Abstract：
Background:Pancreatic cancer (PC) remains one of the most aggressive cancers worldwide. However, genetic factors underlying PC susceptibility remain largely unclear. Long noncoding RNA (lncRNA) HOX transcript antisense RNA (HOTAIR) acts as an oncogene and its genetic variation has been linked to many cancers. However, the associations between genetic variants in HOTAIR gene and PC risk has not yet been reported. Methods:A two-stage, case-control study was conducted to investigate the associations between HOTAIR SNPs and the PC risk. Dual luciferase reporter assay and real-time -PCR (RT-PCR) was conducted to evaluate the potential regulatory function of HOTAIR rs4759314 and rs200349340. Results:We found the minor alleles of rs4759314 (OR = 1.76; 95 CI 1.37-2.25; P = 0.001) and rs200349340 (OR = 1.32; 95 CI 1.12-1.56; P = 0.001) were significantly associated with PC susceptibility. In functional experiments, we found subjects carrying the minor alleles of rs4759314 and rs200349340 had significantly higher HOTAIR RNA levels (mean ± SD) than those carrying the major alleles in PC tissues. For rs4759314, cells transfected with rs4759314 -G allele construct showed higher relative luciferase activity; while for rs200349340, cells transfected with rs200349340 -G allele construct showed more sensitive change of the relative luciferase activity. Conclusion:Our studies revealed that functional SNP rs4759314 and rs200349340 of HOTAIR had strong associations with PC susceptibility. These findings elucidate that functional genetic variants influencing lncRNA expression may explain a portion of PC genetic basis.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Jiang D,Xu L,Ni J,Zhang J,Cai M,Shen Ldoi
10.1186/s12935-019-0761-xsubject
Has Abstractpub_date
2019-02-28 00:00:00pages
47issn
1475-2867pii
761journal_volume
19pub_type
杂志文章abstract：Background:Estrogen sulfotransferase catalyzes conjugation of sulfuryl-group to estradiol/estrone and regulates E2 availability/activity via estrogen-receptor or non-receptor mediated pathways. Sulfoconjugated estrogen fails to bind estrogen-receptor (ER). High estrogen is a known carcinogen in postmenopausal women. Re...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-1153-y
更新日期：2020-03-04 00:00:00
abstract：Background:Schwannoma arising from peripheral nervous sheaths is a benign tumor. Methods:To evaluate cell cytotoxicity, (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction and terminal deoxynucleotidyltransferase UTP nick-end labeling (TUNEL) assays were used. A microRNA (miRNA) array ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-018-0693-x
更新日期：2018-12-04 00:00:00
abstract：OBJECTIVES:Bladder transitional cell carcinoma (TCC) is one of the most common solid malignancies in China. This study examined the antitumor effect and underlying mechanism of action of sunitinib malate in human bladder TCC in vitro. METHODS:Bladder TCC cell lines 5637 and BIU87 were maintained in 1640 medium and T24...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-015-0179-z
更新日期：2015-02-28 00:00:00
abstract：:[This corrects the article DOI: 10.1186/s12935-020-01426-1.]. ...
journal_title：Cancer cell international
pub_type： 已发布勘误
doi：10.1186/s12935-020-01482-7
更新日期：2020-08-18 00:00:00
abstract：Background:Neuroblastoma (NB) is the most common malignant tumor originating from the extracranial sympathetic nervous system in children. The molecular mechanisms underlying this disease are complex, and not completely understood. Methods:Quantitative real-time PCR (qRT-PCR) was applied to quantify the expression of ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-017-0499-2
更新日期：2018-01-04 00:00:00
abstract：BACKGROUND:Although recent studies have shown the utility of miR-203 as a cancer-relevant biomarker, the validated clinical significance of miR-203 in HCC remains obscure. The aim of the present study was to evaluate the relationship between miR-203 expression and clinicopathological features in HCC patients. METHODS:...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-015-0214-0
更新日期：2015-06-18 00:00:00
abstract：:BACKGROUND: The aim of this work was to investigate in vitro the putative role of EGR-1 in the growth of glioma cells. EGR-1 expression was examined during the early passages in vitro of 17 primary cell lines grown from 3 grade III and from 14 grade IV malignant astrocytoma explants. The explanted tumors were genetica...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-4-1
更新日期：2004-01-07 00:00:00
abstract：BACKGROUND:Drug resistance is a major obstacle to successful chemotherapy for epithelial ovarian cancer (EOC). We found a subset of miRNAs associated with the response to first-line platinum-based chemotherapy in EOC by microarray, and miR-206 was one of the most significant miRNAs. The purposes of this study were to e...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01623-y
更新日期：2020-11-03 00:00:00
abstract：:Application of novel methods in cancer therapy is important in terms of management and treatment of the life-threatening disorder. It appears that autophagy is a potential target in cancer therapy, as a variety of drugs targeting autophagy have shown great potential in reducing the viability and proliferation of cance...
