Cancer cell international

    pub_type: 杂志文章,评审


    authors: Xie T,Pan S,Zheng H,Luo Z,Tembo KM,Jamal M,Yu Z,Yu Y,Xia J,Yin Q,Wang M,Yuan W,Zhang Q,Xiong J

    更新日期:2018-08-13 00:00:00

  • Pepsin promotes IL-8 signaling-induced epithelial-mesenchymal transition in laryngeal carcinoma.

    abstract:Background:Laryngopharyngeal reflux (LPR), with its increasing morbidity, is attracting considerable attention. In recent years, the causal role between LPR and laryngeal carcinoma has been debated. The main harmful component of LPR is pepsin, which has been shown to induce mucosal inflammation by damaging the mucous m...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Tan JJ,Wang L,Mo TT,Wang J,Wang MG,Li XP

    更新日期:2019-03-20 00:00:00

  • MicroRNA-1269 promotes cell proliferation via the AKT signaling pathway by targeting RASSF9 in human gastric cancer.

    abstract:Background:MicroRNAs (miRNAs) play key roles in tumorigenesis and progression of gastric cancer (GC). miR-1269 has been reported to be upregulated in several cancers and plays a crucial role in carcinogenesis and cancer progression. However, the biological function of miR-1269 in human GC and its mechanism remain uncle...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Liu WL,Wang HX,Shi CX,Shi FY,Zhao LY,Zhao W,Wang GH

    更新日期:2019-11-21 00:00:00

  • Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma.

    abstract::BACKGROUND: The aim of this work was to investigate in vitro the putative role of EGR-1 in the growth of glioma cells. EGR-1 expression was examined during the early passages in vitro of 17 primary cell lines grown from 3 grade III and from 14 grade IV malignant astrocytoma explants. The explanted tumors were genetica...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Calogero A,Lombari V,De Gregorio G,Porcellini A,Ucci S,Arcella A,Caruso R,Gagliardi FM,Gulino A,Lanzetta G,Frati L,Mercola D,Ragona G

    更新日期:2004-01-07 00:00:00

  • Downregulation of long non-coding RNA MAFG-AS1 represses tumorigenesis of colorectal cancer cells through the microRNA-149-3p-dependent inhibition of HOXB8.

    abstract:Background:Colorectal cancer (CRC) is considered as the second common death-induced cancer. More recently, association of long non-coding RNAs (lncRNAs) with CRC has been extensively investigated. Therefore, the present study was performed to determine whether lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAF...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Ruan Z,Deng H,Liang M,Xu Z,Lai M,Ren H,Deng X,Su X

    更新日期:2020-10-19 00:00:00

  • Par6 is an essential mediator of apoptotic response to transforming growth factor beta in NMuMG immortalized mammary cells.

    abstract:BACKGROUND:We previously observed that the TGFbeta-Par6 pathway mediates loss of polarity and apoptosis in NMuMG cells. Here we investigate the contribution of Par6 versus TGFbeta receptor I activation to TGFbeta-induced apoptosis in association with changes in apico-basal polarity. We focus on the effect of Par6 activ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Avery-Cooper G,Doerr M,Gilbert RW,Youssef M,Richard A,Huether P,Viloria-Petit AM

    更新日期:2014-03-01 00:00:00

  • Overexpression of microRNA-29b inhibits epithelial-mesenchymal transition and angiogenesis of colorectal cancer through the ETV4/ERK/EGFR axis.

    abstract:BACKGROUND:Recent studies have reported the involvement of microRNA-29 (miR-29) family members in human cancers through their ability to regulate cellular functions. The present study investigated biological function of miR-29b in colorectal cancer (CRC). METHODS:CRC tissues and adjacent normal tissues were collected ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Leng Y,Chen Z,Ding H,Zhao X,Qin L,Pan Y

    更新日期:2021-01-06 00:00:00

  • Protease nexin-1 expression is altered in human breast cancer.

    abstract:BACKGROUND:Urokinase-type Plasminogen Activator (uPA), a serine protease, plays a pivotal role in human breast cancer metastasis by mediating the degradation of extracellular matrix proteins and promoting cell motility. In more advanced breast cancers, uPA activity is significantly up regulated and serves as a prognost...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Candia BJ,Hines WC,Heaphy CM,Griffith JK,Orlando RA

    更新日期:2006-05-31 00:00:00

  • MiR-544 promotes immune escape through downregulation of NCR1/NKp46 via targeting RUNX3 in liver cancer.

    abstract:Objective:To study the potential role of miR-544 in the immune escape mechanism of hepatoma cells. Methods:Natural killer (NK) cells were collected from healthy volunteers and patients with liver cancer. Interleukin (IL)-2 activated-NK-92 cells were transfected with miR-544 inhibitor/mimic or NC/pre-NC in HepG2 co-cul...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Pan C,Xiang L,Pan Z,Wang X,Li J,Zhuge L,Fang P,Xie Q,Hu X

