Abstract:
Background:Sarcomas are malignant heterogeneous tumors of mesenchymal derivation. Dedifferentiated liposarcoma (DDLPS) is aggressive with recurrence in 80% and metastasis in 20% of patients. We previously found that miR-133a was significantly underexpressed in liposarcoma tissues. As this miRNA has recently been shown to be a tumor suppressor in many cancers, the objective of this study was to characterize the biological and molecular consequences of miR-133a underexpression in DDLPS. Methods:Real-time PCR was used to evaluate expression levels of miR-133a in human DDLPS tissue, normal fat tissue, and human DDLPS cell lines. DDLPS cells were stably transduced with miR-133a vector to assess the effects in vitro on proliferation, cell cycle, cell death, migration, and metabolism. A Seahorse Bioanalyzer system was also used to assess metabolism in vivo by measuring glycolysis and oxidative phosphorylation (OXPHOS) in subcutaneous xenograft tumors from immunocompromised mice. Results:miR-133a expression was significantly decreased in human DDLPS tissue and cell lines. Enforced expression of miR-133a decreased cell proliferation, impacted cell cycle progression kinetics, decreased glycolysis, and increased OXPHOS. There was no significant effect on cell death or migration. Using an in vivo xenograft mouse study, we showed that tumors with increased miR-133a expression had no difference in tumor growth compared to control, but did exhibit an increase in OXPHOS metabolic respiration. Conclusions:Based on our collective findings, we propose that in DDPLS, loss of miR-133a induces a metabolic shift due to a reduction in oxidative metabolism favoring a Warburg effect in DDLPS tumors, but this regulation on metabolism was not sufficient to affect DDPLS.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Yu PY,Lopez G,Braggio D,Koller D,Bill KLJ,Prudner BC,Zewdu A,Chen JL,Iwenofu OH,Lev D,Strohecker AM,Fenger JM,Pollock RE,Guttridge DCdoi
10.1186/s12935-018-0583-2subject
Has Abstractpub_date
2018-06-26 00:00:00pages
89issn
1475-2867pii
583journal_volume
18pub_type
杂志文章abstract:Background:Osteosarcoma (OS) is still a disease with high mortality from malignant tumors in children and adolescents. Due to its poor treatment, this study explored the involvement of lncRNA ZFAS1/microRNA-135a (miR-135a)/apurinic/apyrimidinic exonuclease 1 (APEX1) axis in the regulation of OS growth and metastasis. ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-1049-x
更新日期:2019-12-03 00:00:00
abstract:Background:miR-429 and TLN1 have been shown to affect the biological behaviours of many carcinomas. However, their effects in nasopharyngeal carcinoma (NPC) are not yet clear. Here, we investigated their regulatory relationships and effects on NPC cells. Methods:TargetScan was used to predict the regulatory relationsh...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0831-0
更新日期:2019-04-30 00:00:00
abstract::Circular RNAs (circRNAs) are small non-coding RNAs with a unique ring structure and play important roles as gene regulators. Disturbed expressions of circRNAs is closely related to varieties of pathological processes. The roles of circRNAs in cancers have gained increasing concerns. The communications between the canc...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
doi:10.1186/s12935-020-01301-z
更新日期:2020-06-03 00:00:00
abstract:OBJECTIVE:The objective of this study was to evaluate the anti-tumor effects of Ad/gTRAIL (an adenoviral vector in which expression of GFP and TRAIL is driven by a human telomerase reverse transcriptase promoter, hTERT) on malignant meningiomas and gliomas. BACKGROUND:Gliomas and meningiomas are the two most common ty...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-11-35
更新日期:2011-10-28 00:00:00
abstract:Objective:This study aimed to investigate the relationship among miR-145-5p, ANGPT2 and the NOD_LIKE_RECEPTOR pathway, thereby revealing the molecular mechanism of these three factors underlying the proliferation, migration and invasion of gastric cancer (GC) epithelial cells. Methods:qRT-PCR was carried out to detect...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01483-6
更新日期:2020-08-28 00:00:00
abstract:BACKGROUND:Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant and adjuvant chemotherapy; however, drug resistance often hinders therapy in OS patients. Also, the post-relapse survival of OS patients is as low as 20%. We the...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01720-y
更新日期:2021-01-14 00:00:00
abstract:BACKGROUND:Breast cancer (BrCa) is the most common female malignancy worldwide and has the highest morbidity among all cancers in females. Unfortunately, the mechanisms of BrCa growth and metastasis, which lead to a poor prognosis in BrCa patients, have not been well characterized. METHODS:Immunohistochemistry (IHC) w...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01733-7
