Abstract:
Background:Schwannoma arising from peripheral nervous sheaths is a benign tumor. Methods:To evaluate cell cytotoxicity, (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) tetrazolium reduction and terminal deoxynucleotidyltransferase UTP nick-end labeling (TUNEL) assays were used. A microRNA (miRNA) array was used to identify the miRNAs involved in curcumin-induced apoptosis. To examine miRNA expression, quantitative RT-PCR was used. Results:In this study, curcumin exerted cellular cytotoxicity against RT4 schwannoma cells, with an increase in TUNEL-positive cells. Curcumin also activated the expression of apoptotic proteins, such as polyADP ribose polymerase, caspase-3, and caspase-9. The miRNA array revealed that seven miRNAs (miRNA 350, miRNA 17-2-3p, let 7e-3p, miRNA1224, miRNA 466b-1-3p, miRNA 18a-5p, and miRNA 322-5p) were downregulated following treatment with both 10 and 20 μM curcumin in RT4 cells, while four miRNAs (miRNA122-5p, miRNA 3473, miRNA182, and miRNA344a-3p) were upregulated. Interestingly, transfection with a miRNA 344a-3p mimic downregulated the mRNA expression of Bcl2 and upregulated that of Bax, Curcumin treatment in RT 4 cells also reduced the mRNA expression of Bcl2 and enhanced expression of Bax, Overexpression of miRNA344a-3p mimic combined with curcumin treatment activated the expression of apoptotic proteins, including procaspase-9 and cleaved caspase-3 while inhibition of miRNA 344a-3p using miR344a-3p inhibitor repressed cleaved caspase-3 and -9 in curcumin treated RT-4 cells compared to control. Conclusions:Our findings demonstrate that curcumin induces apoptosis in schwannoma cells via miRNA 344a-3p. Thus, curcumin may serve as a potent therapeutic agent for the treatment of schwannoma.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Sohn EJ,Bak KM,Nam YK,Park HTdoi
10.1186/s12935-018-0693-xsubject
Has Abstractpub_date
2018-12-04 00:00:00pages
199issn
1475-2867pii
693journal_volume
18pub_type
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-018-0716-7
更新日期:2018-12-22 00:00:00
abstract:Background:Long noncoding RNAs (lncRNAs) play essential roles in tumor progression. However, the functions and targets of lncRNAs in neuroblastoma (NB) progression still remain to be determined. In this study, we aimed to investigate the effect of lncRNA DLX6 antisense RNA 1 (DLX6-AS1) on NB and the underlying mechanis...
journal_title:Cancer cell international
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0759-4
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abstract::Application of novel methods in cancer therapy is important in terms of management and treatment of the life-threatening disorder. It appears that autophagy is a potential target in cancer therapy, as a variety of drugs targeting autophagy have shown great potential in reducing the viability and proliferation of cance...
journal_title:Cancer cell international
pub_type: 杂志文章,评审
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journal_title:Cancer cell international
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journal_title:Cancer cell international
pub_type: 杂志文章
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journal_title:Cancer cell international
pub_type: 杂志文章
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journal_title:Cancer cell international
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更新日期:2018-12-27 00:00:00
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doi:10.1186/s12935-020-01263-2
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pub_type: 杂志文章
doi:10.1186/s12935-018-0638-4
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journal_title:Cancer cell international
pub_type: 杂志文章
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更新日期:2019-09-11 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-019-0810-5
更新日期:2019-04-11 00:00:00
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pub_type: 杂志文章
doi:10.1186/s12935-015-0163-7
更新日期:2015-01-28 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2019-02-12 00:00:00
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pub_type: 杂志文章
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journal_title:Cancer cell international
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2020-11-13 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
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更新日期:2018-09-03 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-020-01591-3
更新日期:2020-10-07 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-015-0214-0
更新日期:2015-06-18 00:00:00
abstract:UNLABELLED: BACKGROUND:Anticancer research resulted in the discovery of a promising antimitotic metabolite, 2-methoxyestradiol. 2-Methoxyestradiol-bis-sulphamate, a bis-sulphamoylated analogue exerts antiproliferative- and antimitotic activity. Investigating the anticancer potential of 2-methoxyestradiol-bis-sulphamat...
journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/1475-2867-12-37
更新日期:2012-08-20 00:00:00
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pub_type: 杂志文章
doi:10.1186/1475-2867-11-35
更新日期:2011-10-28 00:00:00
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pub_type: 杂志文章
doi:10.1186/1475-2867-11-13
更新日期:2011-05-15 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章
doi:10.1186/s12935-017-0383-0
更新日期:2017-01-25 00:00:00
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journal_title:Cancer cell international
pub_type: 杂志文章,评审
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更新日期:2020-01-29 00:00:00