Silencing lncRNA ZFAS1 or elevated microRNA-135a represses proliferation, migration, invasion and resistance to apoptosis of osteosarcoma cells.

abstract：Background:Casticin, an isoflavone compound extracted from the herb Fructus Viticis, has demonstrated anti-inflammatory and anticancer activities and properties. The aim of this study was to investigate the effects and mechanisms of casticin in nasopharyngeal carcinoma (NPC) cells and to determine its potential for tar...

journal_title：Cancer cell international

authors： Liu J,Yang J,Hou Y,Zhu Z,He J,Zhao H,Ye X,Li D,Wu Z,Huang Z,Hao B,Yao K

更新日期：2019-12-21 00:00:00

abstract：UNLABELLED: BACKGROUND:Anticancer research resulted in the discovery of a promising antimitotic metabolite, 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate, a bis-sulphamoylated analogue exerts antiproliferative- and antimitotic activity. Investigating the anticancer potential of 2-methoxyestradiol-bis-sulphamat...

journal_title：Cancer cell international

authors： Visagie MH,Joubert AM

更新日期：2012-08-20 00:00:00

abstract：BACKGROUND:Tumor tissue resembles chronically inflamed tissue. Since chronic inflammatory conditions are a strong stimulus for bone marrow-derived cells (BMDCs) it can be assumed that recruitment of BMDCs into cancer tissue should be a common phenomenon. Several data have outlined that BMDC can influence tumor growth a...

journal_title：Cancer cell international

authors： Nagler C,Hardt C,Zänker KS,Dittmar T

更新日期：2011-06-28 00:00:00

abstract：BACKGROUND:Circular RNAs (circRNAs) is a newly discovered type of non-coding RNA, the abnormal expression of which has been demonstrated in many types of human tumors. So they have been considered as promising candidates as diagnostic and therapeutic targets in cancer. This research aimed to screen the profile of circR...

journal_title：Cancer cell international

authors： Han J,Han N,Xu Z,Zhang C,Liu J,Ruan M

更新日期：2021-01-07 00:00:00

abstract：:An area of research that has been recently gaining attention is the relationship between cancer stem cell (CSC) biology and chemo-resistance in colon cancer patients. It is well recognized that tumor initiation, growth, invasion and metastasis are promoted by CSCs. An important reason for the widespread interest in th...

journal_title：Cancer cell international

authors： Garza-Treviño EN,Said-Fernández SL,Martínez-Rodríguez HG

更新日期：2015-01-28 00:00:00

abstract：OBJECTIVES:Bladder transitional cell carcinoma (TCC) is one of the most common solid malignancies in China. This study examined the antitumor effect and underlying mechanism of action of sunitinib malate in human bladder TCC in vitro. METHODS:Bladder TCC cell lines 5637 and BIU87 were maintained in 1640 medium and T24...

journal_title：Cancer cell international

authors： Wen J,Li HZ,Ji ZG,Jin J

更新日期：2015-02-28 00:00:00

abstract：Background:Programmed cell death 1 (PD-1) functions as an immune checkpoint in the process of anti-tumor immune response. The PD-1 blockade is now becoming a fundamental part in cancer immunotherapy. So it's essential to elicit the PD-1 related immune process in different types of cancer. Methods:The Cancer Genome Atl...

journal_title：Cancer cell international

authors： Shang J,Song Q,Yang Z,Sun X,Xue M,Chen W,Yang J,Wang S

更新日期：2018-12-27 00:00:00

abstract：Background:In recent years, the B cell receptor (BCR) signaling pathway has become a "hot point" because it plays a critical role in B-cell proliferation and function. Bruton's tyrosine kinase (BTK) is overexpressed in many subtypes of B-cell lymphoma as a downstream kinase in the BCR signaling pathway. Ibrutinib, the ...

journal_title：Cancer cell international

authors： Xue C,Wang X,Zhang L,Qu Q,Zhang Q,Jiang Y

更新日期：2020-09-29 00:00:00

abstract：Background:Recent studies have demonstrated that the kallikrein and kallikrein-related peptidases (KLKs) exhibit aberrant expression in patients with colorectal cancer (CRC) and might be considered as potential prognostic biomarkers of CRC. However, inconsistent findings have been reported, which promote us to summariz...

journal_title：Cancer cell international

authors： Peng Q,Shen Y,Zhao P,Cheng M,Wu Y,Zhu Y

更新日期：2020-06-22 00:00:00

abstract：Background:Kinesin superfamily (KIFs) has a long-reported significant influence on the initiation, development, and progress of breast cancer. However, the prognostic value of whole family members was poorly done. Our study intends to demonstrate the value of kinesin superfamily members as prognostic biomarkers as well...

journal_title：Cancer cell international

authors： Li TF,Zeng HJ,Shan Z,Ye RY,Cheang TY,Zhang YJ,Lu SH,Zhang Q,Shao N,Lin Y

