HIF-2alpha downregulation in the absence of functional VHL is not sufficient for renal cell differentiation.

abstract：BACKGROUND:In vivo, the transforming growth factor-beta1 (TGF-β1)-induced epithelial to mesenchymal transition (EMT) occurs in seconds during cancer cells intravasation and extravasation. Although it has been established that cellular stiffness can change as a cancer cell transformed, the precise relationship between T...

journal_title：Cancer cell international

authors： Wu TH,Chou YW,Chiu PH,Tang MJ,Hu CW,Yeh ML

更新日期：2014-03-03 00:00:00

abstract：Background:Alternative splicing (AS) is a key factor in protein-coding gene diversity, and is associated with the development and progression of malignant tumours. However, the role of AS in cervical cancer is unclear. Methods:The AS data for cervical squamous cell carcinoma and endocervical adenocarcinoma (CESC) were...

journal_title：Cancer cell international

authors： Ouyang D,Yang P,Cai J,Sun S,Wang Z

更新日期：2020-06-08 00:00:00

abstract：BACKGROUND:Patients with dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine are resistant to chemotherapeutic treatment and external irradiation and thus are difficult to treat. Direct induction of apoptosis is a promising approach in these apoptosis-resistant tumor cells. The BH3 mimeti...

journal_title：Cancer cell international

authors： Broecker-Preuss M,Becher-Boveleth N,Müller S,Mann K

更新日期：2016-04-02 00:00:00

abstract：Background:Cutaneous melanoma is one of the most aggressive and lethal skin cancers. It is greatly important to identify prognostic biomarkers to guide the clinical management. However, it is technically challenging for untrained researchers to process high dimensional profiling data and identify potential prognostic g...

journal_title：Cancer cell international

authors： Zhang L,Wang Q,Wang L,Xie L,An Y,Zhang G,Zhu W,Li Y,Liu Z,Zhang X,Tang P,Huo X,Guo X

更新日期：2020-05-19 00:00:00

abstract：Background:Despite improvements in nasopharyngeal carcinoma (NPC) treatment, patients with recurrence and metastasis still have a poor prognosis. Thus, the identification of novel biomarkers is urgently needed to predict outcomes and tailor treatment for NPC. Methods:Four data sets were downloaded from Gene Expression...

journal_title：Cancer cell international

authors： Huang D,Liu Q,Zhang W,Huang C,Zheng R,Xie G,Wang H,Jia B,Shi J,Yuan Y,Deng M

更新日期：2020-10-12 00:00:00

abstract：BACKGROUND:Prostate cancer is a leading cause of male cancer specific mortality. When cure by radical prostatectomy is not possible the next line of prostate cancer treatment is androgen deprivation. However prolonged androgen deprivation often results in relapse and androgen-independent prostate cancer that is inevita...

journal_title：Cancer cell international

authors： Shaw G,Prowse DM

更新日期：2008-03-18 00:00:00

abstract：BACKGROUND:Epithelial mesenchymal transition (EMT) mediated by TGF-β pays an important role in malignant tumor acquired abilities of migration and invasion. Our previous study showed that the extract of Stellera chamaejasme L. (ESC) was against proliferation of a variety of tumor cells, but there were no studies in the...

journal_title：Cancer cell international

authors： Liu XN,Wang S,Yang Q,Wang YJ,Chen DX,Zhu XX

更新日期：2015-12-10 00:00:00

abstract：Background:Hepatocellular carcinoma (HCC) is one of the most common malignancies with a high morbidity and mortality worldwide. MicroRNAs are key regulators of HCC genesis. However, the regulatory role and underlying mechanisms of microRNA in HCC is still limited. Methods:Cyclin B1 (CCNB1) mRNA levels were examined in...

journal_title：Cancer cell international

authors： Gu J,Liu X,Li J,He Y

更新日期：2019-01-14 00:00:00

abstract：BACKGROUND:Endometrial cancer is an invasive gynecological cancer prevalent in the world. The pathogenesis of endometrial cancer is related to multiple levels of regulation, referring to oestrogen, tumor-suppressor gene (e.g. PTEN) or microRNAs (e.g. miR-23a and miR-29b). Metapristone is a hormone-related drug, which i...

journal_title：Cancer cell international

authors： Chang Y,Hao M,Jia R,Zhao Y,Cai Y,Liu Y

更新日期：2021-01-07 00:00:00

abstract：Background:Angiogenesis plays critical roles in the progression and metastasis of malignant tumors. Gastric neuroendocrine carcinoma is an uncommon stomach cancer that is rich in blood vessels and exhibits highly malignant biological behavior with a poor prognosis. The role of CDK5RAP3 in GNEC has not been reported to ...

journal_title：Cancer cell international

authors： Lin JX,Weng XF,Xie XS,Lian NZ,Qiu SL,Wang JB,Lu J,Chen QY,Cao LL,Lin M,Tu RH,Yang YH,Liu SJ,Hu M,Lin YK,Huang CM,Zheng CH,Li P,Xie JW

