Transgelin interacts with PARP1 in human colon cancer cells.

abstract：:Circular RNAs (circRNAs) are small non-coding RNAs with a unique ring structure and play important roles as gene regulators. Disturbed expressions of circRNAs is closely related to varieties of pathological processes. The roles of circRNAs in cancers have gained increasing concerns. The communications between the canc...

journal_title：Cancer cell international

authors： Song H,Liu Q,Liao Q

更新日期：2020-06-03 00:00:00

abstract：BACKGROUND:The digallic acid (DGA) purified from Pistacia lentiscus. L fruits was investigated for its antiproliferative and apoptotic activities on human lymphoblastoid TK6 cells. METHODS:We attempt to characterize the apoptotic pathway activated by DGA. Apoptosis was detected by DNA fragmentation, PARP cleavage and ...

journal_title：Cancer cell international

authors： Bhouri W,Boubaker J,Skandrani I,Ghedira K,Chekir Ghedira L

更新日期：2012-06-11 00:00:00

abstract：BACKGROUND:Natural killer (NK) cells eliminate virus-infected and tumor cells through the release of perforins and granzymes; they also produce Interferon gamma (IFN-γ) and Tumor necrosis factor alpha (TNF-α), which induce apoptosis in target cells. Many tumors express Heme oxygenase 1 (HO-1), and this expression has b...

journal_title：Cancer cell international

authors： Gómez-Lomelí P,Bravo-Cuellar A,Hernández-Flores G,Jave-Suárez LF,Aguilar-Lemarroy A,Lerma-Díaz JM,Domínguez-Rodríguez JR,Sánchez-Reyes K,Ortiz-Lazareno PC

更新日期：2014-10-01 00:00:00

abstract：Background:Chimeric antigen receptors (CARs) represent a novel facet of modern day synthetic biology that exemplifies personalized medicine at work through their ability to harness and redirect a patient's immune system to fight cancer. Body:By combining the target-specificity of antibodies to the effector capabilitie...

journal_title：Cancer cell international

authors： Leyfman Y

更新日期：2018-11-14 00:00:00

abstract：Background:Pancreatic cancer (PC) remains one of the most aggressive cancers worldwide. However, genetic factors underlying PC susceptibility remain largely unclear. Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) acts as an oncogene and its genetic variation has been linked to many cancers. However, ...

journal_title：Cancer cell international

authors： Jiang D,Xu L,Ni J,Zhang J,Cai M,Shen L

更新日期：2019-02-28 00:00:00

abstract：Background:The aim of the study was to explore the association between the SIRT1 single nucleotide polymorphism (SNP) rs3758391 and diffuse large B cell lymphoma (DLBCL) in a Chinese Han population. Methods:206 patients diagnosed with DLBCL and 219 healthy individuals were recruited in the present study. The genotypin...

journal_title：Cancer cell international

authors： Kan Y,Ge P,Wang X,Xiao G,Zhao H

更新日期：2018-10-22 00:00:00

abstract：Background:Many circRNAs have been reported to play important roles in cancer development and have the potential to serve as a novel class of biomarkers for clinical diagnosis. However, the role of circRNAs in esophageal carcinoma (EC) remains unclear. In the current study, we investigated the potential role of circPVT...

journal_title：Cancer cell international

authors： Zhong R,Chen Z,Mo T,Li Z,Zhang P

更新日期：2019-10-15 00:00:00

abstract：BACKGROUND:Despite the modern therapies available for treating glioblastoma multiforme (GBM), it is still a deadly disease. The development of new therapeutic strategies for the management of gliomas is therefore crucial. The present study is designed to analyze the therapeutic potentials of synthetic compound N-(2-hyd...

journal_title：Cancer cell international

authors： Hanif F,Perveen K,Jawed H,Ahmed A,Malhi SM,Jamall S,Simjee SU

更新日期：2014-11-30 00:00:00

abstract：Background:A number of JmjC domain-containing histone demethylases have been identified and biochemically characterized in mammalian models and humans. JMJD2A is a transcriptional co-factor and enzyme that catalyzes the demethylation of histone H3 lysine 9 and 36 (H3K9 and H3K36). Here in this study, we reported the ro...

journal_title：Cancer cell international

authors： Li M,Cheng J,Ma Y,Guo H,Shu H,Huang H,Kuang Y,Yang T

更新日期：2020-03-30 00:00:00

abstract：Background:New drugs for adrenocortical carcinoma (ACC) are needed because most patients undergo rapid disease progression despite surgery and adjuvant therapy with mitotane. In this study, we aimed to investigate the in vitro effects of different chemotherapy drugs, alone or combined with mitotane, on the viability of...

