Abstract:
BACKGROUND:ErbB3-binding protein 1 (Ebp1) is a member of the PA2G4 family of proliferation-regulated proteins that is expressed in multiple malignant and non-malignant cells. ErbB3 and other members of the EGFR family have been implicated in cancer progression, it however remains unknown whether Ebp1 participate in prostate cancer progression in vivo. Therefore, the present study examines Ebp1 expression in cancerous and non-cancerous prostates tissues. Ebp1 expression was also correlated to known Ebp1 regulated proteins (Androgen receptor (AR), Cyclin D1 & ErbB3) and the proliferation marker Ki67. Furthermore we evaluated whether Ebp1 expression correlated with biochemical recurrence (BCR) following radical prostatectomy. METHODS:The expression of Ebp1, AR, Cyclin D1, ErbB3 and Ki67 were evaluated by immunohistochemistry using three separate tissue micro-arrays containing normal prostate tissues, non-cancerous tissue adjacent to the primary tumor, hormone-sensitive and hormone-refractory cancerous tissues. Multivariate COX regression analysis was performed with four clinical parameters in order to correlate Ebp1 expression with PCa progression. RESULTS:The expression of Ebp1 significantly increased with the progression from normal to hormone sensitive and to hormone refractory PCa. Furthermore, we observed strong correlation between Ebp1 expression and the nuclear expression of AR, Cyclin D1 and ErbB3 in both normal adjacent and cancer tissues. The expression of AR, Cyclin D1 and ErbB3 in normal adjacent tissues correlated with PSA relapse, whereas Ebp1 on its own did not significantly predict PSA relapse. Finally, in a multivariate analysis with a base clinical model (Gleason, Pre-op PSA, surgical margins and P-stage) we identified the multi-marker combination of Ebp1+/Cyclin D1- as an independent predictor of PSA relapse with a hazard ratio of 4.79. CONCLUSION:Although not related to disease recurrence, this is the first in vivo study to report that Ebp1 expression correlates with PCa progression.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Gannon PO,Koumakpayi IH,Le Page C,Karakiewicz PI,Mes-Masson AM,Saad Fdoi
10.1186/1475-2867-8-18subject
Has Abstractpub_date
2008-11-24 00:00:00pages
18issn
1475-2867pii
1475-2867-8-18journal_volume
8pub_type
杂志文章abstract:Background:Abnormally expressed circular RNAs (circRNAs) are implicated in the development and treatment of gastric cancer (GC). Previous study has reported that hsa_circ_0003159 is expressed in GC. However, the role and mechanism of hsa_circ_0003159 in GC progression remain unclear. Methods:GC tissues and normal tiss...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-1119-0
更新日期:2020-02-19 00:00:00
abstract:Background:Long non-coding RNAs (lncRNAs) play significant roles in tumorigenesis and can contribute to identification of novel therapeutic targets for cancers. This paper was aimed at exploring the role of CTBP1 divergent transcript (CTBP1-AS2) in cervical cancer (CC) progression. Methods:qRT-PCR and western blot ass...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01430-5
更新日期:2020-07-28 00:00:00
abstract:BACKGROUND:Castration-resistance in prostate cancer (PC) is a critical event hallmarking a switch to a more aggressive phenotype. Neuroendocrine differentiation and upregulation of NFκB transcriptional activity are two mechanisms that have been independently linked to this process. METHODS:We investigated these two pa...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-11-13
更新日期:2011-05-15 00:00:00
abstract:Background:Oxidative stress is responsible for some alterations in the chemical structure and, consequently, in the function of proteins, lipids, and DNA. Recent studies have linked oxidative stress to cancers, particularly thyroid cancer, but the mechanisms remain unclear. Here, we further characterize the role of oxi...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0504-4
更新日期:2018-01-15 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the anti-tumor effects of Ad/gTRAIL (an adenoviral vector in which expression of GFP and TRAIL is driven by a human telomerase reverse transcriptase promoter, hTERT) on malignant meningiomas and gliomas. BACKGROUND:Gliomas and meningiomas are the two most common ty...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-11-35
更新日期:2011-10-28 00:00:00
abstract:BACKGROUND:Celecoxib is a selective cyclooxygenase (COX)-2 inhibitor that has been reported to reduce the risk of breast cancer. In our previous study, celecoxib induced apoptosis and caused cell cycle arrest at the G0/G1 phase in the breast cancer cell line MDA-MB-231, and its effects were mediated by downregulation o...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-13-14
更新日期:2013-02-12 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01289-6
更新日期:2020-05-29 00:00:00
abstract:BACKGROUND:G protein-coupled receptor family C group 5 member A (GPRC5A), a retinoic acid-inducible gene, is a lung tumor suppressor. Previously, we showed that repression of GPRC5A expression was associated with pathologic differentiation grade of oral squamous cell carcinomas (OSCC) and overexpression of GPRC5A gene ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0406-x
更新日期:2017-03-02 00:00:00
abstract::[This corrects the article DOI: 10.1186/s12935-019-0742-0.]. ...