更新日期:2021-01-06 00:00:00
abstract:BACKGROUND:Non-small cell lung cancer comprises the majority of lung cancer cases and is insensitive to chemotherapy. Most patients develop drug resistance. Recently, tetrandrine (TET), a bis-benzylisoquinoline alkaloid, was identified as a novel anti-cancer agent. However, the effect of tetrandrine combined with cispl...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0410-1
更新日期:2017-03-27 00:00:00
abstract:BACKGROUND:We studied the role of caspase-2 in apoptosis induction by taxanes (paclitaxel, novel taxane SB-T-1216) in breast cancer cells using SK-BR-3 (nonfunctional p53, functional caspase-3) and MCF-7 (functional p53, nonfunctional caspase-3) cell lines. RESULTS:Both taxanes induced apoptosis in SK-BR-3 as well as ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-13-42
更新日期:2013-05-15 00:00:00
abstract:BACKGROUND:Patients with dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine are resistant to chemotherapeutic treatment and external irradiation and thus are difficult to treat. Direct induction of apoptosis is a promising approach in these apoptosis-resistant tumor cells. The BH3 mimeti...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-016-0303-8
更新日期:2016-04-02 00:00:00
abstract:Background:Lung adenocarcinoma (LUAD) patients experiencing lymph node metastasis (LNM) always exhibit poor clinical outcomes. A biomarker or gene signature that could predict survival in these patients would have a substantial clinical impact, allowing for earlier detection of mortality risk and for individualized the...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0822-1
更新日期:2019-04-16 00:00:00
abstract:Background:Abnormal expressions of long noncoding RNAs (lncRNAs) are very common in clear cell renal cell carcinoma (ccRCC), and some of these have been reported to be highly correlated with prognosis of ccRCC patients. Methods:"edgeR" AND "DEseq" R packages were used to explore differentially expressed genes (DEGs) b...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0928-5
更新日期:2019-08-05 00:00:00
abstract:BACKGROUND:Ca2+ is known to be involved in a number of metastatic processes including motility and proliferation which can result in store-depletion of Ca2+. Up regulation of genes which contribute to store operated channel (SOC) activity may plausibly be necessary for these processes to take place efficiently. TRPC pr...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-9-23
更新日期:2009-08-18 00:00:00
abstract:BACKGROUND:Prostate cancer is a leading cause of male cancer specific mortality. When cure by radical prostatectomy is not possible the next line of prostate cancer treatment is androgen deprivation. However prolonged androgen deprivation often results in relapse and androgen-independent prostate cancer that is inevita...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-8-3
更新日期:2008-03-18 00:00:00
abstract:BACKGROUND:Circular RNAs (circRNAs) is a newly discovered type of non-coding RNA, the abnormal expression of which has been demonstrated in many types of human tumors. So they have been considered as promising candidates as diagnostic and therapeutic targets in cancer. This research aimed to screen the profile of circR...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01681-2
更新日期:2021-01-07 00:00:00
abstract:Background:Thyroid cancer (TC) is the most frequent endocrine malignancy. Long noncoding RNAs (lncRNAs) have been confirmed to act as significant roles in tumor development. The role of lncRNA TMPO-AS1 in TC is still unclear, so it remains to be explored. The aim of the research is to investigate the role and regulator...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01334-4
更新日期:2020-07-08 00:00:00
abstract:BACKGROUND:CircRNAs play crucial roles in multiple tumours. However, the functions of most circRNAs in cervical cancer remain unclear. METHODS:This study collected GSE113696 data from the GEO database to search for differentially expressed circRNAs in cervical cancer. Quantitative reverse transcription PCR was used to...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01736-4
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:MicroRNAs are 22-24 nt non-coding RNAs that bind to the 3' UTR of target mRNAs, thereby inducing mRNA degradation or inhibiting mRNA translation. Due to their implication in the regulation of post-transcriptional processes, the role of miRNAs in hepatocellular carcinoma (HCC) has been extensively studied. Ho...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0386-x
更新日期:2017-02-21 00:00:00