更新日期：2019-11-07 00:00:00

abstract：Background:Colorectal cancer (CRC) is considered as the second common death-induced cancer. More recently, association of long non-coding RNAs (lncRNAs) with CRC has been extensively investigated. Therefore, the present study was performed to determine whether lncRNA MAF BZIP Transcription Factor G Antisense RNA 1 (MAF...

journal_title：Cancer cell international

authors： Ruan Z,Deng H,Liang M,Xu Z,Lai M,Ren H,Deng X,Su X

更新日期：2020-10-19 00:00:00

abstract：BACKGROUND:Tumor tissue resembles chronically inflamed tissue. Since chronic inflammatory conditions are a strong stimulus for bone marrow-derived cells (BMDCs) it can be assumed that recruitment of BMDCs into cancer tissue should be a common phenomenon. Several data have outlined that BMDC can influence tumor growth a...

journal_title：Cancer cell international

authors： Nagler C,Hardt C,Zänker KS,Dittmar T

更新日期：2011-06-28 00:00:00

abstract：BACKGROUND:Avenanthramides (AVN) are a relatively unstudied family of phytochemicals that could be novel chemotherapeutics. These compounds, found in oats, are non-toxic to healthy cells and have been shown to reduce viability of human colon and liver cancers in vitro. However, these studies do not elucidate a molecula...

journal_title：Cancer cell international

authors： Hastings J,Kenealey J

更新日期：2017-10-18 00:00:00

abstract：BACKGROUND:Celecoxib is a selective cyclooxygenase (COX)-2 inhibitor that has been reported to reduce the risk of breast cancer. In our previous study, celecoxib induced apoptosis and caused cell cycle arrest at the G0/G1 phase in the breast cancer cell line MDA-MB-231, and its effects were mediated by downregulation o...

journal_title：Cancer cell international

authors： Wang L,Kang F,Li J,Zhang J,Shan B

更新日期：2013-02-12 00:00:00

abstract：BACKGROUND:Drug resistance is a major obstacle to successful chemotherapy for epithelial ovarian cancer (EOC). We found a subset of miRNAs associated with the response to first-line platinum-based chemotherapy in EOC by microarray, and miR-206 was one of the most significant miRNAs. The purposes of this study were to e...

journal_title：Cancer cell international

authors： Yu X,Zhang X,Wang G,Wang B,Ding Y,Zhao J,Liu H,Cui S

更新日期：2020-11-03 00:00:00

abstract：Background:Lung cancer is the most common malignant tumor in the world. The Whole-proteome microarray showed that ubiquitin ligase chromatin assembly factor 1 subunit B (CHAF1B) expression in A549/DDP cells is higher than in A549 cells. Our study explored the molecular mechanism of CHAF1B affecting cisplatin resistance...

journal_title：Cancer cell international

authors： Gong L,Hu Y,He D,Zhu Y,Xiang L,Xiao M,Bao Y,Liu X,Zeng Q,Liu J,Zhou M,Zhou Y,Cheng Y,Zhang Y,Deng L,Zhu R,Lan H,Cao K

更新日期：2020-05-25 00:00:00

abstract：UNLABELLED: BACKGROUND:Anticancer research resulted in the discovery of a promising antimitotic metabolite, 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate, a bis-sulphamoylated analogue exerts antiproliferative- and antimitotic activity. Investigating the anticancer potential of 2-methoxyestradiol-bis-sulphamat...

journal_title：Cancer cell international

authors： Visagie MH,Joubert AM

更新日期：2012-08-20 00:00:00

abstract：BACKGROUND:In this report the phytochemical profile of Nitraria. Retusa (N. Retusa) leaf extracts were identified and their ability to induce apoptosis in human chronic myelogenous erythroleukaemia (K562) was evaluated. METHODS:Apoptosis of the human chronic myelogenous erythroleukaemia (K562) was evidenced by investi...

journal_title：Cancer cell international

authors： Boubaker J,Bhouri W,Sghaier MB,Bouhlel I,Skandrani I,Ghedira K,Chekir-Ghedira L

更新日期：2011-10-31 00:00:00

abstract：Background:Pancreatic cancer (PC) remains one of the most aggressive cancers worldwide. However, genetic factors underlying PC susceptibility remain largely unclear. Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) acts as an oncogene and its genetic variation has been linked to many cancers. However, ...

journal_title：Cancer cell international

authors： Jiang D,Xu L,Ni J,Zhang J,Cai M,Shen L

更新日期：2019-02-28 00:00:00

abstract：Background:In addition to morphological and cytogenetic features, acute myeloid leukemias are characterized by mutations that can be used for target-therapy; also the minimal/measurable residual disease (MRD) could be an important prognostic factor. The purpose of this retrospective study was to investigate if somatic ...

journal_title：Cancer cell international

authors： Salehzadeh S,Guerrini F,Pizzano U,Grassi S,Ciabatti E,Iovino L,Buda G,Caracciolo F,Benedetti E,Orciuolo E,Pelosini M,Consani G,Carulli G,Metelli MR,Martini F,Mazziotta F,Mazzantini E,Rossi P,Tavarozzi R,Ricci F,Pe

