当前位置： SCI文献检索 > Cancer Cell International期刊下所有文献 > Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma.

Inhibition of cell growth by EGR-1 in human primary cultures from malignant glioma.

Abstract：

:BACKGROUND: The aim of this work was to investigate in vitro the putative role of EGR-1 in the growth of glioma cells. EGR-1 expression was examined during the early passages in vitro of 17 primary cell lines grown from 3 grade III and from 14 grade IV malignant astrocytoma explants. The explanted tumors were genetically characterized at the p53, MDM2 and INK4a/ARF loci, and fibronectin expression and growth characteristics were examined. A recombinant adenovirus overexpressing EGR-1 was tested in the primary cell lines. RESULTS: Low levels of EGR-1 protein were found in all primary cultures examined, with lower values present in grade IV tumors and in cultures carrying wild-type copies of p53 gene. The levels of EGR-1 protein were significantly correlated to the amount of intracellular fibronectin, but only in tumors carrying wild-type copies of the p53 gene (R = 0,78, p = 0.0082). Duplication time, plating efficiency, colony formation in agarose, and contact inhibition were also altered in the p53 mutated tumor cultures compared to those carrying wild-type p53. Growth arrest was achieved in both types of tumor within 1-2 weeks following infection with a recombinant adenovirus overexpressing EGR-1 but not with the control adenovirus. CONCLUSIONS: Suppression of EGR-1 is a common event in gliomas and in most cases this is achieved through down-regulation of gene expression. Expression of EGR-1 by recombinant adenovirus infection almost completely abolishes the growth of tumor cells in vitro, regardless of the mutational status of the p53 gene.

journal_name

Cancer Cell Int

journal_title

Cancer cell international

authors

Calogero A,Lombari V,De Gregorio G,Porcellini A,Ucci S,Arcella A,Caruso R,Gagliardi FM,Gulino A,Lanzetta G,Frati L,Mercola D,Ragona G

doi

10.1186/1475-2867-4-1

keywords:

subject

Has Abstract

pub_date

2004-01-07 00:00:00

pages

1

issue

1

issn

1475-2867

pii

1475-2867-4-1

journal_volume

4

pub_type

杂志文章

相关文献

Cancer Cell International文献大全
  • The assessment of minimal residual disease versus that of somatic mutations for predicting the outcome of acute myeloid leukemia patients.

    abstract：Background:In addition to morphological and cytogenetic features, acute myeloid leukemias are characterized by mutations that can be used for target-therapy; also the minimal/measurable residual disease (MRD) could be an important prognostic factor. The purpose of this retrospective study was to investigate if somatic ...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0807-0

    authors： Salehzadeh S,Guerrini F,Pizzano U,Grassi S,Ciabatti E,Iovino L,Buda G,Caracciolo F,Benedetti E,Orciuolo E,Pelosini M,Consani G,Carulli G,Metelli MR,Martini F,Mazziotta F,Mazzantini E,Rossi P,Tavarozzi R,Ricci F,Pe

    更新日期：2019-04-04 00:00:00

  • LncRNA ST8SIA6-AS1 promotes hepatocellular carcinoma cell proliferation and resistance to apoptosis by targeting miR-4656/HDAC11 axis.

    abstract：Background:Dysregulation of long non-coding RNAs (lncRNAs) results in development of human diseases including hepatocellular carcinoma (HCC). Although several HCC related lncRNAs have been reported, the biological functions of many lncRNAs during the development of HCC remains unknown. Methods:The expression of ST8SIA...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01325-5

    authors： Fei Q,Song F,Jiang X,Hong H,Xu X,Jin Z,Zhu X,Dai B,Yang J,Sui C,Xu M

    更新日期：2020-06-11 00:00:00

  • Investigation of the apoptotic way induced by digallic acid in human lymphoblastoid TK6 cells.

