Abstract：
Background:To investigate the expression of RASSF-1A in oral squamous cell carcinoma (OSCC) and adjacent tissues, and to explore its mechanism of action in the development of OSCC. Methods:RASSF-1A and proliferation-related protein expression in clinical and OSCC mouse models were detected by qPCR and western blot. In vitro experiments were used siRNA knockdown of RASSF-1A gene in SCC9 cells to detect cell proliferation, migration and apoptosis. In vivo experiments were performed using adenovirus overexpressing RASSF-1A gene in mice and observing tumor growth. Results:The results of qPCR and western blot showed that the expression of RASSF-1A gene was decreased in OSCC, and the expression of CyclinD1 protein was increased. The results of co-immunoprecipitation showed that the two proteins were significantly combined in the oral cancer cell line. Knocking down the RASSF-1A gene in SCC9 cells promotes cell migration and proliferation, while reducing apoptosis and increasing CyclinD1 protein expression. Overexpression of RASSF-1A gene in mice reduces tumor volume and inhibits CyclinD1 protein expression. Conclusions:Low expression of RASSF-1A gene in OSCC promotes the expression of CyclinD1 protein and tumor growth.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Sun Jdoi
10.1186/s12935-019-0932-9subject
Has Abstractpub_date
2019-08-13 00:00:00pages
213issn
1475-2867pii
932journal_volume
19pub_type
杂志文章abstract：Background:Accumulating studies showed that long noncoding RNAs (lncRNAs) played vital roles in cancer progression. LncRNA MIR4435-2HG was proved to act as an oncogene in various tumors. However, the underlying function of MIR4435-2HG in ovarian cancer (OC) remains unclear. Methods:The expression levels of MIR4435-2HG...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01227-6
更新日期：2020-05-01 00:00:00
abstract：:Sineoculis homeobox homolog 1 (Six1), normally a developmentally restricted transcriptional regulator, is frequently dysregulated in mutiple cancers. Increasing evidences show that overexpression of Six1 plays a key role in tumorigenesis. However, the Six1 expression status and its relationship with the clinicopatholo...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-015-0215-z
更新日期：2015-06-20 00:00:00
abstract：BACKGROUND:CD44 has been reported to be involved with tumor growth and metastasis and has also been implicated as a CSC marker in hepatocellular carcinoma (HCC). However, the prognostic value of CD44 still remains controversial; hence, we investigated the correlation between CD44 and the clinicopathological features of...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-016-0325-2
更新日期：2016-06-17 00:00:00
abstract：Objective:To study the potential role of miR-544 in the immune escape mechanism of hepatoma cells. Methods:Natural killer (NK) cells were collected from healthy volunteers and patients with liver cancer. Interleukin (IL)-2 activated-NK-92 cells were transfected with miR-544 inhibitor/mimic or NC/pre-NC in HepG2 co-cul...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-018-0542-y
更新日期：2018-04-03 00:00:00
abstract：Background:Abnormal expressions of long noncoding RNAs (lncRNAs) are very common in clear cell renal cell carcinoma (ccRCC), and some of these have been reported to be highly correlated with prognosis of ccRCC patients. Methods:"edgeR" AND "DEseq" R packages were used to explore differentially expressed genes (DEGs) b...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0928-5
更新日期：2019-08-05 00:00:00
abstract：BACKGROUND:Celecoxib is a selective cyclooxygenase (COX)-2 inhibitor that has been reported to reduce the risk of breast cancer. In our previous study, celecoxib induced apoptosis and caused cell cycle arrest at the G0/G1 phase in the breast cancer cell line MDA-MB-231, and its effects were mediated by downregulation o...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-13-14
更新日期：2013-02-12 00:00:00
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journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-11-35
更新日期：2011-10-28 00:00:00
abstract：Background:This study aims to investigate the role of microRNA-92a (miR-92a) in metastasis of osteosarcoma (OS) cells in vivo and in vitro by regulatingTCF21 with the transmission of bone marrow derived mesenchymal stem cells (BMSCs). Methods:BMSCs were isolated, purified and cultured from healthy adult bone marrow ti...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0741-1
更新日期：2019-02-12 00:00:00
abstract：BACKGROUND:Curcumin, a natural compound derived from the turmeric rhizome Curcuma longa Linn, has anticancer and chemoresistance reduction biological activities. We evaluated the efficacy of curcumin in sensitizing chemotherapy drugs through regulation of Bcl-2-mediated apoptosis in breast cancer stem-like cells (BCSCs...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-017-0453-3
更新日期：2017-09-26 00:00:00
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journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01649-2
更新日期：2020-12-09 00:00:00
abstract：BACKGROUND:Germline mutations in the von Hippel-Lindau (VHL) tumor suppressor gene predispose individuals to clear cell renal carcinomas, hemangioblastomas, and pheochromocytomas. The VHL gene product forms an ubiquitin E3 ligase complex, with regulation of hypoxia-inducible factor alpha (HIF-α) as its best known funct...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-015-0175-3
更新日期：2015-02-22 00:00:00
abstract：Background:Pancreatic cancer is a common malignant tumor of the digestive tract. It has a high degree of malignancy and poor prognosis. Finding effective molecular markers has great significance for pancreatic cancer diagnosis and treatment. This study aimed to investigate DLGAP5 expression in pancreatic cancer and exp...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01474-7
更新日期：2020-08-08 00:00:00
abstract：Background:Newly identified lncRNA zinc finger protein, FOG family member 2 antisense RNA 1 (ZFPM2-AS1) is identified as an oncogenic gene. However, the role of ZFPM2-AS1 in small cell lung cancer (SCLC) is poorly comprehended. Methods:The expression of genes in SCLC tissues and cells was measured by qRT-PCR. Colony f...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-1157-7
更新日期：2020-04-03 00:00:00
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journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0762-9
更新日期：2019-02-28 00:00:00
