Abstract:
Background:Immunotherapies that targeting programmed cell death 1 (PD-1) and programmed death-ligand 1 (PD-L1) have obtained prominent success in breast cancer (BC). However, not all the patients benefit from the antibody therapy. This study aimed to identify PD-1/PD-L1 correlated genes and pathways as well as investigate their potential as prognostic marker in BC. Materials and methods:By analysing transcriptional data of BC from TCGA, we identified PD-1 and PD-L1 correlated genes by WGCNA analysis and explored the biological process as well as pathways they enriched. Co-expression analysis were performed for PD-1/PD-L1 with immune infiltration and checkpoints. The prognostic value of PD-1 and PD-L1 were also investigated. Results:PD-1 and PD-L1 expression showed significant difference in different molecular subtypes and stages. PD-1 correlated genes enriched in T cell activation, lymphocyte activation, leukocyte migration while PD-L1 correlated genes demonstrated enrichment including T cell apoptotic process, tolerance induction and cytolysis. Immune infiltration analysis suggested that PD-1 and PD-L1 were related with Neutrophils (r = 0.65, r = 0.48) and Fibroblasts (r = 0.59, r = 0.47). For immune checkpoints analysis, PD-1 was associated with HLA-A (r = 0.804) and INPP5D (r = 0.782) while PD-L1 correlated with CTLA4 (r = 0.843) and CD27 (r = 0.823). PD-1 was associated favorable survival of BC (HR = 0.67, P = 0.012) while PD-L1 did not demonstrate significant association with BC prognosis (HR = 0.85, P = 0.313). Conclusion:PD-1 and PD-L1 correlated genes participated in biological process including T cell activation, lymphocyte activation, leukocyte migration, T cell apoptotic process, tolerance induction and cytolysis. PD-1/PD-L1 expression also demonstrated relation with immune infiltration and immune checkpoints. High PD-1 expression predicted better survival of breast cancer patients.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Jiang C,Cao S,Li N,Jiang L,Sun Tdoi
10.1186/s12935-019-0955-2subject
Has Abstractpub_date
2019-09-09 00:00:00pages
233issn
1475-2867pii
955journal_volume
19pub_type
杂志文章abstract::Osteosarcoma (OS) is one of the most prevalent malignant cancers with lower survival and poor overall prognosis mainly in children and adolescents. Identifying the molecular mechanisms and OS stem cells (OSCs) as new concepts involved in disease pathogenesis and progression may potentially lead to new therapeutic targ...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-018-0654-4
更新日期:2018-10-16 00:00:00
abstract:Background and aims:microRNAs (miRNAs) have been reported to regulate proliferation and migration by down-regulating the expression of target genes. The aims of this study were to investigate whether miR-4316 inhibited proliferation and migration by downregulating vascular endothelial growth factor A (VEGF-A) and its c...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1132-3
更新日期:2020-02-22 00:00:00
abstract:BACKGROUND:Celecoxib is a selective cyclooxygenase (COX)-2 inhibitor that has been reported to reduce the risk of breast cancer. In our previous study, celecoxib induced apoptosis and caused cell cycle arrest at the G0/G1 phase in the breast cancer cell line MDA-MB-231, and its effects were mediated by downregulation o...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-13-14
更新日期:2013-02-12 00:00:00
abstract:BACKGROUND:Patients with dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine are resistant to chemotherapeutic treatment and external irradiation and thus are difficult to treat. Direct induction of apoptosis is a promising approach in these apoptosis-resistant tumor cells. The BH3 mimeti...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-016-0303-8
更新日期:2016-04-02 00:00:00
abstract:Background:Transgelin, an actin-binding protein, is associated with cytoskeleton remodeling. Findings from our previous studies demonstrated that transgelin was up-regulated in node-positive colorectal cancer (CRC) versus node-negative disease. Over-expression of TAGLN affected the expression of 256 downstream transcri...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01461-y
更新日期:2020-08-03 00:00:00
abstract:: Cancer-initiating cells display aberrant functional and phenotypic characteristics of normal stem cells from which they evolved by accumulation of multiple cytogenetic and/or epigenetic alterations. Signal transduction pathways which are essential for normal stem cell function are abnormally expressed by cancer cells...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-12-24
更新日期:2012-06-07 00:00:00
abstract:BACKGROUND:Gastric cancer is one of the common cancers seen in south India. Unfortunately more than 90% are advanced by the time they report to a tertiary centre in the country. There is an urgent need to characterize these cancers and try to identify potential biomarkers and novel therapeutic targets. MATERIALS AND M...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-10-45
更新日期:2010-11-24 00:00:00
abstract:BACKGROUND:ErbB3-binding protein 1 (Ebp1) is a member of the PA2G4 family of proliferation-regulated proteins that is expressed in multiple malignant and non-malignant cells. ErbB3 and other members of the EGFR family have been implicated in cancer progression, it however remains unknown whether Ebp1 participate in pro...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-8-18
