Abstract：
BACKGROUND:miR-222 has been reported to be overexpressed in colorectal cancer and it influences cancer cell proliferation, drug resistance and metastasis. However, the underlying molecular mechanism of miR-222 in colorectal cancer cell invasion and migration has not been thoroughly elucidated to date. METHODS:The cell cycle distribution and apoptosis were assessed by flow cytometry. Cell migration and invasion were analyzed by Transwell assays. The possible target gene of miR-222 was searched and identified by bioinformatics, dual luciferase reporter assay and western blot analysis. The siRNA method was used to confirm the function of the target gene. RESULTS:Overexpression of miR-222 effectively promotes migration and invasion of colorectal cancer (CRC) cells in vitro. Bioinformatics and the dual luciferase reporter assay revealed that miR-222 specifically targeted the 3'-UTR of melanoma inhibitory activity member 3 (MIA3), down-regulating its expression at the protein level. Inhibition of MIA3 by siRNA enhanced the migration and invasion of CRC cell lines. CONCLUSIONS:Our study showed that miR-222 enhances the migration and invasion in CRC cells, primarily by down-regulation of MIA3.
journal_name
Cancer Cell Intjournal_title
Cancer cell internationalauthors
Gao H,Cong X,Zhou J,Guan Mdoi
10.1186/s12935-017-0447-1subject
Has Abstractpub_date
2017-08-29 00:00:00pages
78issn
1475-2867pii
447journal_volume
17pub_type
杂志文章abstract：Background:In recent years, the B cell receptor (BCR) signaling pathway has become a "hot point" because it plays a critical role in B-cell proliferation and function. Bruton's tyrosine kinase (BTK) is overexpressed in many subtypes of B-cell lymphoma as a downstream kinase in the BCR signaling pathway. Ibrutinib, the ...
journal_title：Cancer cell international
pub_type： 杂志文章,评审
doi：10.1186/s12935-020-01518-y
更新日期：2020-09-29 00:00:00
abstract：BACKGROUND:Phenethyl isothiocyanate (PEITC), present naturally in cruciferous vegetables, is a chemopreventive agent. It blocks initiation and post-initiation progression of carcinogenesis. Mechanism study in human prostate cancer cells revealed that PEITC is a dual inhibitor of aberrant DNA hypermethylation and histon...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-14-30
更新日期：2014-03-31 00:00:00
abstract：BACKGROUND:Expression of P-glycoprotein (P-gp), the multidrug resistance (MDR) 1 gene product, can lead to multidrug resistance in tumours. However, the physiological role of P-gp in tumours growing as multicellular spheroids is not well understood. Recent evidence suggests that P-gp activity may be modulated by cellul...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-5-20
更新日期：2005-07-07 00:00:00
abstract：Background:Colorectal cancer (CRC) is one of the most common malignant tumors in the world. Siah E3 ubiquitin protein ligase 1 (Siah1) has been identified as a tumor suppressor gene and plays an important role in the development of malignant tumors. However, the potential role and molecular mechanism of Siah1 in the de...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-1124-3
更新日期：2020-02-13 00:00:00
abstract：BACKGROUND:Hepatocellular carcinoma is a common cancer, ranking third in cancer-associated deaths. An important cause of cancer patients' mortality is metastasis. At the start of metastasis progression, there is an epithelial-mesenchymal transition, characterized by matrix degradation, junction reductions and vessels f...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-016-0370-x
更新日期：2017-01-04 00:00:00
abstract：:[This corrects the article DOI: 10.1186/s12935-017-0407-9.]. ...
journal_title：Cancer cell international
pub_type： 已发布勘误
doi：10.1186/s12935-020-01375-9
更新日期：2020-07-17 00:00:00
abstract：:[This corrects the article DOI: 10.1186/s12935-020-01426-1.]. ...