更新日期：2020-04-15 00:00:00

abstract：Background:The aim of the study was to explore the association between the SIRT1 single nucleotide polymorphism (SNP) rs3758391 and diffuse large B cell lymphoma (DLBCL) in a Chinese Han population. Methods:206 patients diagnosed with DLBCL and 219 healthy individuals were recruited in the present study. The genotypin...

journal_title：Cancer cell international

authors： Kan Y,Ge P,Wang X,Xiao G,Zhao H

更新日期：2018-10-22 00:00:00

abstract：Background:It is well known that hepatocellular carcinoma (HCC) has been one of the most life-threatening diseases all over the world. Plenty of internal and extrinsic factors have been proven to be related to HCC, such as gene mutation, viral hepatitis, and Nitrosamines. Though previous studies demonstrated that gluta...

journal_title：Cancer cell international

authors： Li S,Xue F,Zheng Y,Yang P,Lin S,Deng Y,Xu P,Zhou L,Hao Q,Zhai Z,Wu Y,Dai Z,Chen S

更新日期：2019-03-29 00:00:00

abstract：Background:LncRNAs are key regulators in cancer. The current study explored the role of lncRNA LINC00261 (LINC00261) in lung cancer (LC). Methods:Expression of LINC00261 in LC tissues and cells was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Pearson's Chi square test and Kaplan-Meier anal...

journal_title：Cancer cell international

authors： Guo C,Shi H,Shang Y,Zhang Y,Cui J,Yu H

更新日期：2020-06-26 00:00:00

abstract：BACKGROUND:Compounds of plant origin and food components have attracted scientific attention for use as agents for cancer prevention and treatment. Wine contains polyphenols that were shown to have anti-cancer and other health benefits. The survival pathways of Akt and extracellular signal-regulated kinase (Erk), and t...

journal_title：Cancer cell international

authors： Barron CC,Moore J,Tsakiridis T,Pickering G,Tsiani E

更新日期：2014-01-23 00:00:00

abstract：Background:Transgelin, an actin-binding protein, is associated with cytoskeleton remodeling. Findings from our previous studies demonstrated that transgelin was up-regulated in node-positive colorectal cancer (CRC) versus node-negative disease. Over-expression of TAGLN affected the expression of 256 downstream transcri...

journal_title：Cancer cell international

authors： Lew ZX,Zhou HM,Fang YY,Ye Z,Zhong W,Yang XY,Yu Z,Chen DY,Luo SM,Chen LF,Lin Y

更新日期：2020-08-03 00:00:00

abstract：BACKGROUND:Hepatocellular carcinoma (HCC) is an aggressive cancer with high mortality and morbidity worldwide. The limited clinically relevant model has impeded the development of effective HCC treatment strategy. Patient-derived xenograft (PDX) models retain most of the characteristics of original tumors and were show...

journal_title：Cancer cell international

authors： Cheung PF,Yip CW,Ng LW,Lo KW,Chow C,Chan KF,Cheung TT,Cheung ST

更新日期：2016-06-08 00:00:00

abstract：BACKGROUND:Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant and adjuvant chemotherapy; however, drug resistance often hinders therapy in OS patients. Also, the post-relapse survival of OS patients is as low as 20%. We the...

journal_title：Cancer cell international

authors： Saini H,Sharma H,Mukherjee S,Chowdhury S,Chowdhury R

更新日期：2021-01-14 00:00:00

abstract：:Cancer is a major public health problem as one of the leading causes of death worldwide. Deciphering the molecular regulation mechanisms of tumor progression can make way for tumor diagnosis and therapy. Paternally expressed gene 10 (PEG10), located on human chromosome 7q21.3, has turned out to be an oncogene implicat...

journal_title：Cancer cell international

authors： Xie T,Pan S,Zheng H,Luo Z,Tembo KM,Jamal M,Yu Z,Yu Y,Xia J,Yin Q,Wang M,Yuan W,Zhang Q,Xiong J

更新日期：2018-08-13 00:00:00

abstract：BACKGROUND:Serum Deprivation Protein Response (SDPR) plays an important role in formation of pulmonary alveoli. However, the functions and values of SDPR in lung cancer remain unknown. We explored prognostic value, expression pattern, and biological function of SDPR in non-small cell lung cancer (NSCLC) and KRAS-mutant...

journal_title：Cancer cell international

authors： Luo X,Peng S,Ding S,Zeng Q,Wang R,Ma Y,Chen S,Wang Y,Wang W

更新日期：2021-01-12 00:00:00

abstract：BACKGROUND:Resistance to drug therapy is a major impediment for successful treatment of patients suffering from breast cancer (BC). Tamoxifen (TAM) is an extensively used therapeutic agent, which substantially reduces the risk of recurrence and associated mortality in BC. This study demonstrated that exosomal transfer ...