更新日期:2008-11-24 00:00:00
abstract::Sineoculis homeobox homolog 1 (Six1), normally a developmentally restricted transcriptional regulator, is frequently dysregulated in mutiple cancers. Increasing evidences show that overexpression of Six1 plays a key role in tumorigenesis. However, the Six1 expression status and its relationship with the clinicopatholo...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0215-z
更新日期:2015-06-20 00:00:00
abstract:Background:Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Siah E3 ubiquitin protein ligase 1 (Siah1) has been identified as a tumor suppressor gene and plays an important role in the development of malignant tumors. However, the potential role and molecular mechanism of Siah1 in the de...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1124-3
更新日期:2020-02-13 00:00:00
abstract:Background:New drugs for adrenocortical carcinoma (ACC) are needed because most patients undergo rapid disease progression despite surgery and adjuvant therapy with mitotane. In this study, we aimed to investigate the in vitro effects of different chemotherapy drugs, alone or combined with mitotane, on the viability of...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0527-x
更新日期:2018-03-01 00:00:00
abstract:Background:Endometrial cancer (EC) is the fourth most common malignancy of the female genital tract worldwide. MicroRNAs are important gene regulators with critical roles in diverse biological processes, including tumorigenesis. Several study's show that miR-139-5p is involved in the tumorigenesis and metastasis of var...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0545-8
更新日期:2018-04-02 00:00:00
abstract:Background:Bridging integrator 1 (BIN1) has showed outstanding tumor-suppressive potential via inhibiting c-MYC-mediated tumorigenesis. However, a frequent phosphorylation of c-MYC at Ser-62 site could block the BIN1/c-MYC interaction and limits the tumor-suppressive effect of BIN1. Cyclin-dependent kinase 5 (CDK5), a ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0952-5
更新日期:2019-09-02 00:00:00
abstract:BACKGROUND:SATB1 is a nuclear protein that has been recently reported to be a 'genome organizer' which delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. In this study, the level of mRNA expression of SATB1 a...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-9-18
更新日期:2009-07-30 00:00:00
abstract:Background:Fyn has been documented to have oncogenic features in multiple tumors, which might be a potential therapeutic target, however, few studies on the function role of Fyn and its specific inhibitors in melanoma. Methods:We investigated the impacts of Fyn and its inhibitor Lj-1-60 on melanoma through bioinformat...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01336-2
更新日期:2020-06-18 00:00:00
abstract:BACKGROUND:Without doubt, natural products have been, and still are, the cornerstone of the health care armamentarium. Of all natural sources, the marine environment is clearly the last great frontier for pharmaceutical and medical research. METHODS:This work progresses in the direction of identifying component(s) fro...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-12-18
更新日期:2012-05-15 00:00:00
abstract::Survivin is the smallest member of the Inhibitor of apoptosis (IAP) family of proteins, involved in inhibition of apoptosis and regulation of cell cycle. These functional attributes make Survivin a unique protein exhibiting divergent functions i.e. regulating cell proliferation and cell death. Expression pattern of Su...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-016-0326-1
更新日期:2016-06-23 00:00:00
abstract:BACKGROUND:Non-small cell lung cancer comprises the majority of lung cancer cases and is insensitive to chemotherapy. Most patients develop drug resistance. Recently, tetrandrine (TET), a bis-benzylisoquinoline alkaloid, was identified as a novel anti-cancer agent. However, the effect of tetrandrine combined with cispl...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0410-1
更新日期:2017-03-27 00:00:00
abstract:Background:miR-429 and TLN1 have been shown to affect the biological behaviours of many carcinomas. However, their effects in nasopharyngeal carcinoma (NPC) are not yet clear. Here, we investigated their regulatory relationships and effects on NPC cells. Methods:TargetScan was used to predict the regulatory relationsh...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0831-0
更新日期:2019-04-30 00:00:00
abstract:Background:Accumulating studies showed that long noncoding RNAs (lncRNAs) played vital roles in cancer progression. LncRNA MIR4435-2HG was proved to act as an oncogene in various tumors. However, the underlying function of MIR4435-2HG in ovarian cancer (OC) remains unclear. Methods:The expression levels of MIR4435-2HG...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01227-6
更新日期:2020-05-01 00:00:00
abstract:Background:MicroRNAs have been involved in regulating crucial biological function in some tumors. However, the clinical role and functional effects of miR-591 in breast cancer remain unknown. Methods:The expression of miR-591 was detected in breast cancer tissues and their paired normal tissues by qRT-PCR. Functional ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0818-x
更新日期:2019-04-24 00:00:00
abstract::[This corrects the article DOI: 10.1186/s12935-017-0407-9.]. ...