abstract：BACKGROUND:Urokinase-type Plasminogen Activator (uPA), a serine protease, plays a pivotal role in human breast cancer metastasis by mediating the degradation of extracellular matrix proteins and promoting cell motility. In more advanced breast cancers, uPA activity is significantly up regulated and serves as a prognost...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-6-16
更新日期：2006-05-31 00:00:00
abstract：Background:MicroRNA (MiRNA) is a small non-coding RNA which is implicated in a cohort of biological function in cancer, including proliferation, metastasis, apoptosis and invasion. MiR-96 has been reported to be involved in many cancers, including papillary thyroid cancer. However, the role of miR-96-3p in papillary th...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-1003-y
更新日期：2019-11-12 00:00:00
abstract：Background:Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies and a major cause of cancer related death worldwide, especially in China. Cell lines are widely used disease models for basic medical research, however, well characterized ESCC cell models from China were seldom reported. Mis...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01268-x
更新日期：2020-05-24 00:00:00
abstract：BACKGROUND:Although recent studies have shown the utility of miR-203 as a cancer-relevant biomarker, the validated clinical significance of miR-203 in HCC remains obscure. The aim of the present study was to evaluate the relationship between miR-203 expression and clinicopathological features in HCC patients. METHODS:...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-015-0214-0
更新日期：2015-06-18 00:00:00
abstract：Background:Melanoma as a type of skin cancer, is associated with a high mortality rate. Therefore, early diagnosis and efficient surgical treatment of this disease is very important. Photodynamic therapy (PDT) involves the activation of a photosensitizer by light at specific wavelength that interacts with oxygen and cr...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01616-x
更新日期：2020-10-29 00:00:00
abstract：Background:Acute myeloid leukemia (AML) is a clinically and biologically heterogeneous disease. The survival of older patients is generally poor. In the current study, we sought to investigate the differences in molecular gene mutations between younger and older AML patients, and to identify those newly diagnosed AML p...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-018-0716-7
更新日期：2018-12-22 00:00:00
abstract：BACKGROUND:Prostate cancer progression to androgen independence is the primary cause of mortality by this tumor type. The IGF-1/IGF-1R axis is well known to contribute to prostate cancer initiation, but its contribution to invasiveness and the downstream signalling mechanisms that are involved are unclear at present. ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-8-10
更新日期：2008-07-03 00:00:00
abstract：:Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of proteins, involved in inhibition of apoptosis and regulation of cell cycle. These functional attributes make Survivin a unique protein exhibiting divergent functions i.e. regulating cell proliferation and cell death. Expression pattern of Su...
journal_title：Cancer cell international
pub_type： 杂志文章,评审
doi：10.1186/s12935-016-0326-1
更新日期：2016-06-23 00:00:00
abstract：BACKGROUND:The incidence and mortalities from cancers remain on the rise worldwide. Despite significant efforts to discover and develop novel anticancer agents, many cancers remain in the unmet need category. As such, efforts to discover and develop new and more effective and less toxic agents against cancer remain a t...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-017-0404-z
更新日期：2017-03-07 00:00:00
abstract：:Circular RNAs (circRNAs) are small non-coding RNAs with a unique ring structure and play important roles as gene regulators. Disturbed expressions of circRNAs is closely related to varieties of pathological processes. The roles of circRNAs in cancers have gained increasing concerns. The communications between the canc...
journal_title：Cancer cell international
pub_type： 杂志文章,评审
doi：10.1186/s12935-020-01301-z
更新日期：2020-06-03 00:00:00
abstract：Background:Acute lymphoblastic leukemia (ALL) is an aggressive hematopoietic malignancy that is most commonly observed in children. Alantolactone (ALT) has been reported to exhibit anti-tumor activity in different types of cancer. The aim of the present study was to investigate the anti-tumor activity and molecular mec...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01537-9
更新日期：2020-09-09 00:00:00
abstract：Background:Growing evidence suggests that MiRNAs play essential roles in the initiation and progression of colorectal cancer (CRC). The aberrant expression of miR-384 has been reported in some cancers. However, the role and mechanism of miR-384 in CRC proliferation remains unknown. Methods:The expression of miR-384 wa...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-018-0628-6
更新日期：2018-09-03 00:00:00
abstract：BACKGROUND:Patients with dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine are resistant to chemotherapeutic treatment and external irradiation and thus are difficult to treat. Direct induction of apoptosis is a promising approach in these apoptosis-resistant tumor cells. The BH3 mimeti...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-016-0303-8
更新日期：2016-04-02 00:00:00
abstract：:[This corrects the article DOI: 10.1186/s12935-017-0407-9.]. ...
journal_title：Cancer cell international
pub_type： 已发布勘误
doi：10.1186/s12935-020-01375-9
更新日期：2020-07-17 00:00:00
abstract：Background:At the present time, colorectal cancer (CRC) is still known as a disease with a high mortality rate. Theranostics are flawless scenarios that link diagnosis with therapy, including precision medicine as a critical platform that relies on the development of biomarkers particularly "liquid biopsy". Circulating...
journal_title：Cancer cell international
pub_type： 杂志文章,评审
doi：10.1186/s12935-020-01389-3
更新日期：2020-07-06 00:00:00
abstract：OBJECTIVE:To explore the relationship between tumor necrosis factor receptor-associated factor 6 (TRAF6) and the clinicopathological features in HCC as well as its biological function. METHODS:Totally, 412 liver tissues were collected, including 171 hepatocellular carcinoma (HCC) and their corresponding non-tumor tiss...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-016-0352-z
更新日期：2016-09-29 00:00:00