    abstract：BACKGROUND:The digallic acid (DGA) purified from Pistacia lentiscus. L fruits was investigated for its antiproliferative and apoptotic activities on human lymphoblastoid TK6 cells. METHODS:We attempt to characterize the apoptotic pathway activated by DGA. Apoptosis was detected by DNA fragmentation, PARP cleavage and ...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-12-26

    authors： Bhouri W,Boubaker J,Skandrani I,Ghedira K,Chekir Ghedira L

    更新日期：2012-06-11 00:00:00

  • The prognostic role of the cancer stem cell marker CD44 in ovarian cancer: a meta-analysis.

    abstract：BACKGROUND:CD44 has recently been reported as a cancer stem cell marker in ovarian cancer. However, the clinicopathological and prognostic value of this marker in ovarian cancer remains controversial; Here, we aimed to investigate the correlation between CD44 expression and the clinicopathological features or survival ...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-016-0376-4

    authors： Lin J,Ding D

    更新日期：2017-01-05 00:00:00

  • Expression profile analysis identifies IER3 to predict overall survival and promote lymph node metastasis in tongue cancer.

    abstract：Background:Lymph node metastasis is one of the most important factors affecting the prognosis of tongue cancer, and the molecular mechanism regulating lymph node metastasis of tongue cancer is poorly known. Methods:The gene expression dataset GSE2280 and The Cancer Genome Atlas (TCGA) tongue cancer dataset were downlo...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-1028-2

    authors： Xiao F,Dai Y,Hu Y,Lu M,Dai Q

    更新日期：2019-11-21 00:00:00

  • Role of IGF-1/IGF-1R in regulation of invasion in DU145 prostate cancer cells.

    abstract：BACKGROUND:Prostate cancer progression to androgen independence is the primary cause of mortality by this tumor type. The IGF-1/IGF-1R axis is well known to contribute to prostate cancer initiation, but its contribution to invasiveness and the downstream signalling mechanisms that are involved are unclear at present. ...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-8-10

    authors： Saikali Z,Setya H,Singh G,Persad S

    更新日期：2008-07-03 00:00:00

  • BCYRN1, a c-MYC-activated long non-coding RNA, regulates cell metastasis of non-small-cell lung cancer.

    abstract：BACKGROUND:Long non-coding RNAs (lncRNAs) are increasingly implicated in the regulation of the progression of malignancy. AIM:To clarify the relations among BCYRN1 (brain cytoplasmic RNA 1, a long non-coding RNA), c-MYC and cell metastasis of non-small-cell lung cancer (NSCLC). METHODS:Real-time PCR was used to measu...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-015-0183-3

    authors： Hu T,Lu YR

    更新日期：2015-04-01 00:00:00

  • Functional promoter -765 G > C variant in COX-2 gene is associated with the susceptibility of breast cancer in Chinese Han women.

    abstract：BACKGROUND:Cyclooxygenase (COX) is a rate-limiting enzyme in prostaglandins synthesis which exists in two isoforms, COX-1 and COX-2. Over-expression of COX-2 was considered to increase the proliferation and enhance the invasiveness of breast cancer cells. It was suggested that genetic variations in COX-2 could influenc...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-14-38

    authors： Gao J,Kang HF,Ma XB,Tang W,Liu D,Zhao Y,Zhang SQ,Guan HT,Lin S,Ren HT,Wang XJ,Dai ZJ

    更新日期：2014-05-06 00:00:00

  • Inhibition of androgen-independent prostate cancer cell growth is enhanced by combination therapy targeting Hedgehog and ErbB signalling.

    abstract：BACKGROUND:Prostate cancer is a leading cause of male cancer specific mortality. When cure by radical prostatectomy is not possible the next line of prostate cancer treatment is androgen deprivation. However prolonged androgen deprivation often results in relapse and androgen-independent prostate cancer that is inevita...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-8-3

    authors： Shaw G,Prowse DM

    更新日期：2008-03-18 00:00:00

  • Epigenetic regulation of osteopontin splicing isoform c defines its role as a microenvironmental factor to promote the survival of colon cancer cells from 5-FU treatment.