    更新日期:2018-04-03 00:00:00

  • Analysis of PD-1 related immune transcriptional profile in different cancer types.

    abstract:Background:Programmed cell death 1 (PD-1) functions as an immune checkpoint in the process of anti-tumor immune response. The PD-1 blockade is now becoming a fundamental part in cancer immunotherapy. So it's essential to elicit the PD-1 related immune process in different types of cancer. Methods:The Cancer Genome Atl...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Shang J,Song Q,Yang Z,Sun X,Xue M,Chen W,Yang J,Wang S

    更新日期:2018-12-27 00:00:00

  • Human umbilical cord mesenchymal stem cells promote carcinoma growth and lymph node metastasis when co-injected with esophageal carcinoma cells in nude mice.

    abstract:BACKGROUND:Human umbilical cord blood derived-mesenchymal stem cells (hUCMSCs) offer an attractive alternative to bone marrow-derived MSCs (BMMSCs) for cell-based therapy as it is a less invasive source of biological material. However, limited studies have been conducted with hUCMSCs as compared to BMMSCs. The present ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Yang X,Li Z,Ma Y,Gao J,Liu S,Gao Y,Wang G

    更新日期:2014-09-24 00:00:00

  • Implications of HIF-1α in the tumorigenesis and progression of pancreatic cancer.

    abstract::Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha (HIF-1α) is a major regulator of cellular response to changes in oxygen concentration, supporting the adaptation of tumor cells to hypoxia in...

    journal_title:Cancer cell international

    pub_type: 杂志文章,评审


    authors: Jin X,Dai L,Ma Y,Wang J,Liu Z

    更新日期:2020-06-24 00:00:00

  • SMAD6, positively regulated by the DNM3OS-miR-134-5p axis, confers promoting effects to cell proliferation, migration and EMT process in retinoblastoma.

    abstract:Background:Retinoblastoma (RB) is acknowledged to be the commonest intraocular malignancy in infants and children and the outcome of RB patients is unfavorable due to limited early diagnosis and effective therapy. SMAD family member 6 (SMAD6) has been reported in the initiation and progression of human cancers by actin...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Wang H,Ji X

    更新日期:2020-01-22 00:00:00

  • 2-Methoxyestradiol-bis-sulphamate refrains from inducing apoptosis and autophagy in a non-tumorigenic breast cell line.

    abstract:UNLABELLED: BACKGROUND:Anticancer research resulted in the discovery of a promising antimitotic metabolite, 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate, a bis-sulphamoylated analogue exerts antiproliferative- and antimitotic activity. Investigating the anticancer potential of 2-methoxyestradiol-bis-sulphamat...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Visagie MH,Joubert AM

    更新日期:2012-08-20 00:00:00

  • Identification and validation of genes involved in gastric tumorigenesis.

    abstract:BACKGROUND:Gastric cancer is one of the common cancers seen in south India. Unfortunately more than 90% are advanced by the time they report to a tertiary centre in the country. There is an urgent need to characterize these cancers and try to identify potential biomarkers and novel therapeutic targets. MATERIALS AND M...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Rajkumar T,Vijayalakshmi N,Gopal G,Sabitha K,Shirley S,Raja UM,Ramakrishnan SA

    更新日期:2010-11-24 00:00:00

  • Phorbol myristate acetate and Bryostatin 1 rescue IFN-gamma inducibility of MHC class II molecules in LS1034 colorectal carcinoma cell line.

    abstract:BACKGROUND:The expression of major histocompatibility complex class II (MHCII) antigens in both mouse and human tumors is rare, and these antigens are not easily inducible by IFN-gamma (IFNg). Since MHCII may play an important role in the development of host antitumor immune response, we explored the possibility of res...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Kudinov Y,Wiseman CL,Kharazi AI

    更新日期:2003-03-25 00:00:00

  • Targeting cellular metabolism using rapamycin and/or doxycycline enhances anti-tumour effects in human glioma cells.

    abstract:Background:Glioma is the most common highly aggressive, primary adult brain tumour. Clinical data show that therapeutic approaches cannot reach the expectations in patients, thus gliomas are mainly incurable diseases. Tumour cells can adapt rapidly to alterations during therapeutic treatments related to their metabolic...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Petővári G,Hujber Z,Krencz I,Dankó T,Nagy N,Tóth F,Raffay R,Mészáros K,Rajnai H,Vetlényi E,Takács-Vellai K,Jeney A,Sebestyén A

    更新日期:2018-12-19 00:00:00

  • Deregulation of histone lysine methyltransferases contributes to oncogenic transformation of human bronchoepithelial cells.

    abstract:BACKGROUND:Alterations in the processing of the genetic information in carcinogenesis result from stable genetic mutations or epigenetic modifications. It is becoming clear that nucleosomal histones are central to proper gene expression and that aberrant DNA methylation of genes and histone methylation plays important ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Watanabe H,Soejima K,Yasuda H,Kawada I,Nakachi I,Yoda S,Naoki K,Ishizaka A