journal_title:Cancer cell international
pub_type: 已发布勘误
doi:10.1186/s12935-020-01375-9
更新日期:2020-07-17 00:00:00
abstract:BACKGROUND:miR-222 has been reported to be overexpressed in colorectal cancer and it influences cancer cell proliferation, drug resistance and metastasis. However, the underlying molecular mechanism of miR-222 in colorectal cancer cell invasion and migration has not been thoroughly elucidated to date. METHODS:The cell...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0447-1
更新日期:2017-08-29 00:00:00
abstract:Background:T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood. In this study, we tried to explore the physiological role of CD59 in T-ALL. Methods:In this study, we collected the bone marrow samples from 17 T-A...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0714-9
更新日期:2019-01-08 00:00:00
abstract:Background:To investigate the expression of RASSF-1A in oral squamous cell carcinoma (OSCC) and adjacent tissues, and to explore its mechanism of action in the development of OSCC. Methods:RASSF-1A and proliferation-related protein expression in clinical and OSCC mouse models were detected by qPCR and western blot. In...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0932-9
更新日期:2019-08-13 00:00:00
abstract:BACKGROUND:Chemoresistance is a major obstacle to successful chemotherapy for colorectal cancer. Eukaryotic translation initiation factor 5A2 (eIF5A2), one of the two isoforms in the eIF5A family, has been reported to be a new oncogene in many types of human cancer. In the present study, we aimed to investigate whether...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0250-9
更新日期:2015-11-17 00:00:00
abstract:Background:Breast cancer has been the first death cause of cancer in women all over the world. Metastasis is believed to be the most important process for treating breast cancer. There is evidence that lncRNA MEG3 functions as a tumor suppressor in breast cancer metastasis. However, upstream regulation of MEG3 in breas...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0642-8
更新日期:2018-10-25 00:00:00
abstract:Background:Tumor necrosis factor-α (TNF-α) immunotherapy controls the progression of human cervical cancer. Here, we explored the detailed molecular mechanisms played by melatonin in human cervical cancer (HeLa cells) death in the presence of TNF-α injury, with a particular attention to the mitochondrial homeostasis. ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0777-2
更新日期:2019-03-14 00:00:00
abstract:BACKGROUND:Urokinase-type Plasminogen Activator (uPA), a serine protease, plays a pivotal role in human breast cancer metastasis by mediating the degradation of extracellular matrix proteins and promoting cell motility. In more advanced breast cancers, uPA activity is significantly up regulated and serves as a prognost...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-6-16
更新日期:2006-05-31 00:00:00
abstract:Background:Tumor necrosis factor-a-induced protein 8 (TNFAIP8) presented a elevated expression in endometrial cancer (EC). However, the relationship of TNFAIP8 gene polymorphisms with EC risk remains unclear. This case-control study aimed to investigate the effect of single nucleotide polymorphisms (SNPs) in TNFAIP8 on...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0827-9
更新日期:2019-04-23 00:00:00