    abstract：Background:Drug resistance to 5-fluorouracil (5-FU) and recurrence after chemotherapy in colorectal cancer remain a challenge to be resolved for the improvement of patient outcomes. It is recognized that a variety of secretory proteins released from the tumor cells exposed to chemo-drugs into the tumor microenvironment...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01541-z

    authors： Chang S,Huang J,Niu H,Wang J,Si Y,Bai Z,Cheng S,Ding W

    更新日期：2020-09-14 00:00:00

  • Pepsin promotes IL-8 signaling-induced epithelial-mesenchymal transition in laryngeal carcinoma.

    abstract：Background:Laryngopharyngeal reflux (LPR), with its increasing morbidity, is attracting considerable attention. In recent years, the causal role between LPR and laryngeal carcinoma has been debated. The main harmful component of LPR is pepsin, which has been shown to induce mucosal inflammation by damaging the mucous m...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0772-7

    authors： Tan JJ,Wang L,Mo TT,Wang J,Wang MG,Li XP

    更新日期：2019-03-20 00:00:00

  • The tyrosine kinase inhibitor nilotinib is more efficient than mitotane in decreasing cell viability in spheroids prepared from adrenocortical carcinoma cells.

    abstract：Background:New drugs for adrenocortical carcinoma (ACC) are needed because most patients undergo rapid disease progression despite surgery and adjuvant therapy with mitotane. In this study, we aimed to investigate the in vitro effects of different chemotherapy drugs, alone or combined with mitotane, on the viability of...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-018-0527-x

    authors： Silveira E,Cavalcante IP,Kremer JL,de Mendonça POR,Lotfi CFP

    更新日期：2018-03-01 00:00:00

  • PEG10 as an oncogene: expression regulatory mechanisms and role in tumor progression.

    abstract：:Cancer is a major public health problem as one of the leading causes of death worldwide. Deciphering the molecular regulation mechanisms of tumor progression can make way for tumor diagnosis and therapy. Paternally expressed gene 10 (PEG10), located on human chromosome 7q21.3, has turned out to be an oncogene implicat...

    journal_title：Cancer cell international

    pub_type： 杂志文章,评审

    doi：10.1186/s12935-018-0610-3

    authors： Xie T,Pan S,Zheng H,Luo Z,Tembo KM,Jamal M,Yu Z,Yu Y,Xia J,Yin Q,Wang M,Yuan W,Zhang Q,Xiong J

    更新日期：2018-08-13 00:00:00

  • 2-Methoxyestradiol-bis-sulphamate refrains from inducing apoptosis and autophagy in a non-tumorigenic breast cell line.

    abstract：UNLABELLED: BACKGROUND:Anticancer research resulted in the discovery of a promising antimitotic metabolite, 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate, a bis-sulphamoylated analogue exerts antiproliferative- and antimitotic activity. Investigating the anticancer potential of 2-methoxyestradiol-bis-sulphamat...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-12-37

    authors： Visagie MH,Joubert AM

    更新日期：2012-08-20 00:00:00

  • HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation.

    abstract：BACKGROUND:Mutational inactivation of the von Hippel-Lindau (VHL) tumor suppressor gene has been linked to hereditary as well as sporadic clear cell renal carcinomas. The product of the VHL gene, pVHL, acts to target hypoxia-inducible factor alpha (HIF-alpha) subunits for ubiquitination and subsequent degradation. Usin...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-7-13

    authors： Hughes MD,Kapllani E,Alexander AE,Burk RD,Schoenfeld AR

    更新日期：2007-06-28 00:00:00

  • DNA methylation-based classification and identification of renal cell carcinoma prognosis-subgroups.

    abstract：Background:Renal cell carcinoma (RCC) is the most common kidney cancer and includes several molecular and histological subtypes with different clinical characteristics. The combination of DNA methylation and gene expression data can improve the classification of tumor heterogeneity, by incorporating differences at the ...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0900-4

    authors： Chen W,Zhuang J,Wang PP,Jiang J,Lin C,Zeng P,Liang Y,Zhang X,Dai Y,Diao H

    更新日期：2019-07-16 00:00:00

  • The mRNA expression of SATB1 and SATB2 in human breast cancer.

