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MiR-384 inhibits the proliferation of colorectal cancer by targeting AKT3.

Abstract：

Background:Growing evidence suggests that MiRNAs play essential roles in the initiation and progression of colorectal cancer (CRC). The aberrant expression of miR-384 has been reported in some cancers. However, the role and mechanism of miR-384 in CRC proliferation remains unknown. Methods:The expression of miR-384 was detected in CRC and their paired normal tissues by real-time PCR. In vivo and in vitro assays were conducted to confirm the role of miR-384 in the proliferation of CRC. Bioinformatics analysis, luciferase reporter assays, western blot and in vitro assays were used to confirm that AKT3 was the target gene of miR-384. Finally, Spearman's correlation analyses was carried out to analyze the relationship between miR-384 expression and AKT3 expression in CRC. Results:MiR-384 was down‑regulated in CRC tissues. The in vivo and vitro functional assays verified that the ectopic upregulation of miR-384 inhibited the proliferation of CRC and the inhibition of miR-384 promoted the proliferation of CRC. Bioinformatics analysis, luciferase reporter assays, western blot and in vitro functional assays confirmed AKT3 as the target gene of miR-384. The expression of miR-384 was negatively correlated with the expressions of AKT3. Conclusion:Our study verified that miR-384 could significantly suppress the proliferation of CRC by directing targeting AKT3.

journal_name

Cancer Cell Int

journal_title

Cancer cell international

authors

Wang YX,Zhu HF,Zhang ZY,Ren F,Hu YH

doi

10.1186/s12935-018-0628-6

subject

Has Abstract

pub_date

2018-09-03 00:00:00

pages

124

issn

1475-2867

pii

628

journal_volume

18

pub_type

杂志文章

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