journal_title：Cancer cell international

authors： Silveira E,Cavalcante IP,Kremer JL,de Mendonça POR,Lotfi CFP

更新日期：2018-03-01 00:00:00

abstract：:Non-small-cell lung cancer (NSCLC) is a type of malignancy with progressive metastasis having poor prognosis and lowered survival resulting from late diagnosis. The therapeutic approaches for the treatment of this incurable cancer are chemo- and radiotherapy. Since current treatments are insufficient and because of dr...

journal_title：Cancer cell international

authors： Pourhanifeh MH,Sharifi M,Reiter RJ,Davoodabadi A,Asemi Z

更新日期：2019-05-16 00:00:00

abstract：BACKGROUND:ErbB3-binding protein 1 (Ebp1) is a member of the PA2G4 family of proliferation-regulated proteins that is expressed in multiple malignant and non-malignant cells. ErbB3 and other members of the EGFR family have been implicated in cancer progression, it however remains unknown whether Ebp1 participate in pro...

journal_title：Cancer cell international

authors： Gannon PO,Koumakpayi IH,Le Page C,Karakiewicz PI,Mes-Masson AM,Saad F

更新日期：2008-11-24 00:00:00

abstract：BACKGROUND:Tumor tissue resembles chronically inflamed tissue. Since chronic inflammatory conditions are a strong stimulus for bone marrow-derived cells (BMDCs) it can be assumed that recruitment of BMDCs into cancer tissue should be a common phenomenon. Several data have outlined that BMDC can influence tumor growth a...

journal_title：Cancer cell international

authors： Nagler C,Hardt C,Zänker KS,Dittmar T

更新日期：2011-06-28 00:00:00

abstract：Background:T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood. In this study, we tried to explore the physiological role of CD59 in T-ALL. Methods:In this study, we collected the bone marrow samples from 17 T-A...

journal_title：Cancer cell international

authors： Jia Y,Qi Y,Wang Y,Ma X,Xu Y,Wang J,Zhang X,Gao M,Cong B,Han S

更新日期：2019-01-08 00:00:00

abstract：:Application of novel methods in cancer therapy is important in terms of management and treatment of the life-threatening disorder. It appears that autophagy is a potential target in cancer therapy, as a variety of drugs targeting autophagy have shown great potential in reducing the viability and proliferation of cance...

journal_title：Cancer cell international

authors： Ashrafizadeh M,Ahmadi Z,Farkhondeh T,Samarghandian S

更新日期：2020-11-04 00:00:00

abstract：BACKGROUND:Compounds of plant origin and food components have attracted scientific attention for use as agents for cancer prevention and treatment. Wine contains polyphenols that were shown to have anti-cancer and other health benefits. The survival pathways of Akt and extracellular signal-regulated kinase (Erk), and t...

journal_title：Cancer cell international

authors： Barron CC,Moore J,Tsakiridis T,Pickering G,Tsiani E

更新日期：2014-01-23 00:00:00

abstract：Background:Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property. Cytosine deaminase (CD), which is derived from bacteria or yeast, can convert a relatively nontoxic prodrug 5-fluorocytosine (5-FC) into the active an...

journal_title：Cancer cell international

authors： Ding Y,Fan J,Deng L,Huang B,Zhou B

更新日期：2020-06-15 00:00:00

abstract：:Prostate cancer is a gland tumor in the male reproductive system. It is a multifaceted and genomically complex disease. Transmembrane protease, serine 2 and v-ets erythroblastosis virus E26 homolog (TMPRSS2-ERG) gene fusions are the common molecular signature of prostate cancer. Although tremendous advances have been ...

journal_title：Cancer cell international

authors： Farooqi AA,Hou MF,Chen CC,Wang CL,Chang HW

更新日期：2014-04-17 00:00:00

abstract：Background:LncRNAs are key regulators in cancer. The current study explored the role of lncRNA LINC00261 (LINC00261) in lung cancer (LC). Methods:Expression of LINC00261 in LC tissues and cells was determined by quantitative real-time polymerase chain reaction (qRT-PCR). Pearson's Chi square test and Kaplan-Meier anal...

journal_title：Cancer cell international

authors： Guo C,Shi H,Shang Y,Zhang Y,Cui J,Yu H

更新日期：2020-06-26 00:00:00

abstract：Background:Long noncoding RNAs (lncRNAs) play essential roles in tumor progression. However, the functions and targets of lncRNAs in neuroblastoma (NB) progression still remain to be determined. In this study, we aimed to investigate the effect of lncRNA DLX6 antisense RNA 1 (DLX6-AS1) on NB and the underlying mechanis...

journal_title：Cancer cell international

authors： Zhang HY,Xing MQ,Guo J,Zhao JC,Chen X,Jiang Z,Zhang H,Dong Q

更新日期：2019-11-27 00:00:00

abstract：BACKGROUND:miR-222 has been reported to be overexpressed in colorectal cancer and it influences cancer cell proliferation, drug resistance and metastasis. However, the underlying molecular mechanism of miR-222 in colorectal cancer cell invasion and migration has not been thoroughly elucidated to date. METHODS:The cell...