journal_title：Cancer cell international
pub_type： 杂志文章,评审
doi：10.1186/s12935-020-01634-9
更新日期：2020-11-04 00:00:00
abstract：Background:Lung cancer is the most common malignant tumor in the world. The Whole-proteome microarray showed that ubiquitin ligase chromatin assembly factor 1 subunit B (CHAF1B) expression in A549/DDP cells is higher than in A549 cells. Our study explored the molecular mechanism of CHAF1B affecting cisplatin resistance...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01263-2
更新日期：2020-05-25 00:00:00
abstract：BACKGROUND:ErbB3-binding protein 1 (Ebp1) is a member of the PA2G4 family of proliferation-regulated proteins that is expressed in multiple malignant and non-malignant cells. ErbB3 and other members of the EGFR family have been implicated in cancer progression, it however remains unknown whether Ebp1 participate in pro...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-8-18
更新日期：2008-11-24 00:00:00
abstract：BACKGROUND:Mononuclear platinum anticancer agents hold a pivotal place in the treatment of many forms of cancers, however, there is a potential to improve response to evade resistance development and toxic side effects. BBR3464 is a promising trinuclear platinum anticancer agent, which is a polyamine mimic. The aim was...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-12-20
更新日期：2012-05-28 00:00:00
abstract：:[This retracts the article DOI: 10.1186/s12935-015-0237-6.]. ...
journal_title：Cancer cell international
pub_type： 撤回出版物
doi：10.1186/s12935-016-0359-5
更新日期：2016-11-04 00:00:00
abstract：Background:To investigate the expression of RASSF-1A in oral squamous cell carcinoma (OSCC) and adjacent tissues, and to explore its mechanism of action in the development of OSCC. Methods:RASSF-1A and proliferation-related protein expression in clinical and OSCC mouse models were detected by qPCR and western blot. In...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0932-9
更新日期：2019-08-13 00:00:00
abstract：BACKGROUND:Recent studies have reported the involvement of microRNA-29 (miR-29) family members in human cancers through their ability to regulate cellular functions. The present study investigated biological function of miR-29b in colorectal cancer (CRC). METHODS:CRC tissues and adjacent normal tissues were collected ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01700-2
更新日期：2021-01-06 00:00:00
abstract：:Circular RNAs (circRNAs) are small non-coding RNAs with a unique ring structure and play important roles as gene regulators. Disturbed expressions of circRNAs is closely related to varieties of pathological processes. The roles of circRNAs in cancers have gained increasing concerns. The communications between the canc...