journal_title：Cancer cell international

authors： Liu J,Zhu S,Tang W,Huang Q,Mei Y,Yang H

更新日期：2021-01-15 00:00:00

abstract：Background:Esophageal squamous cell carcinoma (ESCC) is one of the most prevalent malignancies and a major cause of cancer related death worldwide, especially in China. Cell lines are widely used disease models for basic medical research, however, well characterized ESCC cell models from China were seldom reported. Mis...

journal_title：Cancer cell international

authors： Li X,Tian D,Guo Y,Qiu S,Xu Z,Deng W,Su M

更新日期：2020-05-24 00:00:00

abstract：BACKGROUND:Chemoresistance is a major obstacle to successful chemotherapy for colorectal cancer. Eukaryotic translation initiation factor 5A2 (eIF5A2), one of the two isoforms in the eIF5A family, has been reported to be a new oncogene in many types of human cancer. In the present study, we aimed to investigate whether...

journal_title：Cancer cell international

authors： Bao Y,Lu Y,Wang X,Feng W,Sun X,Guo H,Tang C,Zhang X,Shi Q,Yu H

更新日期：2015-11-17 00:00:00

abstract：:Amongst males, leukaemia is the most common cause of cancer-related death in individuals younger than 40 years of age whereas in female children and adolescents, leukaemia is the most common cause of cancer-related death. Chronic myeloid leukaemia (CML) is a chronic leukaemia of the haematopoietic stem cells affecting...

journal_title：Cancer cell international

authors： Repsold L,Pool R,Karodia M,Tintinger G,Joubert AM

更新日期：2017-10-30 00:00:00

abstract：BACKGROUND:While some risk factors for breast cancer are well-known, the influence of other factors, particularly virus infection, remains unclear. Human cytomegalovirus (HCMV) is widespread in the general population, and both molecular and epidemiological evidence has indicated links between HCMV and breast cancer. Th...

journal_title：Cancer cell international

authors： Valle Oseguera CA,Spencer JV

更新日期：2017-02-13 00:00:00

abstract：Background:Sarcomas are malignant heterogeneous tumors of mesenchymal derivation. Dedifferentiated liposarcoma (DDLPS) is aggressive with recurrence in 80% and metastasis in 20% of patients. We previously found that miR-133a was significantly underexpressed in liposarcoma tissues. As this miRNA has recently been shown ...

journal_title：Cancer cell international

authors： Yu PY,Lopez G,Braggio D,Koller D,Bill KLJ,Prudner BC,Zewdu A,Chen JL,Iwenofu OH,Lev D,Strohecker AM,Fenger JM,Pollock RE,Guttridge DC

更新日期：2018-06-26 00:00:00

abstract：: Autoimmune phenomena were identified in many different cases of hematological diseases and solid tumors, which may be due to alterations in the expression and function of the NF-κB signaling pathway. Recently, a number of studies have shown that the deletion or mutation of A20, a negative regulator of NF-κB, is frequ...

journal_title：Cancer cell international

authors： Zhang F,Yang L,Li Y

更新日期：2012-11-07 00:00:00

abstract：Background:Gastric cancer (GC) is a common cause of cancer-related mortality worldwide, and microRNAs (miRNAs) have been shown to play an important role in GC development. This study aims to explore the effect of microRNA-93-5p (miR-93-5p) on the epithelial-mesenchymal transition (EMT) in GC, via AHNAK and the Wnt sign...

journal_title：Cancer cell international

authors： Shen E,Wang X,Liu X,Lv M,Zhang L,Zhu G,Sun Z

更新日期：2020-03-12 00:00:00

abstract：Background:Breast cancer is one of the most common malignancy among females from the worldwide cancer incidence statistics. Peroxisome gamma coactivator-1β (PGC-1β) has long been identified to be involved in this type of tumorigenesis. However, the mechanisms of PGC-1β in human breast cancer have not been fully underst...

journal_title：Cancer cell international

authors： Cao J,Wang X,Wang D,Ma R,Li X,Feng H,Wang J,Liu S,Wang L

更新日期：2019-04-11 00:00:00

abstract：: Cancer-initiating cells display aberrant functional and phenotypic characteristics of normal stem cells from which they evolved by accumulation of multiple cytogenetic and/or epigenetic alterations. Signal transduction pathways which are essential for normal stem cell function are abnormally expressed by cancer cells...

journal_title：Cancer cell international

authors： Feller L,Kramer B,Lemmer J

更新日期：2012-06-07 00:00:00

abstract：BACKGROUND:LncRNA HOXA-AS2 has been found in the literature to deteriorate glioblastoma. However, its regulatory mechanism is yet to be fully investigated. Our study focused chiefly on the interaction and role of the HOXA-AS2/miR-885-5p/RBBP4 axis in the development of glioblastoma. METHODS:qRT-PCR analysis was perfor...

journal_title：Cancer cell international

authors： Shou J,Gao H,Cheng S,Wang B,Guan H

更新日期：2021-01-11 00:00:00