journal_title：Cancer cell international
pub_type： 已发布勘误
doi：10.1186/s12935-020-01482-7
更新日期：2020-08-18 00:00:00
abstract：Background:Gastric cancer (GC) is a common cause of cancer-related mortality worldwide, and microRNAs (miRNAs) have been shown to play an important role in GC development. This study aims to explore the effect of microRNA-93-5p (miR-93-5p) on the epithelial-mesenchymal transition (EMT) in GC, via AHNAK and the Wnt sign...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-1092-7
更新日期：2020-03-12 00:00:00
abstract：BACKGROUND:Prostate cancer progression to androgen independence is the primary cause of mortality by this tumor type. The IGF-1/IGF-1R axis is well known to contribute to prostate cancer initiation, but its contribution to invasiveness and the downstream signalling mechanisms that are involved are unclear at present. ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-8-10
更新日期：2008-07-03 00:00:00
abstract：Background:Thyroid cancer is the most common type of endocrine malignancy and the incidence rate is rapidly increasing worldwide. Epigallocatechin-3-gallate (EGCG) could suppress cancer growth and induce apoptosis in many types of cancer cells. However, the mechanism of action of EGCG on the growth of human thyroid car...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0762-9
更新日期：2019-02-28 00:00:00
abstract：BACKGROUND:Germline mutations in the von Hippel-Lindau (VHL) tumor suppressor gene predispose individuals to clear cell renal carcinomas, hemangioblastomas, and pheochromocytomas. The VHL gene product forms an ubiquitin E3 ligase complex, with regulation of hypoxia-inducible factor alpha (HIF-α) as its best known funct...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-015-0175-3
更新日期：2015-02-22 00:00:00
abstract：BACKGROUND:Patients with dedifferentiated and anaplastic thyroid carcinomas that do not take up radioiodine are resistant to chemotherapeutic treatment and external irradiation and thus are difficult to treat. Direct induction of apoptosis is a promising approach in these apoptosis-resistant tumor cells. The BH3 mimeti...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-016-0303-8
更新日期：2016-04-02 00:00:00
abstract：Background:Many circRNAs have been reported to play important roles in cancer development and have the potential to serve as a novel class of biomarkers for clinical diagnosis. However, the role of circRNAs in esophageal carcinoma (EC) remains unclear. In the current study, we investigated the potential role of circPVT...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0985-9
更新日期：2019-10-15 00:00:00
abstract：Background:Some studies have investigated the prognostic value exhibited by the Prognostic Nutritional Index (PNI) in patients suffering diffuse large B-cell lymphoma (DLBCL), but varying results were obtained. In order to determine the specific prognostic value more accurately, a meta-analysis was conducted in this st...
journal_title：Cancer cell international
pub_type： 杂志文章,评审
doi：10.1186/s12935-020-01535-x
更新日期：2020-09-15 00:00:00
abstract：Background:At the present time, colorectal cancer (CRC) is still known as a disease with a high mortality rate. Theranostics are flawless scenarios that link diagnosis with therapy, including precision medicine as a critical platform that relies on the development of biomarkers particularly "liquid biopsy". Circulating...
journal_title：Cancer cell international
pub_type： 杂志文章,评审
doi：10.1186/s12935-020-01389-3
更新日期：2020-07-06 00:00:00
abstract：Background:MicroRNAs (miRNAs) play key roles in tumorigenesis and progression of gastric cancer (GC). miR-1269 has been reported to be upregulated in several cancers and plays a crucial role in carcinogenesis and cancer progression. However, the biological function of miR-1269 in human GC and its mechanism remain uncle...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-1026-4
更新日期：2019-11-21 00:00:00
abstract：Background:Neuroblastoma (NB) is the most common malignant tumor originating from the extracranial sympathetic nervous system in children. The molecular mechanisms underlying this disease are complex, and not completely understood. Methods:Quantitative real-time PCR (qRT-PCR) was applied to quantify the expression of ...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-017-0499-2
更新日期：2018-01-04 00:00:00
abstract：Background:To investigate the expression of RASSF-1A in oral squamous cell carcinoma (OSCC) and adjacent tissues, and to explore its mechanism of action in the development of OSCC. Methods:RASSF-1A and proliferation-related protein expression in clinical and OSCC mouse models were detected by qPCR and western blot. In...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0932-9
更新日期：2019-08-13 00:00:00