journal_title：Cancer cell international
pub_type： 杂志文章,评审
doi：10.1186/s12935-020-01301-z
更新日期：2020-06-03 00:00:00
abstract：BACKGROUND:The expression of major histocompatibility complex class II (MHCII) antigens in both mouse and human tumors is rare, and these antigens are not easily inducible by IFN-gamma (IFNg). Since MHCII may play an important role in the development of host antitumor immune response, we explored the possibility of res...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-3-4
更新日期：2003-03-25 00:00:00
abstract：BACKGROUND:CircRNAs play crucial roles in multiple tumours. However, the functions of most circRNAs in cervical cancer remain unclear. METHODS:This study collected GSE113696 data from the GEO database to search for differentially expressed circRNAs in cervical cancer. Quantitative reverse transcription PCR was used to...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01736-4
更新日期：2021-01-07 00:00:00
abstract：BACKGROUND:SATB1 is a nuclear protein that has been recently reported to be a 'genome organizer' which delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. In this study, the level of mRNA expression of SATB1 a...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-9-18
更新日期：2009-07-30 00:00:00
abstract：BACKGROUND:Patients with dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine are resistant to chemotherapeutic treatment and external irradiation and thus are difficult to treat. Direct induction of apoptosis is a promising approach in these apoptosis-resistant tumor cells. The BH3 mimeti...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-016-0303-8
更新日期：2016-04-02 00:00:00
abstract：Background:Vaccinia viruses have emerged as attractive therapeutic candidates for cancer treatment due to their inherent ability of tumor tropism and oncolytic property. Cytosine deaminase (CD), which is derived from bacteria or yeast, can convert a relatively nontoxic prodrug 5-fluorocytosine (5-FC) into the active an...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01340-6
更新日期：2020-06-15 00:00:00
abstract：BACKGROUND:In past few years, long non-coding RNAs (lncRNAs) have been reported to play regulatory roles during cancer progression. LncRNA SNHG10 has been explored in several sorts of cancers. However, its detailed role and mechanism are still not well understood in glioma. METHODS:Expression levels of genes were eval...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01649-2
更新日期：2020-12-09 00:00:00
abstract：BACKGROUND:The incidence and mortalities from cancers remain on the rise worldwide. Despite significant efforts to discover and develop novel anticancer agents, many cancers remain in the unmet need category. As such, efforts to discover and develop new and more effective and less toxic agents against cancer remain a t...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-017-0404-z
更新日期：2017-03-07 00:00:00
abstract：:[This corrects the article DOI: 10.1186/s12935-019-0742-0.]. ...
journal_title：Cancer cell international
pub_type： 杂志文章,已发布勘误
doi：10.1186/s12935-019-0797-y
更新日期：2019-04-11 00:00:00
abstract：Background:Increasing evidences have underlined the importance of long non-coding RNAs (lncRNAs) in human malignancies. LINC00958 has been found involved in some cancers. However, the underlying mechanical performance of LINC00958 in lung adenocarcinoma (LAD) has not been explored yet. Methods:The expression of releva...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-1099-0
更新日期：2020-01-23 00:00:00
abstract：BACKGROUND:miR-222 has been reported to be overexpressed in colorectal cancer and it influences cancer cell proliferation, drug resistance and metastasis. However, the underlying molecular mechanism of miR-222 in colorectal cancer cell invasion and migration has not been thoroughly elucidated to date. METHODS:The cell...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-017-0447-1
更新日期：2017-08-29 00:00:00
abstract：BACKGROUND:G protein-coupled receptor family C group 5 member A (GPRC5A), a retinoic acid-inducible gene, is a lung tumor suppressor. Previously, we showed that repression of GPRC5A expression was associated with pathologic differentiation grade of oral squamous cell carcinomas (OSCC) and overexpression of GPRC5A gene ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-017-0406-x
更新日期：2017-03-02 00:00:00
abstract：Background:Breast cancer is the leading cause of oncological mortality among women. Efficient detection of cancer cells in an early stage and potent therapeutic agents targeting metastatic tumors are highly needed to improve survival rates. Emerging evidence indicates that lncRNAs (long noncoding RNAs) are critical reg...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-018-0638-4
更新日期：2018-09-18 00:00:00
abstract：Background:T-acute lymphoblastic leukemia (T-ALL) was a hematological malignancy characterized by the accumulation of immature T cells in bone marrow and peripheral blood. In this study, we tried to explore the physiological role of CD59 in T-ALL. Methods:In this study, we collected the bone marrow samples from 17 T-A...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-018-0714-9
更新日期：2019-01-08 00:00:00
abstract：Background:SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, over-expressed in human tumor tissues and embryonic cells. Evidences support its function in the cell cycle; however there is no clear mechanism explaining its function in cell proliferation regulation. Here we investigated cancer cell response t...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-018-0618-8
更新日期：2018-09-05 00:00:00