    abstract：BACKGROUND:SATB1 is a nuclear protein that has been recently reported to be a 'genome organizer' which delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. In this study, the level of mRNA expression of SATB1 a...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-9-18

    authors： Patani N,Jiang W,Mansel R,Newbold R,Mokbel K

    更新日期：2009-07-30 00:00:00

  • Abnormal expression, localization and interaction of canonical transient receptor potential ion channels in human breast cancer cell lines and tissues: a potential target for breast cancer diagnosis and therapy.

    abstract：BACKGROUND:Ca2+ is known to be involved in a number of metastatic processes including motility and proliferation which can result in store-depletion of Ca2+. Up regulation of genes which contribute to store operated channel (SOC) activity may plausibly be necessary for these processes to take place efficiently. TRPC pr...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-9-23

    authors： Aydar E,Yeo S,Djamgoz M,Palmer C

    更新日期：2009-08-18 00:00:00

  • MicroRNA-4316 inhibits gastric cancer proliferation and migration via directly targeting VEGF-A.

    abstract：Background and aims:microRNAs (miRNAs) have been reported to regulate proliferation and migration by down-regulating the expression of target genes. The aims of this study were to investigate whether miR-4316 inhibited proliferation and migration by downregulating vascular endothelial growth factor A (VEGF-A) and its c...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-1132-3

    authors： Mousa H,Yuan M,Zhang X,Li X,Shopit A,Almoiliqy M,Alshwmi M,Al-Dherasi A,Xu Y,Zuo Y

    更新日期：2020-02-22 00:00:00

  • MicroRNA-144 inhibits cell proliferation, migration and invasion in human hepatocellular carcinoma by targeting CCNB1.

    abstract：Background:Hepatocellular carcinoma (HCC) is one of the most common malignancies with a high morbidity and mortality worldwide. MicroRNAs are key regulators of HCC genesis. However, the regulatory role and underlying mechanisms of microRNA in HCC is still limited. Methods:Cyclin B1 (CCNB1) mRNA levels were examined in...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0729-x

    authors： Gu J,Liu X,Li J,He Y

    更新日期：2019-01-14 00:00:00

  • Long non-coding RNA CTBP1-AS2 enhances cervical cancer progression via up-regulation of ZNF217 through sponging miR-3163.

    abstract：Background:Long non-coding RNAs (lncRNAs) play significant roles in tumorigenesis and can contribute to identification of novel therapeutic targets for cancers. This paper was aimed at exploring the role of CTBP1 divergent transcript (CTBP1-AS2) in cervical cancer (CC) progression. Methods:qRT-PCR and western blot ass...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01430-5

    authors： Yang S,Shi F,Du Y,Wang Z,Feng Y,Song J,Liu Y,Xiao M

    更新日期：2020-07-28 00:00:00

  • Mammaglobin as a potential molecular target for breast cancer drug delivery.

    abstract：BACKGROUND:Mammaglobin (MAM) has been used as a specific molecular marker for breast cancer diagnosis. Recently, several groups of researchers proposed a number of therapeutic strategies targeting this molecule. Some of the strategies are based upon an essential but not demonstrated hypothesis - mammaglobin is associat...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-9-8

    authors： Zuo L,Li L,Wang Q,Fleming TP,You S

    更新日期：2009-03-23 00:00:00

  • Long noncoding RNA SNHG4 promotes renal cell carcinoma tumorigenesis and invasion by acting as ceRNA to sponge miR-204-5p and upregulate RUNX2.

    abstract：Background:Long noncoding RNAs (lncRNAs) are involved in the tumorigenesis and progression of human cancers, including renal cell carcinoma (RCC). Small nucleolar RNA host gene 4 (SNHG4) is reported to play an essential role in tumor growth and progression. However, the molecular mechanisms and function of SNHG4 in RCC...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01606-z

    authors： Wu J,Liu T,Sun L,Zhang S,Dong G

    更新日期：2020-10-19 00:00:00

  • NEAT1/miR-23a-3p/KLF3: a novel regulatory axis in melanoma cancer progression.