abstract：BACKGROUND:Although recent studies have shown the utility of miR-203 as a cancer-relevant biomarker, the validated clinical significance of miR-203 in HCC remains obscure. The aim of the present study was to evaluate the relationship between miR-203 expression and clinicopathological features in HCC patients. METHODS:...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-015-0214-0
更新日期：2015-06-18 00:00:00
abstract：OBJECTIVE:To explore the relationship between tumor necrosis factor receptor-associated factor 6 (TRAF6) and the clinicopathological features in HCC as well as its biological function. METHODS:Totally, 412 liver tissues were collected, including 171 hepatocellular carcinoma (HCC) and their corresponding non-tumor tiss...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-016-0352-z
更新日期：2016-09-29 00:00:00
abstract：BACKGROUND:Celecoxib is a selective cyclooxygenase (COX)-2 inhibitor that has been reported to reduce the risk of breast cancer. In our previous study, celecoxib induced apoptosis and caused cell cycle arrest at the G0/G1 phase in the breast cancer cell line MDA-MB-231, and its effects were mediated by downregulation o...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-13-14
更新日期：2013-02-12 00:00:00
abstract：Background:Cancer cell viability is strongly modulated by the Hippo pathway, which includes mammalian STE20-like protein kinase 1 (Mst1) and yes-associated protein (Yap). Although the roles of Mst1 and Yap in thyroid carcinoma cell death have been fully addressed, no study has determined whether differential modificati...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-019-0860-8
更新日期：2019-05-22 00:00:00
abstract：BACKGROUND:Gastric cancer is one of the common cancers seen in south India. Unfortunately more than 90% are advanced by the time they report to a tertiary centre in the country. There is an urgent need to characterize these cancers and try to identify potential biomarkers and novel therapeutic targets. MATERIALS AND M...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-10-45
更新日期：2010-11-24 00:00:00
abstract：:BACKGROUND: We describe an alternative method to determine mRNA half-life (t1/2) based on the Real-Time RT-PCR procedure. This approach was evaluated by using the beta-actin gene as a reference molecule for measuring of mRNA stability. RESULTS: Human leukemia Nalm-6 and CCRF-CEM cells were treated with various concent...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/1475-2867-2-1
更新日期：2002-03-07 00:00:00
abstract：:N6-methyl-adenosine(m6A) modification emerges as an abundant and dynamic regulation throughout the Eukaryotic transcriptome. Dysregulation of the m6A regulators has increasingly been found in many neoplasms. It is reasonable to believe that m6A changes the fate of cancer cells and subsequently affected all aspects of ...
journal_title：Cancer cell international
pub_type： 杂志文章,评审
doi：10.1186/s12935-020-01445-y
更新日期：2020-07-29 00:00:00
abstract：BACKGROUND:CD44 has been reported to be involved with tumor growth and metastasis and has also been implicated as a CSC marker in hepatocellular carcinoma (HCC). However, the prognostic value of CD44 still remains controversial; hence, we investigated the correlation between CD44 and the clinicopathological features of...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-016-0325-2
更新日期：2016-06-17 00:00:00
abstract：Background:SOX2 overlapping transcript (SOX2OT) is a long non-coding RNA, over-expressed in human tumor tissues and embryonic cells. Evidences support its function in the cell cycle; however there is no clear mechanism explaining its function in cell proliferation regulation. Here we investigated cancer cell response t...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-018-0618-8
更新日期：2018-09-05 00:00:00
abstract：:[This retracts the article DOI: 10.1186/s12935-015-0237-6.]. ...
journal_title：Cancer cell international
pub_type： 撤回出版物
doi：10.1186/s12935-016-0359-5
更新日期：2016-11-04 00:00:00
abstract：:Pancreatic cancer is one of the leading causes of cancer-related deaths worldwide and is characterized by highly hypoxic tumor microenvironment. Hypoxia-inducible factor-1 alpha (HIF-1α) is a major regulator of cellular response to changes in oxygen concentration, supporting the adaptation of tumor cells to hypoxia in...
journal_title：Cancer cell international
pub_type： 杂志文章,评审
doi：10.1186/s12935-020-01370-0
更新日期：2020-06-24 00:00:00
abstract：Background:Pancreatic cancer is a common malignant tumor of the digestive tract. It has a high degree of malignancy and poor prognosis. Finding effective molecular markers has great significance for pancreatic cancer diagnosis and treatment. This study aimed to investigate DLGAP5 expression in pancreatic cancer and exp...
journal_title：Cancer cell international
pub_type： 杂志文章
doi：10.1186/s12935-020-01474-7
更新日期：2020-08-08 00:00:00