journal_title：Cancer cell international

authors： Gao H,Cong X,Zhou J,Guan M

更新日期：2017-08-29 00:00:00

abstract：BACKGROUND:The voltage gated potassium (K+) channels Eag and HERG have been implicated in the pathogenesis of various cancers, through association with cell cycle changes and programmed cell death. The role of these channels in the onset and progression of ovarian cancer is unknown. An understanding of mechanism by whi...

journal_title：Cancer cell international

authors： Asher V,Warren A,Shaw R,Sowter H,Bali A,Khan R

更新日期：2011-03-10 00:00:00

abstract：Objective:To study the potential role of miR-544 in the immune escape mechanism of hepatoma cells. Methods:Natural killer (NK) cells were collected from healthy volunteers and patients with liver cancer. Interleukin (IL)-2 activated-NK-92 cells were transfected with miR-544 inhibitor/mimic or NC/pre-NC in HepG2 co-cul...

journal_title：Cancer cell international

authors： Pan C,Xiang L,Pan Z,Wang X,Li J,Zhuge L,Fang P,Xie Q,Hu X

更新日期：2018-04-03 00:00:00

abstract：BACKGROUND:Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in children and adolescents. The current treatment approach includes neoadjuvant and adjuvant chemotherapy; however, drug resistance often hinders therapy in OS patients. Also, the post-relapse survival of OS patients is as low as 20%. We the...

journal_title：Cancer cell international

authors： Saini H,Sharma H,Mukherjee S,Chowdhury S,Chowdhury R

更新日期：2021-01-14 00:00:00

abstract：BACKGROUND:This last decade, a lot of emphasis has been placed on developing new cancer cell culture models, closer to in vivo condition, in order to test new drugs and therapies. In the case of colorectal cancer, the use of patient biopsies to seed 3D primary cultures and mimic tumor initiation necessitates the use of...

journal_title：Cancer cell international

authors： Relier S,Yazdani L,Ayad O,Choquet A,Bourgaux JF,Prudhomme M,Pannequin J,Macari F,David A

更新日期：2016-02-12 00:00:00

abstract：Background:Neuroblastoma (NB) is the most common malignant tumor originating from the extracranial sympathetic nervous system in children. The molecular mechanisms underlying this disease are complex, and not completely understood. Methods:Quantitative real-time PCR (qRT-PCR) was applied to quantify the expression of ...

journal_title：Cancer cell international

authors： Yu Y,Zhang J,Jin Y,Yang Y,Shi J,Chen F,Han S,Chu P,Lu J,Wang H,Guo Y,Ni X

更新日期：2018-01-04 00:00:00

abstract：Background:Cancer-associated fibroblasts (CAFs) play important roles in tumor progression. However, the behaviors of activated CAFs in gastric cancer remain to be determined. The aim of the present study was to investigate the correlations between activated gastric CAFs and the prognosis of patients with gastric cancer...

journal_title：Cancer cell international

authors： Ma Y,Zhu J,Chen S,Li T,Ma J,Guo S,Hu J,Yue T,Zhang J,Wang P,Wang X,Chen G,Liu Y

更新日期：2018-07-20 00:00:00

abstract：Background:Helicobacter pylori (H. pylori)-induced gastric cancer is an intricate progression of immune response against H. pylori infection. IL-16, TGF-β1 and TLR4 pathways were the mediators involved in the immune response. We hypothesized that genetic variations in genes of these pathways have potential susceptibili...

journal_title：Cancer cell international

authors： He B,Xu T,Pan B,Pan Y,Wang X,Dong J,Sun H,Xu X,Liu X,Wang S

更新日期：2018-11-20 00:00:00

abstract：:Cancer is a major public health problem as one of the leading causes of death worldwide. Deciphering the molecular regulation mechanisms of tumor progression can make way for tumor diagnosis and therapy. Paternally expressed gene 10 (PEG10), located on human chromosome 7q21.3, has turned out to be an oncogene implicat...

journal_title：Cancer cell international

authors： Xie T,Pan S,Zheng H,Luo Z,Tembo KM,Jamal M,Yu Z,Yu Y,Xia J,Yin Q,Wang M,Yuan W,Zhang Q,Xiong J

更新日期：2018-08-13 00:00:00

abstract：BACKGROUND:BRAF inhibitors are effective anticancer agents in BRAF-mutated melanomas. By contrast, evidences about sensitivity of thyroid carcinomas to BRAF inhibition are conflicting and it has been proposed that BRAF V600E thyroid carcinoma cells are less sensitive to BRAF inhibitors due to activation of parallel sig...

journal_title：Cancer cell international

authors： Notarangelo T,Sisinni L,Condelli V,Landriscina M

更新日期：2017-10-04 00:00:00