    abstract：Background:Melanoma is an extremely aggressive malignant skin tumor with high mortality. Many types of long noncoding RNAs and microRNAs have been reported to be associated with the oncogenesis of melanoma. However, a novel lncRNA-NEAT has not been thoroughly investigated in melanoma cancer. The purposes of this study ...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0927-6

    authors： Ding F,Lai J,Gao Y,Wang G,Shang J,Zhang D,Zheng S

    更新日期：2019-08-22 00:00:00

  • Ultraviolet-A radiation induces changes in cyclin G gene expression in mouse melanoma B16-F1 cells.

    abstract：BACKGROUND:We have previously shown that ultraviolet-A (UVA) radiation enhances metastatic lung colonization capacity of B16-F1 melanoma cells. The aim of this study was to examine changes in expression profile of genes in mouse melanoma B16-F1 cells exposed to UVA radiation. RESULTS:B16-F1 melanoma cells were exposed...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/1475-2867-7-7

    authors： Pastila R,Leszczynski D

    更新日期：2007-05-02 00:00:00

  • TP53 mutant cell lines selected for resistance to MDM2 inhibitors retain growth inhibition by MAPK pathway inhibitors but a reduced apoptotic response.

    abstract：Background:Emergence of resistance to molecular targeted therapy constitutes a limitation to clinical benefits in cancer treatment. Cross-resistance commonly happens with chemotherapeutic agents but might not with targeted agents. Methods:In the current study, TP53 wild-type cell lines with druggable MAPK pathway muta...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-019-0768-3

    authors： Wu CE,Koay TS,Ho YH,Lovat P,Lunec J

    更新日期：2019-03-07 00:00:00

  • YY1-induced lncRNA ZFPM2-AS1 facilitates cell proliferation and invasion in small cell lung cancer via upregulating of TRAF4.

    abstract：Background:Newly identified lncRNA zinc finger protein, FOG family member 2 antisense RNA 1 (ZFPM2-AS1) is identified as an oncogenic gene. However, the role of ZFPM2-AS1 in small cell lung cancer (SCLC) is poorly comprehended. Methods:The expression of genes in SCLC tissues and cells was measured by qRT-PCR. Colony f...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-1157-7

    authors： Yan Z,Yang Q,Xue M,Wang S,Hong W,Gao X

    更新日期：2020-04-03 00:00:00

  • LBX2-AS1 up-regulated by NFIC boosts cell proliferation, migration and invasion in gastric cancer through targeting miR-491-5p/ZNF703.

    abstract：Background:The crucial role of long non-coding RNAs (lncRNAs) has been certified in human cancers. The lncRNAs with abnormal expressions could act as tumor inhibitors or oncogenes in the advancement of tumors. LBX2-AS1 was once reported to accelerate esophageal squamous cell carcinoma. Nonetheless, its function in gast...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01207-w

    authors： Xu G,Zhang Y,Li N,Wu Y,Zhang J,Xu R,Ming H

    更新日期：2020-04-26 00:00:00

  • Autophagy regulation using luteolin: new insight into its anti-tumor activity.

    abstract：:Application of novel methods in cancer therapy is important in terms of management and treatment of the life-threatening disorder. It appears that autophagy is a potential target in cancer therapy, as a variety of drugs targeting autophagy have shown great potential in reducing the viability and proliferation of cance...

    journal_title：Cancer cell international

    pub_type： 杂志文章,评审

    doi：10.1186/s12935-020-01634-9

    authors： Ashrafizadeh M,Ahmadi Z,Farkhondeh T,Samarghandian S

    更新日期：2020-11-04 00:00:00

  • Bioinformatics analysis combined with experiments to explore potential prognostic factors for pancreatic cancer.

    abstract：Background:Pancreatic cancer is a common malignant tumor of the digestive tract. It has a high degree of malignancy and poor prognosis. Finding effective molecular markers has great significance for pancreatic cancer diagnosis and treatment. This study aimed to investigate DLGAP5 expression in pancreatic cancer and exp...

    journal_title：Cancer cell international

    pub_type： 杂志文章

    doi：10.1186/s12935-020-01474-7

    authors： Ke MJ,Ji LD,Li YX

    更新日期：2020-08-08 00:00:00