更新日期：2019-04-04 00:00:00

abstract：Background:Angioimmunoblastic T cell lymphoma (AITL) is a distinct subtype of peripheral T cell lymphoma and associated with poor outcomes. The activation status of T cell receptor (TCR) signaling has recently become a focus of attention in terms of the therapeutic targets. However, the molecular pathogenesis mechanism...

journal_title：Cancer cell international

authors： Liu Y,Wang X,Deng L,Ping L,Shi Y,Zheng W,Lin N,Wang X,Tu M,Xie Y,Liu W,Ying Z,Zhang C,Pan Z,Wang X,Ding N,Song Y,Zhu J

更新日期：2019-02-14 00:00:00

abstract：Background:Schwannoma arising from peripheral nervous sheaths is a benign tumor. Methods:To evaluate cell cytotoxicity, (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction and terminal deoxynucleotidyltransferase UTP nick-end labeling (TUNEL) assays were used. A microRNA (miRNA) array ...

journal_title：Cancer cell international

authors： Sohn EJ,Bak KM,Nam YK,Park HT

更新日期：2018-12-04 00:00:00

abstract：Background:Many epidemiological studies have investigated association of AXIN2 variants on overall cancer risks; however, the available results remain inconsistent. Methods:An updated analysis was conducted to ascertain a more accurate estimation of the correlation between AXIN2 148 C/T, 1365 C/T, and rs4791171 A/G po...

journal_title：Cancer cell international

authors： Xu B,Yuan W,Shi L,Zuo L,Wu XY,Zhang W,Wen Q

更新日期：2019-05-06 00:00:00

abstract：Background:Dysregulation of lncRNAs is frequent in glioma and has emerged as an important mechanism involved in tumorigenesis. Previous analysis of Chinese Glioma Genome Atlas (CGGA) database indicated that LBX2-AS1 expression is one of differentially expression lncRNA between lower grade glioma (LGG) (grade II and III...

journal_title：Cancer cell international

authors： Chen Q,Gao J,Zhao Y,Hou R

更新日期：2020-08-26 00:00:00

abstract：Background:Gastric cancer (GC) is a common cause of cancer-related mortality worldwide, and microRNAs (miRNAs) have been shown to play an important role in GC development. This study aims to explore the effect of microRNA-93-5p (miR-93-5p) on the epithelial-mesenchymal transition (EMT) in GC, via AHNAK and the Wnt sign...

journal_title：Cancer cell international

authors： Shen E,Wang X,Liu X,Lv M,Zhang L,Zhu G,Sun Z

更新日期：2020-03-12 00:00:00

abstract：BACKGROUND:Recent studies have reported the involvement of microRNA-29 (miR-29) family members in human cancers through their ability to regulate cellular functions. The present study investigated biological function of miR-29b in colorectal cancer (CRC). METHODS:CRC tissues and adjacent normal tissues were collected ...

journal_title：Cancer cell international

authors： Leng Y,Chen Z,Ding H,Zhao X,Qin L,Pan Y

更新日期：2021-01-06 00:00:00

abstract：Background:Breast cancer has been the first death cause of cancer in women all over the world. Metastasis is believed to be the most important process for treating breast cancer. There is evidence that lncRNA MEG3 functions as a tumor suppressor in breast cancer metastasis. However, upstream regulation of MEG3 in breas...

journal_title：Cancer cell international

authors： Wang XX,Guo GC,Qian XK,Dou DW,Zhang Z,Xu XD,Duan X,Pei XH

更新日期：2018-10-25 00:00:00

abstract：BACKGROUND:Despite the modern therapies available for treating glioblastoma multiforme (GBM), it is still a deadly disease. The development of new therapeutic strategies for the management of gliomas is therefore crucial. The present study is designed to analyze the therapeutic potentials of synthetic compound N-(2-hyd...

journal_title：Cancer cell international

authors： Hanif F,Perveen K,Jawed H,Ahmed A,Malhi SM,Jamall S,Simjee SU

更新日期：2014-11-30 00:00:00

abstract：BACKGROUND:Alterations in the processing of the genetic information in carcinogenesis result from stable genetic mutations or epigenetic modifications. It is becoming clear that nucleosomal histones are central to proper gene expression and that aberrant DNA methylation of genes and histone methylation plays important ...

journal_title：Cancer cell international

authors： Watanabe H,Soejima K,Yasuda H,Kawada I,Nakachi I,Yoda S,Naoki K,Ishizaka A

更新日期：2008-11-03 00:00:00

abstract：BACKGROUND:miR-222 has been reported to be overexpressed in colorectal cancer and it influences cancer cell proliferation, drug resistance and metastasis. However, the underlying molecular mechanism of miR-222 in colorectal cancer cell invasion and migration has not been thoroughly elucidated to date. METHODS:The cell...

journal_title：Cancer cell international

authors： Gao H,Cong X,Zhou J,Guan M

更新日期：2017-08-29 00:00:00