abstract:Background:Acute myeloid leukemia (AML) is a clinically and biologically heterogeneous disease. The survival of older patients is generally poor. In the current study, we sought to investigate the differences in molecular gene mutations between younger and older AML patients, and to identify those newly diagnosed AML p...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0716-7
更新日期:2018-12-22 00:00:00
abstract:: Autoimmune phenomena were identified in many different cases of hematological diseases and solid tumors, which may be due to alterations in the expression and function of the NF-κB signaling pathway. Recently, a number of studies have shown that the deletion or mutation of A20, a negative regulator of NF-κB, is frequ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-12-44
更新日期:2012-11-07 00:00:00
abstract:BACKGROUND:Endometrial cancer is an invasive gynecological cancer prevalent in the world. The pathogenesis of endometrial cancer is related to multiple levels of regulation, referring to oestrogen, tumor-suppressor gene (e.g. PTEN) or microRNAs (e.g. miR-23a and miR-29b). Metapristone is a hormone-related drug, which i...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01682-1
更新日期:2021-01-07 00:00:00
abstract:BACKGROUND:Despite the modern therapies available for treating glioblastoma multiforme (GBM), it is still a deadly disease. The development of new therapeutic strategies for the management of gliomas is therefore crucial. The present study is designed to analyze the therapeutic potentials of synthetic compound N-(2-hyd...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-014-0133-5
更新日期:2014-11-30 00:00:00
abstract:Background:LncRNAs are key regulators in cancer. The current study explored the role of lncRNA LINC00261 (LINC00261) in lung cancer (LC). Methods:Expression of LINC00261 in LC tissues and cells was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Pearson's Chi square test and Kaplan-Meier anal...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01332-6
更新日期:2020-06-26 00:00:00
abstract:BACKGROUND:Non-small cell lung cancer (NSCLC) is the largest histological subgroup of lung cancer and has increased in prevalence in China over the past 5 years. The 5-year survival rate has remained at 15-20 %, with a median survival of 8-12 months. The tumorigenesis and progression of NSCLC is orchestrated by numerou...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0236-7
更新日期:2015-09-17 00:00:00
abstract:Background:Angiogenesis plays critical roles in the progression and metastasis of malignant tumors. Gastric neuroendocrine carcinoma is an uncommon stomach cancer that is rich in blood vessels and exhibits highly malignant biological behavior with a poor prognosis. The role of CDK5RAP3 in GNEC has not been reported to ...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0997-5
更新日期:2019-11-07 00:00:00
abstract:Background:Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property. Cytosine deaminase (CD), which is derived from bacteria or yeast, can convert a relatively nontoxic prodrug 5-fluorocytosine (5-FC) into the active an...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01340-6
更新日期:2020-06-15 00:00:00
abstract:BACKGROUND:BRAF inhibitors are effective anticancer agents in BRAF-mutated melanomas. By contrast, evidences about sensitivity of thyroid carcinomas to BRAF inhibition are conflicting and it has been proposed that BRAF V600E thyroid carcinoma cells are less sensitive to BRAF inhibitors due to activation of parallel sig...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0457-z
更新日期:2017-10-04 00:00:00
abstract:Background:Melanoma as a type of skin cancer, is associated with a high mortality rate. Therefore, early diagnosis and efficient surgical treatment of this disease is very important. Photodynamic therapy (PDT) involves the activation of a photosensitizer by light at specific wavelength that interacts with oxygen and cr...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01616-x
更新日期:2020-10-29 00:00:00
abstract::Sineoculis homeobox homolog 1 (Six1), normally a developmentally restricted transcriptional regulator, is frequently dysregulated in mutiple cancers. Increasing evidences show that overexpression of Six1 plays a key role in tumorigenesis. However, the Six1 expression status and its relationship with the clinicopatholo...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0215-z
更新日期:2015-06-20 00:00:00
abstract:BACKGROUND:ErbB3-binding protein 1 (Ebp1) is a member of the PA2G4 family of proliferation-regulated proteins that is expressed in multiple malignant and non-malignant cells. ErbB3 and other members of the EGFR family have been implicated in cancer progression, it however remains unknown whether Ebp1 participate in pro...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-8-18
更新日期:2008-11-24 00:00:00