    更新日期:2008-11-03 00:00:00

  • The mRNA expression of SATB1 and SATB2 in human breast cancer.

    abstract:BACKGROUND:SATB1 is a nuclear protein that has been recently reported to be a 'genome organizer' which delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. In this study, the level of mRNA expression of SATB1 a...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Patani N,Jiang W,Mansel R,Newbold R,Mokbel K

    更新日期:2009-07-30 00:00:00

  • miR-133a function in the pathogenesis of dedifferentiated liposarcoma.

    abstract:Background:Sarcomas are malignant heterogeneous tumors of mesenchymal derivation. Dedifferentiated liposarcoma (DDLPS) is aggressive with recurrence in 80% and metastasis in 20% of patients. We previously found that miR-133a was significantly underexpressed in liposarcoma tissues. As this miRNA has recently been shown ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Yu PY,Lopez G,Braggio D,Koller D,Bill KLJ,Prudner BC,Zewdu A,Chen JL,Iwenofu OH,Lev D,Strohecker AM,Fenger JM,Pollock RE,Guttridge DC

    更新日期:2018-06-26 00:00:00

  • Silencing lncRNA ZFAS1 or elevated microRNA-135a represses proliferation, migration, invasion and resistance to apoptosis of osteosarcoma cells.

    abstract:Background:Osteosarcoma (OS) is still a disease with high mortality from malignant tumors in children and adolescents. Due to its poor treatment, this study explored the involvement of lncRNA ZFAS1/microRNA-135a (miR-135a)/apurinic/apyrimidinic exonuclease 1 (APEX1) axis in the regulation of OS growth and metastasis. ...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Zhao Z,Lin X,Tong Y,Li W

    更新日期:2019-12-03 00:00:00

  • Biomarker implication of kallikrein-related peptidases as prognostic tissue substrates of poor survival in colorectal cancer.

    abstract:Background:Recent studies have demonstrated that the kallikrein and kallikrein-related peptidases (KLKs) exhibit aberrant expression in patients with colorectal cancer (CRC) and might be considered as potential prognostic biomarkers of CRC. However, inconsistent findings have been reported, which promote us to summariz...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Peng Q,Shen Y,Zhao P,Cheng M,Wu Y,Zhu Y

    更新日期:2020-06-22 00:00:00

  • Is systems biology a promising approach to resolve controversies in cancer research?

    abstract:: At the beginning of the 21st century cancer research has reached an impasse similar to that experienced in developmental biology in the first decades of the 20th century when conflicting results and interpretations co-existed for a long time until these differences were resolved and contradictions were eliminated. In...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Soto AM,Sonnenschein C

    更新日期:2012-03-26 00:00:00

  • miR-206 as a prognostic and sensitivity biomarker for platinum chemotherapy in epithelial ovarian cancer.

    abstract:BACKGROUND:Drug resistance is a major obstacle to successful chemotherapy for epithelial ovarian cancer (EOC). We found a subset of miRNAs associated with the response to first-line platinum-based chemotherapy in EOC by microarray, and miR-206 was one of the most significant miRNAs. The purposes of this study were to e...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Yu X,Zhang X,Wang G,Wang B,Ding Y,Zhao J,Liu H,Cui S

    更新日期:2020-11-03 00:00:00

  • RASSF-1A modulates proliferation-mediated oral squamous cell carcinoma progression.

    abstract:Background:To investigate the expression of RASSF-1A in oral squamous cell carcinoma (OSCC) and adjacent tissues, and to explore its mechanism of action in the development of OSCC. Methods:RASSF-1A and proliferation-related protein expression in clinical and OSCC mouse models were detected by qPCR and western blot. In...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Sun J

    更新日期:2019-08-13 00:00:00

  • A signature of hypoxia-related factors reveals functional dysregulation and robustly predicts clinical outcomes in stage I/II colorectal cancer patients.

    abstract:Background:The hypoxic tumor microenvironment accelerates the invasion and migration of colorectal cancer (CRC) cells. The aim of this study was to develop and validate a hypoxia gene signature for predicting the outcome in stage I/II CRC patients that have limited therapeutic options. Methods:The hypoxic gene signatu...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Zou YF,Rong YM,Tan YX,Xiao J,Yu ZL,Chen YF,Ke J,Li CH,Chen X,Wu XJ,Lan P,Lin XT,Gao F

    更新日期:2019-09-23 00:00:00

  • Association of TNFAIP8 gene polymorphisms with endometrial cancer in northern Chinese women.

    abstract:Background:Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case-control study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) in TNFAIP8 on...

    journal_title:Cancer cell international

    pub_type: 杂志文章


    authors: Liu T,Jiang L,Yu L,Ge T,Wang J,Gao H

    更新日期:2019-04-23 00:00:00