journal_title:Cancer cell international
pub_type: 杂志文章,已发布勘误
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更新日期:2019-04-11 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-14-30
更新日期:2014-03-31 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-1049-x
更新日期:2019-12-03 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0928-5
更新日期:2019-08-05 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0638-4
更新日期:2018-09-18 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0183-3
更新日期:2015-04-01 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0860-8
更新日期:2019-05-22 00:00:00
abstract::[This corrects the article DOI: 10.1186/s12935-017-0407-9.]. ...
journal_title:Cancer cell international
pub_type: 已发布勘误
doi:10.1186/s12935-020-01375-9
更新日期:2020-07-17 00:00:00
abstract::BACKGROUND: The aim of this work was to investigate in vitro the putative role of EGR-1 in the growth of glioma cells. EGR-1 expression was examined during the early passages in vitro of 17 primary cell lines grown from 3 grade III and from 14 grade IV malignant astrocytoma explants. The explanted tumors were genetica...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-4-1
更新日期:2004-01-07 00:00:00
abstract:BACKGROUND:Gastric cancer is one of the common cancers seen in south India. Unfortunately more than 90% are advanced by the time they report to a tertiary centre in the country. There is an urgent need to characterize these cancers and try to identify potential biomarkers and novel therapeutic targets. MATERIALS AND M...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-10-45
更新日期:2010-11-24 00:00:00
abstract:Background:Sarcomas are malignant heterogeneous tumors of mesenchymal derivation. Dedifferentiated liposarcoma (DDLPS) is aggressive with recurrence in 80% and metastasis in 20% of patients. We previously found that miR-133a was significantly underexpressed in liposarcoma tissues. As this miRNA has recently been shown ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0583-2
更新日期:2018-06-26 00:00:00
abstract:Background:Transgelin, an actin-binding protein, is associated with cytoskeleton remodeling. Findings from our previous studies demonstrated that transgelin was up-regulated in node-positive colorectal cancer (CRC) versus node-negative disease. Over-expression of TAGLN affected the expression of 256 downstream transcri...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01461-y
更新日期:2020-08-03 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-13-54
更新日期:2013-06-01 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0722-9
更新日期:2019-01-03 00:00:00
abstract:BACKGROUND:While some risk factors for breast cancer are well-known, the influence of other factors, particularly virus infection, remains unclear. Human cytomegalovirus (HCMV) is widespread in the general population, and both molecular and epidemiological evidence has indicated links between HCMV and breast cancer. Th...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0399-5
更新日期:2017-02-13 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0447-1
更新日期:2017-08-29 00:00:00
abstract:Background:Growing evidence suggests that MiRNAs play essential roles in the initiation and progression of colorectal cancer (CRC). The aberrant expression of miR-384 has been reported in some cancers. However, the role and mechanism of miR-384 in CRC proliferation remains unknown. Methods:The expression of miR-384 wa...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0628-6
更新日期:2018-09-03 00:00:00
abstract:Background:Long non-coding RNA (lncRNA) BM742401 is a tumor suppressor in gastric cancer and chronic lymphocytic leukemia. As the promoter and coding region of BM742401 are fully embedded in a CpG island, we hypothesized that BM742401 is a tumor suppressor lncRNA epigenetically silenced by promoter DNA methylation in m...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01504-4
更新日期:2020-08-25 00:00:00
abstract:Background:Breast cancer is one of the most common malignancy among females from the worldwide cancer incidence statistics. Peroxisome gamma coactivator-1β (PGC-1β) has long been identified to be involved in this type of tumorigenesis. However, the mechanisms of PGC-1β in human breast cancer have not been fully underst...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0810-5
更新日期:2019-04-11 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
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更新日期:2020-04-22 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
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更新日期:2020-10-31 00:00:00
abstract:BACKGROUND:Mammaglobin (MAM) has been used as a specific molecular marker for breast cancer diagnosis. Recently, several groups of researchers proposed a number of therapeutic strategies targeting this molecule. Some of the strategies are based upon an essential but not demonstrated hypothesis - mammaglobin is associat...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-9-8
更新日期:2009-03-23 00:00:00